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    A new way to swiftly eliminate micropollutants from water

    “Zwitterionic” might not be a word you come across every day, but for Professor Patrick Doyle of the MIT Department of Chemical Engineering, it’s a word that’s central to the technology his group is developing to remove micropollutants from water. Derived from the German word “zwitter,” meaning “hybrid,” “zwitterionic” molecules are those with an equal number of positive and negative charges.

    Devashish Gokhale, a PhD student in Doyle’s lab, uses the example of a magnet to describe zwitterionic materials. “On a magnet, you have a north pole and a south pole that stick to each other, and on a zwitterionic molecule, you have a positive charge and a negative charge which stick to each other in a similar way.” Because many inorganic micropollutants and some organic micropollutants are themselves charged, Doyle and his team have been investigating how to deploy zwitterionic molecules to capture micropollutants in water. 

    In a new paper in Nature Water, Doyle, Gokhale, and undergraduate student Andre Hamelberg explain how they use zwitterionic hydrogels to sustainably capture both organic and inorganic micropollutants from water with minimal operational complexity. In the past, zwitterionic molecules have been used as coatings on membranes for water treatment because of their non-fouling properties. But in the Doyle group’s system, zwitterionic molecules are used to form the scaffold material, or backbone within the hydrogel — a porous three-dimensional network of polymer chains that contains a significant amount of water. “Zwitterionic molecules have very strong attraction to water compared to other materials which are used to make hydrogels or polymers,” says Gokhale. What’s more, the positive and negative charges on zwitterionic molecules cause the hydrogels to have lower compressibility than what has been commonly observed in hydrogels. This makes for significantly more swollen, robust, and porous hydrogels, which is important for the scale up of the hydrogel-based system for water treatment.

    The early stages of this research were supported by a seed grant from MIT’s Abdul Latif Jameel Water and Food Systems Lab (J-WAFS). Doyle’s group is now pursuing commercialization of the platform for both at-home use and industrial scale applications, with support from a J-WAFS Solutions grant.

    Seeking a sustainable solution

    Micropollutants are chemically diverse materials that can be harmful to human health and the environment, even though they are typically found at low concentrations (micrograms to milligrams per liter) relative to conventional contaminants. Micropollutants can be organic or inorganic and can be naturally-occurring or synthetic. Organic micropollutants are mostly carbon-based molecules and include pesticides and per- and polyfluoroalkyl substances (PFAS), known as “forever chemicals.” Inorganic micropollutants, such as heavy metals like lead and arsenic, tend to be smaller than organic micropollutants. Unfortunately, both organic and inorganic micropollutants are pervasive in the environment.

    Many micropollutants come from industrial processes, but the effects of human-induced climate change are also contributing to the environmental spread of micropollutants. Gokhale explains that, in California, for example, fires burn plastic electrical cables and leech micropollutants into natural ecosystems. Doyle adds that “outside of climate change, things like pandemics can spike the number of organic micropollutants in the environment due to high concentrations of pharmaceuticals in wastewater.”

    It’s no surprise then, that over the past few years micropollutants have become more and more of a concern. These chemicals have garnered attention in the media and led to “significant change in the environmental engineering and regulatory landscape” says Gokhale. In March 2023, the U.S. Environmental Protection Agency (EPA) proposed a strict, federal standard that would regulate six different PFAS chemicals in drinking water. Just last October, the EPA proposed banning the micropollutant trichloroethylene, a cancer-causing chemical that can be found in brake cleaners and other consumer products. And as recently as November, the EPA proposed that water utilities nationwide be required to replace all of their lead pipes to protect the public from lead exposure. Internationally, Gokhale notes the Oslo Paris Convention, whose mission is to protect the marine environment of the northeast Atlantic Ocean, including phasing out the discharge of offshore chemicals from the oil and gas industries. 

    With each new, necessary regulation to protect the safety of our water resources, the need for effective water treatment processes grows. Compounding this challenge is the need to make water treatment processes that are sustainable and energy-efficient. 

    The benchmark method to treat micropollutants in water is activated carbon. However, making filters with activated carbon is energy-intensive, requiring very high temperatures in large, centralized facilities. Gokhale says approximately “four kilograms of coal are needed to make one kilogram of activated carbon, so you lose a significant amount of carbon dioxide to the environment.” According to the World Economic Forum, global water and wastewater treatment accounts for 5 percent of annual emissions. In the U.S. alone, the EPA reports that drinking water and wastewater systems account for over 45 million tons of greenhouse gas emissions annually.

    “We need to develop methods which have smaller climate footprints than methods which are being used industrially today,” says Gokhale.

    Supporting a “high-risk” project

    In September 2019, Doyle and his lab embarked on an initial project to develop a microparticle-based platform to remove a broad range of micropollutants from water. Doyle’s group had been using hydrogels in pharmaceutical processing to formulate drug molecules into pill format. When he learned about the J-WAFS seed grant opportunity for early-stage research in water and food systems, Doyle realized his pharmaceutical work with hydrogels could be applied to environmental issues like water treatment. “I would never have gotten funding for this project if I went to the NSF [National Science Foundation], because they would just say, ‘you’re not a water person.’ But the J-WAFS seed grant offered a way for a high-risk, high-reward kind of project,” Doyle says.

    In March 2022, Doyle, Gokhale, and MIT undergraduate Ian Chen published findings from the seed grant work, describing their use of micelles within hydrogels for water treatment. Micelles are spherical structures that form when molecules called surfactants (found in things like soap), come in contact with water or other liquids. The team was able to synthesize micelle-laden hydrogel particles that soak up micropollutants from water like a sponge. Unlike activated carbon, the hydrogel particle system is made from environmentally friendly materials. Furthermore, the system’s materials are made at room temperature, making them exceedingly more sustainable than activated carbon.

