More stories

  • in

    Scientists chart how exercise affects the body

    Exercise is well-known to help people lose weight and avoid gaining it. However, identifying the cellular mechanisms that underlie this process has proven difficult because so many cells and tissues are involved.

    In a new study in mice that expands researchers’ understanding of how exercise and diet affect the body, MIT and Harvard Medical School researchers have mapped out many of the cells, genes, and cellular pathways that are modified by exercise or high-fat diet. The findings could offer potential targets for drugs that could help to enhance or mimic the benefits of exercise, the researchers say.

    “It is extremely important to understand the molecular mechanisms that are drivers of the beneficial effects of exercise and the detrimental effects of a high-fat diet, so that we can understand how we can intervene, and develop drugs that mimic the impact of exercise across multiple tissues,” says Manolis Kellis, a professor of computer science in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and a member of the Broad Institute of MIT and Harvard.

    The researchers studied mice with high-fat or normal diets, who were either sedentary or given the opportunity to exercise whenever they wanted. Using single-cell RNA sequencing, the researchers cataloged the responses of 53 types of cells found in skeletal muscle and two types of fatty tissue.

    “One of the general points that we found in our study, which is overwhelmingly clear, is how high-fat diets push all of these cells and systems in one way, and exercise seems to be pushing them nearly all in the opposite way,” Kellis says. “It says that exercise can really have a major effect throughout the body.”

    Kellis and Laurie Goodyear, a professor of medicine at Harvard Medical School and senior investigator at the Joslin Diabetes Center, are the senior authors of the study, which appears today in the journal Cell Metabolism. Jiekun Yang, a research scientist in MIT CSAIL; Maria Vamvini, an instructor of medicine at the Joslin Diabetes Center; and Pasquale Nigro, an instructor of medicine at the Joslin Diabetes Center, are the lead authors of the paper.

    The risks of obesity

    Obesity is a growing health problem around the world. In the United States, more than 40 percent of the population is considered obese, and nearly 75 percent is overweight. Being overweight is a risk factor for many diseases, including heart disease, cancer, Alzheimer’s disease, and even infectious diseases such as Covid-19.

    “Obesity, along with aging, is a global factor that contributes to every aspect of human health,” Kellis says.

    Several years ago, his lab performed a study on the FTO gene region, which has been strongly linked to obesity risk. In that 2015 study, the research team found that genes in this region control a pathway that prompts immature fat cells called progenitor adipocytes to either become fat-burning cells or fat-storing cells.

    That finding, which demonstrated a clear genetic component to obesity, motivated Kellis to begin looking at how exercise, a well-known behavioral intervention that can prevent obesity, might act on progenitor adipocytes at the cellular level.

    To explore that question, Kellis and his colleagues decided to perform single-cell RNA sequencing of three types of tissue — skeletal muscle, visceral white adipose tissue (found packed around internal organs, where it stores fat), and subcutaneous white adipose tissue (which is found under the skin and primarily burns fat).

    These tissues came from mice from four different experimental groups. For three weeks, two groups of mice were fed either a normal diet or a high-fat diet. For the next three weeks, each of those two groups were further divided into a sedentary group and an exercise group, which had continuous access to a treadmill.

    By analyzing tissues from those mice, the researchers were able to comprehensively catalog the genes that were activated or suppressed by exercise in 53 different cell types.

    The researchers found that in all three tissue types, mesenchymal stem cells (MSCs) appeared to control many of the diet and exercise-induced effects that they observed. MSCs are stem cells that can differentiate into other cell types, including fat cells and fibroblasts. In adipose tissue, the researchers found that a high-fat diet modulated MSCs’ capacity to differentiate into fat-storing cells, while exercise reversed this effect.

    In addition to promoting fat storage, the researchers found that a high-fat diet also stimulated MSCs to secrete factors that remodel the extracellular matrix (ECM) — a network of proteins and other molecules that surround and support cells and tissues in the body. This ECM remodeling helps provide structure for enlarged fat-storing cells and also creates a more inflammatory environment.

    “As the adipocytes become overloaded with lipids, there’s an extreme amount of stress, and that causes low-grade inflammation, which is systemic and preserved for a long time,” Kellis says. “That is one of the factors that is contributing to many of the adverse effects of obesity.”

    Circadian effects

    The researchers also found that high-fat diets and exercise had opposing effects on cellular pathways that control circadian rhythms — the 24-hour cycles that govern many functions, from sleep to body temperature, hormone release, and digestion. The study revealed that exercise boosts the expression of genes that regulate these rhythms, while a high-fat diet suppresses them.

    “There have been a lot of studies showing that when you eat during the day is extremely important in how you absorb the calories,” Kellis says. “The circadian rhythm connection is a very important one, and shows how obesity and exercise are in fact directly impacting that circadian rhythm in peripheral organs, which could act systemically on distal clocks and regulate stem cell functions and immunity.”

    The researchers then compared their results to a database of human genes that have been linked with metabolic traits. They found that two of the circadian rhythm genes they identified in this study, known as DBP and CDKN1A, have genetic variants that have been associated with a higher risk of obesity in humans.

    “These results help us see the translational values of these targets, and how we could potentially target specific biological processes in specific cell types,” Yang says.

