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      Two first-year students named Rise Global Winners for 2022

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      In 2019, former Google CEO Eric Schmidt and his wife, Wendy, launched a $1 billion philanthropic commitment to identify global talent. Part of that effort is the Rise initiative, which selects 100 young scholars, ages 15-17, from around the world who show unusual promise and a drive to serve others. This year’s cohort of 100 Rise Global Winners includes two MIT first-year students, Jacqueline Prawira and Safiya Sankari.

      Rise intentionally targets younger-aged students and focuses on identifying what the program terms “hidden brilliance” in any form, anywhere in the world, whether it be in a high school or a refugee camp. Another defining aspect of the program is that Rise winners receive sustained support — not just in secondary school, but throughout their lives.

      “We believe that the answers to the world’s toughest problems lie in the imagination of the world’s brightest minds,” says Eric Braverman, CEO of Schmidt Futures, which manages Rise along with the Rhodes Trust. “Rise is an integral part of our mission to create the best, largest, and most enduring pipeline of exceptional talent globally and match it to opportunities to serve others for life.”

      The Rise program creates this enduring pipeline by providing a lifetime of benefits, including funding, programming, and mentoring opportunities. These resources can be tailored to each person as they evolve throughout their career. In addition to a four-year college scholarship, winners receive mentoring and career services; networking opportunities with other Rise recipients and partner organizations; technical equipment such as laptops or tablets; courses on topics like leadership and human-centered design; and opportunities to apply for graduate scholarships and for funding throughout their careers to support their innovative ideas, such as grants or seed money to start a social enterprise.

      Prawira and Sankari’s winning service projects focus on global sustainability and global medical access, respectively. Prawira invented a way to use upcycled fish-scale waste to absorb heavy metals in wastewater. She first started experimenting with fish-scale waste in middle school to try to find a bio-based alternative to plastic. More recently, she discovered that the calcium salts and collagen in fish scales can absorb up to 82 percent of heavy metals from water, and 91 percent if an electric current is passed through the water. Her work has global implications for treating contaminated water at wastewater plants and in developing countries.

      Prawiri published her research in 2021 and has won awards from the U.S. Environmental Protection Agency and several other organizations. She’s planning to major in Course 3 (materials science and engineering), perhaps with an environmentally related minor. “I believe that sustainability and solving environmental problems requires a multifaced approach,” she says. “Creating greener materials for use in our daily lives will have a major impact in solving current environmental issues.”

      For Sankari’s service project, she developed an algorithm to analyze data from electronic nano-sensor devices, or e-noses, which can detect certain diseases from a patient’s breath. The devices are calibrated to detect volatile organic compound biosignatures that are indicative of diseases like diabetes and cancer. “E-nose disease detection is much faster and cheaper than traditional methods of diagnosis, making medical care more accessible to many,” she explains. The Python-based algorithm she created can translate raw data from e-noses into a result that the user can read.

      Sankari is a lifetime member of the American Junior Academy of Science and has been a finalist in several prestigious science competitions. She is considering a major in Course 6-7 (computer science and molecular biology) at MIT and hopes to continue to explore the intersection between nanotechnology and medicine.

      While the 2022 Rise recipients share a desire to tackle some of the world’s most intractable problems, their ideas and interests, as reflected by their service projects, are broad, innovative, and diverse. A winner from Belarus used bioinformatics to predict the molecular effect of a potential Alzheimer’s drug. A Romanian student created a magazine that aims to promote acceptance of transgender bodies. A Vietnamese teen created a prototype of a toothbrush that uses a nano chip to detect cancerous cells in saliva. And a recipient from the United States designed modular, tiny homes for the unhoused that are affordable and sustainable, as an alternative to homeless shelters.

      This year’s winners were selected from over 13,000 applicants from 47 countries, from Azerbaijan and Burkina Faso to Lebanon and Paraguay. The selection process includes group interviews, peer and expert review of each applicant’s service project, and formal talent assessments. More

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      MIT student club Engineers Without Borders works with local village in Tanzania

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      Four students from the MIT club Engineers Without Borders (EWB) spent part of their summer in Tanzania to begin assessment work for a health and sanitation project that will benefit the entire village, and an irrigated garden for the Mkutani Primary School.

      The club has been working with the Boston Professional Chapter of Engineers Without Borders (EWB-BPC) since 2019. The Boston chapter finds projects in underserved communities in the developing world and helped connect the MIT students with local government and school officials.

      Juniors Fiona Duong, female health and sanitation team lead, and Lai Wa Chu, irrigation team lead, spent two weeks over the summer in Mkutani conducting research for their projects. Chu was faced with finding more water supplies and a way to get water from the nearby river to the school to use in the gardens they were planting. Duong was charged with assessing the needs of the people who visit The Mkutani Dispensary, which serves as a local medical clinic. Juniors Hung Huynh, club president, and Vivian Cheng, student advisor, also made the trip to work on the projects.

      Health and sanitation project

      Duong looked into ways to help pregnant women with privacy issues as the facility they give birth in — The Mkutani Dispensary — is very small, with just two beds, and is in need of repairs and upgrades. Before leaving Cambridge, Duong led FaceTime meetings with government officials and facilities managers in the village. Once on the ground, she began collecting information and conducted focus groups with the local women and other constituents. She learned that one in three women were not giving birth in the dispensary due to privacy concerns and the lack of modern equipment needed for high-risk pregnancies.