    Building off the success of the seed grant, Doyle and his team were awarded a J-WAFS Solutions grant in September 2022 to help move their technology from the lab to the market. With this support, the researchers have been able to build, test, and refine pilot-scale prototypes of their hydrogel platform. System iterations during the solutions grant period have included the use of the zwitterionic molecules, a novel advancement from the seed grant work.  

    Rapid elimination of micropollutants is of special importance in commercial water treatment processes, where there is a limited amount of time water can spend inside the operational filtration unit. This is referred to as contact time, explains Gokhale. In municipal-scale or industrial-scale water treatment systems, contact times are usually less than 20 minutes and can be as short as five minutes. 

    “But as people have been trying to target these emerging micropollutants of concern, they realized they can’t get to sufficiently low concentrations on the same time scales as conventional contaminants,” Gokhale says. “Most technologies focus only on specific molecules or specific classes of molecules. So, you have whole technologies which are focusing only on PFAS, and then you have other technologies for lead and metals. When you start thinking about removing all of these contaminants from water, you end up with designs which have a very large number of unit operations. And that’s an issue because you have plants which are in the middle of large cities, and they don’t necessarily have space to expand to increase their contact times to efficiently remove multiple micropollutants,” he adds.

    Since zwitterionic molecules possess unique properties that confer high porosity, the researchers have been able to engineer a system for quicker uptake of micropollutants from water. Tests show that the hydrogels can eliminate six chemically diverse micropollutants at least 10 times faster than commercial activated carbon. The system is also compatible with a diverse set of materials, making it multifunctional. Micropollutants can bind to many different sites within the hydrogel platform: organic micropollutants bind to the micelles or surfactants while inorganic micropollutants bind to the zwitterionic molecules. Micelles, surfactants, zwitterionic molecules, and other chelating agents can be swapped in and out to essentially tune the system with different functionalities based on the profile of the water being treated. This kind of “plug-and-play” addition of various functional agents does not require a change in the design or synthesis of the hydrogel platform, and adding more functionalities does not take away from existing functionality. In this way, the zwitterionic-based system can rapidly remove multiple contaminants at lower concentrations in a single step, without the need for large, industrial units or capital expenditure. 

    Perhaps most importantly, the particles in the Doyle group’s system can be regenerated and used over and over again. By simply soaking the particles in an ethanol bath, they can be washed of micropollutants for indefinite use without loss of efficacy. When activated carbon is used for water treatment, the activated carbon itself becomes contaminated with micropollutants and must be treated as toxic chemical waste and disposed of in special landfills. Over time, micropollutants in landfills will reenter the ecosystem, perpetuating the problem.

    Arjav Shah, a PhD-MBA candidate in MIT’s Department of Chemical Engineering and the MIT Sloan School of Management, respectively, recently joined the team to lead commercialization efforts. The team has found that the zwitterionic hydrogels could be used in several real-world contexts, ranging from large-scale industrial packed beds to small-scale, portable, off-grid applications — for example, in tablets that could clean water in a canteen — and they have begun piloting the technology through a number of commercialization programs at MIT and in the greater Boston area.

    The combined strengths of each member of the team continue to drive the project forward in impactful ways, including undergraduate students like Andre Hamelberg, the third author on the Nature Water paper. Hamelberg is a participant in MIT’s Undergraduate Research Opportunities Program (UROP). Gokhale, who is also a J-WAFS Fellow, provides training and mentorship to Hamelberg and other UROP students in the lab.

    “We see this as an educational opportunity,” says Gokhale, noting that the UROP students learn science and chemical engineering through the research they conduct in the lab. The J-WAFS project has also been “a way of getting undergrads interested in water treatment and the more sustainable aspects of chemical engineering,” Gokhale says. He adds that it’s “one of the few projects which goes all the way from designing specific chemistries to building small filters and units and scaling them up and commercializing them. It’s a really good learning opportunity for the undergrads and we’re always excited to have them work with us.”

    In four years, the technology has been able to grow from an initial idea to a technology with scalable, real-world applications, making it an exemplar J-WAFS project. The fruitful collaboration between J-WAFS and the Doyle lab serves as inspiration for any MIT faculty who may want to apply their research to water or food systems projects.

    “The J-WAFS project serves as a way to demystify what a chemical engineer does,” says Doyle. “I think that there’s an old idea of chemical engineering as working in just oil and gas. But modern chemical engineering is focused on things which make life and the environment better.” More

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    Shell joins MIT.nano Consortium

    MIT.nano has announced that Shell, a global group of energy and petrochemical companies, has joined the MIT.nano Consortium.

    “With an international perspective on the world’s energy challenges, Shell is an exciting addition to the MIT.nano Consortium,” says Vladimir Bulović, the founding faculty director of MIT.nano and the Fariborz Maseeh (1990) Professor of Emerging Technologies. “The quest to build a sustainable energy future will require creative thinking backed by broad and deep expertise that our Shell colleagues bring. They will be insightful collaborators for the MIT community and for our member companies as we work together to explore innovative technology strategies.”

    Founded in 1907 when Shell Transport and Trading Co. merged with Royal Dutch, Shell has more than a century’s worth of experience in the exploration, production, refining, and marketing of oil and natural gas and the manufacturing and marketing of chemicals. Operating in over 70 countries, Shell has set a target to become a net-zero emissions energy business by 2050. To achieve this, Shell is supporting developments of low-carbon energy solutions such as biofuels, hydrogen, charging for electric vehicles, and electricity generated by solar and wind power.

