Abdul Latif Jameel Water and Food Systems Lab (J-WAFS)

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    MIT engineers solve the sticky-cell problem in bioreactors and other industries

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    To help mitigate climate change, companies are using bioreactors to grow algae and other microorganisms that are hundreds of times more efficient at absorbing CO2 than trees. Meanwhile, in the pharmaceutical industry, cell culture is used to manufacture biologic drugs and other advanced treatments, including lifesaving gene and cell therapies.Both processes are hampered by cells’ tendency to stick to surfaces, which leads to a huge amount of waste and downtime for cleaning. A similar problem slows down biofuel production, interferes with biosensors and implants, and makes the food and beverage industry less efficient.Now, MIT researchers have developed an approach for detaching cells from surfaces on demand, using electrochemically generated bubbles. In an open-access paper published in Science Advances, the researchers demonstrated their approach in a lab prototype and showed it could work across a range of cells and surfaces without harming the cells.“We wanted to develop a technology that could be high-throughput and plug-and-play, and that would allow cells to attach and detach on demand to improve the workflow in these industrial processes,” says Professor Kripa Varanasi, senior author of the study. “This is a fundamental issue with cells, and we’ve solved it with a process that can scale. It lends itself to many different applications.”Joining Varanasi on the study are co-first authors Bert Vandereydt, a PhD student in mechanical engineering, and former postdoc Baptiste Blanc.Solving a sticky problem

    Credit: Joy Zheng

    The researchers began with a mission.“We’ve been working on figuring out how we can efficiently capture CO2 across different sources and convert it into valuable products for various end markets,” Varanasi says. “That’s where this photobioreactor and cell detachment comes into the picture.”Photobioreactors are used to grow carbon-absorbing algae cells by creating tightly controlled environments involving water and sunlight. They feature long, winding tubes with clear surfaces to let in the light algae need to grow. When algae stick to those surfaces, they block out the light, requiring cleaning.“You have to shut down and clean up the entire reactor as frequently as every two weeks,” Varanasi says. “It’s a huge operational challenge.”The researchers realized other industries have similar problem due to many cells’ natural adhesion, or stickiness. Each industry has its own solution for cell adhesion depending on how important it is that the cells survive. Some people scrape the surfaces clean, while others use special coatings that are toxic to cells.In the pharmaceutical and biotech industries, cell detachment is typically carried out using enzymes. However, this method poses several challenges — it can damage cell membranes, is time-consuming, and requires large amounts of consumables, resulting in millions of liters of biowaste.To create a better solution, the researchers began by studying other efforts to clear surfaces with bubbles, which mainly involved spraying bubbles onto surfaces and had been largely ineffective.“We realized we needed the bubbles to form on the surfaces where we don’t want these cells to stick, so when the bubbles detach it creates a local fluid flow that creates shear stress at the interface and removes the cells,” Varanasi explains.Electric currents generate bubbles by splitting water into hydrogen and oxygen. But previous attempts at using electricity to detach cells were hampered because the cell culture mediums contain sodium chloride, which turns into bleach when combined with an electric current. The bleach damages the cells, making it impractical for many applications.“The culprit is the anode — that’s where the sodium chloride turns to bleach,” Vandereydt explained. “We figured if we could separate that electrode from the rest of the system, we could prevent bleach from being generated.”To make a better system, the researchers built a 3-square-inch glass surface and deposited a gold electrode on top of it. The layer of gold is so thin it doesn’t block out light. To keep the other electrode separate, the researchers integrated a special membrane that only allows protons to pass through. The set up allowed the researchers to send a current through without generating bleach.To test their setup, they allowed algae cells from a concentrated solution to stick to the surfaces. When they applied a voltage, the bubbles separated the cells from the surfaces without harming them.The researchers also studied the interaction between the bubbles and cells, finding the higher the current density, the more bubbles were created and the more algae was removed. They developed a model for understanding how much current would be needed to remove algae in different settings and matched it with results from experiments involving algae as well as cells from ovarian cancer and bones.“Mammalian cells are orders of magnitude more sensitive than algae cells, but even with those cells, we were able to detach them with no impact to the viability of the cell,” Vandereydt says.Getting to scaleThe researchers say their system could represent a breakthrough in applications where bleach or other chemicals would harm cells. That includes pharmaceutical and food production.“If we can keep these systems running without fouling and other problems, then we can make them much more economical,” Varanasi says.For cell culture plates used in the pharmaceutical industry, the team envisions their system comprising an electrode that could be robotically moved from one culture plate to the next, to detach cells as they’re grown. It could also be coiled around algae harvesting systems.“This has general applicability because it doesn’t rely on any specific biological or chemical treatments, but on a physical force that is system-agnostic,” Varanasi says. “It’s also highly scalable to a lot of different processes, including particle removal.”Varanasi cautions there is much work to be done to scale up the system. But he hopes it can one day make algae and other cell harvesting more efficient.“The burning problem of our time is to somehow capture CO2 in a way that’s economically feasible,” Varanasi says. “These photobioreactors could be used for that, but we have to overcome the cell adhesion problem.”The work was supported, in part, by Eni S.p.A through the MIT Energy Initiative, the Belgian American Educational Foundation Fellowship, and the Maria Zambrano Fellowship. More

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      Optimizing food subsidies: Applying digital platforms to maximize nutrition