    The researchers are now analyzing samples of small intestine, liver, and brain tissue from the mice in this study, to explore the effects of exercise and high-fat diets on those tissues. They are also conducting work with human volunteers to sample blood and biopsies and study similarities and differences between human and mouse physiology. They hope that their findings will help guide drug developers in designing drugs that might mimic some of the beneficial effects of exercise.

    “The message for everyone should be, eat a healthy diet and exercise if possible,” Kellis says. “For those for whom this is not possible, due to low access to healthy foods, or due to disabilities or other factors that prevent exercise, or simply lack of time to have a healthy diet or a healthy lifestyle, what this study says is that we now have a better handle on the pathways, the specific genes, and the specific molecular and cellular processes that we should be manipulating therapeutically.”

    The research was funded by the National Institutes of Health and the Novo Nordisk Research Center in Seattle. More

  • in

    Taking a magnifying glass to data center operations

    When the MIT Lincoln Laboratory Supercomputing Center (LLSC) unveiled its TX-GAIA supercomputer in 2019, it provided the MIT community a powerful new resource for applying artificial intelligence to their research. Anyone at MIT can submit a job to the system, which churns through trillions of operations per second to train models for diverse applications, such as spotting tumors in medical images, discovering new drugs, or modeling climate effects. But with this great power comes the great responsibility of managing and operating it in a sustainable manner — and the team is looking for ways to improve.

    “We have these powerful computational tools that let researchers build intricate models to solve problems, but they can essentially be used as black boxes. What gets lost in there is whether we are actually using the hardware as effectively as we can,” says Siddharth Samsi, a research scientist in the LLSC. 

    To gain insight into this challenge, the LLSC has been collecting detailed data on TX-GAIA usage over the past year. More than a million user jobs later, the team has released the dataset open source to the computing community.

    Their goal is to empower computer scientists and data center operators to better understand avenues for data center optimization — an important task as processing needs continue to grow. They also see potential for leveraging AI in the data center itself, by using the data to develop models for predicting failure points, optimizing job scheduling, and improving energy efficiency. While cloud providers are actively working on optimizing their data centers, they do not often make their data or models available for the broader high-performance computing (HPC) community to leverage. The release of this dataset and associated code seeks to fill this space.

    “Data centers are changing. We have an explosion of hardware platforms, the types of workloads are evolving, and the types of people who are using data centers is changing,” says Vijay Gadepally, a senior researcher at the LLSC. “Until now, there hasn’t been a great way to analyze the impact to data centers. We see this research and dataset as a big step toward coming up with a principled approach to understanding how these variables interact with each other and then applying AI for insights and improvements.”

    Papers describing the dataset and potential applications have been accepted to a number of venues, including the IEEE International Symposium on High-Performance Computer Architecture, the IEEE International Parallel and Distributed Processing Symposium, the Annual Conference of the North American Chapter of the Association for Computational Linguistics, the IEEE High-Performance and Embedded Computing Conference, and International Conference for High Performance Computing, Networking, Storage and Analysis. 

    Workload classification

    Among the world’s TOP500 supercomputers, TX-GAIA combines traditional computing hardware (central processing units, or CPUs) with nearly 900 graphics processing unit (GPU) accelerators. These NVIDIA GPUs are specialized for deep learning, the class of AI that has given rise to speech recognition and computer vision.

    The dataset covers CPU, GPU, and memory usage by job; scheduling logs; and physical monitoring data. Compared to similar datasets, such as those from Google and Microsoft, the LLSC dataset offers “labeled data, a variety of known AI workloads, and more detailed time series data compared with prior datasets. To our knowledge, it’s one of the most comprehensive and fine-grained datasets available,” Gadepally says. 

    Notably, the team collected time-series data at an unprecedented level of detail: 100-millisecond intervals on every GPU and 10-second intervals on every CPU, as the machines processed more than 3,000 known deep-learning jobs. One of the first goals is to use this labeled dataset to characterize the workloads that different types of deep-learning jobs place on the system. This process would extract features that reveal differences in how the hardware processes natural language models versus image classification or materials design models, for example.   

    The team has now launched the MIT Datacenter Challenge to mobilize this research. The challenge invites researchers to use AI techniques to identify with 95 percent accuracy the type of job that was run, using their labeled time-series data as ground truth.

    Such insights could enable data centers to better match a user’s job request with the hardware best suited for it, potentially conserving energy and improving system performance. Classifying workloads could also allow operators to quickly notice discrepancies resulting from hardware failures, inefficient data access patterns, or unauthorized usage.

    Too many choices

    Today, the LLSC offers tools that let users submit their job and select the processors they want to use, “but it’s a lot of guesswork on the part of users,” Samsi says. “Somebody might want to use the latest GPU, but maybe their computation doesn’t actually need it and they could get just as impressive results on CPUs, or lower-powered machines.”

    Professor Devesh Tiwari at Northeastern University is working with the LLSC team to develop techniques that can help users match their workloads to appropriate hardware. Tiwari explains that the emergence of different types of AI accelerators, GPUs, and CPUs has left users suffering from too many choices. Without the right tools to take advantage of this heterogeneity, they are missing out on the benefits: better performance, lower costs, and greater productivity.