      “The women said that the most pressing need there was water. The women were expected to bring their own water to their deliveries. The rain-catching system there was not enough to fulfill their needs and the river water wasn’t clean. When in labor, they relied on others to gather it and bring it to the dispensary by bike,” Duong says. “With broken windows, the dispensary did not allow for privacy or sanitary conditions.”

      Duong will also analyze the data she collected and share it with others before more MIT students head to Mkutani next summer.

      Farming, sustainability, and irrigation projectBefore heading to Mkutani, Chu conducted research regarding irrigation methods and water collection methods. She confirmed that the river water still contained E.coli and advised the teachers that it would need to be boiled or placed in the sun for a few hours before it could be used. Her technical background in fluid dynamics was helpful for the project.

      “We also found that there was a need for supplemental food for the school, as many children lived too far away to walk home for lunch. The headmaster reached out to us about building the garden, as the garden provides supplemental fruit and vegetables for many of the 600 students to eat. They needed water from the river that was quite far away from the school. We looked at ways to get the water to the garden,” Chu says.

      The group is considering conducting an ecological survey of the area to see if there is another source of water so they could drill another borehole. They will complete their analysis and then decide the best solution to implement.

      “Watching the whole team’s hard work pay off when the travel team got to Mkutani was so amazing,” says second-year student Maria Hernandez, club internal relations chair. “Now, we’re ready to get to work again so we can go back next year. I love being a part of Engineers Without Borders because it’s such a unique way to apply technical skills outside of the classroom and see the impact you make on the community. It’s a beautiful project that truly impacts so many people, and I can’t wait to go back to Mkutani next year.”

      Both Duong and Chu hope they’ll return to the school and the dispensary in summer 2023 to work on the implementation phase of their projects. “This project is one of the reasons I came to MIT. I wanted to work on a social impact project to help improve the world,” Chu says.

      “I hope to go back next summer and implement the project,” adds Duong. “If I do, we’ll go during the two most crucial weeks of the project — after the contractors have started the repair work on the dispensary, so we can see how things are going and then help with anything else related to the project.”

      Duong and Chu said students don’t have to be engineers to help with the EWB’s work — any MIT student interested in joining the club may do so. Both agree that fundraising is a priority, but there are numerous other roles students can help with.

      “MIT students shouldn’t be afraid to just dive right in. There’s a lot that needs to be done there, and even if you don’t have experience in a certain area, don’t let that be a barrier. It’s very rewarding work and it’s also great to get international work experience,” Duong says.

      Chu added, “The project may not seem flashy now, but the rewards are great. Students will get new technical skills and get to experience a new culture as well.” More

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      Scientists chart how exercise affects the body

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      Exercise is well-known to help people lose weight and avoid gaining it. However, identifying the cellular mechanisms that underlie this process has proven difficult because so many cells and tissues are involved.

      In a new study in mice that expands researchers’ understanding of how exercise and diet affect the body, MIT and Harvard Medical School researchers have mapped out many of the cells, genes, and cellular pathways that are modified by exercise or high-fat diet. The findings could offer potential targets for drugs that could help to enhance or mimic the benefits of exercise, the researchers say.

      “It is extremely important to understand the molecular mechanisms that are drivers of the beneficial effects of exercise and the detrimental effects of a high-fat diet, so that we can understand how we can intervene, and develop drugs that mimic the impact of exercise across multiple tissues,” says Manolis Kellis, a professor of computer science in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and a member of the Broad Institute of MIT and Harvard.

      The researchers studied mice with high-fat or normal diets, who were either sedentary or given the opportunity to exercise whenever they wanted. Using single-cell RNA sequencing, the researchers cataloged the responses of 53 types of cells found in skeletal muscle and two types of fatty tissue.

      “One of the general points that we found in our study, which is overwhelmingly clear, is how high-fat diets push all of these cells and systems in one way, and exercise seems to be pushing them nearly all in the opposite way,” Kellis says. “It says that exercise can really have a major effect throughout the body.”

      Kellis and Laurie Goodyear, a professor of medicine at Harvard Medical School and senior investigator at the Joslin Diabetes Center, are the senior authors of the study, which appears today in the journal Cell Metabolism. Jiekun Yang, a research scientist in MIT CSAIL; Maria Vamvini, an instructor of medicine at the Joslin Diabetes Center; and Pasquale Nigro, an instructor of medicine at the Joslin Diabetes Center, are the lead authors of the paper.

      The risks of obesity

      Obesity is a growing health problem around the world. In the United States, more than 40 percent of the population is considered obese, and nearly 75 percent is overweight. Being overweight is a risk factor for many diseases, including heart disease, cancer, Alzheimer’s disease, and even infectious diseases such as Covid-19.

      “Obesity, along with aging, is a global factor that contributes to every aspect of human health,” Kellis says.

      Several years ago, his lab performed a study on the FTO gene region, which has been strongly linked to obesity risk. In that 2015 study, the research team found that genes in this region control a pathway that prompts immature fat cells called progenitor adipocytes to either become fat-burning cells or fat-storing cells.

