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Corn grown on dredged sediments alters rat behavior in the elevated plus maze via the gut mycobiome

Abstract

The use of marginal lands for growing food has increased worldwide. Many of these lands are supplemented with soil amendments to enhance their productivity, but they may also introduce contaminants depending on their origin. The use of sediments dredged from commercial waterways as a soil amendment has increased in recent years. However, there is significant concern regarding their potential to negatively affect public health by transferring contaminants, like metals, to the food supply. This study examined the behavior, microbiome and physiology of rats fed corn grown on dredged sediments with rats fed commercial feed corn and related those metrics to kernel metal content. Metal content did not differ between kernels grown on dredged sediments and feed corn for most metals except iron which was greater in commercial feed corn. Although there is some variability by animal response, animals fed corn grown on dredged sediments had a gut microbial community that generally promoted anxiety-like behavior while animals fed feed corn had a gut microbial community that promoted a more typical response. These findings suggest the effect of corn grown on dredged sediments on public health is complex and highlights the need for further investigation.

Acknowledgements

The research team would like to thank Sandra Kosek-Sills and Lynn Garrity at the Ohio Lake Erie Commission, who coordinated this project. Joe Cappel at the Toledo Port Authority provided access to the GLDMCI. We would also like to thank Wright State undergraduates Emily Kahlert, Lea Kelty, Sarah Krafcik, Mike McKean, and Taylor Ross helped with data collection in the field and laboratory and Bowling Green State University’s Animal Husbandry Technicians for daily care of experimental animals.

Funding

This research was financially supported by the Ohio Lake Erie Commission – Lake Erie Protection Fund (Grant No. SG 540–2019) to MAR and LMS and start-up funds and an internal grant from BGSU to LMS and JW.

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Megan A. Rúa.

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This manuscript has been authored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-access-plan).

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Rúa, M.A., Flanigan, K.A., Julian, A.N. et al. Corn grown on dredged sediments alters rat behavior in the elevated plus maze via the gut mycobiome.
Sci Rep (2026). https://doi.org/10.1038/s41598-026-67211-8

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  • DOI: https://doi.org/10.1038/s41598-026-67211-8

Keywords

  • Metals
  • Neurotoxicity
  • Open field
  • Soil amendment

  • Zea mays


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