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    To design better water filters, MIT engineers look to manta rays

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    Filter feeders are everywhere in the animal world, from tiny crustaceans and certain types of coral and krill, to various molluscs, barnacles, and even massive basking sharks and baleen whales. Now, MIT engineers have found that one filter feeder has evolved to sift food in ways that could improve the design of industrial water filters.In a paper appearing this week in the Proceedings of the National Academy of Sciences, the team characterizes the filter-feeding mechanism of the mobula ray — a family of aquatic rays that includes two manta species and seven devil rays. Mobula rays feed by swimming open-mouthed through plankton-rich regions of the ocean and filtering plankton particles into their gullet as water streams into their mouths and out through their gills.The floor of the mobula ray’s mouth is lined on either side with parallel, comb-like structures, called plates, that siphon water into the ray’s gills. The MIT team has shown that the dimensions of these plates may allow for incoming plankton to bounce all the way across the plates and further into the ray’s cavity, rather than out through the gills. What’s more, the ray’s gills absorb oxygen from the outflowing water, helping the ray to simultaneously breathe while feeding.“We show that the mobula ray has evolved the geometry of these plates to be the perfect size to balance feeding and breathing,” says study author Anette “Peko” Hosoi, the Pappalardo Professor of Mechanical Engineering at MIT.The engineers fabricated a simple water filter modeled after the mobula ray’s plankton-filtering features. They studied how water flowed through the filter when it was fitted with 3D-printed plate-like structures. The team took the results of these experiments and drew up a blueprint, which they say designers can use to optimize industrial cross-flow filters, which are broadly similar in configuration to that of the mobula ray.“We want to expand the design space of traditional cross-flow filtration with new knowledge from the manta ray,” says lead author and MIT postdoc Xinyu Mao PhD ’24. “People can choose a parameter regime of the mobula ray so they could potentially improve overall filter performance.”Hosoi and Mao co-authored the new study with Irmgard Bischofberger, associate professor of mechanical engineering at MIT.A better trade-offThe new study grew out of the group’s focus on filtration during the height of the Covid pandemic, when the researchers were designing face masks to filter out the virus. Since then, Mao has shifted focus to study filtration in animals and how certain filter-feeding mechanisms might improve filters used in industry, such as in water treatment plants.Mao observed that any industrial filter must strike a balance between permeability (how easily fluid can flow through a filter), and selectivity (how successful a filter is at keeping out particles of a target size). For instance, a membrane that is studded with large holes might be highly permeable, meaning a lot of water can be pumped through using very little energy. However, the membrane’s large holes would let many particles through, making it very low in selectivity. Likewise, a membrane with much smaller pores would be more selective yet also require more energy to pump the water through the smaller openings.“We asked ourselves, how do we do better with this tradeoff between permeability and selectivity?” Hosoi says.As Mao looked into filter-feeding animals, he found that the mobula ray has struck an ideal balance between permeability and selectivity: The ray is highly permeable, in that it can let water into its mouth and out through its gills quickly enough to capture oxygen to breathe. At the same time, it is highly selective, filtering and feeding on plankton rather than letting the particles stream out through the gills.The researchers realized that the ray’s filtering features are broadly similar to that of industrial cross-flow filters. These filters are designed such that fluid flows across a permeable membrane that lets through most of the fluid, while any polluting particles continue flowing across the membrane and eventually out into a reservoir of waste.The team wondered whether the mobula ray might inspire design improvements to industrial cross-flow filters. For that, they took a deeper dive into the dynamics of mobula ray filtration.A vortex keyAs part of their new study, the team fabricated a simple filter inspired by the mobula ray. The filter’s design is what engineers refer to as a “leaky channel” — effectively, a pipe with holes along its sides. In this case, the team’s “channel” consists of two flat, transparent acrylic plates that are glued together at the edges, with a slight opening between the plates through which fluid can be pumped. At one end of the channel, the researchers inserted 3D-printed structures resembling the grooved plates that run along the floor of the mobula ray’s mouth.The team then pumped water through the channel at various rates, along with colored dye to visualize the flow. They took images across the channel and observed an interesting transition: At slow pumping rates, the flow was “very peaceful,” and fluid easily slipped through the grooves in the printed plates and out into a reservoir. When the researchers increased the pumping rate, the faster-flowing fluid did not slip through, but appeared to swirl at the mouth of each groove, creating a vortex, similar to a small knot of hair between the tips of a comb’s teeth.“This vortex is not blocking water, but it is blocking particles,” Hosoi explains. “Whereas in a slower flow, particles go through the filter with the water, at higher flow rates, particles try to get through the filter but are blocked by this vortex and are shot down the channel instead. The vortex is helpful because it prevents particles from flowing out.”The team surmised that vortices are the key to mobula rays’ filter-feeding ability. The ray is able to swim at just the right speed that water, streaming into its mouth, can form vortices between the grooved plates. These vortices effectively block any plankton particles — even those that are smaller than the space between plates. The particles then bounce across the plates and head further into the ray’s cavity, while the rest of the water can still flow between the plates and out through the gills.The researchers used the results of their experiments, along with dimensions of the filtering features of mobula rays, to develop a blueprint for cross-flow filtration.“We have provided practical guidance on how to actually filter as the mobula ray does,” Mao offers.“You want to design a filter such that you’re in the regime where you generate vortices,” Hosoi says. “Our guidelines tell you: If you want your plant to pump at a certain rate, then your filter has to have a particular pore diameter and spacing to generate vortices that will filter out particles of this size. The mobula ray is giving us a really nice rule of thumb for rational design.”This work was supported, in part, by the U.S. National Institutes of Health, and the Harvey P. Greenspan Fellowship Fund.  More