      That finding, which demonstrated a clear genetic component to obesity, motivated Kellis to begin looking at how exercise, a well-known behavioral intervention that can prevent obesity, might act on progenitor adipocytes at the cellular level.

      To explore that question, Kellis and his colleagues decided to perform single-cell RNA sequencing of three types of tissue — skeletal muscle, visceral white adipose tissue (found packed around internal organs, where it stores fat), and subcutaneous white adipose tissue (which is found under the skin and primarily burns fat).

      These tissues came from mice from four different experimental groups. For three weeks, two groups of mice were fed either a normal diet or a high-fat diet. For the next three weeks, each of those two groups were further divided into a sedentary group and an exercise group, which had continuous access to a treadmill.

      By analyzing tissues from those mice, the researchers were able to comprehensively catalog the genes that were activated or suppressed by exercise in 53 different cell types.

      The researchers found that in all three tissue types, mesenchymal stem cells (MSCs) appeared to control many of the diet and exercise-induced effects that they observed. MSCs are stem cells that can differentiate into other cell types, including fat cells and fibroblasts. In adipose tissue, the researchers found that a high-fat diet modulated MSCs’ capacity to differentiate into fat-storing cells, while exercise reversed this effect.

      In addition to promoting fat storage, the researchers found that a high-fat diet also stimulated MSCs to secrete factors that remodel the extracellular matrix (ECM) — a network of proteins and other molecules that surround and support cells and tissues in the body. This ECM remodeling helps provide structure for enlarged fat-storing cells and also creates a more inflammatory environment.

      “As the adipocytes become overloaded with lipids, there’s an extreme amount of stress, and that causes low-grade inflammation, which is systemic and preserved for a long time,” Kellis says. “That is one of the factors that is contributing to many of the adverse effects of obesity.”

      Circadian effects

      The researchers also found that high-fat diets and exercise had opposing effects on cellular pathways that control circadian rhythms — the 24-hour cycles that govern many functions, from sleep to body temperature, hormone release, and digestion. The study revealed that exercise boosts the expression of genes that regulate these rhythms, while a high-fat diet suppresses them.

      “There have been a lot of studies showing that when you eat during the day is extremely important in how you absorb the calories,” Kellis says. “The circadian rhythm connection is a very important one, and shows how obesity and exercise are in fact directly impacting that circadian rhythm in peripheral organs, which could act systemically on distal clocks and regulate stem cell functions and immunity.”

      The researchers then compared their results to a database of human genes that have been linked with metabolic traits. They found that two of the circadian rhythm genes they identified in this study, known as DBP and CDKN1A, have genetic variants that have been associated with a higher risk of obesity in humans.

      “These results help us see the translational values of these targets, and how we could potentially target specific biological processes in specific cell types,” Yang says.

      The researchers are now analyzing samples of small intestine, liver, and brain tissue from the mice in this study, to explore the effects of exercise and high-fat diets on those tissues. They are also conducting work with human volunteers to sample blood and biopsies and study similarities and differences between human and mouse physiology. They hope that their findings will help guide drug developers in designing drugs that might mimic some of the beneficial effects of exercise.

      “The message for everyone should be, eat a healthy diet and exercise if possible,” Kellis says. “For those for whom this is not possible, due to low access to healthy foods, or due to disabilities or other factors that prevent exercise, or simply lack of time to have a healthy diet or a healthy lifestyle, what this study says is that we now have a better handle on the pathways, the specific genes, and the specific molecular and cellular processes that we should be manipulating therapeutically.”

      The research was funded by the National Institutes of Health and the Novo Nordisk Research Center in Seattle. More

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      J-WAFS awards $150K Solutions grant to Patrick Doyle and team for rapid removal of micropollutants from water

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      The Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) has awarded a 2022 J-WAFS Solutions grant to Patrick S. Doyle, the Robert T. Haslam Professor of Chemical Engineering at MIT, for his innovative system to tackle water pollution. Doyle will be working with co-Principal Investigator Rafael Gomez-Bombarelli, assistant professor in materials processing in the Department of Materials Science, as well as PhD students Devashish Gokhale and Tynan Perez. Building off of findings from a 2019 J-WAFS seed grant, Doyle and the research team will create cost-effective industry-scale processes to remove micropollutants from water. Project work will commence this month.

      The J-WAFS Solutions program provides one-year, renewable, commercialization grants to help move MIT technology from the laboratory to market. Grants of up to $150,000 are awarded to researchers with breakthrough technologies and inventions in water or food. Since its launch in 2015, J-WAFS Solutions grants have led to seven spinout companies and helped commercialize two products as open-source technologies. The grant program is supported by Community Jameel.

      A widespread problem 

      Micropollutants are contaminants that occur in low concentrations in the environment, yet continuous exposure and bioaccumulation of micropollutants make them a cause for concern. According to the U.S. Environmental Protection Agency, the plastics derivative Bisphenol A (BPA), the “forever chemicals” per-and polyfluoroalkyl substances (PFAS), and heavy metals like lead are common micropollutants known to be found in more than 85 percent of rivers, ponds, and lakes in the United States. Many of these bodies of water are sources of drinking water. Over long periods of time, exposure to micropollutants through drinking water can cause physiological damage in humans, increasing the risk of cancer, developmental disorders, and reproductive failure.