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      Oct. 16 is World Food Day, a global campaign to celebrate the founding of the Food and Agriculture Organization 80 years ago, and to work toward a healthy, sustainable, food-secure future. More than 670 million people in the world are facing hunger. Millions of others are facing rising obesity rates and struggle to get healthy food for proper nutrition. World Food Day calls on not only world governments, but business, academia, the media, and even the youth to take action to promote resilient food systems and combat hunger. This year, the Abdul Latif Jameel Water and Food Systems Laboratory (J-WAFS) is spotlighting an MIT researcher who is working toward this goal by studying food and water systems in the Global South.J-WAFS seed grants provide funding to early-stage research projects that are unique to prior work. In an 11th round of seed grant funding in 2025, 10 MIT faculty members received support to carry out their cutting-edge water and food research. Ali Aouad PhD ’17, assistant professor of operations management at the MIT Sloan School of Management, was one of those grantees. “I had searched before joining MIT what kind of research centers and initiatives were available that tried to coalesce research on food systems,” Aouad says. “And so, I was very excited about J-WAFS.” Aouad gathered more information about J-WAFS at the new faculty orientation session in August 2024, where he spoke to J-WAFS staff and learned about the program’s grant opportunities for water and food research. Later that fall semester, he attended a few J-WAFS seminars on agricultural economics and water resource management. That’s when Aouad knew that his project was perfectly aligned with the J-WAFS mission of securing humankind’s water and food.Aouad’s seed project focuses on food subsidies. With a background in operations research and an interest in digital platforms, much of his work has centered on aligning supply-side operations with heterogeneous customer preferences. Past projects include ones on retail and matching systems. “I started thinking that these types of demand-driven approaches may be also very relevant to important social challenges, particularly as they relate to food security,” Aouad says. Before starting his PhD at MIT, Aouad worked on projects that looked at subsidies for smallholder farmers in low- and middle-income countries. “I think in the back of my mind, I’ve always been fascinated by trying to solve these issues,” he noted.His seed grant project, Optimal subsidy design: Application to food assistance programs, aims to leverage data on preferences and purchasing habits from local grocery stores in India to inform food assistance policy and optimize the design of subsidies. Typical data collection systems, like point-of-sales, are not as readily available in India’s local groceries, making this type of data hard to come by for low-income individuals. “Mom-and-pop stores are extremely important last-mile operators when it comes to nutrition,” he explains. For this project, the research team gave local grocers point-of-sale scanners to track purchasing habits. “We aim to develop an algorithm that converts these transactions into some sort of ‘revelation’ of the individuals’ latent preferences,” says Aouad. “As such, we can model and optimize the food assistance programs — how much variety and flexibility is offered, taking into account the expected demand uptake.” He continues, “now, of course, our ability to answer detailed design questions [across various products and prices] depends on the quality of our inference from  the data, and so this is where we need more sophisticated and robust algorithms.”Following the data collection and model development, the ultimate goal of this research is to inform policy surrounding food assistance programs through an “optimization approach.” Aouad describes the complexities of using optimization to guide policy. “Policies are often informed by domain expertise, legacy systems, or political deliberation. A lot of researchers build rigorous evidence to inform food policy, but it’s fair to say that the kind of approach that I’m proposing in this research is not something that is commonly used. I see an opportunity for bringing a new approach and methodological tradition to a problem that has been central for policy for many decades.” The overall health of consumers is the reason food assistance programs exist, yet measuring long-term nutritional impacts and shifts in purchase behavior is difficult. In past research, Aouad notes that the short-term effects of food assistance interventions can be significant. However, these effects are often short-lived. “This is a fascinating question that I don’t think we will be able to address within the space of interventions that we will be considering. However, I think it is something I would like to capture in the research, and maybe develop hypotheses for future work around how we can shift nutrition-related behaviors in the long run.”While his project develops a new methodology to calibrate food assistance programs, large-scale applications are not promised. “A lot of what drives subsidy mechanisms and food assistance programs is also, quite frankly, how easy it is and how cost-effective it is to implement these policies in the first place,” comments Aouad. Cost and infrastructure barriers are unavoidable to this kind of policy research, as well as sustaining these programs. Aouad’s effort will provide insights into customer preferences and subsidy optimization in a pilot setup, but replicating this approach on a real scale may be costly. Aouad hopes to be able to gather proxy information from customers that would both feed into the model and provide insight into a more cost-effective way to collect data for large-scale implementation.There is still much work to be done to ensure food security for all, whether it’s advances in agriculture, food-assistance programs, or ways to boost adequate nutrition. As the 2026 seed grant deadline approaches, J-WAFS will continue its mission of supporting MIT faculty as they pursue innovative projects that have practical and real impacts on water and food system challenges. More

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      Matthew Shoulders named head of the Department of Chemistry