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      Unlocking the secrets of natural materials

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      Growing up in Milan, Benedetto Marelli liked figuring out how things worked. He repaired broken devices simply to have the opportunity to take them apart and put them together again. Also, from a young age, he had a strong desire to make a positive impact on the world. Enrolling at the Polytechnic University of Milan, he chose to study engineering.

      “Engineering seemed like the right fit to fulfill my passions at the intersection of discovering how the world works, together with understanding the rules of nature and harnessing this knowledge to create something new that could positively impact our society,” says Marelli, MIT’s Paul M. Cook Career Development Associate Professor of Civil and Environmental Engineering.

      Marelli decided to focus on biomedical engineering, which at the time was the closest thing available to biological engineering. “I liked the idea of pursuing studies that provided me a background to engineer life,” in order to improve human health and agriculture, he says.

      Marelli went on to earn a PhD in materials science and engineering at McGill University and then worked in Tufts University’s biomaterials Silklab as a postdoc. After his postdoc, Marelli was drawn to MIT’s Department of Civil and Environmental in large part because of the work of Markus Buehler, MIT’s McAfee Professor of Engineering, who studies how to design new materials by understanding the architecture of natural ones.

      “This resonated with my training and idea of using nature’s building blocks to build a more sustainable society,” Marelli says. “It was a big leap forward for me to go from biomedical engineering to civil and environmental engineering. It meant completely changing my community, understanding what I could teach and how to mentor students in a new engineering branch. As Markus is working with silk to study how to engineer better materials, this made me see a clear connection with what I was doing and what I could be doing. I consider him one of my mentors here at MIT and was fortunate to end up collaborating with him.”

      Marelli’s research is aimed at mitigating several pressing global problems, he says.

      “Boosting food production to provide food security to an ever-increasing population, soil restoration, decreasing the environmental impact of fertilizers, and addressing stressors coming from climate change are societal challenges that need the development of rapidly scalable and deployable technologies,” he says.

      Marelli and his fellow researchers have developed coatings derived from natural silk that extend the shelf life of food, deliver biofertilizers to seeds planted in salty, unproductive soils, and allow seeds to establish healthier plants and increase crop yield in drought-stricken lands. The technologies have performed well in field tests being conducted in Morocco in collaboration with the Mohammed VI Polytechnic University in Ben Guerir, according to Marelli, and offer much potential.

