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    Food for thought

    MIT graduate student Juana De La O describes herself as a food-motivated organism, so it’s no surprise that she reaches for food and baking analogies when she’s discussing her thesis work in the lab of undergraduate officer and professor of biology Adam Martin. 

    Consider the formative stages of a croissant, she offers, occasionally providing homemade croissants to accompany the presentation: When one is forming the puff pastry, the dough is folded over the butter again and again. Tissues in a developing mouse embryo must similarly fold and bend, creating layers and structures that become the spine, head, and organs — but these tissues have no hands to induce those formative movements. 

    De La O is studying neural tube closure, the formation of the structure that becomes the spinal cord and the brain. Disorders like anencephaly and craniorachischisis occur when the head region fails to close in a developing fetus. It’s a heartbreaking defect, De La O says, because it’s 100 percent lethal — but the fetus fully develops otherwise. 

    “Your entire central nervous system hinges on this one event happening successfully,” she says. “On the fundamental level, we have a very limited understanding of the mechanisms required for neural closure to happen at all, much less an understanding of what goes wrong that leads to those defects.” 

    Hypothetically speaking

    De La O hails from Chicago, where she received an undergraduate degree from the University of Chicago and worked in the lab of Ilaria Rebay. De La O’s sister was the first person in her family to go to and graduate from college — De La O, in turn, is the first person in her family to pursue a PhD. 

    From her first time visiting campus, De La O could see MIT would provide a thrilling environment in which to study.

    “MIT was one of the few places where the students weren’t constantly complaining about how hard their life was,” she says. “At lunch with prospective students, they’d be talking to each other and then just organically slip into conversations about science.”

    The department emails acceptance letters and sends a physical copy via snail mail. De La O’s letter included a handwritten note from department head Amy Keating, then a graduate officer, who had interviewed De La O during her campus visit. 

    “That’s what really sold it for me,” she recalls. “I went to my PI [principal investigator]’s office and said, ‘I have new data’” and I showed her the letter, and there was lots of unintelligible crying.” 

    To prepare her for graduate school, her parents, both immigrants from Mexico, spent the summer teaching De La O to make all her favorite dishes because “comfort food feels like home.”   

    When she reached MIT, however, the Covid-19 pandemic ground the world to a halt and severely limited what students could experience during rotations. Far from home and living alone, De La O taught herself to bake, creating the confections she craved but couldn’t leave her apartment to purchase. De La O didn’t get to work as extensively as she would have liked during her rotation in the Martin lab. 

    Martin had recently returned from a sabbatical that was spent learning a new research model; historically a fly lab, Martin was planning to delve into mouse research. 

    “My final presentation was, ‘Here’s a hypothetical project I would hypothetically do if I were hypothetically going to work with mice in a fly lab,’” De La O says. 

    Martin recalls being impressed. De La O is skilled at talking about science in an earnest and engaging way, and she dug deep into the literature and identified points Martin hadn’t considered. 

    “This is a level of independence that I look for in a student because it is important to the science to have someone who is contributing their ideas and independent reading and research to a project,” Martin says. 

    After agreeing to join the lab — news she shared with Martin via a meme — she got to work. 

    Charting mouse development

    The neural tube forms from a flat sheet whose sides rise and meet to create a hollow cylinder. De La O has observed patterns of actin and myosin changing in space and time as the embryo develops. Actin and myosin are fibrous proteins that provide structure in eukaryotic cells. They are responsible for some cell movement, like muscle contraction or cell division. Fibers of actin and myosin can also connect across cells, forming vast networks that coordinate the movements of whole tissues. By looking at the structure of these networks, researchers can make predictions about how force is affecting those tissues.

    De La O has found indications of a difference in the tension across the tissue during the critical stages of neural tube closure, which contributes to the tissue’s ability to fold and form a tube. They are not the first research group to propose this, she notes, but they’re suggesting that the patterns of tension are not uniform during a single stage of development.

    “My project, on a really fundamental level, is an atlas for a really early stage of mouse development for actin and myosin,” De La O says. “This dataset doesn’t exist in the field yet.” 

    However, De La O has been performing analyses exclusively in fixed samples, so she may be quantifying phenomena that are not actually how tissues behave. To determine whether that’s the case, De La O plans to analyze live samples.

    The idea is that if one could carefully cut tissue and observe how quickly it recoils, like slicing through a taught rubber band, those measurements could be used to approximate force across the tissue. However, the techniques required are still being developed, and the greater Boston area currently lacks the equipment and expertise needed to attempt those experiments. 

    A big part of her work in the lab has been figuring out how to collect and analyze relevant data. This research has already taken her far and wide, both literally and virtually. 

    “We’ve found that people have been very generous with their time and expertise,” De La O says. “One of the benefits we, as fly people, brought into this field is we don’t know anything — so we’re going to question everything.”

    De La O traveled to the University of Virginia to learn live imaging techniques from associate professor of cell biology Ann Sutherland, and she’s also been in contact with Gabriel Galea at University College London, where Martin and De La O are considering a visit for further training. 

    “There are a lot of reasons why these experiments could go wrong, and one of them is that I’m not trained yet,” she says. “Once you know how to do things on an optimal setup, you can figure out how to make it work on a less-optimal setup.”

    Collaboration and community

    De La O has now expanded her cooking repertoire far beyond her family’s recipes and shares her new creations when she visits home. At MIT, she hosts dinner parties, including one where everything from the savory appetizers to the sweet desserts contained honey, thanks to an Independent Activities Period course about the producers of the sticky substance, and she made and tried apple pie for the first time with her fellow graduate students after an afternoon of apple picking. 

    De La O says she’s still learning how to say no to taking on additional work outside of her regular obligations as a PhD student; she’s found there’s a lot of pressure for underrepresented students to be at the forefront of diversity efforts, and although she finds that work extremely fulfilling, she can, and has, stretched herself too thin in the past. 

    “Every time I see an application that asks ‘How will you work to increase diversity,’ my strongest instinct is just to write ‘I’m brown and around — you’re welcome,’” she jokes. “The greatest amount of diversity work I will do is to get where I’m going. Me achieving my goals increases diversity inherently, but I also want to do well because I know if I do, I will make everything better for people coming after me.”

    De La O is confident her path will be in academia, and troubleshooting, building up protocols, and setting up standards for her work in the Martin Lab has been “an excellent part of my training program.” 

    De La O and Martin embarked on a new project in a new model for the lab for De La O’s thesis, so much of her graduate studies will be spent laying the groundwork for future research. 