    “In line with our Powering Progress strategy, our research efforts to become a net-zero emission energy company by 2050 will require intense collaboration with academic leaders across a wide range of disciplines,” says Rolf van Benthem, Shell’s chief scientist for materials science. “We look forward to engaging with the top-notch PIs [principal investigators] at MIT.nano who excel in fields like materials design and nanoscale characterization for use in energy applications and carbon utilization. Together we can work on truly sustainable solutions for our society.”

    Shell has been engaged in research collaborations with MIT since 2002 and is a founding member of the MIT Energy Initiative (MITEI). Recent MIT projects supported by Shell include an urban building energy model with the MIT Sustainable Design Laboratory that explores energy-saving building retrofits, a study of the role and impact of hydrogen-based technology pathways with MITEI, and a materials science and engineering project to design better batteries for electric vehicles.

    The MIT.nano Consortium is a platform for academia-industry collaboration centered around research and innovation emerging from nanoscale science and engineering at MIT. Through activities that include quarterly industry consortium meetings, Shell will gain insight into the work of MIT.nano’s community of users and provide advice to help guide and advance nanoscale innovations at MIT alongside the 11 other consortium companies:

    Analog Devices;
    Draper;
    Edwards;
    Fujikura;
    IBM Research;
    Lam Research;
    NC;
    NEC;
    Raith;
    UpNano; and
    Viavi Solutions.
    MIT.nano continues to welcome new companies as sustaining members. For more details, visit the MIT.nano Consortium page. More

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    Engineers develop a vibrating, ingestible capsule that might help treat obesity

    When you eat a large meal, your stomach sends signals to your brain that create a feeling of fullness, which helps you realize it’s time to stop eating. A stomach full of liquid can also send these messages, which is why dieters are often advised to drink a glass of water before eating.

    MIT engineers have now come up with a new way to take advantage of that phenomenon, using an ingestible capsule that vibrates within the stomach. These vibrations activate the same stretch receptors that sense when the stomach is distended, creating an illusory sense of fullness.

    In animals who were given this pill 20 minutes before eating, the researchers found that this treatment not only stimulated the release of hormones that signal satiety, but also reduced the animals’ food intake by about 40 percent. Scientists have much more to learn about the mechanisms that influence human body weight, but if further research suggests this technology could be safely used in humans, such a pill might offer a minimally invasive way to treat obesity, the researchers say.

    “For somebody who wants to lose weight or control their appetite, it could be taken before each meal,” says Shriya Srinivasan PhD ’20, a former MIT graduate student and postdoc who is now an assistant professor of bioengineering at Harvard University. “This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there.”

    Srinivasan is the lead author of the new study, which appears today in Science Advances. Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital, is the senior author of the paper.

    A sense of fullness

    When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates production of insulin, as well as hormones such as C-peptide, Pyy, and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down.

    While a graduate student at MIT, Srinivasan became interested in the idea of controlling this process by artificially stretching the mechanoreceptors that line the stomach, through vibration. Previous research had shown that vibration applied to a muscle can induce a sense that the muscle has stretched farther than it actually has.

    “I wondered if we could activate stretch receptors in the stomach by vibrating them and having them perceive that the entire stomach has been expanded, to create an illusory sense of distension that could modulate hormones and eating patterns,” Srinivasan says.

    As a postdoc in MIT’s Koch Institute for Integrative Cancer Research, Srinivasan worked closely with Traverso’s lab, which has developed many novel approaches to oral delivery of drugs and electronic devices. For this study, Srinivasan, Traverso, and a team of researchers designed a capsule about the size of a multivitamin, that includes a vibrating element. When the pill, which is powered by a small silver oxide battery, reaches the stomach, acidic gastric fluids dissolve a gelatinous membrane that covers the capsule, completing the electronic circuit that activates the vibrating motor.

    In a study in animals, the researchers showed that once the pill begins vibrating, it activates mechanoreceptors, which send signals to the brain through stimulation of the vagus nerve. The researchers tracked hormone levels during the periods when the device was vibrating and found that they mirrored the hormone release patterns seen following a meal, even when the animals had fasted.

    The researchers then tested the effects of this stimulation on the animals’ appetite. They found that when the pill was activated for about 20 minutes, before the animals were offered food, they consumed 40 percent less, on average, than they did when the pill was not activated. The animals also gained weight more slowly during periods when they were treated with the vibrating pill.

    “The behavioral change is profound, and that’s using the endogenous system rather than any exogenous therapeutic. We have the potential to overcome some of the challenges and costs associated with delivery of biologic drugs by modulating the enteric nervous system,” Traverso says.

    The current version of the pill is designed to vibrate for about 30 minutes after arriving in the stomach, but the researchers plan to explore the possibility of adapting it to remain in the stomach for longer periods of time, where it could be turned on and off wirelessly as needed. In the animal studies, the pills passed through the digestive tract within four or five days.

    The study also found that the animals did not show any signs of obstruction, perforation, or other negative impacts while the pill was in their digestive tract.

    An alternative approach

    This type of pill could offer an alternative to the current approaches to treating obesity, the researchers say. Nonmedical interventions such as diet exercise don’t always work, and many of the existing medical interventions are fairly invasive. These include gastric bypass surgery, as well as gastric balloons, which are no longer used widely in the United States due to safety concerns.

    Drugs such as GLP-1 agonists can also aid weight loss, but most of them have to be injected, and they are unaffordable for many people. According to Srinivasan, the MIT capsules could be manufactured at a cost that would make them available to people who don’t have access to more expensive treatment options.