      “I believe that with this technology, together with the common efforts shared by the MIT PIs participating in the Climate Grand Challenge on Revolutionizing Agriculture, we have a  real opportunity to positively impact planetary health and find new solutions that work in both rural settings and highly modernized agricultural fields,” says Marelli, who recently earned tenure.

      As a researcher and entrepreneur with about 20 patents to his name and awards including a National Science Foundation CAREER award, the Presidential Early Career Award for Scientists and Engineers award, and the Ole Madsen Mentoring Award, Marelli says that in general his insights into structural proteins — and how to use that understanding to manufacture advanced materials at multiple scales — are among his proudest achievements.

      More specifically, Marelli cites one of his breakthroughs involving a strawberry. Having dipped the berry in an odorless, tasteless edible silk suspension as part of a cooking contest held in his postdoctoral lab, he accidentally left it on his bench, only to find a week or so later that it had been well-preserved.

      “The coating of the strawberry to increase its shelf life is difficult to beat when it comes to inspiring people that natural polymers can serve as technical materials that can positively impact our society” by lessening food waste and the need for energy-intensive refrigerated shipping, Marelli says.

      When Marelli won the BioInnovation Institute and Science Prize for Innovation in 2022, he told the journal Science that he thinks students should be encouraged to choose an entrepreneurial path. He acknowledged the steepness of the learning curve of being an entrepreneur but also pointed out how the impact of research can be exponentially increased.

      He expanded on this idea more recently.

      “I believe an increasing number of academics and graduate students should try to get their hands ‘dirty’ with entrepreneurial efforts. We live in a time where academics are called to have a tangible impact on our society, and translating what we study in our labs is clearly a good way to employ our students and enhance the global effort to develop new technology that can make our society more sustainable and equitable,” Marelli says.

      Referring to a spinoff company, Mori, that grew out of the coated strawberry discovery and that develops silk-based products to preserve a wide range of perishable foods, Marelli says he finds it very satisfying to know that Mori has a product on the market that came out of his research efforts — and that 80 people are working to translate the discovery from “lab to fork.”

      “Knowing that the technology can move the needle in crises such as food waste and food-related environmental impact is the highest reward of all,” he says.

      Marelli says he tells students who are seeking solutions to extremely complicated problems to come up with one solution, “however crazy it might be,” and then do an extensive literature review to see what other researchers have done and whether “there is any hint that points toward developing their solution.”

      “Once we understand the feasibility, I typically work with them to simplify it as much as we can, and then to break down the problem in small parts that are addressable in series and/or in parallel,” Marelli says.

      That process of discovery is ongoing. Asked which of his technologies will have the greatest impact on the world, Marelli says, “I’d like to think it’s the ones that still need to be discovered.” More

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      in Security

      Scientists uncover the amazing way sandgrouse hold water in their feathers

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      Many birds’ feathers are remarkably efficient at shedding water — so much so that “like water off a duck’s back” is a common expression. Much more unusual are the belly feathers of the sandgrouse, especially Namaqua sandgrouse, which absorb and retain water so efficiently the male birds can fly more than 20 kilometers from a distant watering hole back to the nest and still retain enough water in their feathers for the chicks to drink and sustain themselves in the searing deserts of Namibia, Botswana, and South Africa.

      How do those feathers work? While scientists had inferred a rough picture, it took the latest tools of microscopy, and patient work with a collection of sandgrouse feathers, to unlock the unique structural details that enable the feathers to hold water. The findings appear today in the Journal of the Royal Society Interface, in a paper by Lorna Gibson, the Matoula S. Salapatas Professor of Materials Science and Engineering and a professor of mechanical engineering at MIT, and Professor Jochen Mueller of Johns Hopkins University.

      The unique water-carrying ability of sandgrouse feathers was first reported back in 1896, Gibson says, by E.G.B. Meade-Waldo, who was breeding the birds in captivity. “He saw them behaving like this, and nobody believed him! I mean, it just sounded so outlandish,” Gibson says.

