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    Study measures the psychological toll of wildfires

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    Wildfires in Southeast Asia significantly affect peoples’ moods, especially if the fires originate outside a person’s own country, according to a new study.

    The study, which measures sentiment by analyzing large amounts of social media data, helps show the psychological toll of wildfires that result in substantial air pollution, at a time when such fires are becoming a high-profile marker of climate change.  

    “It has a substantial negative impact on people’s subjective well-being,” says Siqi Zheng, an MIT professor and co-author of a new paper detailing the results. “This is a big effect.”

    The magnitude of the effect is about the same as another shift uncovered through large-scale studies of sentiment expressed online: When the weekend ends and the work week starts, people’s online postings reflect a sharp drop in mood. The new study finds that daily exposure to typical wildfire smoke levels in the region produces an equivalently large change in sentiment.

    “People feel anxious or sad when they have to go to work on Monday, and what we find with the fires is that this is, in fact, comparable to a Sunday-to-Monday sentiment drop,” says co-author Rui Du, a former MIT postdoct who is now an economist at Oklahoma State University.

    The paper, “Transboundary Vegetation Fire Smoke and Expressed Sentiment: Evidence from Twitter,” has been published online in the Journal of Environmental Economics and Management.

    The authors are Zheng, who is the STL Champion Professor of Urban and Real Estate Sustainability in the Center for Real Estate and the Department of Urban Studies and Planning at MIT; Du, an assistant professor of economics at Oklahoma State University’s Spears School of Business; Ajkel Mino, of the Department of Data Science and Knowledge Engineering at Maastricht University; and Jianghao Wang, of the Institute of Geographic Sciences and Natural Resources Research at the Chinese Academy of Sciences.

    The research is based on an examination of the events of 2019 in Southeast Asia, in which a huge series of Indonesian wildfires, seemingly related to climate change and deforestation for the palm oil industry, produced a massive amount of haze in the region. The air-quality problems affected seven countries: Brunei, Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam.

    To conduct the study, the scholars produced a large-scale analysis of postings from 2019 on X (formerly known as Twitter) to sample public sentiment. The study involved 1,270,927 tweets from 378,300 users who agreed to have their locations made available. The researchers compiled the data with a web crawler program and multilingual natural language processing applications that review the content of tweets and rate them in affective terms based on the vocabulary used. They also used satellite data from NASA and NOAA to create a map of wildfires and haze over time, linking that to the social media data.

    Using this method creates an advantage that regular public-opinion polling does not have: It creates a measurement of mood that is effectively a real-time metric rather than an after-the-fact assessment. Moreover, substantial wind shifts in the region at the time in 2019 essentially randomize which countries were exposed to more haze at various points, making the results less likely to be influenced by other factors.

    The researchers also made a point to disentangle the sentiment change due to wildfire smoke and that due to other factors. After all, people experience mood changes all the time from various natural and socioeconomic events. Wildfires may be correlated with some of them, which makes it hard to tease out the singular effect of the smoke. By comparing only the difference in exposure to wildfire smoke, blown in by wind, within the same locations over time, this study is able to isolate the impact of local wildfire haze on mood, filtering out nonpollution influences.

    “What we are seeing from our estimates is really just the pure causal effect of the transboundary wildfire smoke,” Du says.

    The study also revealed that people living near international borders are much more likely to be upset when affected by wildfire smoke that comes from a neighboring country. When similar conditions originate in their own country, there is a considerably more muted reaction.

    “Notably, individuals do not seem to respond to domestically produced fire plumes,” the authors write in the paper. The small size of many countries in the region, coupled with a fire-prone climate, make this an ongoing source of concern, however.

    “In Southeast Asia this is really a big problem, with small countries clustered together,” Zheng observes.

    Zheng also co-authored a 2022 study using a related methodology to study the impact of the Covid-19 pandemic on the moods of residents in about 100 countries. In that case, the research showed that the global pandemic depressed sentiment about 4.7 times as much as the normal Sunday-to-Monday shift.

    “There was a huge toll of Covid on people’s sentiment, and while the impact of the wildfires was about one-fifth of Covid, that’s still quite large,” Du says.

    In policy terms, Zheng suggests that the global implications of cross-border smoke pollution could give countries a shared incentive to cooperate further. If one country’s fires become another country’s problem, they may all have reason to limit them. Scientists warn of a rising number of wildfires globally, fueled by climate change conditions in which more fires can proliferate, posing a persistent threat across societies.

    “If they don’t work on this collaboratively, it could be damaging to everyone,” Zheng says.

    The research at MIT was supported, in part, by the MIT Sustainable Urbanization Lab. Jianghao Wang was supported by the National Natural Science Foundation of China. More

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      MIT engineering students take on the heat of Miami

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      Think back to the last time you had to wait for a bus. How miserable were you? If you were in Boston, your experience might have included punishing wind and icy sleet — or, more recently, a punch of pollen straight to the sinuses. But in Florida’s Miami-Dade County, where the effects of climate change are both drastic and intensifying, commuters have to contend with an entirely different set of challenges: blistering temperatures and scorching humidity, making long stints waiting in the sun nearly unbearable.