    “For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point,” she says. “I’d love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today.”

    The researchers now plan to explore ways to scale up the manufacturing of the capsules, which could enable clinical trials in humans. Such studies would be important to learn more about the devices’ safety, as well as determine the best time to swallow the capsule before to a meal and how often it would need to be administered.

    Other authors of the paper include Amro Alshareef, Alexandria Hwang, Ceara Byrne, Johannes Kuosmann, Keiko Ishida, Joshua Jenkins, Sabrina Liu, Wiam Abdalla Mohammed Madani, Alison Hayward, and Niora Fabian.

    The research was funded by the National Institutes of Health, Novo Nordisk, the Department of Mechanical Engineering at MIT, a Schmidt Science Fellowship, and the National Science Foundation. More

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    MIT in the media: 2023 in review

    It was an eventful trip around the sun for MIT this year, from President Sally Kornbluth’s inauguration and Mark Rober’s Commencement address to Professor Moungi Bawendi winning the Nobel Prize in Chemistry. In 2023 MIT researchers made key advances, detecting a dying star swallowing a planet, exploring the frontiers of artificial intelligence, creating clean energy solutions, inventing tools aimed at earlier detection and diagnosis of cancer, and even exploring the science of spreading kindness. Below are highlights of some of the uplifting people, breakthroughs, and ideas from MIT that made headlines in 2023.

    The gift: Kindness goes viral with Steve HartmanSteve Hartman visited Professor Anette “Peko” Hosoi to explore the science behind whether a single act of kindness can change the world.Full story via CBS News

    Trio wins Nobel Prize in chemistry for work on quantum dots, used in electronics and medical imaging“The motivation really is the basic science. A basic understanding, the curiosity of ‘how does the world work?’” said Professor Moungi Bawendi of the inspiration for his research on quantum dots, for which he was co-awarded the 2023 Nobel Prize in Chemistry.Full story via the Associated Press

    How MIT’s all-women leadership team plans to change science for the betterPresident Sally Kornbluth, Provost Cynthia Barnhart, and Chancellor Melissa Nobles emphasized the importance of representation for women and underrepresented groups in STEM.Full story via Radio Boston

    MIT via community college? Transfer students find a new path to a degreeUndergraduate Subin Kim shared his experience transferring from community college to MIT through the Transfer Scholars Network, which is aimed at helping community college students find a path to four-year universities.Full story via the Christian Science Monitor

    MIT president Sally Kornbluth doesn’t think we can hit the pause button on AIPresident Kornbluth discussed the future of AI, ethics in science, and climate change with columnist Shirley Leung on her new “Say More” podcast. “I view [the climate crisis] as an existential issue to the extent that if we don’t take action there, all of the many, many other things that we’re working on, not that they’ll be irrelevant, but they’ll pale in comparison,” Kornbluth said.Full story via The Boston Globe 

    It’s the end of a world as we know itAstronomers from MIT, Harvard University, Caltech and elsewhere spotted a dying star swallowing a large planet. Postdoc Kishalay De explained that: “Finding an event like this really puts all of the theories that have been out there to the most stringent tests possible. It really opens up this entire new field of research.”Full story via The New York Times

    Frontiers of AI

    Hey, Alexa, what should students learn about AI?The Day of AI is a program developed by the MIT RAISE initiative aimed at introducing and teaching K-12 students about AI. “We want students to be informed, responsible users and informed, responsible designers of these technologies,” said Professor Cynthia Breazeal, dean of digital learning at MIT.Full story via The New York Times

    AI tipping pointFour faculty members from across MIT — Professors Song Han, Simon Johnson, Yoon Kim and Rosalind Picard — described the opportunities and risks posed by the rapid advancements in the field of AI.Full story via Curiosity Stream 

    A look into the future of AI at MIT’s robotics laboratoryProfessor Daniela Rus, director of MIT’s Computer Science and Artificial Intelligence Laboratory, discussed the future of artificial intelligence, robotics, and machine learning, emphasizing the importance of balancing the development of new technologies with the need to ensure they are deployed in a way that benefits humanity.Full story via Mashable

    Health care providers say artificial intelligence could transform medicineProfessor Regina Barzilay spoke about her work developing new AI systems that could be used to help diagnose breast and lung cancer before the cancers are detectable to the human eye.Full story via Chronicle

    Is AI coming for your job? Tech experts weigh in: “They don’t replace human labor”Professor David Autor discussed how the rise of artificial intelligence could change the quality of jobs available.Full story via CBS News

    Big tech is bad. Big AI will be worse.Institute Professor Daron Acemoglu and Professor Simon Johnson made the case that “rather than machine intelligence, what we need is ‘machine usefulness,’ which emphasizes the ability of computers to augment human capabilities.”Full story via The New York Times

    Engineering excitement

    MIT’s 3D-printed hearts could pump new life into customized treatments MIT engineers developed a technique for 3D printing a soft, flexible, custom-designed replica of a patient’s heart.Full story via WBUR

    Mystery of why Roman buildings have survived so long has been unraveled, scientists sayScientists from MIT and other institutions discovered that ancient Romans used lime clasts when manufacturing concrete, giving the material self-healing properties.Full story via CNN

    The most interesting startup in America is in Massachusetts. You’ve probably never heard of it.VulcanForms, an MIT startup, is at the “leading edge of a push to transform 3D printing from a niche technology — best known for new-product prototyping and art-class experimentation — into an industrial force.”Full story via The Boston Globe

