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    Balancing economic development with natural resources protection

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    It’s one of the paradoxes of economic development: Many countries currently offer large subsidies to their industrial fishing fleets, even though the harms of overfishing are well-known. Governments might be willing to end this practice, if they saw that its costs outweighed its benefits. But each country, acting individually, faces an incentive to keep subsidies in place.This trap evokes the classic “tragedy of the commons” that economists have studied for generations. But despite the familiarity of the problem in theory, they don’t yet have a lot of hard evidence to offer policymakers about solutions, especially on a global scale. PhD student Aaron Berman is working on a set of projects that may change that.“Our goal is to get some empirical traction on the problem,” he says.Berman and his collaborators are combining a variety of datasets — not only economic data but also projections from ecological models — to identify how these subsidies are impacting fish stocks. They also hope to determine whether countries might benefit instead from sustainability measures to help rebuild fisheries, say through new trade arrangements or other international policy agreements.As a fourth-year doctoral candidate in MIT’s Department of Economics, Berman has a variety of other research projects underway as well, all connected by the central question of how to balance economic development with the pressure it puts on the environment and natural resources. While his study of fishing subsidies is global in scope, other projects are distinctly local: He is studying air pollution generated by road infrastructure in Pakistan, groundwater irrigation in Texas, the scallop fishing industry in New England, and industrial carbon-reduction measures in Turkey. For all of these projects, Berman and his collaborators are bringing data and models from many fields of science to bear on economic questions, from seafloor images taken by NOAA to atmospheric models of pollution dispersion.“One thing I find really exciting and joyful about the work I’m doing in environmental economics is that all of these projects involve some kind of crossover into the natural sciences,” he says.Several of Berman’s projects are so ambitious that he hopes to continue working on them even after completing his PhD. He acknowledges that keeping so many irons in the fire is a lot of work, but says he finds motivation in the knowledge that his research could shape policy and benefit society in a concrete way.“Something that MIT has really instilled in me is the value of going into the field and learning about how the research you’re doing connects to real-world issues,” he says. “You want your findings as a researcher to ultimately be useful to someone.”Testing the watersThe son of two public school teachers, Berman grew up in Maryland and then attended Yale University, where he majored in global affairs as an undergraduate, then stayed to get his master’s in public health, concentrating on global health in both programs.A pivotal moment came while taking an undergraduate class in development economics. “That class helped me realize the same questions I cared a lot about from a public health standpoint were also being studied by economists using very rigorous methods,” Berman says. “Economics has a lot to say about very pressing societal issues.”After reading the work of MIT economists and Nobel laureates Esther Duflo and Abhijit Banerjee in that same class, he decided to pivot and “test the waters of economics a little bit more seriously.” The professor teaching that class also played an important role, by encouraging Berman to pursue a predoctoral research position as a first step toward a graduate degree in economics.Following that advice, Berman landed at the Harvard Kennedy School’s Evidence for Policy Design, a research initiative seeking to foster economic development by improving the policy design process. His time with this organization included five months in Jakarta, Indonesia, where he collaborated with professors Rema Hanna and Ben Olken — of Harvard and MIT, respectively — on a portfolio of projects focused on analyzing social protection and poverty alleviation.The work, which included working closely with government partners, “required me to think creatively about how to talk about economics research to several different types of audiences,” he says. “This also gave me experience thinking about the intersection between what is academically interesting and what is a policy priority.”The experience also gave him the skills and confidence to apply to the economics PhD program at MIT.(Re)discovering teachingAs an economist, Berman is now channeling his interests in global affairs to exploring the relationship between economic development and protecting the natural environment. (He’s aided by an affinity for languages — he speaks five, with varying degrees of proficiency, in addition to English: Mandarin, Cantonese, Spanish, Portuguese, and Indonesian.) His interest in natural resource governance was piqued while co-authoring a paper on the economic drivers of climate-altering tropical deforestation.The review article, written alongside Olken and two professors from the London School of Economics, explored questions such as “What does the current state of the evidence tell us about what causes deforestation in the tropics, and what further evidence is needed?” and “What are the economic barriers to implementing policies to prevent deforestation?” — the kinds of questions he seeks to answer broadly in his ongoing dissertation work.“I gained an appreciation for the importance and complexity of natural resource governance, both in developing and developed countries,” he says. “It really was a launching point for a lot of the things that I’m doing now.”These days, when not doing research, Berman can be found playing on MIT’s club tennis team or working as a teaching assistant, which he particularly enjoys. He’s ever mindful of the Yale professor whose encouragement shaped his own path, and he hopes that he can pay that forward in his own teaching roles.“The fact that he saw I had the ability to make this transition and encouraged me to take a leap of faith is really meaningful to me. I would like to be able to do that for others,” Berman says.His interest in teaching also connects him further with his family: His father is a middle school science teacher and mother is a paraeducator for students with special needs. He says they’ve encouraged him throughout his academic journey, even though they initially didn’t know much about what a PhD in economics entailed. Berman jokes that the most common question people ask economists is what stocks they should invest in, and his family was no exception.“But they’ve always been very excited to hear about the kinds of things I’m working on and very supportive,” he says. “It’s been a really amazing learning experience thus far,” Berman says about his doctoral program. “One of the coolest parts of economics research is to have a sense that you’re tangibly doing something that’s going to have an impact in the world.” More

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      MIT scholars will take commercial break with entrepreneurial scholarship