      Since micropollutants occur in low concentrations, it is difficult to detect and monitor their presence, and the chemical diversity of micropollutants makes it difficult to inexpensively remove them from water. Currently, activated carbon is the industry standard for micropollutant elimination, but this method cannot efficiently remove contaminants at parts-per-billion and parts-per-trillion concentrations. There are also strong sustainability concerns associated with activated carbon production, which is energy-intensive and releases large volumes of carbon dioxide.

      A solution with societal and economic benefits

      Doyle and his team are developing a technology that uses sustainable hydrogel microparticles to remove micropollutants from water. The polymeric hydrogel microparticles use chemically anchored structures including micelles and other chelating agents that act like a sponge by absorbing organic micropollutants and heavy metal ions. The microparticles are large enough to separate from water using simple gravitational settling. The system is sustainable because the microparticles can be recycled for continuous use. In testing, the long-lasting, reusable microparticles show quicker removal of contaminants than commercial activated carbon. The researchers plan to utilize machine learning to find optimal microparticle compositions that maximize performance on complex combinations of micropollutants in simulated and real wastewater samples.

      Economically, the technology is a new offering that has applications in numerous large markets where micropollutant elimination is vital, including municipal and industrial water treatment equipment, as well as household water purification systems. The J-WAFS Solutions grant will allow the team to build and test prototypes of the water treatment system, identify the best use cases and customers, and perform technoeconomic analyses and market research to formulate a preliminary business plan. With J-WAFS commercialization support, the project could eventually lead to a startup company.

      “Emerging micropollutants are a growing threat to drinking water supplies worldwide,” says J-WAFS Director John H. Lienhard, the Abdul Latif Jameel Professor of Water at MIT. “Cost-effective and scalable technologies for micropollutant removal are urgently needed. This project will develop and commercialize a promising new tool for water treatment, with the goal of improving water quality for millions of people.” More

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      Promoting systemic change in the Middle East, the “MIT way”

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      The Middle East is a region that is facing complicated challenges. MIT programs have been committed to building scalable methodologies through which students and the broader MIT community can learn and make an impact. These processes ensure programs work alongside others across cultures to support change aligned with their needs. Through MIT International Science and Technology Initiatives (MISTI), faculty and staff at the Institute continue to build opportunities to connect with and support the region.

      In this spirit, MISTI launched the Leaders Journey Workshop in 2021. This program partnered MIT students with Palestinian and Israeli alumni from three associate organizations: Middle East Entrepreneurs for Tomorrow (MEET), Our Generation Speaks (OGS), and Tech2Peace. Teams met monthly to engage with speakers and work with one another to explore the best ways to leverage science, technology, and entrepreneurship across borders.

      Building on the success of this workshop, the program piloted a for-credit course: SP.258 (MISTI: Middle East Cross-Border Development and Leadership) in fall 2021. The course involved engaging with subject matter experts through five mini-consulting projects in collaboration with regional stakeholders. Topics included climate, health care, and economic development. The course was co-instructed by associate director of the MIT Regional Entrepreneurship Acceleration Program (REAP) Sinan AbuShanab, managing director of MISTI programs in the Middle East David Dolev, and Kathleen Schwind ’19, with MIT CIS/ MISTI Research Affiliate Steven Koltai as lead mentor. The course also drew support from alumni mentors and regional industry partners.

      The course was developed during the height of the pandemic and thus successfully leveraged the intense culture of online engagement prevalent at the time by layering in-person coursework with strategic digital group engagement. Pedagogically, the structure was inspired by multiple MIT methodologies: MISTI preparation and training courses, Sloan Action Learning, REAP/REAL multi-party stakeholder model, the Media Lab Learning Initiative, and the multicultural framework of associate organizations.

      “We worked to develop a series of aims and a methodology that would enrich MIT students and their peers in the region and support the important efforts of Israelis and Palestinians to make systemic change,” said Dolev.

      During the on-campus sessions, MIT students explored the region’s political and historical complexities and the meaning of being a global leader and entrepreneur. Guest presenters included: Boston College Associate Professor Peter Krause (MIT Security Studies Program alumnus), Gilad Rosenzweig (MITdesignX), Ari Jacobovits (MIT-Africa), and Mollie Laffin-Rose Agbiboa (MIT-REAP). Group projects focused on topics that fell under three key regional verticals: water, health care, and economic development. The teams were given a technical or business challenge they were tasked with solving. These challenges were sourced directly from for-profit and nonprofit organizations in the region.

      “This was a unique opportunity for me to learn so much about the area I live in, work on a project together with people from the ‘other side,’ MIT students, and incredible mentors,” shared a participant from the region. “Furthermore, getting a glimpse of the world of MIT was a great experience for me.”

      For their final presentations, teams pitched their solutions, including their methodology for researching/addressing the problem, a description of solutions to be applied, what is needed to execute the idea itself, and potential challenges encountered. Teams received feedback and continued to deepen their experience in cross-cultural teamwork.

      “As an education manager, I needed guidance with these digital tools and how to approach them,” says an EcoPeace representative. “The MIT program provided me with clear deliverables I can now implement in my team’s work.”

      “This course has broadened my knowledge of conflicts, relationships, and how geography plays an important role in the region,” says an MIT student participant. “Moving forward, I feel more confident working with business and organizations to develop solutions for problems in real time, using the skills I have to supplement the project work.”