      One of Miami’s most urgent transportation needs is shared by car-clogged Boston: coaxing citizens to use the municipal bus network, rather than the emissions-heavy individual vehicles currently contributing to climate change. But buses can be a tough sell in a sunny city where humidity hovers between 60 and 80 percent year-round. 

      Enter MIT’s Department of Electrical Engineering and Computer Science (EECS) and the MIT Priscilla King Gray (PKG) Public Service Center. The result of close collaboration between the two organizations, class 6.900 (Engineering For Impact) challenges EECS students to apply their engineering savvy to real-world problems beyond the MIT campus.

      This spring semester, the real-world problem was heat. 

      Miami-Dade County Department of Transportation and Public Works Chief Innovation Officer Carlos Cruz-Casas explains: “We often talk about the city we want to live in, about how the proper mix of public transportation, on-demand transit, and other mobility solutions, such as e-bikes and e-scooters, could help our community live a car-light life. However, none of this will be achievable if the riders are not comfortable when doing so.” 

      “When people think of South Florida and climate change, they often think of sea level rise,” says Juan Felipe Visser, deputy director of equity and engagement within the Office of the Mayor in Miami-Dade. “But heat really is the silent killer. So the focus of this class, on heat at bus stops, is very apt.” With little tree cover to give relief at some of the hottest stops, Miami-Dade commuters cluster in tiny patches of shade behind bus stops, sometimes giving up when the heat becomes unbearable. 

      A more conventional electrical engineering course might use temperature monitoring as an abstract example, building sample monitors in isolation and grading them as a merely academic exercise. But Professor Joel Volman, EECS faculty head of electrical engineering, and Joe Steinmeyer, senior lecturer in EECS, had something more impactful in mind.

      “Miami-Dade has a large population of people who are living in poverty, undocumented, or who are otherwise marginalized,” says Voldman. “Waiting, sometimes for a very long time, in scorching heat for the bus is just one aspect of how a city population can be underserved, but by measuring patterns in how many people are waiting for a bus, how long they wait, and in what conditions, we can begin to see where services are not keeping up with demand.”

      Only after that gap is quantified can the work of city and transportation planners begin, Cruz-Casas explains: “We needed to quantify the time riders are exposed to extreme heat and prioritize improvements, including on-time performance improvements, increasing service frequency, or looking to enhance the tree canopy near the bus stop.” 

      Quantifying that time — and the subjective experience of the wait — proved tricky, however. With over 7,500 bus stops along 101 bus routes, Miami-Dade’s transportation network presents a considerable data-collection challenge. A network of physical temperature monitors could be useful, but only if it were carefully calibrated to meet the budgetary, environmental, privacy, and implementation requirements of the city. But how do you work with city officials — not to mention all of bus-riding Miami — from over 2,000 miles away? 

      This is where the PKG Center comes in. “We are a hub and a connector and facilitator of best practices,” explains Jill Bassett, associate dean and director of the center, who worked with Voldman and Steinmeyer to find a municipal partner organization for the course. “We bring knowledge of current pedagogy around community-engaged learning, which includes: help with framing a partnership that centers community-identified concerns and is mutually beneficial; identifying and learning from a community partner; talking through ways to build in opportunities for student learners to reflect on power dynamics, reciprocity, systems thinking, long-term planning, continuity, ethics, all the types of things that come up with this kind of shared project.”

      Through a series of brainstorming conversations, Bassett helped Voldman and Steinmeyer structure a well-defined project plan, as Cruz-Casas weighed in on the county’s needed technical specifications (including affordability, privacy protection, and implementability).

      “This course brings together a lot of subject area experts,” says Voldman. “We brought in guest lecturers, including Abby Berenson from the Sloan Leadership Center, to talk about working in teams; engineers from BOSE to talk about product design, certification, and environmental resistance; the co-founder and head of engineering from MIT spinout Butlr to talk about their low-power occupancy sensor; Tony Hu from MIT IDM [Integrated Design and Management] to talk about industrial design; and Katrina LaCurts from EECS to talk about communications and networking.”

      With the support of two generous donations and a gift of software from Altium, 6.900 developed into a hands-on exercise in hardware/software product development with a tangible goal in sight: build a better bus monitor.