    “We are fixing this very capability gap — making users more productive and helping users do science better and faster without worrying about managing heterogeneous hardware,” says Tiwari. “My PhD student, Baolin Li, is building new capabilities and tools to help HPC users leverage heterogeneity near-optimally without user intervention, using techniques grounded in Bayesian optimization and other learning-based optimization methods. But, this is just the beginning. We are looking into ways to introduce heterogeneity in our data centers in a principled approach to help our users achieve the maximum advantage of heterogeneity autonomously and cost-effectively.”

    Workload classification is the first of many problems to be posed through the Datacenter Challenge. Others include developing AI techniques to predict job failures, conserve energy, or create job scheduling approaches that improve data center cooling efficiencies.

    Energy conservation 

    To mobilize research into greener computing, the team is also planning to release an environmental dataset of TX-GAIA operations, containing rack temperature, power consumption, and other relevant data.

    According to the researchers, huge opportunities exist to improve the power efficiency of HPC systems being used for AI processing. As one example, recent work in the LLSC determined that simple hardware tuning, such as limiting the amount of power an individual GPU can draw, could reduce the energy cost of training an AI model by 20 percent, with only modest increases in computing time. “This reduction translates to approximately an entire week’s worth of household energy for a mere three-hour time increase,” Gadepally says.

    They have also been developing techniques to predict model accuracy, so that users can quickly terminate experiments that are unlikely to yield meaningful results, saving energy. The Datacenter Challenge will share relevant data to enable researchers to explore other opportunities to conserve energy.

    The team expects that lessons learned from this research can be applied to the thousands of data centers operated by the U.S. Department of Defense. The U.S. Air Force is a sponsor of this work, which is being conducted under the USAF-MIT AI Accelerator.

    Other collaborators include researchers at MIT Computer Science and Artificial Intelligence Laboratory (CSAIL). Professor Charles Leiserson’s Supertech Research Group is investigating performance-enhancing techniques for parallel computing, and research scientist Neil Thompson is designing studies on ways to nudge data center users toward climate-friendly behavior.

    Samsi presented this work at the inaugural AI for Datacenter Optimization (ADOPT’22) workshop last spring as part of the IEEE International Parallel and Distributed Processing Symposium. The workshop officially introduced their Datacenter Challenge to the HPC community.

    “We hope this research will allow us and others who run supercomputing centers to be more responsive to user needs while also reducing the energy consumption at the center level,” Samsi says. More

  • in

    New program bolsters innovation in next-generation artificial intelligence hardware

    The MIT AI Hardware Program is a new academia and industry collaboration aimed at defining and developing translational technologies in hardware and software for the AI and quantum age. A collaboration between the MIT School of Engineering and MIT Schwarzman College of Computing, involving the Microsystems Technologies Laboratories and programs and units in the college, the cross-disciplinary effort aims to innovate technologies that will deliver enhanced energy efficiency systems for cloud and edge computing.

    “A sharp focus on AI hardware manufacturing, research, and design is critical to meet the demands of the world’s evolving devices, architectures, and systems,” says Anantha Chandrakasan, dean of the MIT School of Engineering and Vannevar Bush Professor of Electrical Engineering and Computer Science. “Knowledge-sharing between industry and academia is imperative to the future of high-performance computing.”

    Based on use-inspired research involving materials, devices, circuits, algorithms, and software, the MIT AI Hardware Program convenes researchers from MIT and industry to facilitate the transition of fundamental knowledge to real-world technological solutions. The program spans materials and devices, as well as architecture and algorithms enabling energy-efficient and sustainable high-performance computing.

    “As AI systems become more sophisticated, new solutions are sorely needed to enable more advanced applications and deliver greater performance,” says Daniel Huttenlocher, dean of the MIT Schwarzman College of Computing and Henry Ellis Warren Professor of Electrical Engineering and Computer Science. “Our aim is to devise real-world technological solutions and lead the development of technologies for AI in hardware and software.”

    The inaugural members of the program are companies from a wide range of industries including chip-making, semiconductor manufacturing equipment, AI and computing services, and information systems R&D organizations. The companies represent a diverse ecosystem, both nationally and internationally, and will work with MIT faculty and students to help shape a vibrant future for our planet through cutting-edge AI hardware research.

    The five inaugural members of the MIT AI Hardware Program are:  

    Amazon, a global technology company whose hardware inventions include the Kindle, Amazon Echo, Fire TV, and Astro; 
    Analog Devices, a global leader in the design and manufacturing of analog, mixed signal, and DSP integrated circuits; 
    ASML, an innovation leader in the semiconductor industry, providing chipmakers with hardware, software, and services to mass produce patterns on silicon through lithography; 
    NTT Research, a subsidiary of NTT that conducts fundamental research to upgrade reality in game-changing ways that improve lives and brighten our global future; and 
    TSMC, the world’s leading dedicated semiconductor foundry.

    The MIT AI Hardware Program will create a roadmap of transformative AI hardware technologies. Leveraging MIT.nano, the most advanced university nanofabrication facility anywhere, the program will foster a unique environment for AI hardware research.  