      Layers of engagement with mentors, facilitators, and whole-team leadership ensured that participants gained project management experience, learning objectives were met, and professional development opportunities were available. Each team was assigned an MIT-MEET alumni mentor with whom they met throughout the course. Mentors coached the teams on methods for managing a client project and how to collaborate for successful completion. Joint sessions with MIT guest speakers deepened participants’ regional understanding of water, health care, economic development, and their importance in the region. Speakers included: Mohamed Aburawi, Phil Budden (MIT-REAP) Steven Koltai, Shari Loessberg, Dina Sherif (MIT Legatum Center, Greg Sixt (J-WAFS), and Shriya Srinivasan.

      “The program is unlike any other I’ve come across,” says one of the alumni mentors. “The chance for MIT students to work directly with peers from the region, to propose and create technical solutions to real problems on the ground, and partner with local organizations is an incredibly meaningful opportunity. I wish I had been able to participate in something like this when I was at MIT.”

      Each team also assigned a fellow group member as a facilitator, who served as the main point of contact for the team and oversaw project management: organizing workstreams, ensuring deadlines were met, and mediating any group disagreements. This model led to successful project outcomes and innovative suggestions.

      “The superb work of the MISTI group gave us a critical eye and made significant headway on a product that can hopefully be a game changer to over 150 Israeli and Palestinian organizations,” says a representative from Alliance for Middle East Peace (ALLMEP).

      Leadership team meetings included MIT staff and Israeli and Palestinian leadership of the partner organizations for discussing process, content, recent geopolitical developments, and how to adapt the class to the ongoing changing situation.

      “The topic of Palestine/Israel is contentious: globally, in the region, and also, at times, on the MIT campus,” says Dolev. “I myself have questioned how we can make a systemic impact with our partners from the region. How can we be side-by-side on that journey for the betterment of all? I have now seen first-hand how this multilayered model can work.”

      MIT International Science and Technology Initiatives (MISTI) is MIT’s hub for global experiences. MISTI’s unparalleled internship, research, teaching, and study abroad programs offer students unique experiences that bring MIT’s one-of-a-kind education model to life in countries around the world. MISTI programs are carefully designed to complement on-campus course work and research, and rigorous, country-specific preparation enables students to forge cultural connections and play a role in addressing important global challenges while abroad. Students come away from their experiences with invaluable perspectives that inform their education, career, and worldview. MISTI embodies MIT’s commitment to global engagement and prepares students to thrive in an increasingly interconnected world. More

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      Assay determines the percentage of Omicron, other variants in Covid wastewater

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      Wastewater monitoring emerged amid the Covid-19 pandemic as an effective and noninvasive way to track a viral outbreak, and advances in the technology have enabled researchers to not only identify but also quantify the presence of particular variants of concern (VOCs) in wastewater samples.

      Last year, researchers with the Singapore-MIT Alliance for Research and Technology (SMART) made the news for developing a quantitative assay for the Alpha variant of SARS-CoV-2 in wastewater, while also working on a similar assay for the Delta variant. Previously, conventional wastewater detection methods could only detect the presence of SARS-CoV-2 viral material in a sample, without identifying the variant of the virus.

      Now, a team at SMART has developed a quantitative RT-qPCR assay that can detect the Omicron variant of SARS-CoV-2. This type of assay enables wastewater surveillance to accurately trace variant dynamics in any given community or population, and support and inform the implementation of appropriate public health measures tailored according to the specific traits of a particular viral pathogen.

      The capacity to count and assess particular VOCs is unique to SMART’s open-source assay, and allows researchers to accurately determine displacement trends in a community. Hence, the new assay can reveal what proportion of SARS-CoV-2 virus circulating in a community belongs to a particular variant. This is particularly significant, as different SARS-CoV-2 VOCs — Alpha, Delta, Omicron, and their offshoots — have emerged at various points throughout the pandemic, each causing a new wave of infections to which the population was more susceptible.

      The team’s new allele-specific RT-qPCR assay is described in a paper, “Rapid displacement of SARS-CoV-2 variant Delta by Omicron revealed by allele-specific PCR in wastewater,” published this month in Water Research. Senior author on the work is Eric Alm, professor of biological engineering at MIT and a principal investigator in the Antimicrobial Resistance (AMR) interdisciplinary research group within SMART, MIT’s research enterprise in Singapore. Co-authors include researchers from Nanyang Technological University (NTU), Singapore National University (NUS), MIT, Singapore Centre for Environmental Life Sciences Engineering (SCELSE), and Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER) in Italy.

      Omicron overtakes delta within three weeks in Italy study

      In their study, SMART researchers found that the increase in booster vaccine population coverage in Italy concurred with the complete displacement of the Delta variant by the Omicron variant in wastewater samples obtained from the Torbole Casaglia wastewater treatment plant, with a catchment size of 62,722 people. Taking less than three weeks, the rapid pace of this displacement can be attributed to Omicron’s infection advantage over the previously dominant Delta in vaccinated individuals, which may stem from Omicron’s more efficient evasion of vaccination-induced immunity.

      “In a world where Covid-19 is endemic, the monitoring of VOCs through wastewater surveillance will be an effective tool for the tracking of variants circulating in the community and will play an increasingly important role in guiding public health response,” says paper co-author Federica Armas, a senior postdoc at SMART AMR. “This work has demonstrated that wastewater surveillance can be used to quickly and quantitatively trace VOCs present in a community.”