      The challenges involved in this undertaking became apparent as soon as the 6.900 students began designing their monitors. “The most challenging requirement to meet was that the monitor be able to count how many people were waiting — and for how long they’d been standing there — while still maintaining privacy,” says Fabian Velazquez ’23 a recent EECS graduate. The task was complicated by commuters’ natural tendency to stand where the shade goes — whether beneath a tree or awning or snaking against a nearby wall in a line — rather than directly next to the bus sign or inside the bus shelter. “Accurately measuring people count with a camera — the most straightforward choice — is already quite difficult since you have to incorporate machine learning to identify which objects in frame are people. Maintaining privacy added an extra layer of constraint … since there is no guarantee the collected data wouldn’t be vulnerable.”

      As the groups weighed various privacy-preserving options, including lidar, radar, and thermal imaging, the class realized that Wi-Fi “sniffers,” which count the number of Wi-Fi enabled signals in the immediate area, were their best option to count waiting passengers. “We were all excited and ready for this amazing, answer-to-all-our-problems radar sensor to count people,” says Velasquez. “That component was extremely complex, however, and the complexity would have ultimately made my team use a lot of time and resources to integrate with our system. We also had a short time-to-market for this system we developed. We made the trade-off of complexity for robustness.” 

      The weather also posed its own set of challenges. “Environmental conditions were big factors on the structure and design of our devices,” says Yong Yan (Crystal) Liang, a rising junior majoring in EECS. “We incorporated humidity and temperature sensors into our data to show the weather at individual stops. Additionally, we also considered how our enclosure may be affected by extreme heat or potential hurricanes.”

      The heat variable proved problematic in multiple ways. “People detection was especially difficult, for in the Miami heat, thermal cameras may not be able to distinguish human body temperature from the surrounding air temperature, and the glare of the sun off of other surfaces in the area makes most forms of imaging very buggy,” says Katherine Mohr ’23. “My team had considered using mmWave sensors to get around these constraints, but we found the processing to be too difficult, and (like the rest of the class), we decided to only move forward with Wi-Fi/BLE [Bluetooth Low Energy] sniffers.”

      The most valuable component of the new class may well have been the students’ exposure to real-world hardware/software engineering product development, where limitations on time and budget always exist, and where client requests must be carefully considered.  “Having an actual client to work with forced us to learn how to turn their wants into more specific technical specifications,” says Mohr. “We chose deliverables each week to complete by Friday, prioritizing tasks which would get us to a minimum viable product, as well as tasks that would require extra manufacturing time, like designing the printed-circuit board and enclosure.”

      Play video

      Joel Voldman, who co-designed 6.900 (Engineering For Impact) with Joe Steinmeyer and MIT’s Priscilla King Gray (PKG) Public Service Center, describes how the course allowed students help develop systems for the public good. Voldman is the winner of the 2023 Teaching with Digital Technology Award, which is co-sponsored by MIT Open Learning and the Office of the Vice Chancellor. Video: MIT Open Learning

      Crystal Liang counted her conversations with city representatives as among her most valuable 6.900 experiences. “We generated a lot of questions and were able to communicate with the community leaders of this project from Miami-Dade, who made time to answer all of them and gave us ideas from the goals they were trying to achieve,” she reports. “This project gave me a new perspective on problem-solving because it taught me to see things from the community members’ point of view.” Some of those community leaders, including Marta Viciedo, co-founder of Transit Alliance Miami, joined the class’s final session on May 16 to review the students’ proposed solutions. 

      The students’ thoughtful approach paid off when it was time to present the heat monitors to the class’s client. In a group conference call with Miami-Dade officials toward the end of the semester, the student teams shared their findings and the prototypes they’d created, along with videos of the devices at work. Juan Felipe Visser was among those in attendance. “This is a lot of work,” he told the students following their presentation. “So first of all, thank you for doing that, and for presenting to us. I love the concept. I took the bus this morning, as I do every morning, and was battered by the sun and the heat. So I personally appreciated the focus.” 

      Cruz-Casas agreed: “I am pleasantly surprised by the diverse approach the students are taking. We presented a challenge, and they have responded to it and managed to think beyond the problem at hand. I’m very optimistic about how the outcomes of this project will have a long-lasting impact for our community. At a minimum, I’m thinking that the more awareness we raise about this topic, the more opportunities we have to have the brightest minds seeking for a solution.”

      The creators of 6.900 agree, and hope that their class helps more MIT engineers to broaden their perspective on the meaning and application of their work. 

      “We are really excited about students applying their skills within a real-world, complex environment that will impact real people,” says Bassett. “We are excited that they are learning that it’s not just the design of technology that matters, but that climate; environment and built environment; and issues around socioeconomics, race, and equity, all come into play. There are layers and layers to the creation and deployment of technology in a demographically diverse multilingual community that is at the epicenter of climate change.” More

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      in Environment

      Volunteer committee helps the MIT community live and work sustainably

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      April 22 marks the arrival of Earth Day, which provides all of us with a good reason to think of ways to live more sustainably. For more than 20 years, the MIT Working Green Committee has helped community members do just that by encouraging the reuse and recycling of possessions.