      In 1967, Tom Cade and Gordon MacLean reported detailed observations of the birds at watering holes, in a study that proved the unique behavior was indeed real. The scientists found that male sandgrouse feathers could hold about 25 milliliters of water, or about a tenth of a cup, after the bird had spent about five minutes dipping in the water and fluffing its feathers.

      About half of that amount can evaporate during the male bird’s half-hour-long flight back to the nest, where the chicks, which cannot fly for about their first month, drink the remainder straight from the feathers.

      Cade and MacLean “had part of the story,” Gibson says, but the tools didn’t exist at the time to carry out the detailed imaging of the feather structures that the new study was able to do.

      Gibson and Mueller carried out their study using scanning electron microscopy, micro-computed tomography, and video imaging. They borrowed Namaqua sandgrouse belly feathers from Harvard University’s Museum of Comparative Zoology, which has a collection of specimens of about 80 percent of the world’s birds.

      Bird feathers in general have a central shaft, from which smaller barbs extend, and then smaller barbules extend out from those. Sandgrouse feathers are structured differently, however. In the inner zone of the feather, the barbules have a helically coiled structure close to their base and then a straight extension. In the outer zone of the feather, the barbules lack the helical coil and are simply straight. Both parts lack the grooves and hooks that hold the vane of contour feathers together in most other birds.
      Video of water spreading through the specialized sandgrouse feathers, under magnification, shows the uncoiling and spreading of the feather’s barbules as they become wet. Initially, most barbules in the outer zone of the feather form tubular features.Credit: Specimen #142928, Museum of Comparative Zoology, Harvard University © President and Fellows of Harvard College.

      When wetted, the coiled portions of the barbules unwind and rotate to be perpendicular to the vane, producing a dense forest of fibers that can hold water through capillary action. At the same time, the barbules in the outer zone curl inward, helping to hold the water in.

      The microscopy techniques used in the new study allowed the dimensions of the different parts of the feather to be measured. In the inner zone, the barb shafts are large and stiff enough to provide a rigid base about which the other parts of the feather deform, and the barbules are small and flexible enough that surface tension is sufficient to bend the straight extensions into tear-like structures that hold water. And in the outer zone, the barb shafts and barbules are smaller still, allowing them to curl around the inner zone, further retaining water.

      While previous work had suggested that surface tension produced the water retention characteristics, “what we did was make measurements of the dimensions and do some calculations to show that that’s what is actually happening,” Gibson says. Her group’s work demonstrated that the varying stiffnesses of the different feather parts plays a key role in their ability to hold water.

      The study was mostly driven by intellectual curiosity about this unique behavioral phenomenon, Gibson says. “We just wanted to see how it works. The whole story just seemed so interesting.” But she says it might lead to some useful applications. For example, in desert regions where water is scarce but fog and dew regularly occur, such as in Chile’s Atacama Desert, some adaptation of this feather structure might be incorporated into the systems of huge nets that are used to collect water. “You could imagine this could be a way to improve those systems,” she says. “A material with this kind of structure might be more effective at fog harvesting and holding the water.”

      “This fascinating and in-depth study reveals how the different parts of the sandgrouse’s belly feathers — including the microscopic barb shafts and barbules — work together to hold water,” says Mary Caswell Stoddard, an evolutionary biologist at Princeton University, who was not associated with this study. “By using a suite of advanced imaging techniques to describe the belly feathers and estimate their bending stiffnesses, Mueller and Gibson add rich new details to our understanding of the sandgrouse’s water-carrying feathers. … This study may inspire others to take a closer look at diverse feather microstructures across bird species — and to wonder whether these structures, as in sandgrouse, help support unusual or surprising functions.”

      The work was partly supported by the National Science Foundation and the Matoula S. Salapatas Professorship in Materials Science and Engineering at MIT. More

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      in Environment

      Exploring the nanoworld of biogenic gems

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      A new research collaboration with The Bahrain Institute for Pearls and Gemstones (DANAT) will seek to develop advanced characterization tools for the analysis of the properties of pearls and to explore technologies to assign unique identifiers to individual pearls.