      Wastewater surveillance vital for future pandemic responses

      As the global population becomes increasingly vaccinated and exposed to prior infections, nations have begun transitioning toward the classification of SARS-CoV-2 as an endemic disease, rolling back active clinical surveillance toward decentralized antigen rapid tests, and consequently reducing sequencing of patient samples. However, SARS-CoV-2 has been shown to produce novel VOCs that can swiftly emerge and spread rapidly across populations, displacing previously dominant variants of the virus. This was observed when Delta displaced Alpha across the globe after the former’s emergence in India in December 2020, and again when Omicron displaced Delta at an even faster rate following its discovery in South Africa in November 2021. The continuing emergence of novel VOCs therefore necessitates continued vigilance on the monitoring of circulating SARS-CoV-2 variants in communities.

      In a separate review paper on wastewater surveillance titled “Making Waves: Wastewater Surveillance of SARS-CoV-2 in an Endemic Future,” published in the journal Water Research, SMART researchers and collaborators found that the utility of wastewater surveillance in the near future could include 1) monitoring the trend of viral loads in wastewater for quantified viral estimates circulating in a community; 2) sampling of wastewater at the source — e.g., taking samples from particular neighborhoods or buildings — for pinpointing infections in neighborhoods and at the building level; 3) integrating wastewater and clinical surveillance for cost-efficient population surveillance; and 4) genome sequencing wastewater samples to track circulating and emerging variants in the population.

      “Our experience with SARS-CoV-2 has shown that clinical testing can often only paint a limited picture of the true extent of an outbreak or pandemic. With Covid-19 becoming prevalent and with the anticipated emergence of further variants of concern, qualitative and quantitative data from wastewater surveillance will be an integral component of a cost- and resource-efficient public health surveillance program, empowering authorities to make more informed policy decisions,” adds corresponding author Janelle Thompson, associate professor at SCELSE and NTU. “Our review provides a roadmap for the wider deployment of wastewater surveillance, with opportunities and challenges that, if addressed, will enable us to not only better manage Covid-19, but also future-proof societies for other viral pathogens and future pandemics.”

      In addition, the review suggests that future wastewater research should comply with a set of standardized wastewater processing methods to reduce inconsistencies in wastewater data toward improving epidemiological inference. Methods developed in the context of SARS-CoV-2 and its analyses could be of invaluable benefit for future wastewater monitoring work on discovering emerging zoonotic pathogens — pathogens that can be transmitted from animals to humans — and for early detection of future pandemics.

      Furthermore, far from being confined to SARS-CoV-2, wastewater surveillance has already been adapted for use in combating other viral pathogens. Another paper from September 2021 described an advance in the development of effective wastewater surveillance for dengue, Zika, and yellow fever viruses, with SMART researchers successfully measuring decay rates of these medically significant arboviruses in wastewater. This was followed by another review paper by SMART published in July 2022 that explored current progress and future challenges and opportunities in wastewater surveillance for arboviruses. These developments represent an important first step toward establishing arbovirus wastewater surveillance, which would help policymakers in Singapore and beyond make better informed and more targeted public health measures in controlling arbovirus outbreaks such as dengue, which is a significant public health concern in Singapore.

      “Our learnings from using wastewater surveillance as a key tool over the course of Covid-19 will be crucial in helping researchers develop similar methods to monitor and tackle other viral pathogens and future pandemics,” says Lee Wei Lin, first author of the latest SMART paper and research scientist at SMART AMR. “Wastewater surveillance has already shown promising utility in helping to fight other viral pathogens, including some of the world’s most prevalent mosquito-borne diseases, and there is significant potential for the technology to be adapted for use against other infectious viral diseases.”

      The research is carried out by SMART and its collaborators at SCELSE, NTU, and NUS, co-led by Professor Eric Alm (SMART and MIT) and Associate Professor Janelle Thompson (SCELSE and NTU), and is supported by Singapore’sNational Research Foundation (NRF) under its Campus for Research Excellence And Technological Enterprise (CREATE) program. The research is part of an initiative funded by the NRF to develop sewage-based surveillance for rapid outbreak detection and intervention in Singapore.

      SMART was established by MIT in partnership with the NRF in 2007. SMART is the first entity in CREATE developed by NRF and serves as an intellectual and innovation hub for research interactions between MIT and Singapore, undertaking cutting-edge research projects in areas of interest to both Singapore and MIT. SMART currently comprises an Innovation Centre and five interdisciplinary research groups: AMR, Critical Analytics for Manufacturing Personalized-Medicine, Disruptive & Sustainable Technologies for Agricultural Precision, Future Urban Mobility, and Low Energy Electronic Systems.

      The AMR IRG is a translational research and entrepreneurship program that tackles the growing threat of antimicrobial resistance. By leveraging talent and convergent technologies across Singapore and MIT, they tackle AMR head-on by developing multiple innovative and disruptive approaches to identify, respond to, and treat drug-resistant microbial infections. Through strong scientific and clinical collaborations, our goal is to provide transformative, holistic solutions for Singapore and the world. More

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      These neurons have food on the brain

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      A gooey slice of pizza. A pile of crispy French fries. Ice cream dripping down a cone on a hot summer day. When you look at any of these foods, a specialized part of your visual cortex lights up, according to a new study from MIT neuroscientists.