    Catalyzing climate innovations

    Can Boston’s energy innovators save the world?Boston Magazine reporter Rowan Jacobsen spotlighted how MIT faculty, students, and alumni are leading the charge in clean energy startups. “When it comes to game-changing breakthroughs in energy, three letters keep surfacing again and again: MIT,” writes Jacobsen.Full story via Boston Magazine

    MIT research could be game changer in combating water shortagesMIT researchers discovered that a common hydrogel used in cosmetic creams, industrial coatings, and pharmaceutical capsules can absorb moisture from the atmosphere even as the temperature rises. “For a planet that’s getting hotter, this could be a game-changing discovery.”Full story via NBC Boston

    Energy-storing concrete could form foundations for solar-powered homesMIT engineers uncovered a new way of creating an energy supercapacitor by combining cement, carbon black, and water that could one day be used to power homes or electric vehicles.Full story via New Scientist

    MIT researchers tackle key question of EV adoption: When to charge?MIT scientists found that delayed charging and strategic placement of EV charging stations could help reduce additional energy demands caused by more widespread EV adoption.Full story via Fast Company

    Building better buildingsProfessor John Fernández examined how to reduce the climate footprints of homes and office buildings, recommending creating airtight structures, switching to cleaner heating sources, using more environmentally friendly building materials, and retrofitting existing homes and offices.Full story via The New York Times

    They’re building an “ice penetrator” on a hillside in WestfordResearchers from MIT’s Haystack Observatory built an “ice penetrator,” a device designed to monitor the changing conditions of sea ice.Full story via The Boston Globe

    Healing health solutions

    How Boston is beating cancerMIT researchers are developing drug-delivery nanoparticles aimed at targeting cancer cells without disturbing healthy cells. Essentially, the nanoparticles are “engineered for selectivity,” explained Professor Paula Hammond, head of MIT’s Department of Chemical Engineering.Full story via Boston Magazine

    A new antibiotic, discovered with artificial intelligence, may defeat a dangerous superbugUsing a machine-learning algorithm, researchers from MIT discovered a type of antibiotic that’s effective against a particular strain of drug-resistant bacteria.Full story via CNN

    To detect breast cancer sooner, an MIT professor designs an ultrasound braMIT researchers designed a wearable ultrasound device that attaches to a bra and could be used to detect early-stage breast tumors.Full story via STAT

    The quest for a switch to turn on hungerAn ingestible pill developed by MIT scientists can raise levels of hormones to help increase appetite and decrease nausea in patients with gastroparesis.Full story via Wired

    Here’s how to use dreams for creative inspirationMIT scientists found that the earlier stages of sleep are key to sparking creativity and that people can be guided to dream about specific topics, further boosting creativity.Full story via Scientific American

    Astounding art

    An AI opera from 1987 reboots for a new generationProfessor Tod Machover discussed the restaging of his opera “VALIS” at MIT, which featured an artificial intelligence-assisted musical instrument developed by Nina Masuelli ’23.Full story via The Boston Globe

    Surfacing the stories hidden in migration dataAssociate Professor Sarah Williams discussed the Civic Data Design Lab’s “Motivational Tapestry,” a large woven art piece that uses data from the United Nations World Food Program to visually represent the individual motivations of 1,624 Central Americans who have migrated to the U.S.Full story via Metropolis

    Augmented reality-infused production of Wagner’s “Parsifal” opens Bayreuth FestivalProfessor Jay Scheib’s augmented reality-infused production of Richard Wagner’s “Parsifal” brought “fantastical images” to audience members.Full story via the Associated Press

    Understanding our universe

    New image reveals violent events near a supermassive black holeScientists captured a new image of M87*, the black hole at the center of the Messier 87 galaxy, showing the “launching point of a colossal jet of high-energy particles shooting outward into space.”Full story via Reuters

    Gravitational waves: A new universeMIT researchers Lisa Barsotti, Deep Chatterjee, and Victoria Xu explored how advances in gravitational wave detection are enabling a better understanding of the universe.Full story via Curiosity Stream 

    Nergis Mavalvala helped detect the first gravitational wave. Her work doesn’t stop thereProfessor Nergis Mavalvala, dean of the School of Science, discussed her work searching for gravitational waves, the importance of skepticism in scientific research, and why she enjoys working with young people.Full story via Wired

    Hitting the books

    “The Transcendent Brain” review: Beyond ones and zeroesIn his book “The Transcendent Brain: Spirituality in the Age of Science,” Alan Lightman, a professor of the practice of humanities, displayed his gift for “distilling complex ideas and emotions to their bright essence.”Full story via The Wall Street Journal

    What happens when CEOs treat workers better? Companies (and workers) win.Professor of the practice Zeynep Ton published a book, “The Case for Good Jobs,” and is “on a mission to change how company leaders think, and how they treat their employees.”Full story via The Boston Globe

    How to wage war on conspiracy theoriesProfessor Adam Berinsky’s book, “Political Rumors: Why We Accept Misinformation and How to Fight it,” examined “attitudes toward both politics and health, both of which are undermined by distrust and misinformation in ways that cause harm to both individuals and society.”Full story via Politico

    What it takes for Mexican coders to cross the cultural border with Silicon ValleyAssistant Professor Héctor Beltrán discussed his new book, “Code Work: Hacking across the U.S./México Techno-Borderlands,” which explores the culture of hackathons and entrepreneurship in Mexico.Full story via Marketplace

    Cultivating community

    The Indigenous rocketeerNicole McGaa, a fourth-year student at MIT, discussed her work leading MIT’s all-Indigenous rocket team at the 2023 First Nations Launch National Rocket Competition.Full story via Nature