    “I hope her travels open Juana’s eyes to science being a larger community and to teach her about how to lead a collaboration,” Martin says. “Overall, I think this project is excellent for a student with aspirations to be a PI. I benefited from extremely open-ended projects as a student and see, in retrospect, how they prepared me for my work today.” More

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    A new way to swiftly eliminate micropollutants from water

    “Zwitterionic” might not be a word you come across every day, but for Professor Patrick Doyle of the MIT Department of Chemical Engineering, it’s a word that’s central to the technology his group is developing to remove micropollutants from water. Derived from the German word “zwitter,” meaning “hybrid,” “zwitterionic” molecules are those with an equal number of positive and negative charges.

    Devashish Gokhale, a PhD student in Doyle’s lab, uses the example of a magnet to describe zwitterionic materials. “On a magnet, you have a north pole and a south pole that stick to each other, and on a zwitterionic molecule, you have a positive charge and a negative charge which stick to each other in a similar way.” Because many inorganic micropollutants and some organic micropollutants are themselves charged, Doyle and his team have been investigating how to deploy zwitterionic molecules to capture micropollutants in water. 

    In a new paper in Nature Water, Doyle, Gokhale, and undergraduate student Andre Hamelberg explain how they use zwitterionic hydrogels to sustainably capture both organic and inorganic micropollutants from water with minimal operational complexity. In the past, zwitterionic molecules have been used as coatings on membranes for water treatment because of their non-fouling properties. But in the Doyle group’s system, zwitterionic molecules are used to form the scaffold material, or backbone within the hydrogel — a porous three-dimensional network of polymer chains that contains a significant amount of water. “Zwitterionic molecules have very strong attraction to water compared to other materials which are used to make hydrogels or polymers,” says Gokhale. What’s more, the positive and negative charges on zwitterionic molecules cause the hydrogels to have lower compressibility than what has been commonly observed in hydrogels. This makes for significantly more swollen, robust, and porous hydrogels, which is important for the scale up of the hydrogel-based system for water treatment.

    The early stages of this research were supported by a seed grant from MIT’s Abdul Latif Jameel Water and Food Systems Lab (J-WAFS). Doyle’s group is now pursuing commercialization of the platform for both at-home use and industrial scale applications, with support from a J-WAFS Solutions grant.

    Seeking a sustainable solution

    Micropollutants are chemically diverse materials that can be harmful to human health and the environment, even though they are typically found at low concentrations (micrograms to milligrams per liter) relative to conventional contaminants. Micropollutants can be organic or inorganic and can be naturally-occurring or synthetic. Organic micropollutants are mostly carbon-based molecules and include pesticides and per- and polyfluoroalkyl substances (PFAS), known as “forever chemicals.” Inorganic micropollutants, such as heavy metals like lead and arsenic, tend to be smaller than organic micropollutants. Unfortunately, both organic and inorganic micropollutants are pervasive in the environment.

    Many micropollutants come from industrial processes, but the effects of human-induced climate change are also contributing to the environmental spread of micropollutants. Gokhale explains that, in California, for example, fires burn plastic electrical cables and leech micropollutants into natural ecosystems. Doyle adds that “outside of climate change, things like pandemics can spike the number of organic micropollutants in the environment due to high concentrations of pharmaceuticals in wastewater.”

    It’s no surprise then, that over the past few years micropollutants have become more and more of a concern. These chemicals have garnered attention in the media and led to “significant change in the environmental engineering and regulatory landscape” says Gokhale. In March 2023, the U.S. Environmental Protection Agency (EPA) proposed a strict, federal standard that would regulate six different PFAS chemicals in drinking water. Just last October, the EPA proposed banning the micropollutant trichloroethylene, a cancer-causing chemical that can be found in brake cleaners and other consumer products. And as recently as November, the EPA proposed that water utilities nationwide be required to replace all of their lead pipes to protect the public from lead exposure. Internationally, Gokhale notes the Oslo Paris Convention, whose mission is to protect the marine environment of the northeast Atlantic Ocean, including phasing out the discharge of offshore chemicals from the oil and gas industries. 

    With each new, necessary regulation to protect the safety of our water resources, the need for effective water treatment processes grows. Compounding this challenge is the need to make water treatment processes that are sustainable and energy-efficient. 

    The benchmark method to treat micropollutants in water is activated carbon. However, making filters with activated carbon is energy-intensive, requiring very high temperatures in large, centralized facilities. Gokhale says approximately “four kilograms of coal are needed to make one kilogram of activated carbon, so you lose a significant amount of carbon dioxide to the environment.” According to the World Economic Forum, global water and wastewater treatment accounts for 5 percent of annual emissions. In the U.S. alone, the EPA reports that drinking water and wastewater systems account for over 45 million tons of greenhouse gas emissions annually.

    “We need to develop methods which have smaller climate footprints than methods which are being used industrially today,” says Gokhale.

    Supporting a “high-risk” project

    In September 2019, Doyle and his lab embarked on an initial project to develop a microparticle-based platform to remove a broad range of micropollutants from water. Doyle’s group had been using hydrogels in pharmaceutical processing to formulate drug molecules into pill format. When he learned about the J-WAFS seed grant opportunity for early-stage research in water and food systems, Doyle realized his pharmaceutical work with hydrogels could be applied to environmental issues like water treatment. “I would never have gotten funding for this project if I went to the NSF [National Science Foundation], because they would just say, ‘you’re not a water person.’ But the J-WAFS seed grant offered a way for a high-risk, high-reward kind of project,” Doyle says.

    In March 2022, Doyle, Gokhale, and MIT undergraduate Ian Chen published findings from the seed grant work, describing their use of micelles within hydrogels for water treatment. Micelles are spherical structures that form when molecules called surfactants (found in things like soap), come in contact with water or other liquids. The team was able to synthesize micelle-laden hydrogel particles that soak up micropollutants from water like a sponge. Unlike activated carbon, the hydrogel particle system is made from environmentally friendly materials. Furthermore, the system’s materials are made at room temperature, making them exceedingly more sustainable than activated carbon.

    Building off the success of the seed grant, Doyle and his team were awarded a J-WAFS Solutions grant in September 2022 to help move their technology from the lab to the market. With this support, the researchers have been able to build, test, and refine pilot-scale prototypes of their hydrogel platform. System iterations during the solutions grant period have included the use of the zwitterionic molecules, a novel advancement from the seed grant work.  