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      Matthew D. Shoulders, the Class of 1942 Professor of Chemistry, a MacVicar Faculty Fellow, and an associate member of the Broad Institute of MIT and Harvard, has been named head of the MIT Department of Chemistry, effective Jan. 16, 2026. “Matt has made pioneering contributions to the chemistry research community through his research on mechanisms of proteostasis and his development of next-generation techniques to address challenges in biomedicine and agriculture,” says Nergis Mavalvala, dean of the MIT School of Science and the Curtis and Kathleen Marble Professor of Astrophysics. “He is also a dedicated educator, beloved by undergraduates and graduates alike. I know the department will be in good hands as we double down on our commitment to world-leading research and education in the face of financial headwinds.”Shoulders succeeds Troy Van Voorhis, the Robert T. Haslam and Bradley Dewey Professor of Chemistry, who has been at the helm since October 2019.“I am tremendously grateful to Troy for his leadership the past six years, building a fantastic community here in our department. We face challenges, but also many exciting opportunities, as a department in the years to come,” says Shoulders. “One thing is certain: Chemistry innovations are critical to solving pressing global challenges. Through the research that we do and the scientists we train, our department has a huge role to play in shaping the future.”Shoulders studies how cells fold proteins, and he develops ​and applies novel protein engineering techniques to challenges in biotechnology. His work across chemistry and biochemistry fields including proteostasis, extracellular matrix biology, virology, evolution, and synthetic biology is yielding not just important insights into topics like how cells build healthy tissues and how proteins evolve, but also influencing approaches to disease therapy and biotechnology development.“Matt is an outstanding researcher whose work touches on fundamental questions about how the cell machinery directs the synthesis and folding of proteins. His discoveries about how that machinery breaks down as a result of mutations or in response to stress has a fundamental impact on how we think about and treat human diseases,” says Van Voorhis.In one part of Matt’s current research program, he is studying how protein folding systems in cells — known as chaperones — shape the evolution of their clients. Amongst other discoveries, his lab has shown that viral pathogens hijack human chaperones to enable their rapid evolution and escape from host immunity. In related recent work, they have discovered that these same chaperones can promote access to malignancy-driving mutations in tumors. Beyond fundamental insights into evolutionary biology, these findings hold potential to open new therapeutic strategies to target cancer and viral infections.“Matt’s ability to see both the details and the big picture makes him an outstanding researcher and a natural leader for the department,” says Timothy Swager, the John D. MacArthur Professor of Chemistry. “MIT Chemistry can only benefit from his dedication to understanding and addressing the parts and the whole.” Shoulders also leads a food security project through the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS). Shoulders, along with MIT Research Scientist Robbie Wilson, assembled an interdisciplinary team based at MIT to enhance climate resilience in agriculture by improving one of the most inefficient aspects of photosynthesis, the carbon dioxide-fixing plant enzyme RuBisCO. J-WAFS funded this high-risk, high-reward MIT Grand Challenge project in 2023, and it has received further support from federal research agencies and the Grantham Foundation for the Protection of the Environment. “Our collaborative team of biochemists and synthetic biologists, computational biologists, and chemists is deeply integrated with plant biologists, creating a robust feedback loop for enzyme engineering,” Shoulders says. “Together, this team is making a concerted effort using state-of-the-art techniques to engineer crop RuBisCO with an eye to helping make meaningful gains in securing a stable crop supply, hopefully with accompanying improvements in both food and water security.”In addition to his research contributions, Shoulders has taught multiple classes for Course V, including 5.54 (Advances in Chemical Biology) and 5.111 (Principles of Chemical Science), along with a number of other key chemistry classes. His contributions to a 5.111 “bootcamp” through the MITx platform served to address gaps in the classroom curriculum by providing online tools to help undergraduate students better grasp the material in the chemistry General Institute Requirement (GIR). His development of Guided Learning Demonstrations to support first-year chemistry courses at MIT has helped bring the lab to the GIR, and also contributed to the popularity of 5.111 courses offered regularly via MITx.“I have had the pleasure of teaching with Matt on several occasions, and he is a fantastic educator. He is an innovator both inside and outside the classroom and has an unwavering commitment to his students’ success,” says Van Voorhis of Shoulders, who was named a 2022 MacVicar Faculty Fellow, and who received a Committed to Caring award through the Office of Graduate Education.Shoulders also founded the MIT Homeschool Internship Program for Science and Technology, which brings high school students to campus for paid summer research experiences in labs across the Institute.He is a founding member of the Department of Chemistry’s Quality of Life Committee and chair for the last six years, helping to improve all aspects of opportunity, professional development, and experience in the department: “countless changes that have helped make MIT a better place for all,” as Van Voorhis notes, including creating a peer mentoring program for graduate students and establishing universal graduate student exit interviews to collect data for department-wide assessment and improvement.At the Institute level, Shoulders has served on the Committee on Graduate Programs, Committee on Sexual Misconduct Prevention and Response (in which he co-chaired the provost’s working group on the Faculty and Staff Sexual Misconduct Survey), and the Committee on Assessment of Biohazards and Embryonic Stem Cell Research Oversight, among other roles.Shoulders graduated summa cum laude from Virginia Tech in 2004, earning a BS in chemistry with a minor in biochemistry. He earned a PhD in chemistry at the University of Wisconsin at Madison in 2009 under Professor Ronald Raines. Following an American Cancer Society Postdoctoral Fellowship at Scripps Research Institute, working with professors Jeffery Kelly and Luke Wiseman, Shoulders joined the MIT Department of Chemistry faculty as an assistant professor in 2012. Shoulders also serves as an associate member of the Broad Institute and an investigator at the Center for Musculoskeletal Research at Massachusetts General Hospital.Among his many awards, Shoulders has received a NIH Director’s New Innovator Award under the NIH High-Risk, High-Reward Research Program; an NSF CAREER Award; an American Cancer Society Research Scholar Award; the Camille Dreyfus Teacher-Scholar Award; and most recently the Ono Pharma Foundation Breakthrough Science Award. More

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      Palladium filters could enable cheaper, more efficient generation of hydrogen fuel