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      Two MIT scholars, each with a strong entrepreneurial drive, have received 2024 Kavanaugh Fellowship awards, advancing their quest to turn pioneering research into profitable commercial enterprises.The Kavanaugh Translational Fellows Program gives scholars training to lead organizations that will bring their research to market. PhD candidates Grant Knappe and Arjav Shah are this year’s recipients. Knappe is developing a drug delivery platform for an emerging class of medicines called nucleic acid therapeutics. Shah is using hydrogel microparticles to clean up water polluted by heavy metals and other contaminants.Knappe and Shah will begin their fellowship with years of entrepreneurial expertise under their belts. They’ve developed and refined their business plans through MIT’s innovation ecosystem, including the Sandbox, the Legatum Center, the Venture Mentoring Service, the National Science Foundation’s I-Corps Program, and Blueprint by The Engine. Now, the yearlong Kavanaugh Fellowship will give the scholars time to focus exclusively on testing their business plans and exercising decision-making skills — critical to startup success — with the guidance of MIT mentors.“It’s a testament to the support and direction they’ve received from the MIT community that their entrepreneurial aspirations have evolved and matured over time,” says Michael J. Cima, program director for the Kavanaugh program and the David H. Koch Professor of Engineering in the Department of Materials Science and Engineering.Founded in 2016, the Kavanaugh program was instrumental in helping past fellows launch several robust startups, including low-carbon cement manufacturer Sublime Systems and SiTration, which is using a new type of filtration membrane to extract critical materials such as lithium.A safer way to deliver breakthrough medicinesNucleic acid therapeutics, including mRNA and CRISPR, are disrupting today’s clinical landscape thanks to their promise of targeting disease treatment according to genetic blueprints. But the first methods of delivering these molecules to the body used viruses as their transport, raising patient safety concerns.“Humans have figured out how to engineer certain viruses found in nature to deliver specific cargoes [for disease treatment],” says Knappe. “But because they look like viruses, the human immune system sees them as a danger signal and creates an immune reaction that can be harmful to patients.”Given the safety profile issues of viral delivery, researchers turned to non-viral technologies that use lipid nanoparticle technology, a mixture of different lipid-like materials, assembled into particles to protect the mRNA therapeutic from getting degraded before it reaches a cell of interest. “Because they don’t look like viruses there, the immune system generally tolerates them,” adds Knappe.Recent data show lipid nanoparticles can now target the lung, opening the potential for novel treatments of deadly cancers and other diseases.Knappe’s work in MIT’s Bathe BioNanoLab focused on building such a non-viral delivery platform based on a different technology: nucleic acid nanoparticles, which combine the attractive components of both viral and non-viral systems. Knappe will spend his Kavanaugh Fellowship year developing proof-of-concept data for his drug delivery method and building the team and funding needed to commercialize the technology.A PhD candidate in the Department of Chemical Engineering (ChemE), Knappe was initially attracted to MIT because of its intellectual openness. “You can work with any faculty member in other departments. I wasn’t restricted to the chemical engineering faculty,” says Knappe, whose supervisor, Professor Mark Bathe, is in the Department of Biological Engineering.Knappe, who is from New Jersey, welcomes the challenges that will come in his Kavanaugh year, including the need to pinpoint the right story that will convince venture capitalists and other funders to bet on his technology. Attracting talent is also top of mind. “How do you convince really talented people that have a lot of opportunities to work on what you work on? Building the first team is going to be critical,” he says. The network Knappe has been building in his years at MIT is paying dividends now.Targeting “forever chemicals” in waterThat network includes Shah. The two fellows met when they worked on the MIT Science Policy Review, a student-run journal concerned with the intersection of science, technology, and policy. Knappe and Shah did not compete directly academically but used their biweekly coffee walks as a welcome sounding board. Naturally, they were pleased when they found out they had both been chosen for the Kavanaugh Fellowship. So far, they have been too busy to celebrate over a beer.“We are good collaborators with research, as well,” says Shah. “Now we’re going on this entrepreneurial journey together. It’s been exciting.”Shah is a PhD candidate in ChemE’s Chemical Engineering Practice program. He got interested in the global imperative for cleaner water at a young age. His hometown of Surat is the heart of India’s textile industry. “Growing up, it wasn’t hard to see the dye-colored water flowing into your rivers and streams,” Shah says. “Playing a role in fostering positive change in water treatment fills me with a profound sense of purpose.”Shah’s work, broadly, is to clean toxic chemicals called micropollutants from water in an efficient and sustainable manner. “It’s humanly impossible to turn a blind eye to our water problems,” he says, which can be categorized as accessibility, availability, and quality. Water problems are global and complex, not just because of the technological challenges but also sociopolitical ones, he adds.Manufactured chemicals called per- and polyfluoroalkyl substances (PFAS), or “forever chemicals,” are in the news these days. PFAS, which go into making nonstick cookware and waterproof clothing, are just one of more than 10,000 such emerging contaminants that have leached into water streams. “These are extremely difficult to remove using existing systems because of their chemical diversity and low concentrations,” Shah says. “The concentrations are akin to dropping an aspirin tablet in an Olympic-sized swimming pool.” But no less toxic for that.In the lab at MIT, Shah is working with Devashish Gokhale, a fellow PhD student, and Patrick S. Doyle, the Robert T. Haslam (1911) Professor of Chemical Engineering, to commercialize an innovative microparticle technology, hydroGel, to remove these micropollutants in an effective, facile, and sustainable manner. Hydrogels are a broad class of polymer materials that can hold large quantities of water.“Our materials are like Boba beads. We are trying to save the world with our Boba beads,” says Shah with a laugh. “And we have functionalized these particles with tunable chemistries to target different micropollutants in a single unit operation.”Due to its outsized environmental impact, industrial water is the first application Shah is targeting. Today, wastewater treatment emits more than 3 percent of global carbon dioxide emissions, which is more than the shipping industry’s emissions, for example. The current state of the art for removing micropollutants in the industry is to use activated carbon filters. “[This technology] comes from coal, so it’s unsustainable,” Shah says. And the activated carbon filters are hard to reuse. “Our particles are reusable, theoretically infinitely.”“I’m very excited to be able to take advantage of the mentorship we have from the Kavanaugh team to take this technology to its next inflection point, so that we are ready to go out in the market and start making a huge impact,” he says.A dream communityShah and Knappe have become adept at navigating the array of support and mentorship opportunities MIT has to offer. Shah worked with a small team of seasoned professionals in the water space from the MIT Venture Mentoring Service. “They’ve helped us every step of the way as we think about commercializing the technology,” he says.Shah worked with MIT Sandbox, which provides a seed grant to help find the right product-market fit. He is also a fellow with the Legatum Center for Development and Entrepreneurship, which focuses on entrepreneurship in emerging countries in growth markets.“We’re exploring the potential for this technology and its application in a lot of different markets, including India. Because that’s close to my heart,” Shah says. “The Legatum community has been unique, where you can have those extremely hard conversations, confront yourself with those fears, and then talk it out with the group of fellows.”The Abdul Latif Jameel Water and Food Systems Lab, or J-WAFS, has been an integral part of Shah’s journey with research and commercialization support through its Solutions Grant and a travel award to the Stockholm World Water Week in August 2023.Knappe has also taken advantage of many innovation programs, including MIT’s Blueprint by the Engine, which helps researchers explore commercial opportunities of their work, plus programs outside of MIT but with strong on-campus ties such as Nucleate Activator and Frequency Bio.It was during one of these programs that he was inspired by two postdocs working in Bathe’s lab and spinning out biotech startups from their research, Floris Engelhardt and James Banal. Engelhardt helped spearhead Kano Therapeutics, and Banal launched Cache DNA.“I was passively absorbing and watching everything that they were going through and what they were excited about and challenged with. I still talk to them pretty regularly to this day,” Knappe says. “It’s been really great to have them as continual mentors, throughout my PhD and as I transition out of the lab.”Shah says he is grateful not only for being selected for the Kavanaugh Fellowship but to MIT as a community. “MIT has been more than a dream come true,” he says. He will have the opportunity to explore a different side of the institution as he enters the MBA program at MIT Sloan School of Management this fall. Shah expects this program, along with his Kavanaugh training, will supply the skills he needs to scale the business so it can make a difference in the world.“I always keep coming back to the question ‘How does what I do matter to the person on the street?’ This guides me to look at the bigger picture, to contextualize my research to solving important problems,” Shah says. “So many great technologies are being worked on each day, but only a minuscule fraction make it to the market.”Knappe is equally dedicated to serving a larger purpose. “With the right infrastructure, between basic fundamental science, conducted in academia, funded by government, and then translated by companies, we can make products that could improve everyone’s life across the world,” he says.Past Kavanaugh Fellows are credited with spearheading commercial outfits that have indeed made a difference. This year’s fellows are poised to follow their lead. But first they will have that beer together to celebrate. More