    Rapid elimination of micropollutants is of special importance in commercial water treatment processes, where there is a limited amount of time water can spend inside the operational filtration unit. This is referred to as contact time, explains Gokhale. In municipal-scale or industrial-scale water treatment systems, contact times are usually less than 20 minutes and can be as short as five minutes. 

    “But as people have been trying to target these emerging micropollutants of concern, they realized they can’t get to sufficiently low concentrations on the same time scales as conventional contaminants,” Gokhale says. “Most technologies focus only on specific molecules or specific classes of molecules. So, you have whole technologies which are focusing only on PFAS, and then you have other technologies for lead and metals. When you start thinking about removing all of these contaminants from water, you end up with designs which have a very large number of unit operations. And that’s an issue because you have plants which are in the middle of large cities, and they don’t necessarily have space to expand to increase their contact times to efficiently remove multiple micropollutants,” he adds.

    Since zwitterionic molecules possess unique properties that confer high porosity, the researchers have been able to engineer a system for quicker uptake of micropollutants from water. Tests show that the hydrogels can eliminate six chemically diverse micropollutants at least 10 times faster than commercial activated carbon. The system is also compatible with a diverse set of materials, making it multifunctional. Micropollutants can bind to many different sites within the hydrogel platform: organic micropollutants bind to the micelles or surfactants while inorganic micropollutants bind to the zwitterionic molecules. Micelles, surfactants, zwitterionic molecules, and other chelating agents can be swapped in and out to essentially tune the system with different functionalities based on the profile of the water being treated. This kind of “plug-and-play” addition of various functional agents does not require a change in the design or synthesis of the hydrogel platform, and adding more functionalities does not take away from existing functionality. In this way, the zwitterionic-based system can rapidly remove multiple contaminants at lower concentrations in a single step, without the need for large, industrial units or capital expenditure. 

    Perhaps most importantly, the particles in the Doyle group’s system can be regenerated and used over and over again. By simply soaking the particles in an ethanol bath, they can be washed of micropollutants for indefinite use without loss of efficacy. When activated carbon is used for water treatment, the activated carbon itself becomes contaminated with micropollutants and must be treated as toxic chemical waste and disposed of in special landfills. Over time, micropollutants in landfills will reenter the ecosystem, perpetuating the problem.

    Arjav Shah, a PhD-MBA candidate in MIT’s Department of Chemical Engineering and the MIT Sloan School of Management, respectively, recently joined the team to lead commercialization efforts. The team has found that the zwitterionic hydrogels could be used in several real-world contexts, ranging from large-scale industrial packed beds to small-scale, portable, off-grid applications — for example, in tablets that could clean water in a canteen — and they have begun piloting the technology through a number of commercialization programs at MIT and in the greater Boston area.

    The combined strengths of each member of the team continue to drive the project forward in impactful ways, including undergraduate students like Andre Hamelberg, the third author on the Nature Water paper. Hamelberg is a participant in MIT’s Undergraduate Research Opportunities Program (UROP). Gokhale, who is also a J-WAFS Fellow, provides training and mentorship to Hamelberg and other UROP students in the lab.

    “We see this as an educational opportunity,” says Gokhale, noting that the UROP students learn science and chemical engineering through the research they conduct in the lab. The J-WAFS project has also been “a way of getting undergrads interested in water treatment and the more sustainable aspects of chemical engineering,” Gokhale says. He adds that it’s “one of the few projects which goes all the way from designing specific chemistries to building small filters and units and scaling them up and commercializing them. It’s a really good learning opportunity for the undergrads and we’re always excited to have them work with us.”

    In four years, the technology has been able to grow from an initial idea to a technology with scalable, real-world applications, making it an exemplar J-WAFS project. The fruitful collaboration between J-WAFS and the Doyle lab serves as inspiration for any MIT faculty who may want to apply their research to water or food systems projects.

    “The J-WAFS project serves as a way to demystify what a chemical engineer does,” says Doyle. “I think that there’s an old idea of chemical engineering as working in just oil and gas. But modern chemical engineering is focused on things which make life and the environment better.” More

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    Engineers develop a vibrating, ingestible capsule that might help treat obesity

    When you eat a large meal, your stomach sends signals to your brain that create a feeling of fullness, which helps you realize it’s time to stop eating. A stomach full of liquid can also send these messages, which is why dieters are often advised to drink a glass of water before eating.

    MIT engineers have now come up with a new way to take advantage of that phenomenon, using an ingestible capsule that vibrates within the stomach. These vibrations activate the same stretch receptors that sense when the stomach is distended, creating an illusory sense of fullness.

    In animals who were given this pill 20 minutes before eating, the researchers found that this treatment not only stimulated the release of hormones that signal satiety, but also reduced the animals’ food intake by about 40 percent. Scientists have much more to learn about the mechanisms that influence human body weight, but if further research suggests this technology could be safely used in humans, such a pill might offer a minimally invasive way to treat obesity, the researchers say.

    “For somebody who wants to lose weight or control their appetite, it could be taken before each meal,” says Shriya Srinivasan PhD ’20, a former MIT graduate student and postdoc who is now an assistant professor of bioengineering at Harvard University. “This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there.”

    Srinivasan is the lead author of the new study, which appears today in Science Advances. Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital, is the senior author of the paper.

    A sense of fullness

    When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates production of insulin, as well as hormones such as C-peptide, Pyy, and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down.

    While a graduate student at MIT, Srinivasan became interested in the idea of controlling this process by artificially stretching the mechanoreceptors that line the stomach, through vibration. Previous research had shown that vibration applied to a muscle can induce a sense that the muscle has stretched farther than it actually has.

    “I wondered if we could activate stretch receptors in the stomach by vibrating them and having them perceive that the entire stomach has been expanded, to create an illusory sense of distension that could modulate hormones and eating patterns,” Srinivasan says.

    As a postdoc in MIT’s Koch Institute for Integrative Cancer Research, Srinivasan worked closely with Traverso’s lab, which has developed many novel approaches to oral delivery of drugs and electronic devices. For this study, Srinivasan, Traverso, and a team of researchers designed a capsule about the size of a multivitamin, that includes a vibrating element. When the pill, which is powered by a small silver oxide battery, reaches the stomach, acidic gastric fluids dissolve a gelatinous membrane that covers the capsule, completing the electronic circuit that activates the vibrating motor.