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      Palladium is one of the keys to jump-starting a hydrogen-based energy economy. The silvery metal is a natural gatekeeper against every gas except hydrogen, which it readily lets through. For its exceptional selectivity, palladium is considered one of the most effective materials at filtering gas mixtures to produce pure hydrogen.Today, palladium-based membranes are used at commercial scale to provide pure hydrogen for semiconductor manufacturing, food processing, and fertilizer production, among other applications in which the membranes operate at modest temperatures. If palladium membranes get much hotter than around 800 kelvins, they can break down.Now, MIT engineers have developed a new palladium membrane that remains resilient at much higher temperatures. Rather than being made as a continuous film, as most membranes are, the new design is made from palladium that is deposited as “plugs” into the pores of an underlying supporting material. At high temperatures, the snug-fitting plugs remain stable and continue separating out hydrogen, rather than degrading as a surface film would.The thermally stable design opens opportunities for membranes to be used in hydrogen-fuel-generating technologies such as compact steam methane reforming and ammonia cracking — technologies that are designed to operate at much higher temperatures to produce hydrogen for zero-carbon-emitting fuel and electricity.“With further work on scaling and validating performance under realistic industrial feeds, the design could represent a promising route toward practical membranes for high-temperature hydrogen production,” says Lohyun Kim PhD ’24, a former graduate student in MIT’s Department of Mechanical Engineering.Kim and his colleagues report details of the new membrane in a study appearing today in the journal Advanced Functional Materials. The study’s co-authors are Randall Field, director of research at the MIT Energy Initiative (MITEI); former MIT chemical engineering graduate student Chun Man Chow PhD ’23; Rohit Karnik, the Jameel Professor in the Department of Mechanical Engineering at MIT and the director of the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS); and Aaron Persad, a former MIT research scientist in mechanical engineering who is now an assistant professor at the University of Maryland Eastern Shore.Compact futureThe team’s new design came out of a MITEI project related to fusion energy. Future fusion power plants, such as the one MIT spinout Commonwealth Fusion Systems is designing, will involve circulating hydrogen isotopes of deuterium and tritium at extremely high temperatures to produce energy from the isotopes’ fusing. The reactions inevitably produce other gases that will have to be separated, and the hydrogen isotopes will be recirculated into the main reactor for further fusion.Similar issues arise in a number of other processes for producing hydrogen, where gases must be separated and recirculated back into a reactor. Concepts for such recirculating systems would require first cooling down the gas before it can pass through hydrogen-separating membranes — an expensive and energy-intensive step that would involve additional machinery and hardware.“One of the questions we were thinking about is: Can we develop membranes which could be as close to the reactor as possible, and operate at higher temperatures, so we don’t have to pull out the gas and cool it down first?” Karnik says. “It would enable more energy-efficient, and therefore cheaper and compact, fusion systems.”The researchers looked for ways to improve the temperature resistance of palladium membranes. Palladium is the most effective metal used today to separate hydrogen from a variety of gas mixtures. It naturally attracts hydrogen molecules (H2) to its surface, where the metal’s electrons interact with and weaken the molecule’s bonds, causing H2 to temporarily break apart into its respective atoms. The individual atoms then diffuse through the metal and join back up on the other side as pure hydrogen.Palladium is highly effective at permeating hydrogen, and only hydrogen, from streams of various gases. But conventional membranes typically can operate at temperatures of up to 800 kelvins before the film starts to form holes or clumps up into droplets, allowing other gases to flow through.Plugging inKarnik, Kim and their colleagues took a different design approach. They observed that at high temperatures, palladium will start to shrink up. In engineering terms, the material is acting to reduce surface energy. To do this, palladium, and most other materials and even water, will pull apart and form droplets with the smallest surface energy. The lower the surface energy, the more stable the material can be against further heating.This gave the team an idea: If a supporting material’s pores could be “plugged” with deposits of palladium — essentially already forming a droplet with the lowest surface energy — the tight quarters might substantially increase palladium’s heat tolerance while preserving the membrane’s selectivity for hydrogen.To test this idea, they fabricated small chip-sized samples of membrane using a porous silica supporting layer (each pore measuring about half a micron wide), onto which they deposited a very thin layer of palladium. They applied techniques to essentially grow the palladium into the pores, and polished down the surface to remove the palladium layer and leave palladium only inside the pores.They then placed samples in a custom-built apparatus in which they flowed hydrogen-containing gas of various mixtures and temperatures to test its separation performance. The membranes remained stable and continued to separate hydrogen from other gases even after experiencing temperatures of up to 1,000 kelvins for over 100 hours — a significant improvement over conventional film-based membranes.“The use of palladium film membranes are generally limited to below around 800 kelvins, at which point they degrade,” Kim says. “Our plug design therefore extends palladium’s effective heat resilience by roughly at least 200 kelvins and maintains integrity far longer under extreme conditions.”These conditions are within the range of hydrogen-generating technologies such as steam methane reforming and ammonia cracking.Steam methane reforming is an established process that has required complex, energy-intensive systems to preprocess methane to a form where pure hydrogen can be extracted. Such preprocessing steps could be replaced with a compact “membrane reactor,” through which a methane gas would directly flow, and the membrane inside would filter out pure hydrogen. Such reactors would significantly cut down the size, complexity, and cost of producing hydrogen from steam methane reforming, and Kim estimates a membrane would have to work reliably in temperatures of up to nearly 1,000 kelvins. The team’s new membrane could work well within such conditions.Ammonia cracking is another way to produce hydrogen, by “cracking” or breaking apart ammonia. As ammonia is very stable in liquid form, scientists envision that it could be used as a carrier for hydrogen and be safely transported to a hydrogen fuel station, where ammonia could be fed into a membrane reactor that again pulls out hydrogen and pumps it directly into a fuel cell vehicle. Ammonia cracking is still largely in pilot and demonstration stages, and Kim says any membrane in an ammonia cracking reactor would likely operate at temperatures of around 800 kelvins — within the range of the group’s new plug-based design.Karnik emphasizes that their results are just a start. Adopting the membrane into working reactors will require further development and testing to ensure it remains reliable over much longer periods of time.“We showed that instead of making a film, if you make discretized nanostructures you can get much more thermally stable membranes,” Karnik says. “It provides a pathway for designing membranes for extreme temperatures, with the added possibility of using smaller amounts of expensive palladium, toward making hydrogen production more efficient and affordable. There is potential there.”This work was supported by Eni S.p.A. via the MIT Energy Initiative. More

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      J-WAFS welcomes Daniela Giardina as new executive director

