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    A new take on carbon capture

    If there was one thing Cameron Halliday SM ’19, MBA ’22, PhD ’22 was exceptional at during the early days of his PhD at MIT, it was producing the same graph over and over again. Unfortunately for Halliday, the graph measured various materials’ ability to absorb CO2 at high temperatures over time — and it always pointed down and to the right. That meant the materials lost their ability to capture the molecules responsible for warming our climate.At least Halliday wasn’t alone: For many years, researchers have tried and mostly failed to find materials that could reliably absorb CO2 at the super-high temperatures of industrial furnaces, kilns, and boilers. Halliday’s goal was to find something that lasted a little longer.Then in 2019, he put a type of molten salt called lithium-sodium ortho-borate through his tests. The salts absorbed more than 95 percent of the CO2. And for the first time, the graph showed almost no degradation over 50 cycles.  The same was true after 100 cycles. Then 1,000.“I honestly don’t know if we ever expected to completely solve the problem,” Halliday says. “We just expected to improve the system. It took another two months to figure out why it worked.”The researchers discovered the salts behave like a liquid at high temperatures, which avoids the brittle cracking responsible for the degradation of many solid materials.“I remember walking home over the Mass Ave bridge at 5 a.m. with all the morning runners going by me,” Halliday recalls. “That was the moment when I realized what this meant. Since then, it’s been about proving it works at larger scales. We’ve just been building the next scaled-up version, proving it still works, building a bigger version, proving that out, until we reach the ultimate goal of deploying this everywhere.”Today, Halliday is the co-founder and CEO of Mantel, a company building systems to capture carbon dioxide at large industrial sites of all types. Although a lot of people think the carbon capture industry is a dead end, Halliday doesn’t give up so easily, and he’s got a growing corpus of performance data to keep him encouraged.Mantel’s system can be added on to the machines of power stations and factories making cement, steel, paper and pulp, oil and gas, and more, reducing their carbon emissions by around 95 percent. Instead of being released into the atmosphere, the emitted CO2 is channeled into Mantel’s system, where the company’s salts are sprayed out from something that looks like a shower head. The CO2 diffuses through the molten salts in a reaction that can be reversed through further temperature increases, so the salts boil off pure CO2 that can be transported for use or stored underground.A key difference from other carbon capture methods that have struggled to be profitable is that Mantel uses the heat from its process to generate steam for customers by combining it with water in another part of its system. Mantel says delivering steam, which is used to drive many common industrial processes, lets its system work with just 3 percent of the net energy that state-of-the-art carbon capture systems require.“We’re still consuming energy, but we get most of it back as steam, whereas the incumbent technology only consumes steam,” says Halliday, who co-founded Mantel with Sean Robertson PhD ’22 and Danielle Rapson. “That steam is a useful revenue stream, so we can turn carbon capture from a waste management process into a value creation process for our customer’s core business — whether that’s a power station using steam to make electricity, or oil and gas refineries. It completely changes the economics of carbon capture.”From science to startupHalliday’s first exposure to MIT came in 2016 when he cold emailed Alan Hatton, MIT’s Ralph Landau Professor of Chemical Engineering Practice, asking if he could come to his lab for the summer and work on research into carbon capture.“He invited me, but he didn’t put me on that project,” Halliday recalls. “At the end of the summer he said, ‘You should consider coming back and doing a PhD.’”Halliday enrolled in a joint PhD-MBA program the following year.“I really wanted to work on something that had an impact,” Halliday says. “The dual PhD-MBA program has some deep technical academic elements to it, but you also work with a company for two months, so you use a lot of what you learn in the real world.”Halliday worked on a few different research projects in Hatton’s lab early on, all three of which eventually turned into companies. The one that he stuck with explored ways to make carbon capture more energy efficient by working at the high temperatures common at emissions-heavy industrial sites.Halliday ran into the same problems as past researchers with materials degrading at such extreme conditions.