      The three-year project will be led by Admir Mašić, associate professor of civil and environmental engineering, in collaboration with Vladimir Bulović, the Fariborz Maseeh Chair in Emerging Technology and professor of electrical engineering and computer science.

      “Pearls are extremely complex and fascinating hierarchically ordered biological materials that are formed by a wide range of different species,” says Mašić. “Working with DANAT provides us a unique opportunity to apply our lab’s multi-scale materials characterization tools to identify potentially species-specific pearl fingerprints, while simultaneously addressing scientific research questions regarding the underlying biomineralization processes that could inform advances in sustainable building materials.”

      DANAT is a gemological laboratory specializing in the testing and study of natural pearls as a reflection of Bahrain’s pearling history and desire to protect and advance Bahrain’s pearling heritage. DANAT’s gemologists support clients and students through pearl, gemstone, and diamond identification services, as well as educational courses.

      Like many other precious gemstones, pearls have been human-made through scientific experimentation, says Noora Jamsheer, chief executive officer at DANAT. Over a century ago, cultured pearls entered markets as a competitive product to natural pearls, similar in appearance but different in value.

      “Gemological labs have been innovating scientific testing methods to differentiate between natural pearls and all other pearls that exist because of direct or indirect human intervention. Today the world knows natural pearls and cultured pearls. However, there are also pearls that fall in between these two categories,” says Jamsheer. “DANAT has the responsibility, as the leading gemological laboratory for pearl testing, to take the initiative necessary to ensure that testing methods keep pace with advances in the science of pearl cultivation.”

      Titled “Exploring the Nanoworld of Biogenic Gems,” the project will aim to improve the process of testing and identifying pearls by identifying morphological, micro-structural, optical, and chemical features sufficient to distinguish a pearl’s area of origin, method of growth, or both. MIT.nano, MIT’s open-access center for nanoscience and nanoengineering will be the organizational home for the project, where Mašić and his team will utilize the facility’s state-of-the-art characterization tools.

      In addition to discovering new methodologies for establishing a pearl’s origin, the project aims to utilize machine learning to automate pearl classification. Furthermore, researchers will investigate techniques to create a unique identifier associated with an individual pearl.

      The initial sponsored research project is expected to last three years, with potential for continued collaboration based on key findings or building upon the project’s success to open new avenues for research into the structure, properties, and growth of pearls. More

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      in Environment

      Silk offers an alternative to some microplastics

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      Microplastics, tiny particles of plastic that are now found worldwide in the air, water, and soil, are increasingly recognized as a serious pollution threat, and have been found in the bloodstream of animals and people around the world.

      Some of these microplastics are intentionally added to a variety of products, including agricultural chemicals, paints, cosmetics, and detergents — amounting to an estimated 50,000 tons a year in the European Union alone, according to the European Chemicals Agency. The EU has already declared that these added, nonbiodegradable microplastics must be eliminated by 2025, so the search is on for suitable replacements, which do not currently exist.

      Now, a team of scientists at MIT and elsewhere has developed a system based on silk that could provide an inexpensive and easily manufactured substitute. The new process is described in a paper in the journal Small, written by MIT postdoc Muchun Liu, MIT professor of civil and environmental engineering Benedetto Marelli, and five others at the chemical company BASF in Germany and the U.S.

      The microplastics widely used in industrial products generally protect some specific active ingredient (or ingredients) from being degraded by exposure to air or moisture, until the time they are needed. They provide a slow release of the active ingredient for a targeted period of time and minimize adverse effects to its surroundings. For example, vitamins are often delivered in the form of microcapsules packed into a pill or capsule, and pesticides and herbicides are similarly enveloped. But the materials used today for such microencapsulation are plastics that persist in the environment for a long time. Until now, there has been no practical, economical substitute available that would biodegrade naturally.

      Much of the burden of environmental microplastics comes from other sources, such as the degradation over time of larger plastic objects such as bottles and packaging, and from the wear of car tires. Each of these sources may require its own kind of solutions for reducing its spread, Marelli says. The European Chemical Agency has estimated that the intentionally added microplastics represent approximately 10-15 percent of the total amount in the environment, but this source may be relatively easy to address using this nature-based biodegradable replacement, he says.