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      The Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) announced that Daniela Giardina has been named the new J-WAFS executive director. Giardina stepped into the role at the start of the fall semester, replacing founding executive director Renee J. Robins ’83, who is retiring after leading the program since its launch in 2014.“Daniela brings a deep background in water and food security, along with excellent management and leadership skills,” says Robins. “Since I first met her nearly 10 years ago, I have been impressed with her commitment to working on global water and food challenges through research and innovation. I am so happy to know that I will be leaving J-WAFS in her experienced and capable hands.”A decade of impactJ-WAFS fuels research, innovation, and collaboration to solve global water and food systems challenges. The mission of J-WAFS is to ensure safe and resilient supplies of water and food to meet the local and global needs of a dramatically growing population on a rapidly changing planet. J-WAFS funding opportunities are open to researchers in every MIT department, lab, and center, spanning all disciplines. Supported research projects include those involving engineering, science, technology, business, social science, economics, architecture, urban planning, and more. J-WAFS research and related activities include early-stage projects, sponsored research, commercialization efforts, student activities and mentorship, events that convene local and global experts, and international-scale collaborations.The global water, food, and climate emergency makes J-WAFS’ work both timely and urgent. J-WAFS-funded researchers are achieving tangible, real-time solutions and results. Since its inception, J-WAFS has distributed nearly $26 million in grants, fellowships, and awards to the MIT community, supporting roughly 10 percent of MIT’s faculty and 300 students, postdocs, and research staff from 40 MIT departments, labs, and centers. J-WAFS grants have also helped researchers launch 13 startups and receive over $25 million in follow-on funding.Giardina joins J-WAFS at an exciting time in the program’s history; in the spring, J-WAFS celebrated 10 years of supporting water and food research at MIT. The milestone was commemorated at a special event attended by MIT leadership, researchers, students, staff, donors, and others in the J-WAFS community. As J-WAFS enters its second decade, interest and opportunities for water and food research continue to grow. “I am truly honored to join J-WAFS at such a pivotal moment,” Giardina says.Putting research into real-world practiceGiardina has nearly two decades of experience working with nongovernmental organizations and research institutions on humanitarian and development projects. Her work has taken her to Africa, Latin America, the Caribbean, and Central and Southeast Asia, where she has focused on water and food security projects. She has conducted technical trainings and assessments, and managed projects from design to implementation, including monitoring and evaluation.Giardina comes to MIT from Oxfam America, where she directed disaster risk reduction and climate resilience initiatives, working on approaches to strengthen local leadership, community-based disaster risk reduction, and anticipatory action. Her role at Oxfam required her to oversee multimillion-dollar initiatives, supervising international teams, managing complex donor portfolios, and ensuring rigorous monitoring across programs. She connected hands-on research with community-oriented implementation, for example, by partnering with MIT’s D-Lab to launch an innovation lab in rural El Salvador. Her experience will help guide J-WAFS as it pursues impactful research that will make a difference on the ground.Beyond program delivery, Giardina has played a strategic leadership role in shaping Oxfam’s global disaster risk reduction strategy and representing the organization at high-level U.N. and academic forums. She is multilingual and adept at building partnerships across cultures, having worked with governments, funders, and community-based organizations to strengthen resilience and advance equitable access to water and food.Giardina holds a PhD in sustainable development from the University of Brescia in Italy. She also holds a master’s degree in environmental engineering from the Politecnico of Milan in Italy and is a chartered engineer since 2005 (equivalent to a professional engineering license in the United States). She also serves as vice chair of the Boston Network for International Development, a nonprofit that connects and strengthens Boston’s global development community.“I have seen first-hand how climate change, misuse of resources, and inequality are undermining water and food security around the globe,” says Giardina. “What particularly excites me about J-WAFS is its interdisciplinary approach in facilitating meaningful partnerships to solve many of these problems through research and innovation. I am eager to help expand J-WAFS’ impact by strengthening existing programs, developing new initiatives, and building strategic partnerships that translate MIT’s groundbreaking research into real-world solutions,” she adds.A legacy of leadershipRenee Robins will retire with over 23 years of service to MIT. Years before joining the staff, she graduated from MIT with dual bachelor’s degrees in both biology and humanities/anthropology. She then went on to earn a master’s degree in public policy from Carnegie Mellon University. In 1998, she came back to MIT to serve in various roles across campus, including with the Cambridge MIT Institute, the MIT Portugal Program, the Mexico City Program, the Program on Emerging Technologies, and the Technology and Policy Program. She also worked at the Harvard Graduate School of Education, where she managed a $15 million research program as it scaled from implementation in one public school district to 59 schools in seven districts across North Carolina.In late 2014, Robins joined J-WAFS as its founding executive director, playing a pivotal role in building it from the ground up and expanding the team to six full-time professionals. She worked closely with J-WAFS founding director Professor John H. Lienhard V to develop and implement funding initiatives, develop, and shepherd corporate-sponsored research partnerships, and mentor students in the Water Club and Food and Agriculture Club, as well as numerous other students. Throughout the years, Robins has inspired a diverse range of researchers to consider how their capabilities and expertise can be applied to water and food challenges. Perhaps most importantly, her leadership has helped cultivate a vibrant community, bringing together faculty, students, and research staff to be exposed to unfamiliar problems and new methodologies, to explore how their expertise might be applied, to learn from one another, and to collaborate.At the J-WAFS 10th anniversary event in May, Robins noted, “it has been a true privilege to work alongside John Lienhard, our dedicated staff, and so many others. It’s been particularly rewarding to see the growth of an MIT network of water and food researchers that J-WAFS has nurtured, which grew out of those few individuals who saw themselves to be working in solitude on these critical challenges.”Lienhard also spoke, thanking Robins by saying she “was my primary partner in building J-WAFS and [she is] a strong leader and strategic thinker.”Not only is Robins a respected leader, she is also a dear friend to so many at MIT and beyond. In 2021, she was recognized for her outstanding leadership and commitment to J-WAFS and the Institute with an MIT Infinite Mile Award in the area of the Offices of the Provost and Vice President for Research.Outside of MIT, Robins has served on the Board of Trustees for the International Honors Program — a comparative multi-site study abroad program, where she previously studied comparative culture and anthropology in seven countries around the world. Robins has also acted as an independent consultant, including work on program design and strategy around the launch of the Université Mohammed VI Polytechnique in Morocco.Continuing the tradition of excellenceGiardina will report to J-WAFS director Rohit Karnik, the Abdul Latif Jameel Professor of Water and Food in the MIT Department of Mechanical Engineering. Karnik was named the director of J-WAFS in January, succeeding John Lienhard, who retired earlier this year.As executive director, Giardina will be instrumental in driving J-WAFS’ mission and impact. She will work with Karnik to help shape J-WAFS’ programs, long-term strategy, and goals. She will also be responsible for supervising J-WAFS staff, managing grant administration, and overseeing and advising on financial decisions.“I am very grateful to John and Renee, who have helped to establish J-WAFS as the Institute’s preeminent program for water and food research and significantly expanded MIT’s research efforts and impact in the water and food space,” says Karnik. “I am confident that with Daniela as executive director, J-WAFS will continue in the tradition of excellence that Renee and John put into place, as we move into the program’s second decade,” he notes.Giardina adds, “I am inspired by the lab’s legacy of Renee Robins and Professor Lienhard, and I look forward to working with Professor Karnik and the J-WAFS staff.” More

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      MIT gears up to transform manufacturing