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      Two MIT PhD students awarded J-WAFS fellowships for their research on water

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      Since 2014, the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) has advanced interdisciplinary research aimed at solving the world’s most pressing water and food security challenges to meet human needs. In 2017, J-WAFS established the Rasikbhai L. Meswani Water Solutions Fellowship and the J-WAFS Graduate Student Fellowship. These fellowships provide support to outstanding MIT graduate students who are pursuing research that has the potential to improve water and food systems around the world. Recently, J-WAFS awarded the 2024-25 fellowships to Jonathan Bessette and Akash Ball, two MIT PhD students dedicated to addressing water scarcity by enhancing desalination and purification processes. This work is of important relevance since the world’s freshwater supply has been steadily depleting due to the effects of climate change. In fact, one-third of the global population lacks access to safe drinking water. Bessette and Ball are focused on designing innovative solutions to enhance the resilience and sustainability of global water systems. To support their endeavors, J-WAFS will provide each recipient with funding for one academic semester for continued research and related activities.“This year, we received many strong fellowship applications,” says J-WAFS executive director Renee J. Robins. “Bessette and Ball both stood out, even in a very competitive pool of candidates. The award of the J-WAFS fellowships to these two students underscores our confidence in their potential to bring transformative solutions to global water challenges.”2024-25 Rasikbhai L. Meswani Fellowship for Water SolutionsThe Rasikbhai L. Meswani Fellowship for Water Solutions is a doctoral fellowship for students pursuing research related to water and water supply at MIT. The fellowship is made possible by Elina and Nikhil Meswani and family. Jonathan Bessette is a doctoral student in the Global Engineering and Research (GEAR) Center within the Department of Mechanical Engineering at MIT, advised by Professor Amos Winter. His research is focused on water treatment systems for the developing world, mainly desalination, or the process in which salts are removed from water. Currently, Bessette is working on designing and constructing a low-cost, deployable, community-scale desalination system for humanitarian crises.In arid and semi-arid regions, groundwater often serves as the sole water source, despite its common salinity issues. Many remote and developing areas lack reliable centralized power and water systems, making brackish groundwater desalination a vital, sustainable solution for global water scarcity. “An overlooked need for desalination is inland groundwater aquifers, rather than in coastal areas,” says Bessette. “This is because much of the population lives far enough from a coast that seawater desalination could never reach them. My work involves designing low-cost, sustainable, renewable-powered desalination technologies for highly constrained situations, such as drinking water for remote communities,” he adds.To achieve this goal, Bessette developed a batteryless, renewable electrodialysis desalination system. The technology is energy-efficient, conserves water, and is particularly suited for challenging environments, as it is decentralized and sustainable. The system offers significant advantages over the conventional reverse osmosis method, especially in terms of reduced energy consumption for treating brackish water. Highlighting Bessette’s capacity for engineering insight, his advisor noted the “simple and elegant solution” that Bessette and a staff engineer, Shane Pratt, devised that negated the need for the system to have large batteries. Bessette is now focusing on simplifying the system’s architecture to make it more reliable and cost-effective for deployment in remote areas.Growing up in upstate New York, Bessette completed a bachelor’s degree at the State University of New York at Buffalo. As an undergrad, he taught middle and high school students in low-income areas of Buffalo about engineering and sustainability. However, he cited his junior-year travel to India and his experience there measuring water contaminants in rural sites as cementing his dedication to a career addressing food, water, and sanitation challenges. In addition to his doctoral research, his commitment to these goals is further evidenced by another project he is pursuing, funded by a J-WAFS India grant, that uses low-cost, remote sensors to better understand water fetching practices. Bessette is conducting this work with fellow MIT student Gokul Sampath in order to help families in rural India gain access to safe drinking water.2024-25 J-WAFS Graduate Student Fellowship for Water and Food SolutionsThe J-WAFS Graduate Student Fellowship is supported by the J-WAFS Research Affiliate Program, which offers companies the opportunity to engage with MIT on water and food research. Current fellowship support was provided by two J-WAFS Research Affiliates: Xylem, a leading U.S.-based provider of water treatment and infrastructure solutions, and GoAigua, a Spanish company at the forefront of digital transformation in the water industry through innovative solutions. Akash Ball is a doctoral candidate in the Department of Chemical Engineering, advised by Professor Heather Kulik. His research focuses on the computational discovery of novel functional materials for energy-efficient ion separation membranes with high selectivity. Advanced membranes like these are increasingly needed for applications such as water desalination, battery recycling, and removal of heavy metals from industrial wastewater. “Climate change, water pollution, and scarce freshwater reserves cause severe water distress for about 4 billion people annually, with 2 billion in India and China’s semiarid regions,” Ball notes. “One potential solution to this global water predicament is the desalination of seawater, since seawater accounts for 97 percent of all water on Earth.”Although several commercial reverse osmosis membranes are currently available, these membranes suffer several problems, like slow water permeation, permeability-selectivity trade-off, and high fabrication costs. Metal-organic frameworks (MOFs) are porous crystalline materials that are promising candidates for highly selective ion separation with fast water transport due to high surface area, the presence of different pore windows, and the tunability of chemical functionality.In the Kulik lab, Ball is developing a systematic understanding of how MOF chemistry and pore geometry affect water transport and ion rejection rates. By the end of his PhD, Ball plans to identify existing, best-performing MOFs with unparalleled water uptake using machine learning models, propose novel hypothetical MOFs tailored to specific ion separations from water, and discover experimental design rules that enable the synthesis of next-generation membranes.  Ball’s advisor praised the creativity he brings to his research, and his leadership skills that benefit her whole lab. Before coming to MIT, Ball obtained a master’s degree in chemical engineering from the Indian Institute of Technology (IIT) Bombay and a bachelor’s degree in chemical engineering from Jadavpur University in India. During a research internship at IIT Bombay in 2018, he worked on developing a technology for in situ arsenic detection in water. Like Bessette, he noted the impact of this prior research experience on his interest in global water challenges, along with his personal experience growing up in an area in India where access to safe drinking water was not guaranteed. More

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      Exploring frontiers of mechanical engineering