    “You totally got this,” YouTube star and former NASA engineer Mark Rober tells MIT graduatesDuring his Commencement address at MIT, Mark Rober urged graduates to embrace their accomplishments and boldly face any challenges they encounter.Full story via The Boston Globe

    MIT Juggling Club going strong after half centuryAfter almost 50 years, the MIT Juggling Club, which was founded in 1975 and then merged with a unicycle club, is the oldest drop-in juggling club in continuous operation and still welcomes any aspiring jugglers to come toss a ball (or three) into the air.Full story via Cambridge Day

    Volpe Transportation Center opens as part of $750 million deal between MIT and fedsThe John A. Volpe National Transportation Systems Center in Kendall Square was the first building to open in MIT’s redevelopment of the 14-acre Volpe site that will ultimately include “research labs, retail, affordable housing, and open space, with the goal of not only encouraging innovation, but also enhancing the surrounding community.”Full story via The Boston Globe

    Sparking conversation

    The future of AI innovation and the role of academics in shaping itProfessor Daniela Rus emphasized the central role universities play in fostering innovation and the importance of ensuring universities have the computing resources necessary to help tackle major global challenges.Full story via The Boston Globe

    Moving the needle on supply chain sustainabilityProfessor Yossi Sheffi examined several strategies companies could use to help improve supply chain sustainability, including redesigning last-mile deliveries, influencing consumer choices and incentivizing returnable containers.Full story via The Hill

    Expelled from the mountain top?Sylvester James Gates Jr. ’73, PhD ’77 made the case that “diverse learning environments expose students to a broader range of perspectives, enhance education, and inculcate creativity and innovative habits of mind.”Full story via Science

    Marketing magic of “Barbie” movie has lessons for women’s sportsMIT Sloan Lecturer Shira Springer explored how the success of the “Barbie” movie could be applied to women’s sports.Full story via Sports Business Journal

    We’re already paying for universal health care. Why don’t we have it?Professor Amy Finkelstein asserted that the solution to health insurance reform in the U.S. is “universal coverage that is automatic, free and basic.”Full story via The New York Times 

    The internet could be so good. Really.Professor Deb Roy described how “new kinds of social networks can be designed for constructive communication — for listening, dialogue, deliberation, and mediation — and they can actually work.”Full story via The Atlantic

    Fostering educational excellence

    MIT students give legendary linear algebra professor standing ovation in last lectureAfter 63 years of teaching and over 10 million views of his online lectures, Professor Gilbert Strang received a standing ovation after his last lecture on linear algebra. “I am so grateful to everyone who likes linear algebra and sees its importance. So many universities (and even high schools) now appreciate how beautiful it is and how valuable it is,” said Strang.Full story via USA Today

    “Brave Behind Bars”: Reshaping the lives of inmates through coding classesGraduate students Martin Nisser and Marisa Gaetz co-founded Brave Behind Bars, a program designed to provide incarcerated individuals with coding and digital literacy skills to better prepare them for life after prison.Full story via MSNBC

    Melrose TikTok user “Ms. Nuclear Energy” teaching about nuclear power through social mediaGraduate student Kaylee Cunningham discussed her work using social media to help educate and inform the public about nuclear energy.Full story via CBS Boston  More

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    Angela Belcher delivers 2023 Dresselhaus Lecture on evolving organisms for new nanomaterials

    “How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”

    The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.

    “I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.

    Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.

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    2023 Mildred S. Dresselhaus Lecture: Angela BelcherVideo: MIT.nano

    Energy storage and environment

    “How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.

    How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.

    Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.

    Imaging tools and therapeutics in cancer

    In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.

    Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.

    Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.

    “We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.

    “Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”

    Honoring Mildred S. Dresselhaus

    Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.

    “Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”

    Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.

    Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.

    “I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.” More

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    Satellite-based method measures carbon in peat bogs

    Peat bogs in the tropics store vast amounts of carbon, but logging, plantations, road building, and other activities have destroyed large swaths of these ecosystems in places like Indonesia and Malaysia. Peat formations are essentially permanently flooded forestland, where dead leaves and branches accumulate because the water table prevents their decomposition.

    The pileup of organic material gives these formations a distinctive domed shape, somewhat raised in the center and tapering toward the edges. Determining how much carbon is contained in each formation has required laborious on-the-ground sampling, and so has been limited in its coverage.

    Now, researchers from MIT and Singapore have developed a mathematical analysis of how peat formations build and develop, that makes it possible to evaluate their carbon content and dynamics mostly from simple elevation measurements. These can be carried out by satellites, without requiring ground-based sampling. This analysis, the team says, should make it possible to make more precise and accurate assessments of the amount of carbon that would be released by any proposed draining of peatlands — and, inversely, how much carbon emissions could be avoided by protecting them.

    The research is being reported today in the journal Nature, in a paper by Alexander Cobb, a postdoc with the Singapore-MIT Alliance for Research and Technology (SMART); Charles Harvey, an MIT professor of civil and environmental engineering; and six others.

    Although it is the tropical peatlands that are at greatest risk — because they are the ones most often drained for timber harvesting or the creation of plantations for palm oil, acacia, and other crops — the new formulas the team derived apply to peatlands all over the globe, from Siberia to New Zealand. The formula requires just two inputs. The first is elevation data from a single transect of a given peat dome — that is, a series of elevation measurements along an arbitrary straight line cutting across from one edge of the formation to the other. The second input is a site-specific factor the team devised that relates to the type of peat bog involved and the internal structure of the formation, which together determine how much of the carbon within remains safely submerged in water, where it can’t be oxidized.

    “The saturation by water prevents oxygen from getting in, and if oxygen gets in, microbes breathe it and eat the peat and turn it into carbon dioxide,” Harvey explains.

