Human-associated microbiota suppress invading bacteria even under disruption by antibiotics

Blair JMA, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJV. Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol. 2015;13:42–51.

CAS  Article  Google Scholar 

Palmer AC, Kishony R. Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance. Nat Rev Genet. 2013;14:243–8.

CAS  Article  Google Scholar 

Blaser MJ. Antibiotic use and its consequences for the normal microbiome. Science. 2016;352:544–5.

CAS  Article  Google Scholar 

Modi SR, Collins JJ, Relman DA. Antibiotics and the gut microbiota. J Clin Investig. 2014;124:4212–8.

Article  Google Scholar 

Lawley TD, Walker AW. Intestinal colonization resistance. Immunology. 2013;138:1–11.

CAS  Article  Google Scholar 

Libertucci J, Young VB. The role of the microbiota in infectious diseases. Nat Microbiol. 2019;4:35–45.

CAS  Article  Google Scholar 

Bhalodi AA, Engelen TSR, van, Virk HS, Wiersinga WJ. Impact of antimicrobial therapy on the gut microbiome. J Antimicrobial Chemother. 2019;74:i6–i15.

CAS  Article  Google Scholar 

Klümper U, Recker M, Zhang L, Yin X, Zhang T, Buckling A, et al. Selection for antimicrobial resistance is reduced when embedded in a natural microbial community. ISME J. 2019;13, 2927–37.

Article  Google Scholar 

Baumgartner M, Bayer F, Pfrunder-Cardozo KR, Buckling A, Hall AR. Resident microbial communities inhibit growth and antibiotic-resistance evolution of Escherichia coli in human gut microbiome samples. PLOS Biol. 2020;18:e3000465.

CAS  Article  Google Scholar 

Ianiro G, Tilg H, Gasbarrini A. Antibiotics as deep modulators of gut microbiota: between good and evil. Gut. 2016;65:1906–15.

CAS  Article  Google Scholar 

Spaulding CN, Klein RD, Schreiber HL, Janetka JW, Hultgren SJ. Precision antimicrobial therapeutics: The path of least resistance? npj Biofilms Microbiomes. 2018;4:1–7.

Article  Google Scholar 

Moya A, Ferrer M. Functional redundancy-induced stability of gut microbiota subjected to disturbance. Trends Microbiol. 2016;24:402–13.

CAS  Article  Google Scholar 

Jernberg C, Löfmark S, Edlund C, Jansson JK. Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology. 2010;156:3216–23.

CAS  Article  Google Scholar 

Stecher B, Chaffron S, Käppeli R, Hapfelmeier S, Freedrich S, Weber TC, et al. Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria. PLoS Pathog. 2010;6:e1000711.

Article  Google Scholar 

Van Der Waaij D, Berghuis-de Vries JM, Lekkerkerk-Van Der Wees JEC. Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J Hyg. 1971;69:405–11.

Article  Google Scholar 

Kim S, Covington A, Pamer EG. The intestinal microbiota: antibiotics, colonization resistance, and enteric pathogens. Immunological Rev. 2017;279:90–105.

CAS  Article  Google Scholar 

Mathieu A, Fleurier S, Frénoy A, Dairou J, Bredeche MF, Sanchez-Vizuete P, et al. Discovery and function of a general core hormetic stress response in E. coli induced by sublethal concentrations of antibiotics. Cell Rep. 2016;17:46–57.

CAS  Article  Google Scholar 

Pamer EG. Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens. Science. 2016;352:535–8.

CAS  Article  Google Scholar 

Louca S, Polz MF, Mazel F, Albright MBN, Huber JA, O’Connor MI, et al. Function and functional redundancy in microbial systems. Nat Ecol Evolution. 2018;2:936–43.

Article  Google Scholar