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A One Health trial design to accelerate Lassa fever vaccines

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We propose an interdisciplinary framework to address the considerable challenges that are restricting the development of vaccines for zoonotic diseases with epidemic potential.

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Fig. 1: The proposed OHTD framework.

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Authors and Affiliations

  1. Department of Anthropology, The Pennsylvania State University, University Park, PA, USA

    David Simons & Sagan Friant

  2. Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA, USA

    David Simons & Sagan Friant

  3. Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK

    Deborah Watson-Jones & Daniela Manno

  4. Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania

    Deborah Watson-Jones

Authors

  1. David Simons
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  2. Deborah Watson-Jones
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  3. Daniela Manno
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  4. Sagan Friant
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David Simons.

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The authors declare no competing interests.

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Simons, D., Watson-Jones, D., Manno, D. et al. A One Health trial design to accelerate Lassa fever vaccines.
Nat Med (2026). https://doi.org/10.1038/s41591-025-04018-6

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  • DOI: https://doi.org/10.1038/s41591-025-04018-6

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