      “We cannot solve the whole microplastics problem with one solution that fits them all,” he says. “Ten percent of a big number is still a big number. … We’ll solve climate change and pollution of the world one percent at a time.”

      Unlike the high-quality silk threads used for fine fabrics, the silk protein used in the new alternative material is widely available and less expensive, Liu says. While silkworm cocoons must be painstakingly unwound to produce the fine threads needed for fabric, for this use, non-textile-quality cocoons can be used, and the silk fibers can simply be dissolved using a scalable water-based process. The processing is so simple and tunable that the resulting material can be adapted to work on existing manufacturing equipment, potentially providing a simple “drop in” solution using existing factories.

      Silk is recognized as safe for food or medical use, as it is nontoxic and degrades naturally in the body. In lab tests, the researchers demonstrated that the silk-based coating material could be used in existing, standard spray-based manufacturing equipment to make a standard water-soluble microencapsulated herbicide product, which was then tested in a greenhouse on a corn crop. The test showed it worked even better than an existing commercial product, inflicting less damage to the plants, Liu says.

      While other groups have proposed degradable encapsulation materials that may work at a small laboratory scale, Marelli says, “there is a strong need to achieve encapsulation of high-content actives to open the door to commercial use. The only way to have an impact is where we can not only replace a synthetic polymer with a biodegradable counterpart, but also achieve performance that is the same, if not better.”

      The secret to making the material compatible with existing equipment, Liu explains, is in the tunability of the silk material. By precisely adjusting the polymer chain arrangements of silk materials and addition of a surfactant, it is possible to fine-tune the properties of the resulting coatings once they dry out and harden. The material can be hydrophobic (water-repelling) even though it is made and processed in a water solution, or it can be hydrophilic (water-attracting), or anywhere in between, and for a given application it can be made to match the characteristics of the material it is being used to replace.

      In order to arrive at a practical solution, Liu had to develop a way of freezing the forming droplets of encapsulated materials as they were forming, to study the formation process in detail. She did this using a special spray-freezing system, and was able to observe exactly how the encapsulation works in order to control it better. Some of the encapsulated “payload” materials, whether they be pesticides or nutrients or enzymes, are water-soluble and some are not, and they interact in different ways with the coating material.

      “To encapsulate different materials, we have to study how the polymer chains interact and whether they are compatible with different active materials in suspension,” she says. The payload material and the coating material are mixed together in a solution and then sprayed. As droplets form, the payload tends to be embedded in a shell of the coating material, whether that’s the original synthetic plastic or the new silk material.

      The new method can make use of low-grade silk that is unusable for fabrics, and large quantities of which are currently discarded because they have no significant uses, Liu says. It can also use used, discarded silk fabric, diverting that material from being disposed of in landfills.

      Currently, 90 percent of the world’s silk production takes place in China, Marelli says, but that’s largely because China has perfected the production of the high-quality silk threads needed for fabrics. But because this process uses bulk silk and has no need for that level of quality, production could easily be ramped up in other parts of the world to meet local demand if this process becomes widely used, he says.

      “This elegant and clever study describes a sustainable and biodegradable silk-based replacement for microplastic encapsulants, which are a pressing environmental challenge,” says Alon Gorodetsky, an associate professor of chemical and biomolecular engineering at the University of California at Irvine, who was not associated with this research. “The modularity of the described materials and the scalability of the manufacturing processes are key advantages that portend well for translation to real-world applications.”

      This process “represents a potentially highly significant advance in active ingredient delivery for a range of industries, particularly agriculture,” says Jason White, director of the Connecticut Agricultural Experiment Station, who also was not associated with this work. “Given the current and future challenges related to food insecurity, agricultural production, and a changing climate, novel strategies such as this are greatly needed.”