    “We are all in awe at the seemingly superhuman capabilities of today’s AI systems. But this comes at a rapidly increasing and unsustainable energy cost,” says Jesús del Alamo, the Donner Professor in MIT’s Department of Electrical Engineering and Computer Science. “Continued progress in AI will require new and vastly more energy-efficient systems. This, in turn, will demand innovations across the entire abstraction stack, from materials and devices to systems and software. The program is in a unique position to contribute to this quest.”

    The program will prioritize the following topics:

    analog neural networks;
    new roadmap CMOS designs;
    heterogeneous integration for AI systems;
    onolithic-3D AI systems;
    analog nonvolatile memory devices;
    software-hardware co-design;
    intelligence at the edge;
    intelligent sensors;
    energy-efficient AI;
    intelligent internet of things (IIoT);
    neuromorphic computing;
    AI edge security;
    quantum AI;
    wireless technologies;
    hybrid-cloud computing; and
    high-performance computation.

    “We live in an era where paradigm-shifting discoveries in hardware, systems communications, and computing have become mandatory to find sustainable solutions — solutions that we are proud to give to the world and generations to come,” says Aude Oliva, senior research scientist in the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) and director of strategic industry engagement in the MIT Schwarzman College of Computing.

    The new program is co-led by Jesús del Alamo and Aude Oliva, and Anantha Chandrakasan serves as chair. More

  • in

    Q&A: Climate Grand Challenges finalists on building equity and fairness into climate solutions

    Note: This is the first in a four-part interview series that will highlight the work of the Climate Grand Challenges finalists, ahead of the April announcement of several multiyear, flagship projects.

    The finalists in MIT’s first-ever Climate Grand Challenges competition each received $100,000 to develop bold, interdisciplinary research and innovation plans designed to attack some of the world’s most difficult and unresolved climate problems. The 27 teams are addressing four Grand Challenge problem areas: building equity and fairness into climate solutions; decarbonizing complex industries and processes; removing, managing, and storing greenhouse gases; and using data and science for improved climate risk forecasting.  

    In a conversation prepared for MIT News, faculty from three of the teams in the competition’s “Building equity and fairness into climate solutions” category share their thoughts on the need for inclusive solutions that prioritize disadvantaged and vulnerable populations, and discuss how they are working to accelerate their research to achieve the greatest impact. The following responses have been edited for length and clarity.

    The Equitable Resilience Framework

    Any effort to solve the most complex global climate problems must recognize the unequal burdens borne by different groups, communities, and societies — and should be equitable as well as effective. Janelle Knox-Hayes, associate professor in the Department of Urban Studies and Planning, leads a team that is developing processes and practices for equitable resilience, starting with a local pilot project in Boston over the next five years and extending to other cities and regions of the country. The Equitable Resilience Framework (ERF) is designed to create long-term economic, social, and environmental transformations by increasing the capacity of interconnected systems and communities to respond to a broad range of climate-related events. 

    Q: What is the problem you are trying to solve?

    A: Inequity is one of the severe impacts of climate change and resonates in both mitigation and adaptation efforts. It is important for climate strategies to address challenges of inequity and, if possible, to design strategies that enhance justice, equity, and inclusion, while also enhancing the efficacy of mitigation and adaptation efforts. Our framework offers a blueprint for how communities, cities, and regions can begin to undertake this work.

    Q: What are the most significant barriers that have impacted progress to date?

    A: There is considerable inertia in policymaking. Climate change requires a rethinking, not only of directives but pathways and techniques of policymaking. This is an obstacle and part of the reason our project was designed to scale up from local pilot projects. Another consideration is that the private sector can be more adaptive and nimble in its adoption of creative techniques. Working with the MIT Climate and Sustainability Consortium there may be ways in which we could modify the ERF to help companies address similar internal adaptation and resilience challenges.

    Protecting and enhancing natural carbon sinks

    Deforestation and forest degradation of strategic ecosystems in the Amazon, Central Africa, and Southeast Asia continue to reduce capacity to capture and store carbon through natural systems and threaten even the most aggressive decarbonization plans. John Fernandez, professor in the Department of Architecture and director of the Environmental Solutions Initiative, reflects on his work with Daniela Rus, professor of electrical engineering and computer science and director of the Computer Science and Artificial Intelligence Laboratory, and Joann de Zegher, assistant professor of Operations Management at MIT Sloan, to protect tropical forests by deploying a three-part solution that integrates targeted technology breakthroughs, deep community engagement, and innovative bioeconomic opportunities. 

    Q: Why is the problem you seek to address a “grand challenge”?

    A: We are trying to bring the latest technology to monitoring, assessing, and protecting tropical forests, as well as other carbon-rich and highly biodiverse ecosystems. This is a grand challenge because natural sinks around the world are threatening to release enormous quantities of stored carbon that could lead to runaway global warming. When combined with deep community engagement, particularly with indigenous and afro-descendant communities, this integrated approach promises to deliver substantially enhanced efficacy in conservation coupled to robust and sustainable local development.

    Q: What is known about this problem and what questions remain unanswered?