“It was the big limiter for the technology,” Halliday recalls.Then Halliday ran his successful experiment with molten borate salts in 2019. The MBA portion of his program began soon after, and Halliday decided to use that time to commercialize the technology. Part of that occurred in Course 15.366 (Climate and Energy Ventures), where Halliday met his co-founders. As it happens, alumni of the class have started more than 150 companies over the years.“MIT tries to pull these great ideas out of academia and get them into the world so they can be valued and used,” Halliday says. “For the Climate and Energy Ventures class, outside speakers showed us every stage of company-building. The technology roadmap for our system is shoebox-sized, shipping container, one-bedroom house, and then the size of a building. It was really valuable to see other companies and say, ‘That’s what we could look like in three years, or six years.”From startup to scale upWhen Mantel was officially founded in 2022 the founders had their shoebox-sized system. After raising early funding, the team built its shipping container-sized system at The Engine, an MIT-affiliated startup incubator. That system has been operational for almost two years.Last year, Mantel announced a partnership with Kruger Inc. to build the next version of its system at a factory in Quebec, which will be operational next year. The plant will run in a two-year test phase before scaling across Kruger’s other plants if successful.“The Quebec project is proving the capture efficiency and proving the step-change improvement in energy use of our system,” Halliday says. “It’s a derisking of the technology that will unlock a lot more opportunities.”Halliday says Mantel is in conversations with close to 100 industrial partners around the world, including the owners of refineries, data centers, cement and steel plants, and oil and gas companies. Because it’s a standalone addition, Halliday says Mantel’s system doesn’t have to change much to be used in different industries.Mantel doesn’t handle CO2 conversion or sequestration, but Halliday says capture makes up the bulk of the costs in the CO2 value chain. It also generates high-quality CO2 that can be transported in pipelines and used in industries including the food and beverage industry — like the CO2 that makes your soda bubbly.“This is the solution our customers are dreaming of,” Halliday says. “It means they don’t have to shut down their billion-dollar asset and reimagine their business to address an issue that they all appreciate is existential. There are questions about the timeline, but most industries recognize this is a problem they’ll have to grapple with eventually. This is a pragmatic solution that’s not trying to reshape the world as we dream of it. It’s looking at the problem at hand today and fixing it.” More

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    From nanoscale to global scale: Advancing MIT’s special initiatives in manufacturing, health, and climate

    “MIT.nano is essential to making progress in high-priority areas where I believe that MIT has a responsibility to lead,” opened MIT president Sally Kornbluth at the 2025 Nano Summit. “If we harness our collective efforts, we can make a serious positive impact.”It was these collective efforts that drove discussions at the daylong event hosted by MIT.nano and focused on the importance of nanoscience and nanotechnology across MIT’s special initiatives — projects deemed critical to MIT’s mission to help solve the world’s greatest challenges. With each new talk, common themes were reemphasized: collaboration across fields, solutions that can scale up from lab to market, and the use of nanoscale science to enact grand-scale change.“MIT.nano has truly set itself apart, in the Institute’s signature way, with an emphasis on cross-disciplinary collaboration and open access,” said Kornbluth. “Today, you’re going to hear about the transformative impact of nanoscience and nanotechnology, and how working with the very small can help us do big things for the world together.”Collaborating on healthAngela Koehler, faculty director of the MIT Health and Life Sciences Collaborative (MIT HEALS) and the Charles W. and Jennifer C. Johnson Professor of Biological Engineering, opened the first session with a question: How can we build a community across campus to tackle some of the most transformative problems in human health? In response, three speakers shared their work enabling new frontiers in medicine.Ana Jaklenec, principal research scientist at the Koch Institute for Integrative Cancer Research, spoke about single-injection vaccines, and how her team looked to the techniques used in fabrication of electrical engineering components to see how multiple pieces could be packaged into a tiny device. “MIT.nano was instrumental in helping us develop this technology,” she said. “We took something that you can do in microelectronics and the semiconductor industry and brought it to the pharmaceutical industry.”While Jaklenec applied insight from electronics to her work in health care, Giovanni Traverso, the Karl Van Tassel Career Development Professor of Mechanical Engineering, who is also a