    In a study in animals, the researchers showed that once the pill begins vibrating, it activates mechanoreceptors, which send signals to the brain through stimulation of the vagus nerve. The researchers tracked hormone levels during the periods when the device was vibrating and found that they mirrored the hormone release patterns seen following a meal, even when the animals had fasted.

    The researchers then tested the effects of this stimulation on the animals’ appetite. They found that when the pill was activated for about 20 minutes, before the animals were offered food, they consumed 40 percent less, on average, than they did when the pill was not activated. The animals also gained weight more slowly during periods when they were treated with the vibrating pill.

    “The behavioral change is profound, and that’s using the endogenous system rather than any exogenous therapeutic. We have the potential to overcome some of the challenges and costs associated with delivery of biologic drugs by modulating the enteric nervous system,” Traverso says.

    The current version of the pill is designed to vibrate for about 30 minutes after arriving in the stomach, but the researchers plan to explore the possibility of adapting it to remain in the stomach for longer periods of time, where it could be turned on and off wirelessly as needed. In the animal studies, the pills passed through the digestive tract within four or five days.

    The study also found that the animals did not show any signs of obstruction, perforation, or other negative impacts while the pill was in their digestive tract.

    An alternative approach

    This type of pill could offer an alternative to the current approaches to treating obesity, the researchers say. Nonmedical interventions such as diet exercise don’t always work, and many of the existing medical interventions are fairly invasive. These include gastric bypass surgery, as well as gastric balloons, which are no longer used widely in the United States due to safety concerns.

    Drugs such as GLP-1 agonists can also aid weight loss, but most of them have to be injected, and they are unaffordable for many people. According to Srinivasan, the MIT capsules could be manufactured at a cost that would make them available to people who don’t have access to more expensive treatment options.

    “For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point,” she says. “I’d love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today.”

    The researchers now plan to explore ways to scale up the manufacturing of the capsules, which could enable clinical trials in humans. Such studies would be important to learn more about the devices’ safety, as well as determine the best time to swallow the capsule before to a meal and how often it would need to be administered.

    Other authors of the paper include Amro Alshareef, Alexandria Hwang, Ceara Byrne, Johannes Kuosmann, Keiko Ishida, Joshua Jenkins, Sabrina Liu, Wiam Abdalla Mohammed Madani, Alison Hayward, and Niora Fabian.

    The research was funded by the National Institutes of Health, Novo Nordisk, the Department of Mechanical Engineering at MIT, a Schmidt Science Fellowship, and the National Science Foundation. More

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    Building a better indoor herb garden

    Randall Briggs ’09, SM ’18 didn’t set out to build indoor gardens when he arrived at MIT. The winner of the 2010 2.007 robot competition class, he was excited to work on designing fighter planes one day.

    But in 2016, halfway through his studies for his master’s degree in mechanical engineering, Briggs’s father passed away unexpectedly. “It was a big blow to me. My motivation took a big hit, so it was hard for me to keep working on my research,” Briggs shares.

    Briggs ordered a home hydroponic garden in the hopes that growing herbs inside his apartment could bring him some positivity. “There is something healing about seeing something organic and beautiful grow and develop,” Briggs says.

    When the garden arrived, Briggs found that many aspects of the design fell short. The plants weren’t getting enough light because the LEDs were dispersing light throughout the room and not focusing it on the plants. “It’s just not very pleasing aesthetically when it’s, like, a fluorescent color of light, and it just fills your room,” Briggs says.

    He set forth to create a better indoor garden. Briggs turned his spare bedroom into a hydroponics lab, testing herbs growing under various lighting conditions and with different nutrient solutions. He read every book and article he could find on the subject. “The same seed pods that I had used in that cheap garden, when I moved them over to my garden, they grew way faster and way healthier and more fragrant and full of flavor,” he says.

    Working on this project became a daily source of joy for Briggs. “Every day when you come home, you want to see if it’s growing a little bit more or to see how they’re doing. I think that made me happy, too.”

    Briggs saw the potential for his garden to improve the well-being of others. “I thought if people had fresh herbs at home, they might be more inspired to cook for themselves instead of always just eating out, as it’s normally a lot healthier to cook your own food at home.”

    After much research and experimentation, GardenByte was born in 2017: a tabletop indoor herb garden that is nearly 3 feet wide with almost 2 feet of height for the plants to grow, which is quite a bit larger than most models on the market. With Briggs’s hydroponics technology, the plants grow three times faster than they would grow outdoors. His garden allows anyone to grow fresh herbs in a wide range of settings. And since plants have a longer shelf life than cut herbs, they also cut down on food waste.

    Briggs was determined to make something that grows plants well and is attractive in a variety of settings. The outer case is handcrafted from solid hardwood from a local Massachusetts lumber yard, ensuring both durability and a visually pleasing aesthetic that seamlessly integrates into any kitchen or restaurant setting. The light bar, crafted from a single piece of crystal-clear acrylic, maintains an unobtrusive and ethereal appearance. This choice complements the overall design while allowing the LED lights to emit a powerful simulation of full sunshine. To ensure a smooth transition from daytime growth to evening, four different types of LEDs were incorporated. Polymer lenses focus the light directly onto the plants, preventing any wastage or unnecessary light spillage in the room. A light and color sensor on top detect the lighting conditions in the room and automatically adjust the lighting in the garden to match, enhancing plant growth. The grid tray is designed to accommodate up to 39 plants at once, offering ample space for an array of herbs. To simplify plant care, the garden is connected to a mobile app that will allow you to care for your plants while you’re away.

    The herb garden contains computer numerical control (CNC) machined-aluminum parts, in contrast with the flimsier plastic most products use. The heat flow capacity of aluminum disperses the heat from all the LEDs and the aluminum grid tray helps keep it compact and thin but rigid, so users can lift the plants up without it bending.

    Briggs received his foundation in machining as an undergrad at the MIT Edgerton Center, where he was on the MIT Motorsports team and MIT Electric Vehicle Team. He learned how to use the CNC machines in the student machine shop at the Area 51 garage under the tutelage of Instructor Pat McAtamney and Briggs’s teammates.

    Building an electric motorcycle on the Electric Vehicle Team for the Isle of Man TT Race in 2011 helped prepare Briggs for creating a robust product for production. The race took place on city streets, raising the potential for deadly crashes. “When we were building that motorcycle, the head of our team, Lennon Rodgers, kept reiterating to us, ‘you got to think aircraft quality, like aircraft quality. This is actually a life-or-death project.’ Seeing the way that he led, and the way that he really set the bar for quality and for execution and kind of kept things moving, was really helpful for me.”