      Made up entirely of volunteers, the committee has played an important role in promoting more sustainable operations at MIT and raising awareness of the importance of conservation.

      “We try to provide a place for people to learn how to live and work in a more environmentally friendly way,” says committee co-chair Rebecca Fowler, a senior administrative assistant in MIT’s Office of Sustainability.

      The committee hosts regular Choose to Reuse events to give MIT’s community members a chance to donate unwanted items — or find free things that just might become prized possessions. It also provides resources to help host more sustainable events, make more sustainable purchasing decisions, and learn more about recycling.

      “The recycling industry is very frustrating, so people are always asking what to do,” Fowler says. “They feel like they make the wrong decisions and just want to know how to do it. We get a lot of questions, and we’re always there to help find answers.”

      Committee members say they’ve realized devoting a little time each month to things like recycling education, and hosting events can make a big difference in reducing waste. In last month’s Choose to Reuse event, more than 100 people dropped off thousands of items including clothing, housewares, and office supplies. MIT’s always-active Reuse email lists, which the committee encourages community members to join, are another great way to pass gently used items to others who can give them new life.

      “The goal is to keep things out of landfills, and the Choose to Reuse event shows you immediate results,” says committee co-chair Gianna Hernandez-Figueroa, who is the assistant to the director at the MIT AgeLab. “It’s inspiring because people are excited to put things in the hands of someone who is going to repurpose it. It’s a circular event that’s really beautiful.”

      Choose to Reuse events are typically on the third Thursday of every other month, although the next one — the last for the spring semester — is on Monday, April 24.

      The committee is one of the only groups on campus run by support staff, whose responsibilities involve clerical duties, data processing, and library and accounting functions, among other things. It is a subcommittee of the Working Group for Support Staff.

      The committee began as the Working Group on Recycling in 2000 at a time when MIT’s recycling rate was around 11 percent. By 2006, MIT had reached a 40 percent recycling rate and received a Go Green Award from the City of Cambridge. That year the committee earned an MIT Excellence Awards for its work.

      Around 2011, the group started hosting Choose to Reuse events, which became an instant success.

      “I really believe in the gift economy, specifically in academic settings where you have a lot of international students,” Hernandez-Figueroa says. “Plus, Boston is an expensive city!”

      For a long time, the group was run by Ruth Davis, who served as MIT’s manager for recycling and materials management and retired last year. Since Davis left, others have stepped up.

      “A lot of the volunteers have been around since the first Choose to Reuse event 13 years ago,” Fowler says, adding that the committee is always looking for more volunteers. “They’re all very committed to the event and to the cause.”

      The organization is also a way for support staff to gain new skills. Fowler credits her experience working on the committee with improving her project management and website design abilities.

      “We really emphasize capacity building,” Fowler says. “If there’s a skill a volunteer would like to develop, we can explore ways to do that through the committee. That’s something I’d like to continue: finding people’s strengths and helping them build their careers.”

      Overall, Fowler says the committee aligns with MIT’s commitment to make an impact.

      The group’s long history “shows a commitment to environmentalism and sustainability and a yearning to do more beyond what is in your job responsibilities,” she says. “It really shows the commitment to volunteerism of MIT’s staff members.” More

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      in Environment

      Study: Extreme heat is changing habits of daily life

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      Extreme temperatures make people less likely to pursue outdoor activities they would otherwise make part of their daily routine, a new study led by MIT researchers has confirmed.

      The data-rich study, set in China, shows that when hourly temperatures reach 30 degrees Celsius (86 degrees Fahrenheit), people are 5 percent less likely to go to public parks, and when hourly temperatures hit 35 C (95 F), people are 13 percent less likely to go to those parks.

      “We did observe adaptation,” says Siqi Zheng, an MIT professor and co-author of a new paper detailing the study’s findings. She adds: “Environmental hazards hurt the daily quality of life. Yes, people protect themselves [by limiting activity], but they lose the benefit of going out to enjoy themselves in nature, or meeting friends in parks.”

      The research adds to our knowledge about the effects of a warming climate by quantifying the effects of hot temperatures on the activity of people within a given day — how they shift their activities from hotter to cooler time periods — and not just across longer periods of time.

      “We found that if we take into account this within-day adaptation, extreme temperatures actually have a much larger effect on human activity than the previous daily or monthly estimations [indicate],” says Yichun Fan, an MIT doctoral candidate and another of the paper’s co-authors.

      The paper, “Intraday Adaptation to Extreme Temperatures in Outdoor Activity,” is published this week in Nature Scientific Reports. The authors are Fan, a doctoral student in MIT’s Department of Urban Studies and Planning (DUSP); Jianghao Wang, a professor at the Chinese Academy of Sciences; Nick Obradovich, chief scientist at Project Regeneration; and Zheng, who is the STL Champion Professor of Urban and Real Estate Sustainability at MIT’s Center for Real Estate and DUSP, and faculty director of the MIT Center for Real Estate.