gastroenterologist at Brigham and Women’s Hospital, found inspiration in nature, studying the cephalopod squid and remora fish to design ingestible drug delivery systems. Representing the industry side of life sciences, Mirai Bio senior vice president Jagesh Shah SM ’95, PhD ’99 presented his company’s precision-targeted lipid nanoparticles for therapeutic delivery. Shah, as well as the other speakers, emphasized the importance of collaboration between industry and academia to make meaningful impact, and the need to strengthen the pipeline for young scientists.Manufacturing, from the classroom to the workforcePaving the way for future generations was similarly emphasized in the second session, which highlighted MIT’s Initiative for New Manufacturing (MIT INM). “MIT’s dedication to manufacturing is not only about technology research and education, it’s also about understanding the landscape of manufacturing, domestically and globally,” said INM co-director A. John Hart, the Class of 1922 Professor and head of the Department of Mechanical Engineering. “It’s about getting people — our graduates who are budding enthusiasts of manufacturing — out of campus and starting and scaling new companies,” he said.On progressing from lab to market, Dan Oran PhD ’21 shared his career trajectory from technician to PhD student to founding his own company, Irradiant Technologies. “How are companies like Dan’s making the move from the lab to prototype to pilot production to demonstration to commercialization?” asked the next speaker, Elisabeth Reynolds, professor of the practice in urban studies and planning at MIT. “The U.S. capital market has not historically been well organized for that kind of support.” She emphasized the challenge of scaling innovations from prototype to production, and the need for workforce development.“Attracting and retaining workforce is a major pain point for manufacturing businesses,” agreed John Liu, principal research scientist in mechanical engineering at MIT. To keep new ideas flowing from the classroom to the factory floor, Liu proposes a new worker type in advanced manufacturing — the technologist — someone who can be a bridge to connect the technicians and the engineers.Bridging ecosystems with nanoscienceBridging people, disciplines, and markets to affect meaningful change was also emphasized by Benedetto Marelli, mission director for the MIT Climate Project and associate professor of civil and environmental engineering at MIT.“If we’re going to have a tangible impact on the trajectory of climate change in the next 10 years, we cannot do it alone,” he said. “We need to take care of ecology, health, mobility, the built environment, food, energy, policies, and trade and industry — and think about these as interconnected topics.”Faculty speakers in this session offered a glimpse of nanoscale solutions for climate resiliency. Michael Strano, the Carbon P. Dubbs Professor of Chemical Engineering, presented his group’s work on using nanoparticles to turn waste methane and urea into renewable materials. Desirée Plata, the School of Engineering Distinguished Climate and Energy Professor, spoke about scaling carbon dioxide removal systems. Mechanical engineering professor Kripa Varanasi highlighted, among other projects, his lab’s work on improving agricultural spraying so pesticides adhere to crops, reducing agricultural pollution and cost.In all of these presentations, the MIT faculty highlighted the tie between climate and the economy. “The economic systems that we have today are depleting to our resources, inherently polluting,” emphasized Plata. “The goal here is to use sustainable design to transition the global economy.”What do people do at MIT.nano?This is where MIT.nano comes in, offering shared access facilities where researchers can design creative solutions to these global challenges. “What do people do at MIT.nano?” asked associate director for Fab.nano Jorg Scholvin ’00, MNG ’01, PhD ’06 in the session on MIT.nano’s ecosystem. With 1,500 individuals and over 20 percent of MIT faculty labs using MIT.nano, it’s a difficult question to quickly answer. However, in a rapid-fire research showcase, students and postdocs gave a response that spanned 3D transistors and quantum devices to solar solutions and art restoration. Their work reflects the challenges and opportunities shared at the Nano Summit: developing technologies ready to scale, uniting disciplines to tackle complex problems, and gaining hands-on experience that prepares them to contribute to the future of hard tech.The researchers’ enthusiasm carried the excitement and curiosity that President Kornbluth mentioned in her opening remarks, and that many faculty emphasized throughout the day. “The solutions to the problems we heard about today may come from inventions that don’t exist yet,” said Strano. “These are some of the most creative people, here at MIT. I think we inspire each other.”Robert N. Noyce (1953) Cleanroom at MIT.nanoCollaborative inspiration is not new to the MIT culture. The Nano Summit sessions focused on where we are today, and where we might be going in the future, but also reflected on how we arrived at this moment. Honoring visionaries of nanoscience and nanotechnology, President Emeritus L. Rafael Reif delivered the closing remarks and an exciting announcement — the dedication of the MIT.nano cleanroom complex. Made possible through a gift by Ray Stata SB ’57, SM ’58, this research space, 45,000 square feet of ISO 5, 6, and 7 cleanrooms, will be named the Robert N. Noyce (1953) Cleanroom.