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      From cutting-edge robotics, design, and bioengineering to sustainable energy solutions, ocean engineering, nanotechnology, and innovative materials science, MechE students and their advisors are doing incredibly innovative work. The graduate students highlighted here represent a snapshot of the great work in progress this spring across the Department of Mechanical Engineering, and demonstrate the ways the future of this field is as limitless as the imaginations of its practitioners.Democratizing design through AILyle RegenwetterHometown: Champaign, IllinoisAdvisor: Assistant Professor Faez AhmedInterests: Food, climbing, skiing, soccer, tennis, cookingLyle Regenwetter finds excitement in the prospect of generative AI to “democratize” design and enable inexperienced designers to tackle complex design problems. His research explores new training methods through which generative AI models can be taught to implicitly obey design constraints and synthesize higher-performing designs. Knowing that prospective designers often have an intimate knowledge of the needs of users, but may otherwise lack the technical training to create solutions, Regenwetter also develops human-AI collaborative tools that allow AI models to interact and support designers in popular CAD software and real design problems. Solving a whale of a problem Loïcka BailleHometown: L’Escale, FranceAdvisor: Daniel ZitterbartInterests: Being outdoors — scuba diving, spelunking, or climbing. Sailing on the Charles River, martial arts classes, and playing volleyballLoïcka Baille’s research focuses on developing remote sensing technologies to study and protect marine life. Her main project revolves around improving onboard whale detection technology to prevent vessel strikes, with a special focus on protecting North Atlantic right whales. Baille is also involved in an ongoing study of Emperor penguins. Her team visits Antarctica annually to tag penguins and gather data to enhance their understanding of penguin population dynamics and draw conclusions regarding the overall health of the ecosystem.Water, water anywhereCarlos Díaz-MarínHometown: San José, Costa RicaAdvisor: Professor Gang Chen | Former Advisor: Professor Evelyn WangInterests: New England hiking, biking, and dancingCarlos Díaz-Marín designs and synthesizes inexpensive salt-polymer materials that can capture large amounts of humidity from the air. He aims to change the way we generate potable water from the air, even in arid conditions. In addition to water generation, these salt-polymer materials can also be used as thermal batteries, capable of storing and reusing heat. Beyond the scientific applications, Díaz-Marín is excited to continue doing research that can have big social impacts, and that finds and explains new physical phenomena. As a LatinX person, Díaz-Marín is also driven to help increase diversity in STEM.Scalable fabrication of nano-architected materialsSomayajulu DhulipalaHometown: Hyderabad, IndiaAdvisor: Assistant Professor Carlos PortelaInterests: Space exploration, taekwondo, meditation.Somayajulu Dhulipala works on developing lightweight materials with tunable mechanical properties. He is currently working on methods for the scalable fabrication of nano-architected materials and predicting their mechanical properties. The ability to fine-tune the mechanical properties of specific materials brings versatility and adaptability, making these materials suitable for a wide range of applications across multiple industries. While the research applications are quite diverse, Dhulipala is passionate about making space habitable for humanity, a crucial step toward becoming a spacefaring civilization.Ingestible health-care devicesJimmy McRaeHometown: Woburn, MassachusettsAdvisor: Associate Professor Giovani TraversoInterests: Anything basketball-related: playing, watching, going to games, organizing hometown tournaments Jimmy McRae aims to drastically improve diagnostic and therapeutic capabilities through noninvasive health-care technologies. His research focuses on leveraging materials, mechanics, embedded systems, and microfabrication to develop novel ingestible electronic and mechatronic devices. This ranges from ingestible electroceutical capsules that modulate hunger-regulating hormones to devices capable of continuous ultralong monitoring and remotely triggerable actuations from within the stomach. The principles that guide McRae’s work to develop devices that function in extreme environments can be applied far beyond the gastrointestinal tract, with applications for outer space, the ocean, and more.Freestyle BMX meets machine learningEva NatesHometown: Narberth, Pennsylvania Advisor: Professor Peko HosoiInterests: Rowing, running, biking, hiking, bakingEva Nates is working with the Australian Cycling Team to create a tool to classify Bicycle Motocross Freestyle (BMX FS) tricks. She uses a singular value decomposition method to conduct a principal component analysis of the time-dependent point-tracking data of an athlete and their bike during a run to classify each trick. The 2024 Olympic team hopes to incorporate this tool in their training workflow, and Nates worked alongside the team at their facilities on the Gold Coast of Australia during MIT’s Independent Activities Period in January.Augmenting Astronauts with Wearable Limbs Erik BallesterosHometown: Spring, TexasAdvisor: Professor Harry AsadaInterests: Cosplay, Star Wars, Lego bricksErik Ballesteros’s research seeks to support astronauts who are conducting planetary extravehicular activities through the use of supernumerary robotic limbs (SuperLimbs). His work is tailored toward design and control manifestation to assist astronauts with post-fall recovery, human-leader/robot-follower quadruped locomotion, and coordinated manipulation between the SuperLimbs and the astronaut to perform tasks like excavation and sample handling.This article appeared in the Spring 2024 edition of the Department of Mechanical Engineering’s magazine, MechE Connects.  More

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      Bringing an investigator’s eye to complex social challenges

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      Anna Russo likes puzzles. They require patience, organization, and a view of the big picture. She brings an investigator’s eye to big institutional and societal challenges whose solutions can have wide-ranging, long-term impacts.

      Russo’s path to MIT began with questions. She didn’t have the whole picture yet. “I had no idea what I wanted to do with my life,” says Russo, who is completing her PhD in economics in 2024. “I was good at math and science and thought I wanted to be a doctor.”

      While completing her undergraduate studies at Yale University, where she double majored in economics and applied math, Russo discovered a passion for problem-solving, where she could apply an analytical lens to answering the kinds of thorny questions whose solutions could improve policy. “Empirical research is fun and exciting,” Russo says.

      After Yale, Russo considered what to do next. She worked as a full-time research assistant with MIT economist Amy Finkelstein. Russo’s work with Finkelstein led her toward identifying, studying, and developing answers to complex questions. 

      “My research combines ideas from two fields of economic inquiry — public finance and industrial organization — and applies them to questions about the design of environmental and health care policy,” Russo says. “I like the way economists think analytically about social problems.”

      Narrowing her focus

      Studying with and being advised by renowned economists as both an undergraduate and a doctoral student helped Russo narrow her research focus, fitting more pieces into the puzzle. “What drew me to MIT was its investment in its graduate students,” Russo says.

      Economic research meant digging into policy questions, identifying market failures, and proposing solutions. Doctoral study allowed Russo to assemble data to rigorously follow each line of inquiry.

      “Doctoral study means you get to write about something you’re really interested in,” Russo notes. This led her to study policy responses to climate change adaptation and mitigation. 

      “In my first year, I worked on a project exploring the notion that floodplain regulation design doesn’t do a good job of incentivizing the right level of development in flood-prone areas,” she says. “How can economists help governments convince people to act in society’s best interest?”

      It’s important to understand institutional details, Russo adds, which can help investigators identify and implement solutions. 

      “Feedback, advice, and support from faculty were crucial as I grew as a researcher at MIT,” she says. Beyond her two main MIT advisors, Finkelstein and economist Nikhil Agarwal — educators she describes as “phenomenal, dedicated advisors and mentors” — Russo interacted regularly with faculty across the department. 

      Russo later discovered another challenge she hoped to solve: inefficiencies in conservation and carbon offset programs. She set her sights on the United States Department of Agriculture’s Conservation Reserve Program because she believes it and programs like it can be improved. 

      The CRP is a land conservation plan administered by USDA’s Farm Service Agency. In exchange for a yearly rental payment, farmers enrolled in the program agree to remove environmentally sensitive land from agricultural production and plant species that will improve environmental health and quality.

      “I think we can tweak the program’s design to improve cost-effectiveness,” Russo says. “There’s a trove of data available.” The data include information like auction participants’ bids in response to well-specified auction rules, which Russo links to satellite data measuring land use outcomes. Understanding how landowners bid in CRP auctions can help identify and improve the program’s function. 