    “There is an internal surface inside the peat dome below which the carbon is safe because it can’t be drained, because the bounding rivers and water bodies are such that it will keep saturated up to that level even if you cut canals and try to drain it,” he adds. In between the visible surface of the bog and this internal layer is the “vulnerable zone” of peat that can rapidly decompose and release its carbon compounds or become dry enough to promote fires that also release the carbon and pollute the air.

    Through years of on-the-ground sampling and testing, and detailed analysis comparing the ground data with satellite lidar data on surface elevations, the team was able to figure out a kind of universal mathematical formula that describes the structure of peat domes of all kinds and in all locations. They tested it by comparing their predicted results with field measurements from several widely distributed locations, including Alaska, Maine, Quebec, Estonia, Finland, Brunei, and New Zealand.

    These bogs contain carbon that has in many cases accumulated over thousands of years but can be released in just a few years when the bogs are drained. “If we could have policies to preserve these, it is a tremendous opportunity to reduce carbon fluxes to the atmosphere. This framework or model gives us the understanding, the intellectual framework, to figure out how to do that,” Harvey says.

    Many people assume that the biggest greenhouse gas emissions from cutting down these forested lands is from the decomposition of the trees themselves. “The misconception is that that’s the carbon that goes to the atmosphere,” Harvey says. “It’s actually a small amount, because the real fluxes to the atmosphere come from draining” the peat bogs. “Then, the much larger pool of carbon, which is underground beneath the forest, oxidizes and goes to the air, or catches fire and burns.”

    But there is hope, he says, that much of this drained peatland can still be restored before the stored carbon all gets released. First of all, he says, “you’ve got to stop draining it.” That can be accomplished by damming up the drainage canals. “That’s what’s good about this mathematical framework: You need to figure out how to do that, where to put your dams. There’s all sorts of interesting complexities. If you just dam up the canal, the water may flow around it. So, it’s a neat geometric and engineering project to figure out how to do this.”

    While much of the peatland in southeast Asia has already been drained, the new analysis should make it possible to make much more accurate assessments of less-well-studied peatlands in places like the Amazon basin, New Guinea and the Congo basin, which are also threatened by development.

    The new formulation should also help to make some carbon offset programs more reliable, because it is now possible to calculate accurately the carbon content of a given peatland. “It’s quantifiable, because the peat is 100 percent organic carbon. So, if you just measure the change in the surface going up or down, you can say with pretty good certainty how much carbon has been accumulated or lost, whereas if you go to a rainforest, it’s virtually impossible to calculate the amount of underground carbon, and it’s pretty hard to calculate what’s above ground too,” Harvey says. “But this is relatively easy to calculate with satellite measurements of elevation.”

    “We can turn the knob,” he says, “because we have this mathematical framework for how the hydrology, the water table position, affects the growth and loss of peat. We can design a scheme that will change emissions by X amount, for Y dollars.”

    The research team included Rene Dommain, Kimberly Yeap, and Cao Hannan at Nanyang Technical University in Singapore, Nathan Dadap at Stanford University, Bodo Bookhagen at the University of Potsdam, Germany, and Paul Glaser at the University of Minnesota. The work was supported by the National Research Foundation Singapore through the SMART program, by the U.S. National Science Foundation, and Singapore’s Office for Space Technology and Industry. More

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    Building a better indoor herb garden

    Randall Briggs ’09, SM ’18 didn’t set out to build indoor gardens when he arrived at MIT. The winner of the 2010 2.007 robot competition class, he was excited to work on designing fighter planes one day.

    But in 2016, halfway through his studies for his master’s degree in mechanical engineering, Briggs’s father passed away unexpectedly. “It was a big blow to me. My motivation took a big hit, so it was hard for me to keep working on my research,” Briggs shares.

    Briggs ordered a home hydroponic garden in the hopes that growing herbs inside his apartment could bring him some positivity. “There is something healing about seeing something organic and beautiful grow and develop,” Briggs says.

    When the garden arrived, Briggs found that many aspects of the design fell short. The plants weren’t getting enough light because the LEDs were dispersing light throughout the room and not focusing it on the plants. “It’s just not very pleasing aesthetically when it’s, like, a fluorescent color of light, and it just fills your room,” Briggs says.

    He set forth to create a better indoor garden. Briggs turned his spare bedroom into a hydroponics lab, testing herbs growing under various lighting conditions and with different nutrient solutions. He read every book and article he could find on the subject. “The same seed pods that I had used in that cheap garden, when I moved them over to my garden, they grew way faster and way healthier and more fragrant and full of flavor,” he says.

    Working on this project became a daily source of joy for Briggs. “Every day when you come home, you want to see if it’s growing a little bit more or to see how they’re doing. I think that made me happy, too.”

    Briggs saw the potential for his garden to improve the well-being of others. “I thought if people had fresh herbs at home, they might be more inspired to cook for themselves instead of always just eating out, as it’s normally a lot healthier to cook your own food at home.”

    After much research and experimentation, GardenByte was born in 2017: a tabletop indoor herb garden that is nearly 3 feet wide with almost 2 feet of height for the plants to grow, which is quite a bit larger than most models on the market. With Briggs’s hydroponics technology, the plants grow three times faster than they would grow outdoors. His garden allows anyone to grow fresh herbs in a wide range of settings. And since plants have a longer shelf life than cut herbs, they also cut down on food waste.