      To conduct the study, the researchers used anonymized data for 900 million cellphone users in China in 2017, studying a total of 60 billion separate cellphone location queries per day available through the technology firm Tencent. With this data, the scholars also examined activity in 10,499 parks across the country, comparing useage totals across a range of conditions. And they obtained temperature data from about 2,000 weather stations in China.

      Ultimately, as the scholars write in the paper, they were able to “document large and significant activity-depressing and activity-delaying effects” on park visits as a result of ultrahot temperatures.

      “People have intraday adaptation patterns that hadn’t been documented in the previous literature,” Fan says. “These have important implications about people’s heat exposure and how future climate change will affect people’s activity and health.”

      As Zheng points out, altered use of public spaces affects daily routines not only in terms of individual activity and exercise, but also in terms of social and community life.

      “Extreme climates will reduce people’s opportunities to socialize in cities, or just watch kids playing basketball or soccer, which is not good,” she says. “We want people to have a wide-ranging urban life. There is a social cost to this adaptation.”

      As the research indicates, people clearly adapt to temperature spikes. The data also show that evening use of parks increases on extremely hot days, but only after conditions have cooled down. While that seems like a beneficial adaptation to very hot weather, the scholars citing existing research suggest people may sleep less as a result of making this kind of change to their daily routines.

      “Adaptation also has its own cost,” Fan says. “People significantly increased their nighttime outdoor activity, which means they delayed their nighttime, which will have a significant health implication, when you consider the potential sleep disruption.”

      All told, the study provides data, and a method, for better characterizing the effects on climate change on human activity in detail.

      “If we have more and more granular data about future climate scenarios, they support better predictions about these scenarios, reflecting people’s dynamic behaviors, and the health implications,” says Fan, whose doctoral research incorporates this work and other related studies on climate and urban activity.

      The researchers also note that the research methods used in this study could be applied to additional future studies of many other aspects of urban life, including street-level retail activities, and other things with implications for economic activity, real estate, and urban planning.

      “This relates to many other issues,” Zheng says.

      Jianghao Wang received funding from the National Key Research and Development Program of China, the National Natural Science Foundation of China, and the Youth Innovation Promotion Association of the Chinese Academy of Sciences. More

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      in Security

      Scientists chart how exercise affects the body

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      Exercise is well-known to help people lose weight and avoid gaining it. However, identifying the cellular mechanisms that underlie this process has proven difficult because so many cells and tissues are involved.

      In a new study in mice that expands researchers’ understanding of how exercise and diet affect the body, MIT and Harvard Medical School researchers have mapped out many of the cells, genes, and cellular pathways that are modified by exercise or high-fat diet. The findings could offer potential targets for drugs that could help to enhance or mimic the benefits of exercise, the researchers say.

      “It is extremely important to understand the molecular mechanisms that are drivers of the beneficial effects of exercise and the detrimental effects of a high-fat diet, so that we can understand how we can intervene, and develop drugs that mimic the impact of exercise across multiple tissues,” says Manolis Kellis, a professor of computer science in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and a member of the Broad Institute of MIT and Harvard.

      The researchers studied mice with high-fat or normal diets, who were either sedentary or given the opportunity to exercise whenever they wanted. Using single-cell RNA sequencing, the researchers cataloged the responses of 53 types of cells found in skeletal muscle and two types of fatty tissue.

      “One of the general points that we found in our study, which is overwhelmingly clear, is how high-fat diets push all of these cells and systems in one way, and exercise seems to be pushing them nearly all in the opposite way,” Kellis says. “It says that exercise can really have a major effect throughout the body.”

      Kellis and Laurie Goodyear, a professor of medicine at Harvard Medical School and senior investigator at the Joslin Diabetes Center, are the senior authors of the study, which appears today in the journal Cell Metabolism. Jiekun Yang, a research scientist in MIT CSAIL; Maria Vamvini, an instructor of medicine at the Joslin Diabetes Center; and Pasquale Nigro, an instructor of medicine at the Joslin Diabetes Center, are the lead authors of the paper.

      The risks of obesity

      Obesity is a growing health problem around the world. In the United States, more than 40 percent of the population is considered obese, and nearly 75 percent is overweight. Being overweight is a risk factor for many diseases, including heart disease, cancer, Alzheimer’s disease, and even infectious diseases such as Covid-19.

      “Obesity, along with aging, is a global factor that contributes to every aspect of human health,” Kellis says.

      Several years ago, his lab performed a study on the FTO gene region, which has been strongly linked to obesity risk. In that 2015 study, the research team found that genes in this region control a pathway that prompts immature fat cells called progenitor adipocytes to either become fat-burning cells or fat-storing cells.

      That finding, which demonstrated a clear genetic component to obesity, motivated Kellis to begin looking at how exercise, a well-known behavioral intervention that can prevent obesity, might act on progenitor adipocytes at the cellular level.