      “We may be able to improve targeting and achieve more cost-effective conservation by adjusting the CRP’s scoring system,” Russo argues. Opportunities may exist to scale the incremental changes under study for other conservation programs and carbon offset markets more generally.  

      Economics, Russo believes, can help us conceptualize problems and recommend effective alternative solutions.

      The next puzzle

      Russo wants to find her next challenge while continuing her research. She plans to continue her work as a junior fellow at the Harvard Society of Fellows, after which she’ll join the Harvard Department of Economics as an assistant professor. Russo also plans to continue helping other budding economists since she believes in the importance of supporting other students.   

      Russo’s advisors are some of her biggest supporters. 

      Finklestein emphasizes Russo’s curiosity, enthusiasm, and energy as key drivers in her success. “Her genuine curiosity and interest in getting to the bottom of a problem with the data — with an econometric analysis, with a modeling issue — is the best antidote for [the stress that can be associated with research],” Finklestein says. “It’s a key ingredient in her ability to produce important and credible work.”

      “She’s also incredibly generous with her time and advice,” Finklestein continues, “whether it’s helping an undergraduate research assistant with her senior thesis, or helping an advisor such as myself navigate a data access process she’s previously been through.”

      “Instead of an advisor-advisee relationship, working with her on a thesis felt more like a collaboration between equals,” Agarwal adds. “[She] has the maturity and smarts to produce pathbreaking research.

      “Doctoral study is an opportunity for students to find their paths collaboratively,” Russo says. “If I can help someone else solve a small piece of their puzzle, that’s a huge positive. Research is a series of many, many small steps forward.” 

      Identifying important causes for further investigation and study will always be important to Russo. “I also want to dig into some other market that’s not working well and figure out how to make it better,” she says. “Right now I’m really excited about understanding California wildfire mitigation.” 

      Puzzles are made to be solved, after all. More

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      Letting the Earth answer back: Designing better planetary conversations

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      For Chen Chu MArch ’21, the invitation to join the 2023-24 cohort of Morningside Academy for Design Design Fellows has been an unparalleled opportunity to investigate the potential of design as an alternative method of problem-solving.

      After earning a master’s degree in architecture at MIT and gaining professional experience as a researcher at an environmental nongovernmental organization, Chu decided to pursue a PhD in the Department of Urban Studies and Planning. “I discovered that I needed to engage in a deeper way with the most difficult ethical challenges of our time, especially those arising from the fact of climate change,” he explains. “For me, MIT has always represented this wonderful place where people are inherently intellectually curious — it’s a very rewarding community to be part of.”

      Chu’s PhD research, guided by his doctoral advisor Delia Wendel, assistant professor of urban studies and international development, focuses on how traditional practices of floodplain agriculture can inform local and global strategies for sustainable food production and distribution in response to climate change. 

      Typically located alongside a river or stream, floodplains arise from seasonal flooding patterns that distribute nutrient-rich silt and create connectivity between species. This results in exceptionally high levels of biodiversity and microbial richness, generating the ideal conditions for agriculture. It’s no accident that the first human civilizations were founded on floodplains, including Mesopotamia (named for its location poised between two rivers, the Euphrates and Tigris), the Indus River Civilization, and the cultures of Ancient Egypt based around the Nile. Riverine transportation networks and predictable flooding rhythms provide a framework for trade and cultivation; nonetheless, floodplain communities must learn to live with risk, subject to the sudden disruptions of high waters, drought, and ecological disequilibrium. 

      For Chu, the “unstable and ungovernable” status of floodplains makes them fertile ground for thinking about. “I’m drawn to these so-called ‘wet landscapes’ — edge conditions that act as transitional spaces between land and water, between humans and nature, between city and river,” he reflects. “The development of extensively irrigated agricultural sites is typically a collective effort, which raises intriguing questions about how communities establish social organizations that simultaneously negotiate top-down state control and adapt to the uncertainty of nature.”

      Chu is in the process of honing the focus of his dissertation and refining his data collection methods, which will include archival research and fieldwork, as well as interviews with floodplain inhabitants to gain an understanding of sociopolitical nuances. Meanwhile, his role as a design fellow gives him the space to address the big questions that fire his imagination. How can we live well on shared land? How can we take responsibility for the lives of future generations? What types of political structures are required to get everyone on board? 

      These are just a few of the questions that Chu recently put to his cohort in a presentation. During the weekly seminars for the fellowship, he has the chance to converse with peers and mentors of multiple disciplines — from researchers rethinking the pedagogy of design to entrepreneurs applying design thinking to new business models to architects and engineers developing new habitats to heal our relationship with the natural world. 

      “I’ll admit — I’m wary of the human instinct to problem-solve,” says Chu. “When it comes to the material conditions and lived experience of people and planet, there’s a limit to our economic and political reasoning, and to conventional architectural practice. That said, I do believe that the mindset of a designer can open up new ways of thinking. At its core, design is an interdisciplinary practice based on the understanding that a problem can’t be solved from a narrow, singular perspective.” 

      The stimulating structure of a MAD Fellowship — free from immediate obligations to publish or produce, fellows learn from one another and engage with visiting speakers via regular seminars and events — has prompted Chu to consider what truly makes for generative conversation in the contexts of academia and the private and public sectors. In his opinion, discussions around climate change often fail to take account of one important voice; an absence he describes as “that silent being, the Earth.”

      “You can’t ask the Earth, ‘What does justice mean to you?’ Nature will not respond,” he reflects. To bridge the gap, Chu believes it’s important to combine the study of specific political and social conditions with broader existential questions raised by the environmental humanities. His own research draws upon the perspectives of thinkers including Dipesh Chakrabarty, Donna Haraway, Peter Singer,  Anna Tsing, and Michael Watts, among others. He cites James C. Scott’s lecture “In Praise of Floods” as one of his most important influences.

      In addition to his instinctive appreciation for theory, Chu’s outlook is grounded by an attention to innovation at the local level. He is currently establishing the parameters of his research, examining case studies of agricultural systems and flood mitigation strategies that have been sustained for centuries. 

      “One example is the polder system that is practiced in the Netherlands, China, Bangladesh, and many parts of the world: small, low-lying tracts of land submerged in water and surrounded by dykes and canals,” he explains. “You’ll find a different but comparable strategy in the colder regions of Japan. Crops are protected from the winter winds by constructing a spatial unit with the house at the center; trees behind the house serve as windbreakers and paddy fields for rice are located in front of the house, providing an integrated system of food and livelihood security.”

      Chu observes that there is a tendency for international policymakers to overlook local solutions in favor of grander visions and ambitious climate pledges — but he is equally keen not to romanticize vernacular practices. “Realistically, it’s always a two-way interaction. Unless you already have a workable local system in place, it’s difficult to implement a solution without top-down support. On the other hand, the large-scale technocratic dreams are empty if ignorant of local traditions and histories.” 

      By navigating between the global and the local, the theoretical and the practical, the visionary and the cautionary, Chu has hope in the possibility of gradually finding a way toward long-term solutions that adapt to specific conditions over time. It’s a model of ambition and criticality that Chu sees played out during dialogue at MAD and within his department; at root, he’s aware that the outcome of these conversations depends on the ethical context that shapes them.