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      “Manufacturing is the engine of society, and it is the backbone of robust, resilient economies,” says John Hart, head of MIT’s Department of Mechanical Engineering (MechE) and faculty co-director of the MIT Initiative for New Manufacturing (INM). “With manufacturing a lively topic in today’s news, there’s a renewed appreciation and understanding of the importance of manufacturing to innovation, to economic and national security, and to daily lives.”Launched this May, INM will “help create a transformation of manufacturing through new technology, through development of talent, and through an understanding of how to scale manufacturing in a way that enables imparts higher productivity and resilience, drives adoption of new technologies, and creates good jobs,” Hart says.INM is one of MIT’s strategic initiatives and builds on the successful three-year-old Manufacturing@MIT program. “It’s a recognition by MIT that manufacturing is an Institute-wide theme and an Institute-wide priority, and that manufacturing connects faculty and students across campus,” says Hart. Alongside Hart, INM’s faculty co-directors are Institute Professor Suzanne Berger and Chris Love, professor of chemical engineering.The initiative is pursuing four main themes: reimagining manufacturing technologies and systems, elevating the productivity and human experience of manufacturing, scaling up new manufacturing, and transforming the manufacturing base.Breaking manufacturing barriers for corporationsAmgen, Autodesk, Flex, GE Vernova, PTC, Sanofi, and Siemens are founding members of INM’s industry consortium. These industry partners will work closely with MIT faculty, researchers, and students across many aspects of manufacturing-related research, both in broad-scale initiatives and in particular areas of shared interests. Membership requires a minimum three-year commitment of $500,000 a year to manufacturing-related activities at MIT, including the INM membership fee of $275,000 per year, which supports several core activities that engage the industry members.One major thrust for INM industry collaboration is the deployment and adoption of AI and automation in manufacturing. This effort will include seed research projects at MIT, collaborative case studies, and shared strategy development.INM also offers companies participation in the MIT-wide New Manufacturing Research effort, which is studying the trajectories of specific manufacturing industries and examining cross-cutting themes such as technology and financing.Additionally, INM will concentrate on education for all professions in manufacturing, with alliances bringing together corporations, community colleges, government agencies, and other partners. “We’ll scale our curriculum to broader audiences, from aspiring manufacturing workers and aspiring production line supervisors all the way up to engineers and executives,” says Hart.In workforce training, INM will collaborate with companies broadly to help understand the challenges and frame its overall workforce agenda, and with individual firms on specific challenges, such as acquiring suitably prepared employees for a new factory.Importantly, industry partners will also engage directly with students. Founding member Flex, for instance, hosted MIT researchers and students at the Flex Institute of Technology in Sorocaba, Brazil, developing new solutions for electronics manufacturing.“History shows that you need to innovate in manufacturing alongside the innovation in products,” Hart comments. “At MIT, as more students take classes in manufacturing, they’ll think more about key manufacturing issues as they decide what research problems they want to solve, or what choices they make as they prototype their devices. The same is true for industry — companies that operate at the frontier of manufacturing, whether through internal capabilities or their supply chains, are positioned to be on the frontier of product innovation and overall growth.”“We’ll have an opportunity to bring manufacturing upstream to the early stage of research, designing new processes and new devices with scalability in mind,” he says.Additionally, MIT expects to open new manufacturing-related labs and to further broaden cooperation with industry at existing shared facilities, such as MIT.nano. Hart says that facilities will also invite tighter collaborations with corporations — not just providing advanced equipment, but working jointly on, say, new technologies for weaving textiles, or speeding up battery manufacturing.Homing in on the United StatesINM is a global project that brings a particular focus on the United States, which remains the world’s second-largest manufacturing economy, but has suffered a significant decline in manufacturing employment and innovation.One key to reversing this trend and reinvigorating the U.S. manufacturing base is advocacy for manufacturing’s critical role in society and the career opportunities it offers.“No one really disputes the importance of manufacturing,” Hart says. “But we need to elevate interest in manufacturing as a rewarding career, from the production workers to manufacturing engineers and leaders, through advocacy, education programs, and buy-in from industry, government, and academia.”MIT is in a unique position to convene industry, academic, and government stakeholders in manufacturing to work together on this vital issue, he points out.Moreover, in times of radical and rapid changes in manufacturing, “we need to focus on deploying new technologies into factories and supply chains,” Hart says. “Technology is not all of the solution, but for the U.S. to expand our manufacturing base, we need to do it with technology as a key enabler, embracing companies of all sizes, including small and medium enterprises.”“As AI becomes more capable, and automation becomes more flexible and more available, these are key building blocks upon which you can address manufacturing challenges,” he says. “AI and automation offer new accelerated ways to develop, deploy, and monitor production processes, which present a huge opportunity and, in some cases, a necessity.”“While manufacturing is always a combination of old technology, new technology, established practice, and new ways of thinking, digital technology gives manufacturers an opportunity to leapfrog competitors,” Hart says. “That’s very, very powerful for the U.S. and any company, or country, that aims to create differentiated capabilities.”Fortunately, in recent years, investors have increasingly bought into new manufacturing in the United States. “They see the opportunity to re-industrialize, to build the factories and production systems of the future,” Hart says.“That said, building new manufacturing is capital-intensive, and takes time,” he adds. “So that’s another area where it’s important to convene stakeholders and to think about how startups and growth-stage companies build their capital portfolios, how large industry can support an ecosystem of small businesses and young companies, and how to develop talent to support those growing companies.”All these concerns and opportunities in the manufacturing ecosystem play to MIT’s strengths. “MIT’s DNA of cross-disciplinary collaboration and working with industry can let us create a lot of impact,” Hart emphasizes. “We can understand the practical challenges. We can also explore breakthrough ideas in research and cultivate successful outcomes, all the way to new companies and partnerships. Sometimes those are seen as disparate approaches, but we like to bring them together.” More

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      Would you like that coffee with iron?

