in

Iron limitation by transferrin promotes simultaneous cheating of pyoverdine and exoprotease in Pseudomonas aeruginosa

  • 1.

    Smith P, Schuster M. Public goods and cheating in microbes. Curr Biol. 2019;29:R442–7.

  • 2.

    Harrison F, McNally A, Da Silva AC, Heeb S, Diggle SP. Optimised chronic infection models demonstrate that siderophore ‘cheating’ in Pseudomonas aeruginosa is context specific. ISME J. 2017;11:2492–509.

  • 3.

    Kümmerli R, Santorelli LA, Granato ET, Dumas Z, Dobay A, Griffin AS, et al. Co-evolutionary dynamics between public good producers and cheats in the bacterium Pseudomonas aeruginosa. J Evol Biol. 2015;28:2264–74.

  • 4.

    Stilwell P, Lowe C, Buckling A. The effect of cheats on siderophore diversity in Pseudomonas aeruginosa. J Evol Biol. 2018;31:1330–9.

  • 5.

    Butaite E, Baumgartner M, Wyder S, Kümmerli R. Siderophore cheating and cheating resistance shape competition for iron in soil and freshwater Pseudomonas communities. Nat Commun. 2017;8:414.

  • 6.

    Jin Z, Li J, Ni L, Zhang R, Xia A, Jin F. Conditional privatization of a public siderophore enables Pseudomonas aeruginosa to resist cheater invasion. Nat Commun. 2018;9:1383.

  • 7.

    Leinweber A, Fredrik Inglis R, Kümmerli R. Cheating fosters species co-existence in well-mixed bacterial communities. ISME J. 2017;11:1179–88.

  • 8.

    Özkaya Ö, Balbontín R, Gordo I, Xavier KB. Cheating on cheaters stabilizes cooperation in Pseudomonas aeruginosa. Curr Biol. 2018;28:2070–80.

  • 9.

    O’Brien S, Kümmerli R, Paterson S, Winstanley C, Brockhurst MA. Transposable temperate phages promote the evolution of divergent social strategies in Pseudomonas aeruginosa populations. Proc R Soc B Biol Sci. 2019;286:20191794.

  • 10.

    Wolz C, Hohloch K, Ocaktan A, Poole K, Evans RW, Rochel N, et al. Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa. Infect Immun. 1994;62:4021–7.

  • 11.

    Kim SJ, Park RY, Kang SM, Choi MH, Kim CM, Shin SH. Pseudomonas aeruginosa alkaline protease can facilitate siderophore-mediated iron-uptake via the proteolytic cleavage of transferrins. Biol Pharm Bull. 2006;29:2295–300.

  • 12.

    Sandoz KM, Mitzimberg SM, Schuster M. Social cheating in Pseudomonas aeruginosa quorum sensing. Proc Natl Acad Sci USA. 2007;104:15876–81.

    CAS  Article  Google Scholar 

  • 13.

    Diggle SP, Griffin AS, Campbell GS, West SA. Cooperation and conflict in quorum-sensing bacterial populations. Nature. 2007;450:411–4.

    CAS  Article  Google Scholar 

  • 14.

    Dandekar AA, Chugani S, Greenberg EP. Bacterial quorum sensing and metabolic incentives to cooperate. Science. 2012;338:264–6.

    CAS  Article  Google Scholar 

  • 15.

    Loarca D, Díaz D, Quezada H, Guzmán-Ortiz AL, Rebollar-Ruiz A, Presas AMF, et al. Seeding public goods is essential for maintaining cooperation in Pseudomonas aeruginosa. Front Microbiol. 2019;10:1–8.

    Article  Google Scholar 

  • 16.

    García-Contreras R, Loarca D, Pérez-González C, Jiménez-Cortés JG, Gonzalez-Valdez A, Soberón-Chávez G. Rhamnolipids stabilize quorum sensing mediated cooperation in Pseudomonas aeruginosa. FEMS Microbiol Lett. 2020;367:1–5.

  • 17.

    García-Contreras R, Lira-Silva E, Jasso-Chávez R, Hernández-González IL, Maeda T, Hashimoto T, et al. Isolation and characterization of gallium resistant Pseudomonas aeruginosa mutants. Int J Med Microbiol. 2013;303:574–82.

  • 18.