“Ray Stata was — and is — the driving force behind nanoscale research at MIT,” said Reif. “I want to thank Ray, whose generosity has allowed MIT to honor Robert Noyce in such a fitting way.”Ray Stata co-founded Analog Devices in 1965, and Noyce co-founded Fairchild Semiconductor in 1957, and later Intel in 1968. Noyce, widely regarded as the “Mayor of Silicon Valley,” became chair of the Semiconductor Industry Association in 1977, and over the next 40 years, semiconductor technology advanced a thousandfold, from micrometers to nanometers.“Noyce was a pioneer of the semiconductor industry,” said Stata. “It is due to his leadership and remarkable contributions that electronics technology is where it is today. It is an honor to be able to name the MIT.nano cleanroom after Bob Noyce, creating a permanent tribute to his vision and accomplishments in the heart of the MIT campus.”To conclude his remarks and the 2025 Nano Summit, Reif brought the nano journey back to today, highlighting technology giants such as Lisa Su ’90, SM ’91, PhD ’94, for whom Building 12, the home of MIT.nano, is named. “MIT has educated a large number of remarkable leaders in the semiconductor space,” said Reif. “Now, with the Robert Noyce Cleanroom, this amazing MIT community is ready to continue to shape the future with the next generation of nano discoveries — and the next generation of nano leaders, who will become living legends in their own time.” More

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    How to reduce greenhouse gas emissions from ammonia production

    Ammonia is one of the most widely produced chemicals in the world, used mostly as fertilizer, but also for the production of some plastics, textiles, and other applications. Its production, through processes that require high heat and pressure, accounts for up to 20 percent of all the greenhouse gases from the entire chemical industry, so efforts have been underway worldwide to find ways to reduce those emissions.Now, researchers at MIT have come up with a clever way of combining two different methods of producing the compound that minimizes waste products, that, when combined with some other simple upgrades, could reduce the greenhouse emissions from production by as much as 63 percent, compared to the leading “low-emissions” approach being used today.The new approach is described in the journal Energy & Fuels, in a paper by MIT Energy Initiative (MITEI) Director William H. Green, graduate student Sayandeep Biswas, MITEI Director of Research Randall Field, and two others.“Ammonia has the most carbon dioxide emissions of any kind of chemical,” says Green, who is the Hoyt C. Hottel Professor in Chemical Engineering. “It’s a very important chemical,” he says, because its use as a fertilizer is crucial to being able to feed the world’s population.Until late in the 19th century, the most widely used source of nitrogen fertilizer was mined deposits of bat or bird guano, mostly from Chile, but that source was beginning to run out, and there were predictions that the world would soon be running short of food to sustain the population. But then a new chemical process, called the Haber-Bosch process after its inventors, made it possible to make ammonia out of nitrogen from the air and hydrogen, which was mostly derived from methane. But both the burning of fossil fuels to provide the needed heat and the use of methane to make the hydrogen led to massive climate-warming emissions from the process.To address this, two newer variations of ammonia production have been developed: so-called “blue ammonia,” where the greenhouse gases are captured right at the factory and then sequestered deep underground, and “green ammonia,” produced by a different chemical pathway, using electricity instead of fossil fuels to hydrolyze water to make hydrogen.Blue ammonia is already beginning to be used, with a few plants operating now in Louisiana, Green says, and the ammonia mostly being shipped to Japan, “so that’s already kind of commercial.” Other parts of the world are starting to use green ammonia, especially in places that have lots of hydropower, solar, or wind to provide inexpensive electricity, including a giant plant now under construction in Saudi Arabia.But in most places, both blue and green ammonia are still more expensive than the traditional fossil-fuel-based version, so many teams around the world have been working on ways to cut these costs as much as possible so that the difference is small enough to be made up through tax subsidies or other incentives.The problem is growing, because as the population grows, and as wealth increases, there will be ever-increasing demands for nitrogen fertilizer. At the same time, ammonia is a promising substitute fuel to power hard-to-decarbonize transportation such as cargo ships and heavy trucks, which could lead to even greater needs for the chemical.