    “My hope in the future is to make a more mass-market version that’s a little bit cheaper and more available to everybody,” Briggs shares.

    The feedback from his first customers has all been positive. After delivering the product to a chef in Boston, Briggs says, “He told me that the whole first evening he was sitting at home with his boyfriend and he just kept staring at it, and he’s like, ‘it is so beautiful. It is so beautiful.’”

    “I feel like something that my dad taught me was that sometimes to do hard things, it does take hard work, and that it’s not always going to be exciting, necessarily,” Briggs shares. “It’s good to be inspired, it’s good to be passionate, but it’s not always going to get you through. And sometimes it’s just hard work that you got to press through the tough parts.” More

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    Microbes could help reduce the need for chemical fertilizers

    Production of chemical fertilizers accounts for about 1.5 percent of the world’s greenhouse gas emissions. MIT chemists hope to help reduce that carbon footprint by replacing some chemical fertilizer with a more sustainable source — bacteria.

    Bacteria that can convert nitrogen gas to ammonia could not only provide nutrients that plants need, but also help regenerate soil and protect plants from pests. However, these bacteria are sensitive to heat and humidity, so it’s difficult to scale up their manufacture and ship them to farms.

    To overcome that obstacle, MIT chemical engineers have devised a metal-organic coating that protects bacterial cells from damage without impeding their growth or function. In a new study, they found that these coated bacteria improved the germination rate of a variety of seeds, including vegetables such as corn and bok choy.

    This coating could make it much easier for farmers to deploy microbes as fertilizers, says Ariel Furst, the Paul M. Cook Career Development Assistant Professor of Chemical Engineering at MIT and the senior author of the study.

    “We can protect them from the drying process, which would allow us to distribute them much more easily and with less cost because they’re a dried powder instead of in liquid,” she says. “They can also withstand heat up to 132 degrees Fahrenheit, which means that you wouldn’t have to use cold storage for these microbes.”

    Benjamin Burke ’23 and postdoc Gang Fan are the lead authors of the open-access paper, which appears in the Journal of the American Chemical Society Au. MIT undergraduate Pris Wasuwanich and Evan Moore ’23 are also authors of the study.

    Protecting microbes

    Chemical fertilizers are manufactured using an energy-intensive process known as Haber-Bosch, which uses extremely high pressures to combine nitrogen from the air with hydrogen to make ammonia.

    In addition to the significant carbon footprint of this process, another drawback to chemical fertilizers is that long-term use eventually depletes the nutrients in the soil. To help restore soil, some farmers have turned to “regenerative agriculture,” which uses a variety of strategies, including crop rotation and composting, to keep soil healthy. Nitrogen-fixing bacteria, which convert nitrogen gas to ammonia, can aid in this approach.

    Some farmers have already begun deploying these “microbial fertilizers,” growing them in large onsite fermenters before applying them to the soil. However, this is cost-prohibitive for many farmers.

    Shipping these bacteria to rural areas is not currently a viable option, because they are susceptible to heat damage. The microbes are also too delicate to survive the freeze-drying process that would make them easier to transport.

    To protect the microbes from both heat and freeze-drying, Furst decided to apply a coating called a metal-phenol network (MPN), which she has previously developed to encapsulate microbes for other uses, such as protecting therapeutic bacteria delivered to the digestive tract.

    The coatings contain two components — a metal and an organic compound called a polyphenol — that can self-assemble into a protective shell. The metals used for the coatings, including iron, manganese, aluminum, and zinc, are considered safe as food additives. Polyphenols, which are often found in plants, include molecules such as tannins and other antioxidants. The FDA classifies many of these polyphenols as GRAS (generally regarded as safe).

    “We are using these natural food-grade compounds that are known to have benefits on their own, and then they form these little suits of armor that protect the microbes,” Furst says.

    For this study, the researchers created 12 different MPNs and used them to encapsulate Pseudomonas chlororaphis, a nitrogen-fixing bacterium that also protects plants against harmful fungi and other pests. They found that all of the coatings protected the bacteria from temperatures up to 50 degrees Celsius (122 degrees Fahrenheit), and also from relative humidity up to 48 percent. The coatings also kept the microbes alive during the freeze-drying process.

    A boost for seeds

    Using microbes coated with the most effective MPN — a combination of manganese and a polyphenol called epigallocatechin gallate (EGCG) — the researchers tested their ability to help seeds germinate in a lab dish. They heated the coated microbes to 50 C before placing them in the dish, and compared them to fresh uncoated microbes and freeze-dried uncoated microbes.

    The researchers found that the coated microbes improved the seeds’ germination rate by 150 percent, compared to seeds treated with fresh, uncoated microbes. This result was consistent across several different types of seeds, including dill, corn, radishes, and bok choy.

    Furst has started a company called Seia Bio to commercialize the coated bacteria for large-scale use in regenerative agriculture. She hopes that the low cost of the manufacturing process will help make microbial fertilizers accessible to small-scale farmers who don’t have the fermenters needed to grow such microbes.

    “When we think about developing technology, we need to intentionally design it to be inexpensive and accessible, and that’s what this technology is. It would help democratize regenerative agriculture,” she says.

    The research was funded by the Army Research Office, a National Institutes of Health New Innovator Award, a National Institute for Environmental Health Sciences Core Center Grant, the CIFAR Azrieli Global Scholars Program, the MIT J-WAFS Program, the MIT Climate and Sustainability Consortium, and the MIT Deshpande Center. More

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    “Move-in day is kind of like our Superbowl”

    The academic year has officially begun at MIT, and the halls are once again filled with the energy and excitement that only students can bring. But MIT’s campus does not come to life automatically.

    The flurry of activity happening around campus this week was preceded by a lot of hard work by thousands of staff members committed to getting the school year off to a seamless start.

    “Getting MIT ready to welcome new and returning students is a real team effort, and much of the work goes on over the summer or behind the scenes when many students are away from campus,” says Suzy Nelson, vice chancellor and dean for student life. “I’m grateful to all of the staff members in the Division of Student Life and across the Institute whose dedication to their job and exceptional efforts help to make the MIT experience so special from the moment students arrive on campus.”

    Describing all of those efforts would require a book-length article, but here we highlight a few examples of the behind-the-scenes work that ushers in the new academic year.

    Housing and Residential Services

    One might think the team responsible for housing at MIT gets a break in June and July when undergraduates leave for the summer. But the housing team stays busy year-round. Summer months offer openings for renovations, planning, and events like summer programs and conferences (some of which provide housing). In fact, team members say the planning alone is nearly a year-round job.