      The research team also included Pierre-Eric Millard, Ophelie Zeyons, Henning Urch, Douglas Findley and Rupert Konradi from the BASF corporation, in Germany and in the U.S. The work was supported by BASF through the Northeast Research Alliance (NORA). More

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      in Environment

      Better living through multicellular life cycles

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      Cooperation is a core part of life for many organisms, ranging from microbes to complex multicellular life. It emerges when individuals share resources or partition a task in such a way that each derives a greater benefit when acting together than they could on their own. For example, birds and fish flock to evade predators, slime mold swarms to hunt for food and reproduce, and bacteria form biofilms to resist stress.

      Individuals must live in the same “neighborhood” to cooperate. For bacteria, this neighborhood can be as small as tens of microns. But in environments like the ocean, it’s rare for cells with the same genetic makeup to co-occur in the same neighborhood on their own. And this necessity poses a puzzle to scientists: In environments where survival hinges on cooperation, how do bacteria build their neighborhood?

      To study this problem, MIT professor Otto X. Cordero and colleagues took inspiration from nature: They developed a model system around a common coastal seawater bacterium that requires cooperation to eat sugars from brown algae. In the system, single cells were initially suspended in seawater too far away from other cells to cooperate. To share resources and grow, the cells had to find a mechanism of creating a neighborhood. “Surprisingly, each cell was able to divide and create its own neighborhood of clones by forming tightly packed clusters,” says Cordero, associate professor in the Department of Civil and Environmental Engineering.

      A new paper, published today in Current Biology, demonstrates how an algae-eating bacterium solves the engineering challenge of creating local cell density starting from a single-celled state.

      “A key discovery was the importance of phenotypic heterogeneity in supporting this surprising mechanism of clonal cooperation,” says Cordero, lead author of the new paper.

      Using a combination of microscopy, transcriptomics, and labeling experiments to profile a cellular metabolic state, the researchers found that cells phenotypically differentiate into a sticky “shell” population and a motile, carbon-storing “core.” The researchers propose that shell cells create the cellular neighborhood needed to sustain cooperation while core cells accumulate stores of carbon that support further clonal reproduction when the multicellular structure ruptures.

      This work addresses a key piece in the bigger challenge of understanding the bacterial processes that shape our earth, such as the cycling of carbon from dead organic matter back into food webs and the atmosphere. “Bacteria are fundamentally single cells, but often what they accomplish in nature is done through cooperation. We have much to uncover about what bacteria can accomplish together and how that differs from their capacity as individuals,” adds Cordero.

      Co-authors include Julia Schwartzman and Ali Ebrahimi, former postdocs in the Cordero Lab. Other co-authors are Gray Chadwick, a former graduate student at Caltech; Yuya Sato, a senior researcher at Japan’s National Institute of Advanced Industrial Science and Technology; Benjamin Roller, a current postdoc at the University of Vienna; and Victoria Orphan of Caltech.

      Funding was provided by the Simons Foundation. Individual authors received support from the Swiss National Science Foundation, Japan Society for the Promotion of Science, the U.S. National Science Foundation, the Kavli Institute of Theoretical Physics, and the National Institutes of Health. More

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      in Energy

      A material difference

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      Eesha Khare has always seen a world of matter. The daughter of a hardware engineer and a biologist, she has an insatiable interest in what substances — both synthetic and biological — have in common. Not surprisingly, that perspective led her to the study of materials.

      “I recognized early on that everything around me is a material,” she says. “How our phones respond to touches, how trees in nature to give us both structural wood and foldable paper, or how we are able to make high skyscrapers with steel and glass, it all comes down to the fundamentals: This is materials science and engineering.”

      As a rising fourth-year PhD student in the MIT Department of Materials Science and Engineering (DMSE), Khare now studies the metal-coordination bonds that allow mussels to bind to rocks along turbulent coastlines. But Khare’s scientific enthusiasm has also led to expansive interests from science policy to climate advocacy and entrepreneurship.

      A material world

      A Silicon Valley native, Khare recalls vividly how excited she was about science as a young girl, both at school and at myriad science fairs and high school laboratory internships. One such internship at the University of California at Santa Cruz introduced her to the study of nanomaterials, or materials that are smaller than a single human cell. The project piqued her interest in how research could lead to energy-storage applications, and she began to ponder the connections between materials, science policy, and the environment.