      “I’ve been fortunate to have many mentors who have taught me the power of humility; a respect for the finitude, fragility,  and uncertainty of life,” he recalls. “It’s a mindset that’s barely apparent in today’s push for economic growth.” The flip-side of hubristic growth is an assumption that technological ingenuity will be enough to solve the climate crisis, but Chu’s optimism arises from a different source: “When I feel overwhelmed by the weight of the problems we’re facing, I just need to look around me,” he says. “Here on campus — at MAD, in my home department, and increasingly among the new generations of students — there’s a powerful ethos of political sensitivity, ethical compassion, and an attention to clear and critical judgment. That always gives me hope for the planet.” More

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      Moving past the Iron Age

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      MIT graduate student Sydney Rose Johnson has never seen the steel mills in central India. She’s never toured the American Midwest’s hulking steel plants or the mini mills dotting the Mississippi River. But in the past year, she’s become more familiar with steel production than she ever imagined.

      A fourth-year dual degree MBA and PhD candidate in chemical engineering and a graduate research assistant with the MIT Energy Initiative (MITEI) as well as a 2022-23 Shell Energy Fellow, Johnson looks at ways to reduce carbon dioxide (CO2) emissions generated by industrial processes in hard-to-abate industries. Those include steel.

      Almost every aspect of infrastructure and transportation — buildings, bridges, cars, trains, mass transit — contains steel. The manufacture of steel hasn’t changed much since the Iron Age, with some steel plants in the United States and India operating almost continually for more than a century, their massive blast furnaces re-lined periodically with carbon and graphite to keep them going.

      According to the World Economic Forum, steel demand is projected to increase 30 percent by 2050, spurred in part by population growth and economic development in China, India, Africa, and Southeast Asia.

      The steel industry is among the three biggest producers of CO2 worldwide. Every ton of steel produced in 2020 emitted, on average, 1.89 tons of CO2 into the atmosphere — around 8 percent of global CO2 emissions, according to the World Steel Association.

      A combination of technical strategies and financial investments, Johnson notes, will be needed to wrestle that 8 percent figure down to something more planet-friendly.

      Johnson’s thesis focuses on modeling and analyzing ways to decarbonize steel. Using data mined from academic and industry sources, she builds models to calculate emissions, costs, and energy consumption for plant-level production.

      “I optimize steel production pathways using emission goals, industry commitments, and cost,” she says. Based on the projected growth of India’s steel industry, she applies this approach to case studies that predict outcomes for some of the country’s thousand-plus factories, which together have a production capacity of 154 million metric tons of steel. For the United States, she looks at the effect of Inflation Reduction Act (IRA) credits. The 2022 IRA provides incentives that could accelerate the steel industry’s efforts to minimize its carbon emissions.

      Johnson compares emissions and costs across different production pathways, asking questions such as: “If we start today, what would a cost-optimal production scenario look like years from now? How would it change if we added in credits? What would have to happen to cut 2005 levels of emissions in half by 2030?”

      “My goal is to gain an understanding of how current and emerging decarbonization strategies will be integrated into the industry,” Johnson says.

      Grappling with industrial problems

      Growing up in Marietta, Georgia, outside Atlanta, the closest she ever came to a plant of any kind was through her father, a chemical engineer working in logistics and procuring steel for an aerospace company, and during high school, when she spent a semester working alongside chemical engineers tweaking the pH of an anti-foaming agent.

      At Kennesaw Mountain High School, a STEM magnet program in Cobb County, students devote an entire semester of their senior year to an internship and research project.

      Johnson chose to work at Kemira Chemicals, which develops chemical solutions for water-intensive industries with a focus on pulp and paper, water treatment, and energy systems.

      “My goal was to understand why a polymer product was falling out of suspension — essentially, why it was less stable,” she recalls. She learned how to formulate a lab-scale version of the product and conduct tests to measure its viscosity and acidity. Comparing the lab-scale and regular product results revealed that acidity was an important factor. “Through conversations with my mentor, I learned this was connected with the holding conditions, which led to the product being oxidized,” she says. With the anti-foaming agent’s problem identified, steps could be taken to fix it.

      “I learned how to apply problem-solving. I got to learn more about working in an industrial environment by connecting with the team in quality control as well as with R&D and chemical engineers at the plant site,” Johnson says. “This experience confirmed I wanted to pursue engineering in college.”

      As an undergraduate at Stanford University, she learned about the different fields — biotechnology, environmental science, electrochemistry, and energy, among others — open to chemical engineers. “It seemed like a very diverse field and application range,” she says. “I was just so intrigued by the different things I saw people doing and all these different sets of issues.”

      Turning up the heat

      At MIT, she turned her attention to how certain industries can offset their detrimental effects on climate.

      “I’m interested in the impact of technology on global communities, the environment, and policy. Energy applications affect every field. My goal as a chemical engineer is to have a broad perspective on problem-solving and to find solutions that benefit as many people, especially those under-resourced, as possible,” says Johnson, who has served on the MIT Chemical Engineering Graduate Student Advisory Board, the MIT Energy and Climate Club, and is involved with diversity and inclusion initiatives.

      The steel industry, Johnson acknowledges, is not what she first imagined when she saw herself working toward mitigating climate change.

      “But now, understanding the role the material has in infrastructure development, combined with its heavy use of coal, has illuminated how the sector, along with other hard-to-abate industries, is important in the climate change conversation,” Johnson says.

      Despite the advanced age of many steel mills, some are quite energy-efficient, she notes. Yet these operations, which produce heat upwards of 3,000 degrees Fahrenheit, are still emission-intensive.

      Steel is made from iron ore, a mixture of iron, oxygen, and other minerals found on virtually every continent, with Brazil and Australia alone exporting millions of metric tons per year. Commonly based on a process dating back to the 19th century, iron is extracted from the ore through smelting — heating the ore with blast furnaces until the metal becomes spongy and its chemical components begin to break down.

      A reducing agent is needed to release the oxygen trapped in the ore, transforming it from its raw form to pure iron. That’s where most emissions come from, Johnson notes.

      “We want to reduce emissions, and we want to make a cleaner and safer environment for everyone,” she says. “It’s not just the CO2 emissions. It’s also sometimes NOx and SOx [nitrogen oxides and sulfur oxides] and air pollution particulate matter at some of these production facilities that can affect people as well.”

      In 2020, the International Energy Agency released a roadmap exploring potential technologies and strategies that would make the iron and steel sector more compatible with the agency’s vision of increased sustainability. Emission reductions can be accomplished with more modern technology, the agency suggests, or by substituting the fuels producing the immense heat needed to process ore. Traditionally, the fuels used for iron reduction have been coal and natural gas. Alternative fuels include clean hydrogen, electricity, and biomass.

      Using the MITEI Sustainable Energy System Analysis Modeling Environment (SESAME), Johnson analyzes various decarbonization strategies. She considers options such as switching fuel for furnaces to hydrogen with a little bit of natural gas or adding carbon-capture devices. The models demonstrate how effective these tactics are likely to be. The answers aren’t always encouraging.