    “We start planning for students coming back in May because first-year students are confirming attendance and starting to indicate their preferences for where they want to live, and housing works really closely with student leaders in each of the undergrad residences because our student leaders are very involved with room assignments,” explains Rich Hilton, associate dean and director for residential services and operations. “On the graduate side, grads typically move in Aug. 1, and departing grad students move out at the end of July, or sometimes earlier, so in those early summer months there’s a lot of transitioning happening.”

    Of course, move-in day for undergraduates and the subsequent Welcome Week are an important time for the Housing and Residential Services team to help the MIT community’s newest members settle in.

    “Move-in day is kind of like our Superbowl,” Hilton says. “All the summer projects we work on are to prepare and maintain the residence halls for new and returning students to be living in the residence halls. The ramp-up involves making sure the residences are refreshed and ready, and the welcome efforts include providing moving bins, materials, and moving assistance. For students who have never been to campus before, residential staff are often the first people they meet, so we want to put a really good impression out there. We pull out all the stops to make sure that welcome efforts are top-notch.”

    Hilton says the atmosphere is always special on move in day.

    “The students are a wonderful motivation,” Hilton says. “It’s great seeing the new students come in with their families. Students are coming from all corners of the world, from different backgrounds, and more often than not the parents are just beaming with pride, so being able to greet them and even reassure them if needed is really rewarding.”

    In all, MIT Housing and Residential Services employs more than 200 people focused on assignments, maintenance, cleaning, residential security, and more, to make living on campus as enjoyable as possible.

    “Housing truly is 24/7, 365,” Hilton says. “Our team members are on campus keeping our residents safe and happy and serving them 24 hours a day. They’re here rain or shine, and it’s nice to keep them in mind.”

    Dining

    MIT Dining works with students to offer healthy, affordable, and culturally meaningful food in environments that promote social connections, sustainability, and innovation. The department oversees nine different third-party contractors to provide services across 20+ locations — and MIT’s own dining staff consists of just two people: Director of Campus Dining Mark Hayes and Assistant Director of Dining Operations Heather Ryall.

    Typical summer months provide an opportunity for the small team to look at food trends, work with dieticians and food allergy specialists, review menus, and explore ways to improve operations. This summer was even busier thanks to renovations at the Stratton Student Center and Maseeh Hall and the introduction of new food stations in CommonWealth Kitchen and at Forbes Café.

    In August, MIT Dining makes sure it has established open lines of communication with new student leaders and other groups around campus

    “We interact with a lot of student groups this time of year,” Hayes says. “It’s exciting to start with a new group of students and get feedback, collaborating and sharing ideas. It reminds us of what we’re here for: students. If things are working, that’s great! If they’re not working, let’s collaborate and figure out what can we do better — let’s make it a pset [problem set]. What are we not doing that we should be? I’ve been lucky in that students at MIT are really engaged.”

    “August is when everyone wants to get together and make sure we’re starting off on the right foot,” Hayes says. “That two-way flow of information is what it’s all about, and it’s really strong here.”

    Some dining locations stay open through the summer to support grad students, faculty and staff, but residential dining halls shut down. By August, some international students and athletes begin moving back to campus. Then Welcome Week begins for first-year students. Then pretty much everyone else returns over Labor Day Weekend.

    “In a way, you go from almost zero to 100,” Hayes says.

    This academic year, DSL will undertake a thorough review of the residence hall dining program, gathering student and community input on enhancements. This follows a similar review of campus retail dining operations completed in December 2022.

    Student Support and Wellbeing

    The Student Support and Wellbeing team, co-led by Associate Dean and Senior Director Jimmy Doan, offers a slate of resources to make it easy for students to seek help if they need it, and to encourage students to take care of themselves throughout their time at MIT. The team also coordinates with faculty, staff, and student groups across the Institute to foster an environment where students’ sense of belonging and well-being is prioritized.

    Ahead of the new school year, team members have been sharing with faculty best practices for fostering student well-being in the classroom and labs, including presenting workshops to new faculty members to inform them of resources to use when they’re concerned about students.

    They have also been connecting with student leaders so they can help their peers prioritize well-being. “Come early August, we’re facilitating a lot of trainings and gearing up for new student orientation programs.” Doan says. “We’re working with a lot of student leaders this time of year. We know students learn as much from each other as they do from us.”

    New student orientation offers a chance to provide a week’s worth of programming to incoming first-year students. In one of those sessions, Dear Future Me, older students share their perspectives on prioritizing well-being and accessing support at MIT.

    “We try to normalize students getting help at MIT when they need it,” Doan says. “Starting from day one of orientation we tell them getting help is for everybody.”

    One office where nearly 80 percent of undergraduate students seek out help before they graduate is Student Support Services, more commonly known as “S3” or “S-Cubed.” The staff in S3 are preparing for the start of the year by revamping their virtual drop-in hours for students, which students can access from the S3 website.

    “We want the ways that students reach out for help to be as accessible as possible,” Doan says. More

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    Tiny magnetic beads produce an optical signal that could be used to quickly detect pathogens

    Getting results from a blood test can take anywhere from one day to a week, depending on what a test is targeting. The same goes for tests of water pollution and food contamination. And in most cases, the wait time has to do with time-consuming steps in sample processing and analysis.

    Now, MIT engineers have identified a new optical signature in a widely used class of magnetic beads, which could be used to quickly detect contaminants in a variety of diagnostic tests. For example, the team showed the signature could be used to detect signs of the food contaminant Salmonella.

    The so-called Dynabeads are microscopic magnetic beads that can be coated with antibodies that bind to target molecules, such as a specific pathogen. Dynabeads are typically used in experiments in which they are mixed into solutions to capture molecules of interest. But from there, scientists have to take additional, time-consuming steps to confirm that the molecules are indeed present and bound to the beads.

    The MIT team found a faster way to confirm the presence of Dynabead-bound pathogens, using optics, specifically, Raman spectroscopy. This optical technique identifies specific molecules based on their “Raman signature,” or the unique way in which a molecule scatters light.

    The researchers found that Dynabeads have an unusually strong Raman signature that can be easily detected, much like a fluorescent tag. This signature, they found, can act as a “reporter.” If detected, the signal can serve as a quick confirmation, within less than one second, that a target pathogen is indeed present in a given sample. The team is currently working to develop a portable device for quickly detecting a range of bacterial pathogens, and their results will appear in an Emerging Investigators special issue of the Journal of Raman Spectroscopy.