    A: Satellites, drones, and other technologies are acquiring more data about natural carbon sinks than ever before. The problem is well-described in certain locations such as the eastern Amazon, which has shifted from a net carbon sink to now a net positive carbon emitter. It is also well-known that indigenous peoples are the most effective stewards of the ecosystems that store the greatest amounts of carbon. One of the key questions that remains to be answered is determining the bioeconomy opportunities inherent within the natural wealth of tropical forests and other important ecosystems that are important to sustained protection and conservation.

    Reducing group-based disparities in climate adaptation

    Race, ethnicity, caste, religion, and nationality are often linked to vulnerability to the adverse effects of climate change, and if left unchecked, threaten to exacerbate long standing inequities. A team led by Evan Lieberman, professor of political science and director of the MIT Global Diversity Lab and MIT International Science and Technology Initiatives, Danielle Wood, assistant professor in the Program in Media Arts and Sciences and the Department of Aeronautics and Astronautics, and Siqi Zheng, professor of urban and real estate sustainability in the Center for Real Estate and the Department of Urban Studies and Planning, is seeking to  reduce ethnic and racial group-based disparities in the capacity of urban communities to adapt to the changing climate. Working with partners in nine coastal cities, they will measure the distribution of climate-related burdens and resiliency through satellites, a custom mobile app, and natural language processing of social media, to help design and test communication campaigns that provide accurate information about risks and remediation to impacted groups. 

    Q: How has this problem evolved?

    A: Group-based disparities continue to intensify within and across countries, owing in part to some randomness in the location of adverse climate events, as well as deep legacies of unequal human development. In turn, economically and politically privileged groups routinely hoard resources for adaptation. In a few cases — notably the United States, Brazil, and with respect to climate-related migrancy, in South Asia — there has been a great deal of research documenting the extent of such disparities. However, we lack common metrics, and for the most part, such disparities are only understood where key actors have politicized the underlying problems. In much of the world, relatively vulnerable and excluded groups may not even be fully aware of the nature of the challenges they face or the resources they require.

    Q: Who will benefit most from your research? 

    A: The greatest beneficiaries will be members of those vulnerable groups who lack the resources and infrastructure to withstand adverse climate shocks. We believe that it will be important to develop solutions such that relatively privileged groups do not perceive them as punitive or zero-sum, but rather as long-term solutions for collective benefit that are both sound and just. More

  • in

    Design’s new frontier

    In the 1960s, the advent of computer-aided design (CAD) sparked a revolution in design. For his PhD thesis in 1963, MIT Professor Ivan Sutherland developed Sketchpad, a game-changing software program that enabled users to draw, move, and resize shapes on a computer. Over the course of the next few decades, CAD software reshaped how everything from consumer products to buildings and airplanes were designed.

    “CAD was part of the first wave in computing in design. The ability of researchers and practitioners to represent and model designs using computers was a major breakthrough and still is one of the biggest outcomes of design research, in my opinion,” says Maria Yang, Gail E. Kendall Professor and director of MIT’s Ideation Lab.

    Innovations in 3D printing during the 1980s and 1990s expanded CAD’s capabilities beyond traditional injection molding and casting methods, providing designers even more flexibility. Designers could sketch, ideate, and develop prototypes or models faster and more efficiently. Meanwhile, with the push of a button, software like that developed by Professor Emeritus David Gossard of MIT’s CAD Lab could solve equations simultaneously to produce a new geometry on the fly.

    In recent years, mechanical engineers have expanded the computing tools they use to ideate, design, and prototype. More sophisticated algorithms and the explosion of machine learning and artificial intelligence technologies have sparked a second revolution in design engineering.

    Researchers and faculty at MIT’s Department of Mechanical Engineering are utilizing these technologies to re-imagine how the products, systems, and infrastructures we use are designed. These researchers are at the forefront of the new frontier in design.

    Computational design

    Faez Ahmed wants to reinvent the wheel, or at least the bicycle wheel. He and his team at MIT’s Design Computation & Digital Engineering Lab (DeCoDE) use an artificial intelligence-driven design method that can generate entirely novel and improved designs for a range of products — including the traditional bicycle. They create advanced computational methods to blend human-driven design with simulation-based design.

    “The focus of our DeCoDE lab is computational design. We are looking at how we can create machine learning and AI algorithms to help us discover new designs that are optimized based on specific performance parameters,” says Ahmed, an assistant professor of mechanical engineering at MIT.

    For their work using AI-driven design for bicycles, Ahmed and his collaborator Professor Daniel Frey wanted to make it easier to design customizable bicycles, and by extension, encourage more people to use bicycles over transportation methods that emit greenhouse gases.

    To start, the group gathered a dataset of 4,500 bicycle designs. Using this massive dataset, they tested the limits of what machine learning could do. First, they developed algorithms to group bicycles that looked similar together and explore the design space. They then created machine learning models that could successfully predict what components are key in identifying a bicycle style, such as a road bike versus a mountain bike.

    Once the algorithms were good enough at identifying bicycle designs and parts, the team proposed novel machine learning tools that could use this data to create a unique and creative design for a bicycle based on certain performance parameters and rider dimensions.