      “Upstream emissions can determine how effective the strategies are,” Johnson says. Charcoal derived from forestry biomass seemed to be a promising alternative fuel, but her models showed that processing the charcoal for use in the blast furnace limited its effectiveness in negating emissions.

      Despite the challenges, “there are definitely ways of moving forward,” Johnson says. “It’s been an intriguing journey in terms of understanding where the industry is at. There’s still a long way to go, but it’s doable.”

      Johnson is heartened by the steel industry’s efforts to recycle scrap into new steel products and incorporate more emission-friendly technologies and practices, some of which result in significantly lower CO2 emissions than conventional production.

      A major issue is that low-carbon steel can be more than 50 percent more costly than conventionally produced steel. “There are costs associated with making the transition, but in the context of the environmental implications, I think it’s well worth it to adopt these technologies,” she says.

      After graduation, Johnson plans to continue to work in the energy field. “I definitely want to use a combination of engineering knowledge and business knowledge to work toward mitigating climate change, potentially in the startup space with clean technology or even in a policy context,” she says. “I’m interested in connecting the private and public sectors to implement measures for improving our environment and benefiting as many people as possible.” More

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      Soaring high, in the Army and the lab

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      Starting off as a junior helicopter pilot, Lt. Col. Jill Rahon deployed to Afghanistan three times. During the last one, she was an air mission commander, the  pilot who is designated to interface with the ground troops throughout the mission.

      Today, Rahon is a fourth-year doctoral student studying applied physics at the Department of Nuclear Science and Engineering (NSE). Under the supervision of Areg Danagoulian, she is working on engineering solutions for enforcement of nuclear nonproliferation treaties. Rahon and her husband have 2-year-old twins: “They have the same warm relationship with my advisor that I had with my dad’s (PhD) advisor,” she says.

      Jill Rahon: Engineering solutions for enforcement of nuclear nonproliferation treaties

      A path to the armed forces

      The daughter of a health physicist father and a food chemist mother, Rahon grew up in the Hudson Valley, very close to New York City. Nine-eleven was a life-altering event: “Many of my friends’ fathers and uncles were policemen and firefighters [who] died responding to the attacks,” Rahon says. A hurt and angry teenager, Rahon was determined to do her part to help: She joined the Army and decided to pursue science, becoming part of the first class to enter West Point after 9/11.

      Rahon started by studying strategic history, a field that covers treaties and geopolitical relationships. It would prove useful later. Inspired by her father, who works in the nuclear field, Rahon added on a nuclear science and engineering track.

      After graduating from West Point, Rahon wanted to join active combat and chose aviation. At flight school in Fort Novosel, Alabama, she discovered that she loved flying. It was there that Rahon learned to fly the legendary Chinook helicopter. In short order, Rahon was assigned to the 101st Airborne Division and deployed to Afghanistan quickly thereafter.

      As expected, flying in Afghanistan, especially on night missions, was adrenaline-charged. “You’re thinking on the fly, you’re talking on five different radios, you’re making decisions for all the helicopters that are part of the mission,” Rahon remembers. Very often Rahon and her cohorts did not have the luxury of time. “We would get information that would need to be acted on quickly,” she says. During the planning meetings, she would be delighted to see a classmate from West Point function as the ground forces commander. “It would be surprising to see somebody you knew from a different setting halfway around the world, working toward common goals,” Rahon says.

      Also awesome: helping launch the first training program for female pilots to be recruited in the Afghan National Air Force. “I got to meet [and mentor] these strong young women who maybe didn’t have the same encouragement that I had growing up and they were out there hanging tough,” Rahon says.

      Exploring physics and nuclear engineering

      After serving in the combat forces, Rahon decided she wanted to teach physics at West Point. She applied to become a part of the Functional Area (FA52) as a nuclear and countering weapons of mass destruction officer.

      FA52 officers provide nuclear technical advice to maneuver commanders about nuclear weapons, effects, and operating in a nuclear environment or battlefield. Rahon’s specialty is radiation detection and operations in a nuclear environment, which poses unique threats and challenges to forces.

      Knowing she wanted to teach at West Point, she “brushed up extensively on math and physics” and applied to MIT NSE to pursue a master’s degree. “My fellow students were such an inspiration. They might not have had the same life experiences that I had but were still so mature and driven and knowledgeable not only about nuclear engineering but how that fits in the energy sector and in politics,” Rahon says.

      Resonance analysis to verify treaties

      Rahon returned to NSE to pursue her doctorate, where she does a “lot of detection and treaty verification work.”

      When looking at nuclear fuels to verify safeguards for treaties, experts search for the presence and quantities of heavy elements such as uranium, plutonium, thorium, and any of their decay products. To do so nondestructively is of high importance so they don’t destroy a piece of the material or fuel to identify it.

      Rahon’s research is built on resonance analysis, the fact that most midrange to heavy isotopes have unique resonance signatures that are accessed by neutrons of epithermal energy, which is relatively low on the scale of possible neutron energies. This means they travel slowly — crossing a distance of 2 meters in tens of microseconds, permitting their detection time to be used to calculate their energy.

      Studying how neutrons of a particular energy interact with a sample to identify worrisome nuclear materials is much like studying fingerprints to solve crimes. Isotopes that have a spike in likelihood of interaction occurring over a small neutron energy are said to have resonances, and these resonance patterns are isotopically unique. Experts can use this technique to nondestructively assess an item, identifying the constituent isotopes and their concentrations.

      Resonance analysis can be used to verify that the fuels are what the nuclear plant owner says they are. “There are a lot of safeguards activities and verification protocols that are managed by the International Atomic Energy Agency (IAEA) to ensure that a state is not misusing nuclear power for ulterior motives,” Rahon points out. And her method helps.

      “Our technique that leverages resonance analysis is nothing new,” Rahon says, “It’s been applied practically since the ’70s at very large beam facilities, hundreds of meters long with a very large accelerator that pulses neutrons, and then you’re able to correlate a neutron time of flight with a resonance profile. What we’ve done that is novel is we’ve shrunk it down to a 3-meter system with a portable neutron residence generator and a 2-meter beam path,” she says.

      Mobility confers many significant advantages: “This is something that could be conceivably put on the back of a truck and moved to a fuel facility, then driven to the next one for inspections or put at a treaty verification site. It could be taken out to a silo field where they are dismantling nuclear weapons,” Rahon says. However, the miniaturization does come with significant challenges, such as the neutron generator’s impacts on the signal to noise ratio.

      Rahon is delighted her research can ensure that a necessary fuel source will not be misused. “We need nuclear power. We need low-carbon solutions for energy and we need safe ones. We need to ensure that this powerful technology is not being misused. And that’s why these engineering solutions are needed for these safeguards,” she says.

      Rahon sees parallels between her time in active duty and her doctoral research. Teamwork and communication are key in both, she says. Her dad is her role model and Rahon is a firm believer in mentorship, something she nurtured both in the armed forces and at MIT. “My advisor is genuinely a wonderful person who has always given me so much support from not only being a student, but also being a parent,” Rahon adds.