    “This technique would be useful in a situation where a doctor is trying to narrow down the source of an infection in order to better inform antibiotic prescription, as well as for the detection of known pathogens in food and water,” says study co-author Marissa McDonald, a graduate student in the Harvard-MIT Program in Health Sciences and Technology. “Additionally, we hope this approach will eventually lead to expanded access to advanced diagnostics in resource-limited environments.”

    Study co-authors at MIT include Postdoctoral Associate Jongwan Lee; Visiting Scholar Nikiwe Mhlanga; Research Scientist Jeon Woong Kang; Tata Professor Rohit Karnik, who is also the associate director of the Abdul Latif Jameel Water and Food Systems Lab; and Assistant Professor Loza Tadesse of the Department of Mechanical Engineering.

    Oil and water

    Looking for diseased cells and pathogens in fluid samples is an exercise in patience.

    “It’s kind of a needle-in-a-haystack problem,” Tadesse says.

    The numbers present are so small that they must be grown in controlled environments to sufficient numbers, and their cultures stained, then studied under a microscope. The entire process can take several days to a week to yield a confident positive or negative result.

    Both Karnik and Tadesse’s labs have independently been developing techniques to speed up various parts of the pathogen testing process and make the process portable, using Dynabeads.

    Dynabeads are commercially available microscopic beads made from a magnetic iron core and a polymer shell that can be coated with antibodies. The surface antibodies act as hooks to bind specific target molecules. When mixed with a fluid, such as a vial of blood or water, any molecules present will glom onto the Dynabeads. Using a magnet, scientists can gently coax the beads to the bottom of a vial and filter them out of a solution. Karnik’s lab is investigating ways to then further separate the beads into those that are bound to a target molecule, and those that are not. “Still, the challenge is, how do we know that we have what we’re looking for?” Tadesse says.

    The beads themselves are not visible by eye. That’s where Tadesse’s work comes in. Her lab uses Raman spectroscopy as a way to “fingerprint” pathogens. She has found that different cell types scatter light in unique ways that can be used as a signature to identify them.

    In the team’s new work, she and her colleagues found that Dynabeads also have a unique and strong Raman signature that can act as a surprisingly clear beacon.

    “We were initially seeking to identify the signatures of bacteria, but the signature of the Dynabeads was actually very strong,” Tadesse says. “We realized this signal could be a means of reporting to you whether you have that bacteria or not.”

    Testing beacon

    As a practical demonstration, the researchers mixed Dynabeads into vials of water contaminated with Salmonella. They then magnetically isolated these beads onto microscope slides and measured the way light scattered through the fluid when exposed to laser light. Within half a second, they quickly detected the Dynabeads’ Raman signature — a confirmation that bound Dynabeads, and by inference, Salmonella, were present in the fluid.

    “This is something that can be used to rapidly give a positive or negative answer: Is there a contaminant or not?” Tadesse says. “Because even a handful of pathogens can cause clinical symptoms.”

    The team’s new technique is significantly faster than conventional methods and uses elements that could be adapted into smaller, more portable forms — a goal that the researchers are currently working toward. The approach is also highly versatile.

    “Salmonella is the proof of concept,” Tadesse says. “You could purchase Dynabeads with E.coli antibodies, and the same thing would happen: It would bind to the bacteria, and we’d be able to detect the Dynabead signature because the signal is super strong.”

    The team is particularly keen to apply the test to conditions such as sepsis, where time is of the essence, and where pathogens that trigger the condition are not rapidly detected using conventional lab tests.

    “There are a lot cases, like in sepsis, where pathogenic cells cannot always be grown on a plate,” says Lee, a member of Karnik’s lab. “In that case, our technique could rapidly detect these pathogens.”

    This research was supported, in part, by the MIT Laser Biomedical Research Center, the National Cancer Institute, and the Abdul Latif Jameel Water and Food Systems Lab at MIT. More

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    System tracks movement of food through global humanitarian supply chain

    Although more than enough food is produced to feed everyone in the world, as many as 828 million people face hunger today. Poverty, social inequity, climate change, natural disasters, and political conflicts all contribute to inhibiting access to food. For decades, the U.S. Agency for International Development (USAID) Bureau for Humanitarian Assistance (BHA) has been a leader in global food assistance, supplying millions of metric tons of food to recipients worldwide. Alleviating hunger — and the conflict and instability hunger causes — is critical to U.S. national security.

    But BHA is only one player within a large, complex supply chain in which food gets handed off between more than 100 partner organizations before reaching its final destination. Traditionally, the movement of food through the supply chain has been a black-box operation, with stakeholders largely out of the loop about what happens to the food once it leaves their custody. This lack of direct visibility into operations is due to siloed data repositories, insufficient data sharing among stakeholders, and different data formats that operators must manually sort through and standardize. As a result, accurate, real-time information — such as where food shipments are at any given time, which shipments are affected by delays or food recalls, and when shipments have arrived at their final destination — is lacking. A centralized system capable of tracing food along its entire journey, from manufacture through delivery, would enable a more effective humanitarian response to food-aid needs.

    In 2020, a team from MIT Lincoln Laboratory began engaging with BHA to create an intelligent dashboard for their supply-chain operations. This dashboard brings together the expansive food-aid datasets from BHA’s existing systems into a single platform, with tools for visualizing and analyzing the data. When the team started developing the dashboard, they quickly realized the need for considerably more data than BHA had access to.

    “That’s where traceability comes in, with each handoff partner contributing key pieces of information as food moves through the supply chain,” explains Megan Richardson, a researcher in the laboratory’s Humanitarian Assistance and Disaster Relief Systems Group.

    Richardson and the rest of the team have been working with BHA and their partners to scope, build, and implement such an end-to-end traceability system. This system consists of serialized, unique identifiers (IDs) — akin to fingerprints — that are assigned to individual food items at the time they are produced. These individual IDs remain linked to items as they are aggregated along the supply chain, first domestically and then internationally. For example, individually tagged cans of vegetable oil get packaged into cartons; cartons are placed onto pallets and transported via railway and truck to warehouses; pallets are loaded onto shipping containers at U.S. ports; and pallets are unloaded and cartons are unpackaged overseas.