      To explore that question, Kellis and his colleagues decided to perform single-cell RNA sequencing of three types of tissue — skeletal muscle, visceral white adipose tissue (found packed around internal organs, where it stores fat), and subcutaneous white adipose tissue (which is found under the skin and primarily burns fat).

      These tissues came from mice from four different experimental groups. For three weeks, two groups of mice were fed either a normal diet or a high-fat diet. For the next three weeks, each of those two groups were further divided into a sedentary group and an exercise group, which had continuous access to a treadmill.

      By analyzing tissues from those mice, the researchers were able to comprehensively catalog the genes that were activated or suppressed by exercise in 53 different cell types.

      The researchers found that in all three tissue types, mesenchymal stem cells (MSCs) appeared to control many of the diet and exercise-induced effects that they observed. MSCs are stem cells that can differentiate into other cell types, including fat cells and fibroblasts. In adipose tissue, the researchers found that a high-fat diet modulated MSCs’ capacity to differentiate into fat-storing cells, while exercise reversed this effect.

      In addition to promoting fat storage, the researchers found that a high-fat diet also stimulated MSCs to secrete factors that remodel the extracellular matrix (ECM) — a network of proteins and other molecules that surround and support cells and tissues in the body. This ECM remodeling helps provide structure for enlarged fat-storing cells and also creates a more inflammatory environment.

      “As the adipocytes become overloaded with lipids, there’s an extreme amount of stress, and that causes low-grade inflammation, which is systemic and preserved for a long time,” Kellis says. “That is one of the factors that is contributing to many of the adverse effects of obesity.”

      Circadian effects

      The researchers also found that high-fat diets and exercise had opposing effects on cellular pathways that control circadian rhythms — the 24-hour cycles that govern many functions, from sleep to body temperature, hormone release, and digestion. The study revealed that exercise boosts the expression of genes that regulate these rhythms, while a high-fat diet suppresses them.

      “There have been a lot of studies showing that when you eat during the day is extremely important in how you absorb the calories,” Kellis says. “The circadian rhythm connection is a very important one, and shows how obesity and exercise are in fact directly impacting that circadian rhythm in peripheral organs, which could act systemically on distal clocks and regulate stem cell functions and immunity.”

      The researchers then compared their results to a database of human genes that have been linked with metabolic traits. They found that two of the circadian rhythm genes they identified in this study, known as DBP and CDKN1A, have genetic variants that have been associated with a higher risk of obesity in humans.

      “These results help us see the translational values of these targets, and how we could potentially target specific biological processes in specific cell types,” Yang says.

      The researchers are now analyzing samples of small intestine, liver, and brain tissue from the mice in this study, to explore the effects of exercise and high-fat diets on those tissues. They are also conducting work with human volunteers to sample blood and biopsies and study similarities and differences between human and mouse physiology. They hope that their findings will help guide drug developers in designing drugs that might mimic some of the beneficial effects of exercise.

      “The message for everyone should be, eat a healthy diet and exercise if possible,” Kellis says. “For those for whom this is not possible, due to low access to healthy foods, or due to disabilities or other factors that prevent exercise, or simply lack of time to have a healthy diet or a healthy lifestyle, what this study says is that we now have a better handle on the pathways, the specific genes, and the specific molecular and cellular processes that we should be manipulating therapeutically.”

      The research was funded by the National Institutes of Health and the Novo Nordisk Research Center in Seattle. More

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      in Environment

      Divorce is more common in albatross couples with shy males, study finds

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      The wandering albatross is the poster bird for avian monogamy. The graceful glider is known to mate for life, partnering up with the same bird to breed, season after season, between long flights at sea.

      But on rare occasions, an albatross pair will “divorce” — a term ornithologists use for instances when one partner leaves the pair for another mate while the other partner remains in the flock. Divorce rates vary widely across the avian world, and the divorce rate for wandering albatrosses is relatively low.

      Nevertheless, the giant drifters can split up. Scientists at MIT and the Woods Hole Oceanographic Institution (WHOI) have found that, at least for one particular population of wandering albatross, whether a pair will divorce boils down to one important factor: personality. 

      In a study appearing today in the journal Biology Letters, the team reports that an albatross couple’s chance of divorce is highly influenced by the male partner’s “boldness.” The bolder and more aggressive the male, the more likely the pair is to stay together. The shyer the male, the higher the chance that the pair will divorce.

      The researchers say their study is the first to link personality and divorce in a wild animal species.

      “We thought that bold males, being more aggressive, would be more likely to divorce, because they would be more likely to take the risk of switching partners to improve future reproductive outcomes,” says study senior author Stephanie Jenouvrier, an associate scientist and seabird ecologist in WHOI’s FLEDGE Lab. “Instead we find the shy divorce more because they are more likely to be forced to divorce by a more competitive intruder. We expect personality may impact divorce rates in many species, but in different ways.”