    Ahmed used a generative adversarial network — or GAN — as the basis of this model. GAN models utilize neural networks that can create new designs based on vast amounts of data. However, using GAN models alone would result in homogeneous designs that lack novelty and can’t be assessed in terms of performance. To address these issues in design problems, Ahmed has developed a new method which he calls “PaDGAN,” performance augmented diverse GAN.

    “When we apply this type of model, what we see is that we can get large improvements in the diversity, quality, as well as novelty of the designs,” Ahmed explains.

    Using this approach, Ahmed’s team developed an open-source computational design tool for bicycles freely available on their lab website. They hope to further develop a set of generalizable tools that can be used across industries and products.

    Longer term, Ahmed has his sights set on loftier goals. He hopes the computational design tools he develops could lead to “design democratization,” putting more power in the hands of the end user.

    “With these algorithms, you can have more individualization where the algorithm assists a customer in understanding their needs and helps them create a product that satisfies their exact requirements,” he adds.

    Using algorithms to democratize the design process is a goal shared by Stefanie Mueller, an associate professor in electrical engineering and computer science and mechanical engineering.

    Personal fabrication

    Platforms like Instagram give users the freedom to instantly edit their photographs or videos using filters. In one click, users can alter the palette, tone, and brightness of their content by applying filters that range from bold colors to sepia-toned or black-and-white. Mueller, X-Window Consortium Career Development Professor, wants to bring this concept of the Instagram filter to the physical world.

    “We want to explore how digital capabilities can be applied to tangible objects. Our goal is to bring reprogrammable appearance to the physical world,” explains Mueller, director of the HCI Engineering Group based out of MIT’s Computer Science and Artificial Intelligence Laboratory.

    Mueller’s team utilizes a combination of smart materials, optics, and computation to advance personal fabrication technologies that would allow end users to alter the design and appearance of the products they own. They tested this concept in a project they dubbed “Photo-Chromeleon.”

    First, a mix of photochromic cyan, magenta, and yellow dies are airbrushed onto an object — in this instance, a 3D sculpture of a chameleon. Using software they developed, the team sketches the exact color pattern they want to achieve on the object itself. An ultraviolet light shines on the object to activate the dyes.

    To actually create the physical pattern on the object, Mueller has developed an optimization algorithm to use alongside a normal office projector outfitted with red, green, and blue LED lights. These lights shine on specific pixels on the object for a given period of time to physically change the makeup of the photochromic pigments.

    “This fancy algorithm tells us exactly how long we have to shine the red, green, and blue light on every single pixel of an object to get the exact pattern we’ve programmed in our software,” says Mueller.

    Giving this freedom to the end user enables limitless possibilities. Mueller’s team has applied this technology to iPhone cases, shoes, and even cars. In the case of shoes, Mueller envisions a shoebox embedded with UV and LED light projectors. Users could put their shoes in the box overnight and the next day have a pair of shoes in a completely new pattern.

    Mueller wants to expand her personal fabrication methods to the clothes we wear. Rather than utilize the light projection technique developed in the PhotoChromeleon project, her team is exploring the possibility of weaving LEDs directly into clothing fibers, allowing people to change their shirt’s appearance as they wear it. These personal fabrication technologies could completely alter consumer habits.

    “It’s very interesting for me to think about how these computational techniques will change product design on a high level,” adds Mueller. “In the future, a consumer could buy a blank iPhone case and update the design on a weekly or daily basis.”

    Computational fluid dynamics and participatory design

    Another team of mechanical engineers, including Sili Deng, the Brit (1961) & Alex (1949) d’Arbeloff Career Development Professor, are developing a different kind of design tool that could have a large impact on individuals in low- and middle-income countries across the world.

    As Deng walked down the hallway of Building 1 on MIT’s campus, a monitor playing a video caught her eye. The video featured work done by mechanical engineers and MIT D-Lab on developing cleaner burning briquettes for cookstoves in Uganda. Deng immediately knew she wanted to get involved.

    “As a combustion scientist, I’ve always wanted to work on such a tangible real-world problem, but the field of combustion tends to focus more heavily on the academic side of things,” explains Deng.

    After reaching out to colleagues in MIT D-Lab, Deng joined a collaborative effort to develop a new cookstove design tool for the 3 billion people across the world who burn solid fuels to cook and heat their homes. These stoves often emit soot and carbon monoxide, leading not only to millions of deaths each year, but also worsening the world’s greenhouse gas emission problem.

    The team is taking a three-pronged approach to developing this solution, using a combination of participatory design, physical modeling, and experimental validation to create a tool that will lead to the production of high-performing, low-cost energy products.

    Deng and her team in the Deng Energy and Nanotechnology Group use physics-based modeling for the combustion and emission process in cookstoves.

    “My team is focused on computational fluid dynamics. We use computational and numerical studies to understand the flow field where the fuel is burned and releases heat,” says Deng.

    These flow mechanics are crucial to understanding how to minimize heat loss and make cookstoves more efficient, as well as learning how dangerous pollutants are formed and released in the process.

    Using computational methods, Deng’s team performs three-dimensional simulations of the complex chemistry and transport coupling at play in the combustion and emission processes. They then use these simulations to build a combustion model for how fuel is burned and a pollution model that predicts carbon monoxide emissions.