    Briggs was determined to make something that grows plants well and is attractive in a variety of settings. The outer case is handcrafted from solid hardwood from a local Massachusetts lumber yard, ensuring both durability and a visually pleasing aesthetic that seamlessly integrates into any kitchen or restaurant setting. The light bar, crafted from a single piece of crystal-clear acrylic, maintains an unobtrusive and ethereal appearance. This choice complements the overall design while allowing the LED lights to emit a powerful simulation of full sunshine. To ensure a smooth transition from daytime growth to evening, four different types of LEDs were incorporated. Polymer lenses focus the light directly onto the plants, preventing any wastage or unnecessary light spillage in the room. A light and color sensor on top detect the lighting conditions in the room and automatically adjust the lighting in the garden to match, enhancing plant growth. The grid tray is designed to accommodate up to 39 plants at once, offering ample space for an array of herbs. To simplify plant care, the garden is connected to a mobile app that will allow you to care for your plants while you’re away.

    The herb garden contains computer numerical control (CNC) machined-aluminum parts, in contrast with the flimsier plastic most products use. The heat flow capacity of aluminum disperses the heat from all the LEDs and the aluminum grid tray helps keep it compact and thin but rigid, so users can lift the plants up without it bending.

    Briggs received his foundation in machining as an undergrad at the MIT Edgerton Center, where he was on the MIT Motorsports team and MIT Electric Vehicle Team. He learned how to use the CNC machines in the student machine shop at the Area 51 garage under the tutelage of Instructor Pat McAtamney and Briggs’s teammates.

    Building an electric motorcycle on the Electric Vehicle Team for the Isle of Man TT Race in 2011 helped prepare Briggs for creating a robust product for production. The race took place on city streets, raising the potential for deadly crashes. “When we were building that motorcycle, the head of our team, Lennon Rodgers, kept reiterating to us, ‘you got to think aircraft quality, like aircraft quality. This is actually a life-or-death project.’ Seeing the way that he led, and the way that he really set the bar for quality and for execution and kind of kept things moving, was really helpful for me.”

    “My hope in the future is to make a more mass-market version that’s a little bit cheaper and more available to everybody,” Briggs shares.

    The feedback from his first customers has all been positive. After delivering the product to a chef in Boston, Briggs says, “He told me that the whole first evening he was sitting at home with his boyfriend and he just kept staring at it, and he’s like, ‘it is so beautiful. It is so beautiful.’”

    “I feel like something that my dad taught me was that sometimes to do hard things, it does take hard work, and that it’s not always going to be exciting, necessarily,” Briggs shares. “It’s good to be inspired, it’s good to be passionate, but it’s not always going to get you through. And sometimes it’s just hard work that you got to press through the tough parts.” More

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    MIT students win Beth Israel Deaconess Medical Center sustainability award

    MIT senior Anna Kwon and sophomore Nicole Doering have been recognized by Beth Israel Deaconess Medical Center (BIDMC) for their work as interns last summer. Both students received Jane Matlaw Environmental Champion Awards, which honor leaders and innovators who have catalyzed changes that align with BIDMC’s sustainability goals and foster a healthier future for staff and patients.

    The awards, which were established 25 years ago, had previously only been given to individuals and teams within BIDMC. “This year, given the significant leadership and alignment with our public commitments that Nicole and Anna had over the summer, our Sustainability Award Review Committee determined that we would include a student category of our awards for both a high school student and undergraduates as well,” says Avery Palardy, the climate and sustainability director at BIDMC.

    Kwon and Doering worked at BIDMC through the Social Impact Internship Program, one of many experiential learning opportunities offered by MIT’s Priscilla King Gray Center for Public Service. The program provides funded internships to students interested in working with government agencies, nonprofits, and social ventures.

    Both students conducted work that will help BIDMC meet two commitments to the Department of Health and Human Services Health Sector Climate Pledge: to develop a climate resilience plan for continuous operations by the end of 2023, and to conduct an inventory of its supply chain emissions by the end of 2024.

    “It was fun — a new challenge for me,” says Kwon, who is majoring in electrical engineering and computer science. “I have never done research in sustainability before. I was able to dive into the field of health care from a new angle, deepening my understanding of the complexities of environmental issues within health care.” Her internship involved performing data analysis related to carbon emissions. In addition, she developed actionable recommendations for conducting a comprehensive supply chain inventory.

    “Anna demonstrated unwavering diligence and attention to detail throughout her work to conduct a greenhouse gas inventory of our supply chain,” says Palardy. “She showcased exceptional skills in market research as she investigated best practices and emerging technologies to ensure that we stay at the forefront of sustainable practices. Her keen insights and forward-thinking approach have equipped us with valuable information for shaping our path forward on our sustainability goals.”

    Doering, a chemical engineering major, guided several departments in an internal assessment of best practices, vulnerabilities, and future directions to integrate climate resilience into the medical center’s operations. She has continued to work this fall to help finalize the climate resilience plan, and she has also been analyzing food procurement data to identify ways to reduce BIDMC’s Scope 3 emissions.

    Climate resilience isn’t an area of sustainability that Doering had considered before, but the internship experience has inspired her to continue pursuing other sustainability roles in the future. “I’m so thankful for all I’ve learned from BIDMC, so I’m really glad that my work was helpful to them. It is an honor that they trusted me to work with them on something that will have such a wonderful impact on our community,” she says.

    “The impact of Nicole’s contributions cannot be overstated,” notes Palardy. “From planning and organizing crucial focus groups to crafting our climate resilience plan, she played a pivotal role in shaping our climate resilience strategies for the better. I’m so grateful for the collaborative spirit, passion, and leadership that she brought to our team. She helped to drive innovation in health-care climate resilience that is necessary for us to ensure this continues to be a priority.” More