    With a trace

    Today, visibility at the single-item level doesn’t exist. Most suppliers mark pallets with a lot number (a lot is a batch of items produced in the same run), but this is for internal purposes (i.e., to track issues stemming back to their production supply, like over-enriched ingredients or machinery malfunction), not data sharing. So, organizations know which supplier lot a pallet and carton are associated with, but they can’t track the unique history of an individual carton or item within that pallet. As the lots move further downstream toward their final destination, they are often mixed with lots from other productions, and possibly other commodity types altogether, because of space constraints. On the international side, such mixing and the lack of granularity make it difficult to quickly pull commodities out of the supply chain if food safety concerns arise. Current response times can span several months.

    “Commodities are grouped differently at different stages of the supply chain, so it is logical to track them in those groupings where needed,” Richardson says. “Our item-level granularity serves as a form of Rosetta Stone to enable stakeholders to efficiently communicate throughout these stages. We’re trying to enable a way to track not only the movement of commodities, including through their lot information, but also any problems arising independent of lot, like exposure to high humidity levels in a warehouse. Right now, we have no way to associate commodities with histories that may have resulted in an issue.”

    “You can now track your checked luggage across the world and the fish on your dinner plate,” adds Brice MacLaren, also a researcher in the laboratory’s Humanitarian Assistance and Disaster Relief Systems Group. “So, this technology isn’t new, but it’s new to BHA as they evolve their methodology for commodity tracing. The traceability system needs to be versatile, working across a wide variety of operators who take custody of the commodity along the supply chain and fitting into their existing best practices.”

    As food products make their way through the supply chain, operators at each receiving point would be able to scan these IDs via a Lincoln Laboratory-developed mobile application (app) to indicate a product’s current location and transaction status — for example, that it is en route on a particular shipping container or stored in a certain warehouse. This information would get uploaded to a secure traceability server. By scanning a product, operators would also see its history up until that point.   

    Hitting the mark

    At the laboratory, the team tested the feasibility of their traceability technology, exploring different ways to mark and scan items. In their testing, they considered barcodes and radio-frequency identification (RFID) tags and handheld and fixed scanners. Their analysis revealed 2D barcodes (specifically data matrices) and smartphone-based scanners were the most feasible options in terms of how the technology works and how it fits into existing operations and infrastructure.

    “We needed to come up with a solution that would be practical and sustainable in the field,” MacLaren says. “While scanners can automatically read any RFID tags in close proximity as someone is walking by, they can’t discriminate exactly where the tags are coming from. RFID is expensive, and it’s hard to read commodities in bulk. On the other hand, a phone can scan a barcode on a particular box and tell you that code goes with that box. The challenge then becomes figuring out how to present the codes for people to easily scan without significantly interrupting their usual processes for handling and moving commodities.” 

    As the team learned from partner representatives in Kenya and Djibouti, offloading at the ports is a chaotic, fast operation. At manual warehouses, porters fling bags over their shoulders or stack cartons atop their heads any which way they can and run them to a drop point; at bagging terminals, commodities come down a conveyor belt and land this way or that way. With this variability comes several questions: How many barcodes do you need on an item? Where should they be placed? What size should they be? What will they cost? The laboratory team is considering these questions, keeping in mind that the answers will vary depending on the type of commodity; vegetable oil cartons will have different specifications than, say, 50-kilogram bags of wheat or peas.

    Leaving a mark

    Leveraging results from their testing and insights from international partners, the team has been running a traceability pilot evaluating how their proposed system meshes with real-world domestic and international operations. The current pilot features a domestic component in Houston, Texas, and an international component in Ethiopia, and focuses on tracking individual cartons of vegetable oil and identifying damaged cans. The Ethiopian team with Catholic Relief Services recently received a container filled with pallets of uniquely barcoded cartons of vegetable oil cans (in the next pilot, the cans will be barcoded, too). They are now scanning items and collecting data on product damage by using smartphones with the laboratory-developed mobile traceability app on which they were trained. 

    “The partners in Ethiopia are comparing a couple lid types to determine whether some are more resilient than others,” Richardson says. “With the app — which is designed to scan commodities, collect transaction data, and keep history — the partners can take pictures of damaged cans and see if a trend with the lid type emerges.”

    Next, the team will run a series of pilots with the World Food Program (WFP), the world’s largest humanitarian organization. The first pilot will focus on data connectivity and interoperability, and the team will engage with suppliers to directly print barcodes on individual commodities instead of applying barcode labels to packaging, as they did in the initial feasibility testing. The WFP will provide input on which of their operations are best suited for testing the traceability system, considering factors like the network bandwidth of WFP staff and local partners, the commodity types being distributed, and the country context for scanning. The BHA will likely also prioritize locations for system testing.

    “Our goal is to provide an infrastructure to enable as close to real-time data exchange as possible between all parties, given intermittent power and connectivity in these environments,” MacLaren says.

    In subsequent pilots, the team will try to integrate their approach with existing systems that partners rely on for tracking procurements, inventory, and movement of commodities under their custody so that this information is automatically pushed to the traceability server. The team also hopes to add a capability for real-time alerting of statuses, like the departure and arrival of commodities at a port or the exposure of unclaimed commodities to the elements. Real-time alerts would enable stakeholders to more efficiently respond to food-safety events. Currently, partners are forced to take a conservative approach, pulling out more commodities from the supply chain than are actually suspect, to reduce risk of harm. Both BHA and WHP are interested in testing out a food-safety event during one of the pilots to see how the traceability system works in enabling rapid communication response.

    To implement this technology at scale will require some standardization for marking different commodity types as well as give and take among the partners on best practices for handling commodities. It will also require an understanding of country regulations and partner interactions with subcontractors, government entities, and other stakeholders.

    “Within several years, I think it’s possible for BHA to use our system to mark and trace all their food procured in the United States and sent internationally,” MacLaren says.

    Once collected, the trove of traceability data could be harnessed for other purposes, among them analyzing historical trends, predicting future demand, and assessing the carbon footprint of commodity transport. In the future, a similar traceability system could scale for nonfood items, including medical supplies distributed to disaster victims, resources like generators and water trucks localized in emergency-response scenarios, and vaccines administered during pandemics. Several groups at the laboratory are also interested in such a system to track items such as tools deployed in space or equipment people carry through different operational environments.

    “When we first started this program, colleagues were asking why the laboratory was involved in simple tasks like making a dashboard, marking items with barcodes, and using hand scanners,” MacLaren says. “Our impact here isn’t about the technology; it’s about providing a strategy for coordinated food-aid response and successfully implementing that strategy. Most importantly, it’s about people getting fed.” More