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      Around the world, about 2 billion people suffer from iron deficiency, which can lead to anemia, impaired brain development in children, and increased infant mortality.To combat that problem, MIT researchers have come up with a new way to fortify foods and beverages with iron, using small crystalline particles. These particles, known as metal-organic frameworks, could be sprinkled on food, added to staple foods such as bread, or incorporated into drinks like coffee and tea.“We’re creating a solution that can be seamlessly added to staple foods across different regions,” says Ana Jaklenec, a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. “What’s considered a staple in Senegal isn’t the same as in India or the U.S., so our goal was to develop something that doesn’t react with the food itself. That way, we don’t have to reformulate for every context — it can be incorporated into a wide range of foods and beverages without compromise.”The particles designed in this study can also carry iodine, another critical nutrient. The particles could also be adapted to carry important minerals such as zinc, calcium, or magnesium.“We are very excited about this new approach and what we believe is a novel application of metal-organic frameworks to potentially advance nutrition, particularly in the developing world,” says Robert Langer, the David H. Koch Institute Professor at MIT and a member of the Koch Institute.Jaklenec and Langer are the senior authors of the study, which appears today in the journal Matter. MIT postdoc Xin Yang and Linzixuan (Rhoda) Zhang PhD ’24 are the lead authors of the paper.Iron stabilizationFood fortification can be a successful way to combat nutrient deficiencies, but this approach is often challenging because many nutrients are fragile and break down during storage or cooking. When iron is added to foods, it can react with other molecules in the food, giving the food a metallic taste.In previous work, Jaklenec’s lab has shown that encapsulating nutrients in polymers can protect them from breaking down or reacting with other molecules. In a small clinical trial, the researchers found that women who ate bread fortified with encapsulated iron were able to absorb the iron from the food.However, one drawback to this approach is that the polymer adds a lot of bulk to the material, limiting the amount of iron or other nutrients that end up in the food.“Encapsulating iron in polymers significantly improves its stability and reactivity, making it easier to add to food,” Jaklenec says. “But to be effective, it requires a substantial amount of polymer. That limits how much iron you can deliver in a typical serving, making it difficult to meet daily nutritional targets through fortified foods alone.”To overcome that challenge, Yang came up with a new idea: Instead of encapsulating iron in a polymer, they could use iron itself as a building block for a crystalline particle known as a metal-organic framework, or MOF (pronounced “moff”).MOFs consist of metal atoms joined by organic molecules called ligands to create a rigid, cage-like structure. Depending on the combination of metals and ligands chosen, they can be used for a wide variety of applications.“We thought maybe we could synthesize a metal-organic framework with food-grade ligands and food-grade micronutrients,” Yang says. “Metal-organic frameworks have very high porosity, so they can load a lot of cargo. That’s why we thought we could leverage this platform to make a new metal-organic framework that could be used in the food industry.”In this case, the researchers designed a MOF consisting of iron bound to a ligand called fumaric acid, which is often used as a food additive to enhance flavor or help preserve food.This structure prevents iron from reacting with polyphenols — compounds commonly found in foods such as whole grains and nuts, as well as coffee and tea. When iron does react with those compounds, it forms a metal polyphenol complex that cannot be absorbed by the body.The MOFs’ structure also allows them to remain stable until they reach an acidic environment, such as the stomach, where they break down and release their iron payload.Double-fortified saltsThe researchers also decided to include iodine in their MOF particle, which they call NuMOF. Iodized salt has been very successful at preventing iodine deficiency, and many efforts are now underway to create “double-fortified salts” that would also contain iron.Delivering these nutrients together has proven difficult because iron and iodine can react with each other, making each one less likely to be absorbed by the body. In this study, the MIT team showed that once they formed their iron-containing MOF particles, they could load them with iodine, in a way that the iron and iodine do not react with each other.In tests of the particles’ stability, the researchers found that the NuMOFs could withstand long-term storage, high heat and humidity, and boiling water.Throughout these tests, the particles maintained their structure. When the researchers then fed the particles to mice, they found that both iron and iodine became available in the bloodstream within several hours of the NuMOF consumption.The researchers are now working on launching a company that is developing coffee and other beverages fortified with iron and iodine. They also hope to continue working toward a double-fortified salt that could be consumed on its own or incorporated into staple food products.The research was partially supported by J-WAFS Fellowships for Water and Food Solutions.Other authors of the paper include Fangzheng Chen, Wenhao Gao, Zhiling Zheng, Tian Wang, Erika Yan Wang, Behnaz Eshaghi, and Sydney MacDonald. More

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      MIT chemists boost the efficiency of a key enzyme in photosynthesis

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      During photosynthesis, an enzyme called rubisco catalyzes a key reaction — the incorporation of carbon dioxide into organic compounds to create sugars. However, rubisco, which is believed to be the most abundant enzyme on Earth, is very inefficient compared to the other enzymes involved in photosynthesis.MIT chemists have now shown that they can greatly enhance a version of rubisco found in bacteria from a low-oxygen environment. Using a process known as directed evolution, they identified mutations that could boost rubisco’s catalytic efficiency by up to 25 percent.The researchers now plan to apply their technique to forms of rubisco that could be used in plants to help boost their rates of photosynthesis, which could potentially improve crop yields.“This is, I think, a compelling demonstration of successful improvement of a rubisco’s enzymatic properties, holding out a lot of hope for engineering other forms of rubisco,” says Matthew Shoulders, the Class of 1942 Professor of Chemistry at MIT.Shoulders and Robert Wilson, a research scientist in the Department of Chemistry, are the senior authors of the new study, which appears this week in the Proceedings of the National Academy of Sciences. MIT graduate student Julie McDonald is the paper’s lead author.Evolution of efficiencyWhen plants or photosynthetic bacteria absorb energy from the sun, they first convert it into energy-storing molecules such as ATP. In the next phase of photosynthesis, cells use that energy to transform a molecule known as ribulose bisphosphate into glucose, which requires several additional reactions. Rubisco catalyzes the first of those reactions, known as carboxylation. During that reaction, carbon from CO2 is added to ribulose bisphosphate.Compared to the other enzymes involved in photosynthesis, rubisco is very slow, catalyzing only one to 10 reactions per second. Additionally, rubisco can also interact with oxygen, leading to a competing reaction that incorporates oxygen instead of carbon — a process that wastes some of the energy absorbed from sunlight.“For protein engineers, that’s a really attractive set of problems because those traits seem like things that you could hopefully make better by making changes to the enzyme’s amino acid sequence,” McDonald says.Previous research has led to improvement in rubisco’s stability and solubility, which resulted in small gains in enzyme efficiency. Most of those studies used directed evolution — a technique in which a naturally occurring protein is randomly mutated and then screened for the emergence of new, desirable features.This process is usually done using error-prone PCR, a technique that first generates mutations in vitro (outside of the cell), typically introducing only one or two mutations in the target gene. In past studies on rubisco, this library of mutations was then introduced into bacteria that grow at a rate relative to rubisco activity. Limitations in error-prone PCR and in the efficiency of introducing new genes restrict the total number of mutations that can be generated and screened using this approach. Manual mutagenesis and selection steps also add more time to the process over multiple rounds of evolution.The MIT team instead used a newer mutagenesis technique that the Shoulders Lab previously developed, called MutaT7. This technique allows the researchers to perform both mutagenesis and screening in living cells, which dramatically speeds up the process. Their technique also enables them to mutate the target gene at a higher rate.“Our continuous directed evolution technique allows you to look at a lot more mutations in the enzyme than has been done in the past,” McDonald says.Better rubiscoFor this study, the researchers began with a version of rubisco, isolated from a family of semi-anaerobic bacteria known as Gallionellaceae, that is one of the fastest rubisco found in nature. During the directed evolution experiments, which were conducted in E. coli, the researchers kept the microbes in an environment with atmospheric levels of oxygen, creating evolutionary pressure to adapt to oxygen.After six rounds of directed evolution, the researchers identified three different mutations that improved the rubisco’s resistance to oxygen. Each of these mutations are located near the enzyme’s active site (where it performs carboxylation or oxygenation). The researchers believe that these mutations improve the enzyme’s ability to preferentially interact with carbon dioxide over oxygen, which leads to an overall increase in carboxylation efficiency.“The underlying question here is: Can you alter and improve the kinetic properties of rubisco to operate better in environments where you want it to operate better?” Shoulders says. “What changed through the directed evolution process was that rubisco began to like to react with oxygen less. That allows this rubisco to function well in an oxygen-rich environment, where normally it would constantly get distracted and react with oxygen, which you don’t want it to do.”In ongoing work, the researchers are applying this approach to other forms of rubisco, including rubisco from plants. Plants are believed to lose about 30 percent of the energy from the sunlight they absorb through a process called photorespiration, which occurs when rubisco acts on oxygen instead of carbon dioxide.“This really opens the door to a lot of exciting new research, and it’s a step beyond the types of engineering that have dominated rubisco engineering in the past,” Wilson says. “There are definite benefits to agricultural productivity that could be leveraged through a better rubisco.”The research was funded, in part, by the National Science Foundation, the National Institutes of Health, an Abdul Latif Jameel Water and Food Systems Lab Grand Challenge grant, and a Martin Family Society Fellowship for Sustainability. More