      Lead author Ruijiao Sun, a graduate student in the MIT-WHOI Joint Program and MIT’s Department of Earth, Atmospheric and Planetary Sciences, says that this new evidence of a link between personality and divorce in the wandering albatross may help scientists predict the resilience of the population.

      “The wandering albatross is a vulnerable species,” Sun says. “Understanding the effect of personality on divorce is important because it can help researchers predict the consequences for population dynamics, and implement conservation efforts.”

      The study’s co-authors include Joanie Van de Walle of WHOI, Samantha Patrick of the University of Liverpool, and Christophe Barbraud, Henri Weimerskirch, and Karine Delord of CNRS- La Rochelle University in France.

      Repeat divorcées

      The new study concentrates on a population of wandering albatross that return regularly to Possession Island in the Southern Indian Ocean to breed. This population has been the focus of a long-term study dating back to the 1950s, in which researchers have been monitoring the birds each breeding season and recording the pairings and breakups of individuals through the years.

      This particular population is skewed toward more male individuals than females because the foraging grounds of female albatrosses overlap with fishing vessels, where they are more prone to being accidentally caught in fishing lines as bycatch.  

      In earlier research, Sun analyzed data from this long-term study and picked up a curious pattern: Those individuals that divorced were more likely to do so again and again.

      “Then we wanted to know, what drives divorce, and why are some individuals divorcing more often,” Jenouvrier says. “In humans, you see this repetitive divorce pattern as well, linked to personality. And the wandering albatross is one of the rare species for which we have both demographic and personality data.”

      That personality data comes from an ongoing study that began in 2008 and is led by co-author Patrick, who has been measuring the personality of individuals among the same population of wandering albatross on Possession Island. In the study of animal behavior, personality is defined as a consistent behavioral difference displayed by an individual. Biologists mainly measure personality in animals as a gradient between shy and bold, or less to more aggressive.

      In Patrick’s study, researchers have measured boldness in albatrosses by gauging a bird’s reaction to a human approaching its nest, from a distance of about 5 meters. A bird is assigned a score depending on how it reacts (a bird that does not respond scores a zero, being the most shy, while a bird that lifts its head, and even stands up, can score higher, being the most bold).

      Patrick has made multiple personality assessments of the same individuals over multiple years. Sun and Jenouvrier wondered: Could an individual’s personality have anything to do with their chance to divorce?

      “We had seen this repetitive divorce pattern, and then talked with Sam (Patrick) to see, could this be related to personality?” Sun recalls. “We know that personality predicts divorce in human beings, and it would be intuitive to make the link between personality and divorce in wild populations.”

      Shy birds

      In their new study, the team used data from both the demographic and personality studies to see whether any patterns between the two emerged. They applied a statistical model to both datasets, to test whether the personality of individuals in an albatross pair affected the fate of that pair.

      They found that for females, personality had little to do with whether the birds divorced. But in males, the pattern was clear: Those that were identified as shy were more likely to divorce, while bolder males stayed with their partner.

      “Divorce does not happen very often,” Jenouvrier says. “But we found that the shyer a bird is, the more likely they are to divorce.”

      But why? In their study, the team puts forth an explanation, which ecologists call “forced divorce.” They point out that, in this particular population of wandering albatross, males far outnumber females and therefore are more likely to compete with each other for mates. Males that are already partnered up, therefore, may be faced with a third “intruder” — a male who is competing for a place in the pair.

      “When there is a third intruder that competes, shy birds could step away and give away their mates, where bolder individuals are aggressive and will guard their partner and secure their partnership,” Sun explains. “That’s why shyer individuals may have higher divorce rates.”

      The team is planning to extend their work to examine how the personality of individuals can affect how the larger population changes and evolves. 

      “Now we’re talking about a connection between personality and divorce at the individual level,” Sun says. “But we want to understand the impact at the population level.”

      This research was supported, in part, by the National Science Foundation. More

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      in Security

      These neurons have food on the brain

      by

      A gooey slice of pizza. A pile of crispy French fries. Ice cream dripping down a cone on a hot summer day. When you look at any of these foods, a specialized part of your visual cortex lights up, according to a new study from MIT neuroscientists.

      This newly discovered population of food-responsive neurons is located in the ventral visual stream, alongside populations that respond specifically to faces, bodies, places, and words. The unexpected finding may reflect the special significance of food in human culture, the researchers say. 

      “Food is central to human social interactions and cultural practices. It’s not just sustenance,” says Nancy Kanwisher, the Walter A. Rosenblith Professor of Cognitive Neuroscience and a member of MIT’s McGovern Institute for Brain Research and Center for Brains, Minds, and Machines. “Food is core to so many elements of our cultural identity, religious practice, and social interactions, and many other things that humans do.”