    Deng’s models are used by a group led by Daniel Sweeney in MIT D-Lab to test the experimental validation in prototypes of stoves. Finally, Professor Maria Yang uses participatory design methods to integrate user feedback, ensuring the design tool can actually be used by people across the world.

    The end goal for this collaborative team is to not only provide local manufacturers with a prototype they could produce themselves, but to also provide them with a tool that can tweak the design based on local needs and available materials.

    Deng sees wide-ranging applications for the computational fluid dynamics her team is developing.

    “We see an opportunity to use physics-based modeling, augmented with a machine learning approach, to come up with chemical models for practical fuels that help us better understand combustion. Therefore, we can design new methods to minimize carbon emissions,” she adds.

    While Deng is utilizing simulations and machine learning at the molecular level to improve designs, others are taking a more macro approach.

    Designing intelligent systems

    When it comes to intelligent design, Navid Azizan thinks big. He hopes to help create future intelligent systems that are capable of making decisions autonomously by using the enormous amounts of data emerging from the physical world. From smart robots and autonomous vehicles to smart power grids and smart cities, Azizan focuses on the analysis, design, and control of intelligent systems.

    Achieving such massive feats takes a truly interdisciplinary approach that draws upon various fields such as machine learning, dynamical systems, control, optimization, statistics, and network science, among others.

    “Developing intelligent systems is a multifaceted problem, and it really requires a confluence of disciplines,” says Azizan, assistant professor of mechanical engineering with a dual appointment in MIT’s Institute for Data, Systems, and Society (IDSS). “To create such systems, we need to go beyond standard approaches to machine learning, such as those commonly used in computer vision, and devise algorithms that can enable safe, efficient, real-time decision-making for physical systems.”

    For robot control to work in the complex dynamic environments that arise in the real world, real-time adaptation is key. If, for example, an autonomous vehicle is going to drive in icy conditions or a drone is operating in windy conditions, they need to be able to adapt to their new environment quickly.

    To address this challenge, Azizan and his collaborators at MIT and Stanford University have developed a new algorithm that combines adaptive control, a powerful methodology from control theory, with meta learning, a new machine learning paradigm.

    “This ‘control-oriented’ learning approach outperforms the existing ‘regression-oriented’ methods, which are mostly focused on just fitting the data, by a wide margin,” says Azizan.

    Another critical aspect of deploying machine learning algorithms in physical systems that Azizan and his team hope to address is safety. Deep neural networks are a crucial part of autonomous systems. They are used for interpreting complex visual inputs and making data-driven predictions of future behavior in real time. However, Azizan urges caution.

    “These deep neural networks are only as good as their training data, and their predictions can often be untrustworthy in scenarios not covered by their training data,” he says. Making decisions based on such untrustworthy predictions could lead to fatal accidents in autonomous vehicles or other safety-critical systems.

    To avoid these potentially catastrophic events, Azizan proposes that it is imperative to equip neural networks with a measure of their uncertainty. When the uncertainty is high, they can then be switched to a “safe policy.”

    In pursuit of this goal, Azizan and his collaborators have developed a new algorithm known as SCOD — Sketching Curvature of Out-of-Distribution Detection. This framework could be embedded within any deep neural network to equip them with a measure of their uncertainty.

    “This algorithm is model-agnostic and can be applied to neural networks used in various kinds of autonomous systems, whether it’s drones, vehicles, or robots,” says Azizan.

    Azizan hopes to continue working on algorithms for even larger-scale systems. He and his team are designing efficient algorithms to better control supply and demand in smart energy grids. According to Azizan, even if we create the most efficient solar panels and batteries, we can never achieve a sustainable grid powered by renewable resources without the right control mechanisms.

    Mechanical engineers like Ahmed, Mueller, Deng, and Azizan serve as the key to realizing the next revolution of computing in design.

    “MechE is in a unique position at the intersection of the computational and physical worlds,” Azizan says. “Mechanical engineers build a bridge between theoretical, algorithmic tools and real, physical world applications.”

    Sophisticated computational tools, coupled with the ground truth mechanical engineers have in the physical world, could unlock limitless possibilities for design engineering, well beyond what could have been imagined in those early days of CAD. More

  • in

    Climate and sustainability classes expand at MIT

    In fall 2019, a new class, 6.S898/12.S992 (Climate Change Seminar), arrived at MIT. It was, at the time, the only course in the Department of Electrical Engineering and Computer Science (EECS) to tackle the science of climate change. The class covered climate models and simulations alongside atmospheric science, policy, and economics.

    Ron Rivest, MIT Institute Professor of Computer Science, was one of the class’s three instructors, with Alan Edelman of the Computer Science and Artificial Intelligence Laboratory (CSAIL) and John Fernández of the Department of Urban Studies and Planning. “Computer scientists have much to contribute to climate science,” Rivest says. “In particular, the modeling and simulation of climate can benefit from advances in computer science.”

    Rivest is one of many MIT faculty members who have been working in recent years to bring topics in climate, sustainability, and the environment to students in a growing variety of fields. And students have said they want this trend to continue.