      In turn, Danagoulian has been impressed by Rahon’s remarkable abilities: “Raising twins, doing research in applied nuclear physics, and flying coalition forces into Taliban territory while evading ground fire … [Jill] developed her own research project with minimal help from me and defended it brilliantly during the first part of the exam,” he says. 

      It seems that Rahon flies high no matter which mission she takes on. More

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      Food for thought

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      MIT graduate student Juana De La O describes herself as a food-motivated organism, so it’s no surprise that she reaches for food and baking analogies when she’s discussing her thesis work in the lab of undergraduate officer and professor of biology Adam Martin. 

      Consider the formative stages of a croissant, she offers, occasionally providing homemade croissants to accompany the presentation: When one is forming the puff pastry, the dough is folded over the butter again and again. Tissues in a developing mouse embryo must similarly fold and bend, creating layers and structures that become the spine, head, and organs — but these tissues have no hands to induce those formative movements. 

      De La O is studying neural tube closure, the formation of the structure that becomes the spinal cord and the brain. Disorders like anencephaly and craniorachischisis occur when the head region fails to close in a developing fetus. It’s a heartbreaking defect, De La O says, because it’s 100 percent lethal — but the fetus fully develops otherwise. 

      “Your entire central nervous system hinges on this one event happening successfully,” she says. “On the fundamental level, we have a very limited understanding of the mechanisms required for neural closure to happen at all, much less an understanding of what goes wrong that leads to those defects.” 

      Hypothetically speaking

      De La O hails from Chicago, where she received an undergraduate degree from the University of Chicago and worked in the lab of Ilaria Rebay. De La O’s sister was the first person in her family to go to and graduate from college — De La O, in turn, is the first person in her family to pursue a PhD. 

      From her first time visiting campus, De La O could see MIT would provide a thrilling environment in which to study.

      “MIT was one of the few places where the students weren’t constantly complaining about how hard their life was,” she says. “At lunch with prospective students, they’d be talking to each other and then just organically slip into conversations about science.”

      The department emails acceptance letters and sends a physical copy via snail mail. De La O’s letter included a handwritten note from department head Amy Keating, then a graduate officer, who had interviewed De La O during her campus visit. 

      “That’s what really sold it for me,” she recalls. “I went to my PI [principal investigator]’s office and said, ‘I have new data’” and I showed her the letter, and there was lots of unintelligible crying.” 

      To prepare her for graduate school, her parents, both immigrants from Mexico, spent the summer teaching De La O to make all her favorite dishes because “comfort food feels like home.”   

      When she reached MIT, however, the Covid-19 pandemic ground the world to a halt and severely limited what students could experience during rotations. Far from home and living alone, De La O taught herself to bake, creating the confections she craved but couldn’t leave her apartment to purchase. De La O didn’t get to work as extensively as she would have liked during her rotation in the Martin lab. 

      Martin had recently returned from a sabbatical that was spent learning a new research model; historically a fly lab, Martin was planning to delve into mouse research. 

      “My final presentation was, ‘Here’s a hypothetical project I would hypothetically do if I were hypothetically going to work with mice in a fly lab,’” De La O says. 

      Martin recalls being impressed. De La O is skilled at talking about science in an earnest and engaging way, and she dug deep into the literature and identified points Martin hadn’t considered. 

      “This is a level of independence that I look for in a student because it is important to the science to have someone who is contributing their ideas and independent reading and research to a project,” Martin says. 

      After agreeing to join the lab — news she shared with Martin via a meme — she got to work. 

      Charting mouse development

      The neural tube forms from a flat sheet whose sides rise and meet to create a hollow cylinder. De La O has observed patterns of actin and myosin changing in space and time as the embryo develops. Actin and myosin are fibrous proteins that provide structure in eukaryotic cells. They are responsible for some cell movement, like muscle contraction or cell division. Fibers of actin and myosin can also connect across cells, forming vast networks that coordinate the movements of whole tissues. By looking at the structure of these networks, researchers can make predictions about how force is affecting those tissues.

      De La O has found indications of a difference in the tension across the tissue during the critical stages of neural tube closure, which contributes to the tissue’s ability to fold and form a tube. They are not the first research group to propose this, she notes, but they’re suggesting that the patterns of tension are not uniform during a single stage of development.

      “My project, on a really fundamental level, is an atlas for a really early stage of mouse development for actin and myosin,” De La O says. “This dataset doesn’t exist in the field yet.” 

      However, De La O has been performing analyses exclusively in fixed samples, so she may be quantifying phenomena that are not actually how tissues behave. To determine whether that’s the case, De La O plans to analyze live samples.

      The idea is that if one could carefully cut tissue and observe how quickly it recoils, like slicing through a taught rubber band, those measurements could be used to approximate force across the tissue. However, the techniques required are still being developed, and the greater Boston area currently lacks the equipment and expertise needed to attempt those experiments. 

      A big part of her work in the lab has been figuring out how to collect and analyze relevant data. This research has already taken her far and wide, both literally and virtually. 

      “We’ve found that people have been very generous with their time and expertise,” De La O says. “One of the benefits we, as fly people, brought into this field is we don’t know anything — so we’re going to question everything.”

      De La O traveled to the University of Virginia to learn live imaging techniques from associate professor of cell biology Ann Sutherland, and she’s also been in contact with Gabriel Galea at University College London, where Martin and De La O are considering a visit for further training. 

      “There are a lot of reasons why these experiments could go wrong, and one of them is that I’m not trained yet,” she says. “Once you know how to do things on an optimal setup, you can figure out how to make it work on a less-optimal setup.”

      Collaboration and community

      De La O has now expanded her cooking repertoire far beyond her family’s recipes and shares her new creations when she visits home. At MIT, she hosts dinner parties, including one where everything from the savory appetizers to the sweet desserts contained honey, thanks to an Independent Activities Period course about the producers of the sticky substance, and she made and tried apple pie for the first time with her fellow graduate students after an afternoon of apple picking. 

      De La O says she’s still learning how to say no to taking on additional work outside of her regular obligations as a PhD student; she’s found there’s a lot of pressure for underrepresented students to be at the forefront of diversity efforts, and although she finds that work extremely fulfilling, she can, and has, stretched herself too thin in the past. 

      “Every time I see an application that asks ‘How will you work to increase diversity,’ my strongest instinct is just to write ‘I’m brown and around — you’re welcome,’” she jokes. “The greatest amount of diversity work I will do is to get where I’m going. Me achieving my goals increases diversity inherently, but I also want to do well because I know if I do, I will make everything better for people coming after me.”

      De La O is confident her path will be in academia, and troubleshooting, building up protocols, and setting up standards for her work in the Martin Lab has been “an excellent part of my training program.” 

      De La O and Martin embarked on a new project in a new model for the lab for De La O’s thesis, so much of her graduate studies will be spent laying the groundwork for future research. 

      “I hope her travels open Juana’s eyes to science being a larger community and to teach her about how to lead a collaboration,” Martin says. “Overall, I think this project is excellent for a student with aspirations to be a PI. I benefited from extremely open-ended projects as a student and see, in retrospect, how they prepared me for my work today.” More