      This newly discovered population of food-responsive neurons is located in the ventral visual stream, alongside populations that respond specifically to faces, bodies, places, and words. The unexpected finding may reflect the special significance of food in human culture, the researchers say. 

      “Food is central to human social interactions and cultural practices. It’s not just sustenance,” says Nancy Kanwisher, the Walter A. Rosenblith Professor of Cognitive Neuroscience and a member of MIT’s McGovern Institute for Brain Research and Center for Brains, Minds, and Machines. “Food is core to so many elements of our cultural identity, religious practice, and social interactions, and many other things that humans do.”

      The findings, based on an analysis of a large public database of human brain responses to a set of 10,000 images, raise many additional questions about how and why this neural population develops. In future studies, the researchers hope to explore how people’s responses to certain foods might differ depending on their likes and dislikes, or their familiarity with certain types of food.

      MIT postdoc Meenakshi Khosla is the lead author of the paper, along with MIT research scientist N. Apurva Ratan Murty. The study appears today in the journal Current Biology.

      Visual categories

      More than 20 years ago, while studying the ventral visual stream, the part of the brain that recognizes objects, Kanwisher discovered cortical regions that respond selectively to faces. Later, she and other scientists discovered other regions that respond selectively to places, bodies, or words. Most of those areas were discovered when researchers specifically set out to look for them. However, that hypothesis-driven approach can limit what you end up finding, Kanwisher says.

      “There could be other things that we might not think to look for,” she says. “And even when we find something, how do we know that that’s actually part of the basic dominant structure of that pathway, and not something we found just because we were looking for it?”

      To try to uncover the fundamental structure of the ventral visual stream, Kanwisher and Khosla decided to analyze a large, publicly available dataset of full-brain functional magnetic resonance imaging (fMRI) responses from eight human subjects as they viewed thousands of images.

      “We wanted to see when we apply a data-driven, hypothesis-free strategy, what kinds of selectivities pop up, and whether those are consistent with what had been discovered before. A second goal was to see if we could discover novel selectivities that either haven’t been hypothesized before, or that have remained hidden due to the lower spatial resolution of fMRI data,” Khosla says.

      To do that, the researchers applied a mathematical method that allows them to discover neural populations that can’t be identified from traditional fMRI data. An fMRI image is made up of many voxels — three-dimensional units that represent a cube of brain tissue. Each voxel contains hundreds of thousands of neurons, and if some of those neurons belong to smaller populations that respond to one type of visual input, their responses may be drowned out by other populations within the same voxel.

      The new analytical method, which Kanwisher’s lab has previously used on fMRI data from the auditory cortex, can tease out responses of neural populations within each voxel of fMRI data.

      Using this approach, the researchers found four populations that corresponded to previously identified clusters that respond to faces, places, bodies, and words. “That tells us that this method works, and it tells us that the things that we found before are not just obscure properties of that pathway, but major, dominant properties,” Kanwisher says.

      Intriguingly, a fifth population also emerged, and this one appeared to be selective for images of food.

      “We were first quite puzzled by this because food is not a visually homogenous category,” Khosla says. “Things like apples and corn and pasta all look so unlike each other, yet we found a single population that responds similarly to all these diverse food items.”

      The food-specific population, which the researchers call the ventral food component (VFC), appears to be spread across two clusters of neurons, located on either side of the FFA. The fact that the food-specific populations are spread out between other category-specific populations may help explain why they have not been seen before, the researchers say.

      “We think that food selectivity had been harder to characterize before because the populations that are selective for food are intermingled with other nearby populations that have distinct responses to other stimulus attributes. The low spatial resolution of fMRI prevents us from seeing this selectivity because the responses of different neural population get mixed in a voxel,” Khosla says.

      “The technique which the researchers used to identify category-sensitive cells or areas is impressive, and it recovered known category-sensitive systems, making the food category findings most impressive,” says Paul Rozin, a professor of psychology at the University of Pennsylvania, who was not involved in the study. “I can’t imagine a way for the brain to reliably identify the diversity of foods based on sensory features. That makes this all the more fascinating, and likely to clue us in about something really new.”

      Food vs non-food

      The researchers also used the data to train a computational model of the VFC, based on previous models Murty had developed for the brain’s face and place recognition areas. This allowed the researchers to run additional experiments and predict the responses of the VFC. In one experiment, they fed the model matched images of food and non-food items that looked very similar — for example, a banana and a yellow crescent moon.

      “Those matched stimuli have very similar visual properties, but the main attribute in which they differ is edible versus inedible,” Khosla says. “We could feed those arbitrary stimuli through the predictive model and see whether it would still respond more to food than non-food, without having to collect the fMRI data.”

      They could also use the computational model to analyze much larger datasets, consisting of millions of images. Those simulations helped to confirm that the VFC is highly selective for images of food.

      From their analysis of the human fMRI data, the researchers found that in some subjects, the VFC responded slightly more to processed foods such as pizza than unprocessed foods like apples. In the future they hope to explore how factors such as familiarity and like or dislike of a particular food might affect individuals’ responses to that food.

