Jones, O. R. et al. Diversity of ageing across the tree of life. Nature 505(7482), 169–173 (2014).
Butler, P. G., Wanamaker, J. A. D., Scourse, J. D., Richardson, C. A. & Reynolds, D. J. Variability of marine climate on the North Icelandic Shelf in a 1357-year proxy archive based on growth increments in the bivalve Arctica islandica. Palaeogeo Palaeoclima Palaeoeco 373, 141–151 (2013).
Tasaki, E., Sakurai, H., Nitao, M., Matsuura, K. & Iuchi, Y. Uric acid, an important antioxidant contributing to survival in termites. PloS One 12, e0179426 (2017).
Keller, L. & Genoud, M. Extraordinary lifespans in ants: A test of evolutionary theories of ageing. Nature 389, 958 (1997).
Keller, L. Queen lifespan and colony characteristics in ants and termites. Insec Soci 45, 235–246 (1998).
Elsner, D., Meusemann, K. & Korb, J. Longevity and transposon defense, the case of termite reproductives. Proc Natl Acad Sci USA 115, 5504–5509 (2018).
Keller, L. & Jemielity, S. Social insects as a model to study the molecular basis of ageing. Expe Geronto 41, 553–556 (2006).
Lucanic, M., Lithgow, G. J. & Alavez, S. Pharmacological lifespan extension of invertebrates. Age Res Rev 12, 445–458 (2013).
Bitto, A., Wang, A. M., Bennett, C. F. & Kaeberlein, M. Biochemical genetic pathways that modulate aging in multiple species. CSH Perspect Med 5, a025114 (2015).
Kolovou, G. D., Kolovou, V. & Mavrogeni, S. We are ageing. BioMed Rese, Inter 2014, 808307 (2014).
Corona, M. et al. Vitellogenin, juvenile hormone, insulin signaling, and queen honeybee longevity. Proc Natl Acad Sci 104, 7128–33 (2007).
Teleman, A. A., Hietakangas, V., Sayadian, A. C. & Cohen, S. M. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab 7, 21–32 (2008).
Luong, N. et al. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell metab 4, 133–142 (2006).
Bartke, A. Insulin and aging. Cell Cycle 7, 3338–3343 (2008).
Zajitschek, F., Zajitschek, S. & Bonduriansky, R. Senescence in wild insects: Key questions and challenges. Funct Ecol 34, 26–37 (2020).
Nussey, D. H., Coulson, T., Festa‐Bianchet, M. & Gaillard, J. M. Measuring senescence in wild animal populations: towards a longitudinal approach. Funct Ecol 22, 393–406 (2008).
Tatar, M. et al. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107–110 (2001).
Clancy, D. J. et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104–106 (2001).
Badisco, L., Van, W. P. & Vanden, B. J. Eat to reproduce: a key role for the insulin signaling pathway in adult insects. Front Physio 4, 202 (2013).
Tasaki, E., Matsuura, K. & Iuchi, Y. Hypoxia adaptation in termites: hypoxic conditions enhance survival and reproductive activity in royals. Insect Mole Biol 27, 808–814 (2018).
Lucas, E. R. & Keller, L. New explanation for the longevity of social insect reproductives: Transposable element activity. Proc Natl Acad Sci USA 115, 5317–5318 (2018).
Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28, 27–30 (2000).
Kanehisa, M., Sato, Y., Furumichi, M., Morishima, K. & Tanabe, M. New approach for understanding genome variations in KEGG. Nucleic Acids Res 47, D590–D595 (2018).
Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci 28, 1947–1951 (2019).
Xu, C. et al. De novo and comparative transcriptome analysis of cultivated and wild spinach. Scie Rep 5, 17706 (2015).
Mitaka, Y., Kobayashi, K. & Matsuura, K. Caste-, sex-, and age-dependent expression of immune-related genes in a Japanese subterranean termite, Reticulitermes speratus. PloS one 12, e0175417 (2017).
Steijger, T. et al. Assessment of transcript reconstruction methods for RNA-seq. Nature Meth 10, 1177 (2013).
Giannakou, M. E. & Partridge, L. Role of insulin-like signalling in Drosophila lifespan. Trends Bioche Scie 32, 180–188 (2007).
Rintelen, F., Stocker, H., Thomas, G. & Hafen, E. PDK1 regulates growth through Akt and S6K in Drosophila. Proc Natl Acad Sci USA 98, 15020–15025 (2001).
Gao, X., Fu, Y., Ajayi, O. E., Guo, D., Zhang, L. & Wu, Q. Identification of genes underlying phenotypic plasticity of wing size via insulin signaling pathway by network-based analysis in Sogatella furcifera. BMC Genomics 20, 01–21 (2019).
Paradis, S., Ailion, M., Toker, A., Thomas, J. H. & Ruvkun, G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Devel 13, 1438–1452 (1999).
Yuan, Q. Z. et al. “Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer.“. Oncogene 19, 2324 (2000).
Sun, M. et al. Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K. Cancer Res 61, 5985–5991 (2001).
Yoeli-Lerner, M. & Toker, A. Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle 5, 603–605 (2006).
Arboleda, M. J. et al. Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 63, 196–206 (2003).
Potter, C. J. et al. The tuberous sclerosis complex (TSC) pathway and mechanism of size control. Biochemical Society Transactions 31, 584–586 (2003).
Giannakou, M. E. & Partridge, L. Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci 32, 180–188 (2007).
Napolioni, V. & Curatolo, P. Genetics and molecular biology of tuberous sclerosis complex. Curr Genomics 9, 475–487 (2008).
Cornu, M., Albert, V. & Hall, M. N. mTOR in aging, metabolism, and cancer. Curr Opin Genet Dev 23, 53–62 (2013).