      As an undergraduate at Harvard University, Khare pursued a degree in engineering sciences and chemistry while also working at the Harvard Kennedy School Institute of Politics. There, she grew fascinated by environmental advocacy in the policy space, working for then-professor Gina McCarthy, who is currently serving in the Biden administration as the first-ever White House climate advisor.

      Following her academic explorations in college, Khare wanted to consider science in a new light before pursuing her doctorate in materials science and engineering. She deferred her program acceptance at MIT in order to attend Cambridge University in the U.K., where she earned a master’s degree in the history and philosophy of science. “Especially in a PhD program, it can often feel like your head is deep in the science as you push new research frontiers, but I wanted take a step back and be inspired by how scientists in the past made their discoveries,” she says.

      Her experience at Cambridge was both challenging and informative, but Khare quickly found that her mechanistic curiosity remained persistent — a realization that came in the form of a biological material.

      “My very first master’s research project was about environmental pollution indicators in the U.K., and I was looking specifically at lichen to understand the social and political reasons why they were adopted by the public as pollution indicators,” Khare explains. “But I found myself wondering more about how lichen can act as pollution indicators. And I found that to be quite similar for most of my research projects: I was more interested in how the technology or discovery actually worked.”

      Enthusiasm for innovation

      Fittingly, these bioindicators confirmed for her that studying materials at MIT was the right course. Now Khare works on a different organism altogether, conducting research on the metal-coordination chemical interactions of a biopolymer secreted by mussels.

      “Mussels secrete this thread and can adhere to ocean walls. So, when ocean waves come, mussels don’t get dislodged that easily,” Khare says. “This is partly because of how metal ions in this material bind to different amino acids in the protein. There’s no input from the mussel itself to control anything there; all the magic is in this biological material that is not only very sticky, but also doesn’t break very readily, and if you cut it, it can re-heal that interface as well! If we could better understand and replicate this biological material in our own world, we could have materials self-heal and never break and thus eliminate so much waste.”

      To study this natural material, Khare combines computational and experimental techniques, experimentally synthesizing her own biopolymers and studying their properties with in silico molecular dynamics. Her co-advisors — Markus Buehler, the Jerry McAfee Professor of Engineering in Civil and Environmental Engineering, and Niels Holten-Andersen, professor of materials science and engineering — have embraced this dual-approach to her project, as well as her abundant enthusiasm for innovation.

      Khare likes to take one exploratory course per semester, and a recent offering in the MIT Sloan School of Management inspired her to pursue entrepreneurship. These days she is spending much of her free time on a startup called Taxie, formed with fellow MIT students after taking the course 15.390 (New Enterprises). Taxie attempts to electrify the rideshare business by making electric rental cars available to rideshare drivers. Khare hopes this project will initiate some small first steps in making the ridesharing industry environmentally cleaner — and in democratizing access to electric vehicles for rideshare drivers, who often hail from lower-income or immigrant backgrounds.

      “There are a lot of goals thrown around for reducing emissions or helping our environment. But we are slowly getting physical things on the road, physical things to real people, and I like to think that we are helping to accelerate the electric transition,” Khare says. “These small steps are helpful for learning, at the very least, how we can make a transition to electric or to a cleaner industry.”

      Alongside her startup work, Khare has pursued a number of other extracurricular activities at MIT, including co-organizing her department’s Student Application Assistance Program and serving on DMSE’s Diversity, Equity, and Inclusion Council. Her varied interests also have led to a diverse group of friends, which suits her well, because she is a self-described “people-person.”

      In a year where maintaining connections has been more challenging than usual, Khare has focused on the positive, spending her spring semester with family in California and practicing Bharatanatyam, a form of Indian classical dance, over Zoom. As she looks to the future, Khare hopes to bring even more of her interests together, like materials science and climate.

      “I want to understand the energy and environmental sector at large to identify the most pressing technology gaps and how can I use my knowledge to contribute. My goal is to figure out where can I personally make a difference and where it can have a bigger impact to help our climate,” she says. “I like being outside of my comfort zone.” More