      The findings, based on an analysis of a large public database of human brain responses to a set of 10,000 images, raise many additional questions about how and why this neural population develops. In future studies, the researchers hope to explore how people’s responses to certain foods might differ depending on their likes and dislikes, or their familiarity with certain types of food.

      MIT postdoc Meenakshi Khosla is the lead author of the paper, along with MIT research scientist N. Apurva Ratan Murty. The study appears today in the journal Current Biology.

      Visual categories

      More than 20 years ago, while studying the ventral visual stream, the part of the brain that recognizes objects, Kanwisher discovered cortical regions that respond selectively to faces. Later, she and other scientists discovered other regions that respond selectively to places, bodies, or words. Most of those areas were discovered when researchers specifically set out to look for them. However, that hypothesis-driven approach can limit what you end up finding, Kanwisher says.

      “There could be other things that we might not think to look for,” she says. “And even when we find something, how do we know that that’s actually part of the basic dominant structure of that pathway, and not something we found just because we were looking for it?”

      To try to uncover the fundamental structure of the ventral visual stream, Kanwisher and Khosla decided to analyze a large, publicly available dataset of full-brain functional magnetic resonance imaging (fMRI) responses from eight human subjects as they viewed thousands of images.

      “We wanted to see when we apply a data-driven, hypothesis-free strategy, what kinds of selectivities pop up, and whether those are consistent with what had been discovered before. A second goal was to see if we could discover novel selectivities that either haven’t been hypothesized before, or that have remained hidden due to the lower spatial resolution of fMRI data,” Khosla says.

      To do that, the researchers applied a mathematical method that allows them to discover neural populations that can’t be identified from traditional fMRI data. An fMRI image is made up of many voxels — three-dimensional units that represent a cube of brain tissue. Each voxel contains hundreds of thousands of neurons, and if some of those neurons belong to smaller populations that respond to one type of visual input, their responses may be drowned out by other populations within the same voxel.

      The new analytical method, which Kanwisher’s lab has previously used on fMRI data from the auditory cortex, can tease out responses of neural populations within each voxel of fMRI data.

      Using this approach, the researchers found four populations that corresponded to previously identified clusters that respond to faces, places, bodies, and words. “That tells us that this method works, and it tells us that the things that we found before are not just obscure properties of that pathway, but major, dominant properties,” Kanwisher says.

      Intriguingly, a fifth population also emerged, and this one appeared to be selective for images of food.

      “We were first quite puzzled by this because food is not a visually homogenous category,” Khosla says. “Things like apples and corn and pasta all look so unlike each other, yet we found a single population that responds similarly to all these diverse food items.”

      The food-specific population, which the researchers call the ventral food component (VFC), appears to be spread across two clusters of neurons, located on either side of the FFA. The fact that the food-specific populations are spread out between other category-specific populations may help explain why they have not been seen before, the researchers say.

      “We think that food selectivity had been harder to characterize before because the populations that are selective for food are intermingled with other nearby populations that have distinct responses to other stimulus attributes. The low spatial resolution of fMRI prevents us from seeing this selectivity because the responses of different neural population get mixed in a voxel,” Khosla says.

      “The technique which the researchers used to identify category-sensitive cells or areas is impressive, and it recovered known category-sensitive systems, making the food category findings most impressive,” says Paul Rozin, a professor of psychology at the University of Pennsylvania, who was not involved in the study. “I can’t imagine a way for the brain to reliably identify the diversity of foods based on sensory features. That makes this all the more fascinating, and likely to clue us in about something really new.”

      Food vs non-food

      The researchers also used the data to train a computational model of the VFC, based on previous models Murty had developed for the brain’s face and place recognition areas. This allowed the researchers to run additional experiments and predict the responses of the VFC. In one experiment, they fed the model matched images of food and non-food items that looked very similar — for example, a banana and a yellow crescent moon.

      “Those matched stimuli have very similar visual properties, but the main attribute in which they differ is edible versus inedible,” Khosla says. “We could feed those arbitrary stimuli through the predictive model and see whether it would still respond more to food than non-food, without having to collect the fMRI data.”

      They could also use the computational model to analyze much larger datasets, consisting of millions of images. Those simulations helped to confirm that the VFC is highly selective for images of food.

      From their analysis of the human fMRI data, the researchers found that in some subjects, the VFC responded slightly more to processed foods such as pizza than unprocessed foods like apples. In the future they hope to explore how factors such as familiarity and like or dislike of a particular food might affect individuals’ responses to that food.

      They also hope to study when and how this region becomes specialized during early childhood, and what other parts of the brain it communicates with. Another question is whether this food-selective population will be seen in other animals such as monkeys, who do not attach the cultural significance to food that humans do.

      The research was funded by the National Institutes of Health, the National Eye Institute, and the National Science Foundation through the MIT Center for Brains, Minds, and Machines. More