      They also hope to study when and how this region becomes specialized during early childhood, and what other parts of the brain it communicates with. Another question is whether this food-selective population will be seen in other animals such as monkeys, who do not attach the cultural significance to food that humans do.

      The research was funded by the National Institutes of Health, the National Eye Institute, and the National Science Foundation through the MIT Center for Brains, Minds, and Machines. More

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      Helping cassava farmers by extending crop life

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      The root vegetable cassava is a major food staple in dozens of countries across the world. Drought-resistant, nutritious, and tasty, it has also become a major source of income for small-scale, rural farmers in places like West Africa and Southeast Asia.

      But the utility of cassava has always been limited by its short postharvest shelf life of two to three days. That puts millions of farmers who rely on the crop in a difficult position. The farmers can’t plant more than they can sell quickly in local markets, and they’re often forced to sell below market prices because buyers know the harvest will spoil rapidly. As a result, cassava farmers are among the world’s poorest people.

      Now the startup CassVita is buying cassava directly from farmers and applying a patent-pending biotechnology to extend its shelf life to 18 months. The approach has the potential to transform economies in rural, impoverished regions where millions of families rely on the crop for income.

      CassVita tells farmers how much cassava the company will buy each month, and processes the cassava at a manufacturing facility in Cameroon. It currently sells the first version of its product as a powdered food to people in Cameroon and to West African immigrants in the U.S.

      But CassVita founder and CEO Pelkins Ajanoh ’18 says the future of the company will revolve around its next product: a cassava-based flour that can act as a direct substitute for wheat. The wheat substitute would dramatically broaden CassVita’s target market to include the fast-growing, trillion-dollar healthy food market.

      Ajanoh says CassVita is currently able to increase farmers’ incomes by about 400 percent through its purchases.

      “Our objective is to leverage proprietary technology to offer a healthier and better-tasting alternative to wheat while creating prosperity for local farmers,” Ajanoh says. “We’re hoping to tap into this huge market while empowering farmers, all by minimizing spoilage and incentivizing farmers to plant more.”

      Gaining confidence to help a community

      While growing up in Cameroon, Ajanoh’s parents always emphasized the importance of education for him and his three siblings. But Ajanoh lost his father when he was 13, and his mother moved to the U.S. a year later to help provide for the family. During that time, Ajanoh lived with his grandmother, a cassava farmer. For many years, Ajanoh watched his grandmother harvest cassava without making any lasting financial gains. He remembers feeling powerless as his grandmother struggled to pay for things like diabetes medication.

      Then Ajanoh earned the top marks on the national exams that Cameroonian students take before college. After high school, he joined his mother in the U.S. and came to MIT to study mechanical engineering. Once on campus, Ajanoh says he had lunch with new people all the time to learn from them.

      “I’d never had this community of intellectuals — and they were from all over the world — so I soaked up as much as I could,” Ajanoh says. “That sparked an interest in entrepreneurship, because MIT is super entrepreneurial. Everyone’s thinking of starting something cool.”

      Ajanoh also got a confidence boost during an internship in the summer after his junior year, when he created self-driving technology for General Motors that was eventually patented.

      “It made me realize I could do something really valuable for the world, and by the end of that internship I was thinking, ‘Now I want to solve a problem in my community,’” he says.

      Returning to the crop he knew well, Ajanoh received a series of grants from the MIT Sandbox Innovation Fund to experiment with ways to extend the shelf life of cassava. In the summer of 2018, the MIT-Africa program sponsored three MIT students to fly to Cameroon with him to participate in internships with the company.

      Today CassVita partners with development banks to help farmers get loans to buy the cassava sticks used for planting. Ajanoh says CassVita decided on a powdered food for its first product because it requires less marketing to sell to West Africans, who are familiar with the dish. Now the company is working on a cassava flour that it will market to all consumers looking for healthy alternatives to wheat that can be used in pastries and other baked goods.

      “Cassava makes sense as a global substitute to wheat because it’s gluten free, grain free, nut free, and it also helps with glucose regulation, to normalize blood sugar levels, to lower triglycerides, so the health benefits are exciting,” Ajanoh says. “But the farmers were still living in poverty, so if we could solve the shelf-life problem then we could empower these farmers to offer healthier wheat alternatives to the global market.”

      The project has taken on additional urgency now that the war in Ukraine is limiting that country’s wheat and grain exports, raising prices, and heightening food insecurity in regions around the globe.

      Showing the value of helping farmers

      Ajanoh says the majority of people farming cassava are women, and he says the challenges related to cassava’s shelf life have contributed to gender inequities in many communities. In fact, of the roughly 500 farmers CassVita works with in Cameroon, 95 percent are women.

      “That has always excited me because I was raised by women, so working on something that could empower women in their communities and give them authority is fulfilling,” Ajanoh says.

      Ajanoh has already heard from farmers who have been able to send their children to school for the first time because of improved financial situations. Now, as CassVita continues to scale, Ajanoh wants to stay focused on the technology that enables these new business models.

      “We’re evolving into a food technology company,” Ajanoh says. “We prefer to focus on leveraging technology to impact lives and improve outcomes in these communities. Right now, we’re going all the way to consumers because this is an opportunity the Nestles and the Unilevers of the world won’t pick up because the market doesn’t make sense to them yet. So, we have to build this company and show them the value.” More