Paul, C. & Robaire, B. Ageing of the male germ line. Nat Rev Urol 10, 227 (2013).
Pan, J. et al. Insulin and 20-hydroxyecdysone oppose each other in the regulation of phosphoinositide-dependent kinase-1 expression during insect pupation. J Biol Chem 293, 18613–18623 (2018).
Yoon, M. S. The role of mammalian target of rapamycin (mTOR) in insulin signaling. Nutrients 9, 1176 (2017).
Zhai, Y. et al. Activation of the TOR signalling pathway by glutamine regulates insect fecundity. Sci Rep 5, 10694 (2015).
Yecies, J. L. & Manning, B. D. mTOR links oncogenic signaling to tumor cell metabolism. J Mol Med (Berl) 89, 221–228 (2011).
Simpson, L. & Parsons, R. PTEN: Life as a tumor suppressor. Exp Cell Res 264, 29–41 (2001).
Graff, J. R. et al. Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J Clin Invest 117, 2638–2648 (2007).
McDonald, J. M. et al. Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung. Clin Cancer Res 14, 7832–7837 (2008).
Mitaka, Y. et al. Caste-specific and sex-specific expression of chemoreceptor genes in a termite. PLoS One 11, e0146125 (2016).
Tasaki, E. et al. High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings. Aging (Albany NY) 10, 2668–2683 (2018).
Tasaki, E., Kobayashi, K., Matsuura, K. & Iuchi, Y. An efficient antioxidant aystem in a long‐lived termite queen. PLoS One 12, e0167412 (2017).
Elsnera, D., Meusemanna, K. & Korba, J. Longevity and transposon defense, the case of termite reproductives. Proc Natl Acad Sci USA 115, 5504–9 (2018).
Tiebe, M. et al. REPTOR and REPTOR-BP regulate organismal metabolism and transcription downstream of TORC1. Dev Cell 4, 272–84 (2015).
Takats, S., Varga, A., Pircs, K. & Juhasz, G. Loss of Drosophila Vps16A enhances autophagosome formation through reduced TOR activity. Autophagy 3, 1209–15 (2015).
Yoon, W. H. et al. Loss of nardilysin, a mitochondrial co-chaperone for α-ketoglutarate dehydrogenase, promotes mTORC1 activation and neurodegeneration. Neuron 4, 115–31 (2017).
Caraa, F. D., Bulowb, M. H., Simmondsa, A. J. & Rachubinskia, R. A. Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy. Mol Biol Cell 1, 2766–83 (2018).
Tang, H. W. et al. The TORC1-regulated CPA complex rewires an RNA processing network to drive autophagy and metabolic reprogramming. Cell Metab 1, 1040–54 (2018).
Ramanathan, S. P., Krajnc, M. & Gibson, M. C. Cell-size pleomorphism drives aberrant clone dispersal in proliferating epithelia. Dev Cell 7, 49–61 (2019).
Lee, B., Barretto, E. C. & Grewal, S. S. TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila. Nat Commu 23, 1878 (2019).
Kim, A. R. & Choi, K. W. TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila. Oncogene 38(24), 4739 (2019).
Kimura, K. D., Tissenbaum, H. A., Liu, Y. & Ruvkun, G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 15, 942–6 (1997).
Tatar, M. & Yin, C. M. Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms. Exp Geron 36, 723–738 (2001).
Garofalo, R. S. Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol Metab 13, 156–162 (2002).
Brogiolo, W. et al. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11, 213–221 (2001).
Baena-Lopez, L. A., Rodriguez, I. & Baonza, A. The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like. Proc Natl Acad Sci USA 105, 9645–9650 (2008).
Augustin, H. et al. Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol 15, 2001655 (2017).
Su, X. et al. Characterization of the transcriptomes and cuticular protein gene expression of alate adult, brachypterous neotenic and adultoid reproductives of Reticulitermes labralis. Sci Rep 6, 1–9 (2016).
Ye, C., Rasheed, H., Ran, Y., Yang, X., Xing, L. & Su, X. Transcriptome changes reveal the genetic mechanisms of the reproductive plasticity of workers in lower termites. BMC Geno 20, 1–13 (2019).
Haas, B. J. et al. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis. Nat Protoc 8, 1494 (2013).
Grabherr, M. G. et al. Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol 29, 644–652 (2011).
Li, R. et al. SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics 25, 1966–1967 (2009).
Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139–140 (2010).
Zhang, J. et al. Transcriptome analysis of Cymbidium sinense and its application to the identification of genes associated with floral development. BMC Genomics 14, 1–17 (2013).
Conesa, A. et al. Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Bioinformatics 21, 3674–3676 (2005).
Ye, J. et al. WEGO: a web tool for plotting GO annotations. Nucleic Acids Res 34, W293–W297 (2006).
Nicot, N., Hausman, J. F., Hoffmann, L. & Evers, D. Housekeeping gene selection for real-time RT-PCR normalization in potato during biotic and abiotic stress. J Exp Bot 56, 2907–2914 (2005).
Tong, Z., Gao, Z., Wang, F., Zhou, J. & Zhang, Z. Selection of reliable reference genes for gene expression studies in peach using real-time PCR. BMC Mol Bio 10, 71 (2009).
Ishitani, K. & Maekawa, K. Ovarian development of female-female pairs in the termite, Reticulitermes speratus. J Insect Sci 10, 1–12 (2010).
Van Hiel, M. B. et al. Identification and validation of housekeeping genes in brains of the desert locust Schistocerca gregaria under different developmental conditions. BMC Mol Biol 10, 1–10 (2009).
Source: Ecology - nature.com