    Castañeda-Tamez P, Ramírez-Peris J, Pérez-Velázquez J, Kuttler C, Jalalimanesh A, Saucedo-Mora M, et al. Pyocyanin restricts social cheating in Pseudomonas aeruginosa. Front Microbiol. 2018;9:1–10.

    Article  Google Scholar 

  • 19.

    Bolger AM, Lohse M, Usadel B. Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30:2114–20.

  • 20.

    Li H. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. arXiv. 2013;00:1–3.

  • 21.

    Garrison E, Marth G. Haplotype-based variant detection from short-read sequencing — Free bayes — Variant Calling — Longranger. arXiv Prepr arXiv12073907 2012.

  • 22.

    Cingolani P, Platts A, Wang LL, Coon M, Nguyen T, Wang L, et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff. Fly. 2012;6:80–92.

  • 23.

    Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009;25:2078–9.

  • 24.

    Quinlan AR, Hall IM BEDTools: A flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841–2.

  • 25.

    Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, et al. SPAdes: A new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol. 2012;19:455–77.

  • 26.

    Carver T, Harris SR, Berriman M, Parkhill J, McQuillan JA. Artemis: An integrated platform for visualization and analysis of high-throughput sequence-based experimental data. Bioinformatics. 2012;28:464–9.

  • 27.

    Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, et al. Current protocols in molecular biology: preface. Curr Protoc Mol Biol. 2010;1:178–89.

  • 28.

    King EO, Ward MK, Raney DE. Two simple media for the demonstration of pyocyanin and fluorescin. J Lab Clin Med. 1954;44:301–7.

  • 29.

    López-Jácome LE, Garza-Ramos G, Hernández-Durán M, Franco-Cendejas R, Loarca D, Romero-Martínez D, et al. AiiM lactonase strongly reduces quorum sensing controlled virulence factors in clinical strains of Pseudomonas aeruginosa isolated from burned patients. Front Microbiol. 2019;10:1–11.

    Article  Google Scholar 

  • 30.

    Sandoz KM, Mitzimberg SM, Schuster M. Social cheating in Pseudomonas aeruginosa quorum sensing. Proc Natl Acad Sci USA. 2007;104:15876–81.

  • 31.

    D’Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, et al. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol. 2010;17:254–64.

  • 32.

    Wang Y, Gao L, Rao X, Wang J, Yu H, Jiang J, et al. Characterization of lasR-deficient clinical isolates of Pseudomonas aeruginosa. Sci Rep. 2018;8:13344.

  • 33.

    Wilder CN, Allada G, Schuster M. Instantaneous within-patient diversity of Pseudomonas aeruginosa quorum-sensing populations from cystic fibrosis lung infections. Infect Immun. 2009;77:5631–9.

    CAS  Article  Google Scholar 

  • 34.

    Brown SP, West SA, Diggle SP, Griffin AS. Social evolution in micro-organisms and a Trojan horse approach to medical intervention strategies. Philos Trans R Soc B Biol Sci. 2009;364:3157–68.

  • 35.

    Rumbaugh KP, Diggle SP, Watters CM, Ross-Gillespie A, Griffin AS, West SA. Quorum sensing and the social evolution of bacterial virulence. Curr Biol. 2009;19:341–5.

  • 36.

    Bonchi C, Frangipani E, Imperi F, Visca P. Pyoverdine and proteases affect the response of Pseudomonas aeruginosa to gallium in human serum. Antimicrob Agents Chemother. 2015;59:5641–6.

  • 37.

    Sathe S, Mathew A, Agnoli K, Eberl L, Kümmerli R. Genetic architecture constrains exploitation of siderophore cooperation in the bacterium Burkholderia cenocepacia. Evol Lett. 2019;3:610–22.

  • 38.

    Liberati NT, Urbach JM, Miyata S, Lee DG, Drenkard E, Wu G, et al. An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants. Proc Natl Acad Sci USA. 2006;103:2833–8.

  • 39.

    Chandler CE, Horspool AM, Hill PJ, Wozniak DJ, Schertzer JW, Rasko DA, et al. Genomic and phenotypic diversity among ten laboratory isolates of Pseudomonas aeruginosa PAO1. J Bacteriol. 2019;201.


  • Source: Ecology - nature.com

    SMART develops analytical tools to enable next-generation agriculture

    MIT Solve announces 2021 global challenges