    “Sustainability is something that touches all disciplines,” says Megan Xu, a rising senior in biological engineering and advisory chair of the Undergraduate Association Sustainability Committee. “As students who have grown up knowing that climate change is real and witnessed climate disaster after disaster, we know this is a huge problem that needs to be addressed by our generation.”

    Expanding the course catalog

    As education program manager at the MIT Environmental Solutions Initiative, Sarah Meyers has repeatedly had a hand in launching new sustainability classes. She has steered grant money to faculty, brought together instructors, and helped design syllabi — all in the service of giving MIT students the same world-class education in climate and sustainability that they get in science and engineering.

    Her work has given Meyers a bird’s-eye view of MIT’s course offerings in this area. By her count, there are now over 120 undergraduate classes, across 23 academic departments, that teach climate, environment, and sustainability principles.

    “Educating the next generation is the most important way that MIT can have an impact on the world’s environmental challenges,” she says. “MIT students are going to be leaders in their fields, whatever they may be. If they really understand sustainable design practices, if they can balance the needs of all stakeholders to make ethical decisions, then that actually changes the way our world operates and can move humanity towards a more sustainable future.”

    Some sustainability classes are established institutions at MIT. Success stories include 2.00A (Fundamentals of Engineering Design: Explore Space, Sea and Earth), a hands-on engineering class popular with first-year students; and 21W.775 (Writing About Nature and Environmental Issues), which has helped undergraduates fulfill their HASS-H (humanities distribution subject) and CI-H (Communication Intensive subject in the Humanities, Arts, and Social Sciences) graduation requirements for 15 years.

    Expanding this list of classes is an institutional priority. In the recently released Climate Action Plan for the Decade, MIT pledged to recruit at least 20 additional faculty members who will teach climate-related classes.

    “I think it’s easy to find classes if you’re looking for sustainability classes to take,” says Naomi Lutz, a senior in mechanical engineering who helped advise the MIT administration on education measures in the Climate Action Plan. “I usually scroll through the titles of the classes in courses 1, 2, 11, and 12 to see if any are of interest. I also have used the Environment & Sustainability Minor class list to look for sustainability-related classes to take.

    “The coming years are critical for the future of our planet, so it’s important that we all learn about sustainability and think about how to address it,” she adds.

    Working with students’ schedules

    Still, despite all this activity, climate and sustainability are not yet mainstream parts of an MIT education. Last year, a survey of over 800 MIT undergraduates, taken by the Undergraduate Association Sustainability Committee, found that only one in four had ever taken a class related to sustainability. But it doesn’t seem to be from lack of interest in the topic. More than half of those surveyed said that sustainability is a factor in their career planning, and almost 80 percent try to practice sustainability in their daily lives.

    “I’ve often had conversations with students who were surprised to learn there are so many classes available,” says Meyers. “We do need to do a better job communicating about them, and making it as easy as possible to enroll.”

    A recurring challenge is helping students fit sustainability into their plans for graduation, which are often tightly mapped-out.

    “We each only have four years — around 32 to 40 classes — to absorb all that we can from this amazing place,” says Xu. “Many of these classes are mandated to be GIRs [General Institute Requirements] and major requirements. Many students recognize that sustainability is important, but might not have the time to devote an entire class to the topic if it would not count toward their requirements.”

    This was a central focus for the students who were involved in forming education recommendations for the Climate Action Plan. “We propose that more sustainability-related courses or tracks are offered in the most common majors, especially in Course 6 [EECS],” says Lutz. “If students can fulfill major requirements while taking courses that address environmental problems, we believe more students will pursue research and careers related to sustainability.”

    She also recommends that students look into the dozens of climate and sustainability classes that fulfill GIRs. “It’s really easy to take sustainability-related courses that fulfill HASS [Humanities, Arts, and Social Sciences] requirements,” she says. For example, students can meet their HASS-S (social sciences sistribution subject) requirement by taking 21H.185 (Environment and History), or fulfill their HASS-A requirement with CMS.374 (Transmedia Art, Extraction and Environmental Justice).

    Classes with impact

    For those students who do seek out sustainability classes early in their MIT careers, the experience can shape their whole education.

    “My first semester at MIT, I took Environment and History, co-taught by professors Susan Solomon and Harriet Ritvo,” says Xu. “It taught me that there is so much more involved than just science and hard facts to solving problems in sustainability and climate. I learned to look at problems with more of a focus on people, which has informed much of the extracurricular work that I’ve gone on to do at MIT.”

    And the faculty, too, sometimes find that teaching in this area opens new doors for them. Rivest, who taught the climate change seminar in Course 6, is now working to build a simplified climate model with his co-instructor Alan Edelman, their teaching assistant Henri Drake, and Professor John Deutch of the Department of Chemistry, who joined the class as a guest lecturer. “I very much enjoyed meeting new colleagues from all around MIT,” Rivest says. “Teaching a class like this fosters connections between computer scientists and climate scientists.”

    Which is why Meyers will continue helping to get these classes off the ground. “We know students think climate is a huge issue for their futures. We know faculty agree with them,” she says. “Everybody wants this to be part of an MIT education. The next step is to really reach out to students and departments to fill the classrooms. That’s the start of a virtuous cycle where enrollment drives more sustainability instruction in every part of MIT.” More