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      How J-WAFS Solutions grants bring research to market

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      For the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS), 2025 marks a decade of translating groundbreaking research into tangible solutions for global challenges. Few examples illustrate that mission better than NONA Technologies. With support from a J-WAFS Solutions grant, MIT electrical engineering and biological engineering Professor Jongyoon Han and his team developed a portable desalination device that transforms seawater into clean drinking water without filters or high-pressure pumps. The device stands apart from traditional systems because conventional desalination technologies, like reverse osmosis, are energy-intensive, prone to fouling, and typically deployed at large, centralized plants. In contrast, the device developed in Han’s lab employs ion concentration polarization technology to remove salts and particles from seawater, producing potable water that exceeds World Health Organization standards. It is compact, solar-powered, and operable at the push of a button — making it an ideal solution for off-grid and disaster-stricken areas.This research laid the foundation for spinning out NONA Technologies along with co-founders Junghyo Yoon PhD ’21 from Han’s lab and Bruce Crawford MBA ’22, to commercialize the technology and address pressing water-scarcity issues worldwide. “This is really the culmination of a 10-year journey that I and my group have been on,” said Han in an earlier MIT News article. “We worked for years on the physics behind individual desalination processes, but pushing all those advances into a box, building a system, and demonstrating it in the ocean … that was a really meaningful and rewarding experience for me.” You can watch this video showcasing the device in action.Moving breakthrough research out of the lab and into the world is a well-known challenge. While traditional “seed” grants typically support early-stage research at Technology Readiness Level (TRL) 1-2, few funding sources exist to help academic teams navigate to the next phase of technology development. The J-WAFS Solutions Program is strategically designed to address this critical gap by supporting technologies in the high-risk, early-commercialization phase that is often neglected by traditional research, corporate, and venture funding. By supporting technologies at TRLs 3-5, the program increases the likelihood that promising innovations will survive beyond the university setting, advancing sufficiently to attract follow-on funding.Equally important, the program gives academic researchers the time, resources, and flexibility to de-risk their technology, explore customer need and potential real-world applications, and determine whether and how they want to pursue commercialization. For faculty-led teams like Han’s, the J-WAFS Solutions Program provided the critical financial runway and entrepreneurial guidance needed to refine the technology, test assumptions about market fit, and lay the foundation for a startup team. While still in the MIT innovation ecosystem, Nona secured over $200,000 in non-dilutive funding through competitions and accelerators, including the prestigious MIT delta v Educational Accelerator. These early wins laid the groundwork for further investment and technical advancement.Since spinning out of MIT, NONA has made major strides in both technology development and business viability. What started as a device capable of producing just over half-a-liter of clean drinking water per hour has evolved into a system that now delivers 10 times that capacity, at 5 liters per hour. The company successfully raised a $3.5 million seed round to advance its portable desalination device, and entered into a collaboration with the U.S. Army Natick Soldier Systems Center, where it co-developed early prototypes and began generating revenue while validating the technology. Most recently, NONA was awarded two SBIR Phase I grants totaling $575,000, one from the National Science Foundation and another from the National Institute of Environmental Health Sciences.Now operating out of Greentown Labs in Somerville, Massachusetts, NONA has grown to a dedicated team of five and is preparing to launch its nona5 product later this year, with a wait list of over 1,000 customers. It is also kicking off its first industrial pilot, marking a key step toward commercial scale-up. “Starting a business as a postdoc was challenging, especially with limited funding and industry knowledge,” says Yoon, who currently serves as CTO of NONA. “J-WAFS gave me the financial freedom to pursue my venture, and the mentorship pushed me to hit key milestones. Thanks to J-WAFS, I successfully transitioned from an academic researcher to an entrepreneur in the water industry.”NONA is one of several J-WAFS-funded technologies that have moved from the lab to market, part of a growing portfolio of water and food solutions advancing through MIT’s innovation pipeline. As J-WAFS marks a decade of catalyzing innovation in water and food, NONA exemplifies what is possible when mission-driven research is paired with targeted early-stage support and mentorship.To learn more or get involved in supporting startups through the J-WAFS Solutions Program, please contact jwafs@mit.edu. More