“It definitely works” as a transportation fuel, by powering fuel cells that have been demonstrated for use by everything from drones to barges and tugboats and trucks, Green says. “People think that the most likely market of that type would be for shipping,” he says, “because the downside of ammonia is it’s toxic and it’s smelly, and that makes it slightly dangerous to handle and to ship around.” So its best uses may be where it’s used in high volume and in relatively remote locations, like the high seas. In fact, the International Maritime Organization will soon be voting on new rules that might give a strong boost to the ammonia alternative for shipping.The key to the new proposed system is to combine the two existing approaches in one facility, with a blue ammonia factory next to a green ammonia factory. The process of generating hydrogen for the green ammonia plant leaves a lot of leftover oxygen that just gets vented to the air. Blue ammonia, on the other hand, uses a process called autothermal reforming that requires a source of pure oxygen, so if there’s a green ammonia plant next door, it can use that excess oxygen.“Putting them next to each other turns out to have significant economic value,” Green says. This synergy could help hybrid “blue-green ammonia” facilities serve as an important bridge toward a future where eventually green ammonia, the cleanest version, could finally dominate. But that future is likely decades away, Green says, so having the combined plants could be an important step along the way.“It might be a really long time before [green ammonia] is actually attractive” economically, he says. “Right now, it’s nowhere close, except in very special situations.” But the combined plants “could be a really appealing concept, and maybe a good way to start the industry,” because so far only small, standalone demonstration plants of the green process are being built.“If green or blue ammonia is going to become the new way of making ammonia, you need to find ways to make it relatively affordable in a lot of countries, with whatever resources they’ve got,” he says. This new proposed combination, he says, “looks like a really good idea that can help push things along. Ultimately, there’s got to be a lot of green ammonia plants in a lot of places,” and starting out with the combined plants, which could be more affordable now, could help to make that happen. The team has filed for a patent on the process.Although the team did a detailed study of both the technology and the economics that show the system has great promise, Green points out that “no one has ever built one. We did the analysis, it looks good, but surely when people build the first one, they’ll find funny little things that need some attention,” such as details of how to start up or shut down the process. “I would say there’s plenty of additional work to do to make it a real industry.” But the results of this study, which shows the costs to be much more affordable than existing blue or green plants in isolation, “definitely encourages the possibility of people making the big investments that would be needed to really make this industry feasible.”This proposed integration of the two methods “improves efficiency, reduces greenhouse gas emissions, and lowers overall cost,” says Kevin van Geem, a professor in the Center for Sustainable Chemistry at Ghent University, who was not associated with this research. “The analysis is rigorous, with validated process models, transparent assumptions, and comparisons to literature benchmarks. By combining techno-economic analysis with emissions accounting, the work provides a credible and balanced view of the trade-offs.”He adds that, “given the scale of global ammonia production, such a reduction could have a highly impactful effect on decarbonizing one of the most emissions-intensive chemical industries.”The research team also included MIT postdoc Angiras Menon and MITEI research lead Guiyan Zang. The work was supported by IHI Japan through the MIT Energy Initiative and the Martin Family Society of Fellows for Sustainability.  More

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    MIT gears up to transform manufacturing

    “Manufacturing is the engine of society, and it is the backbone of robust, resilient economies,” says John Hart, head of MIT’s Department of Mechanical Engineering (MechE) and faculty co-director of the MIT Initiative for New Manufacturing (INM). “With manufacturing a lively topic in today’s news, there’s a renewed appreciation and understanding of the importance of manufacturing to innovation, to economic and national security, and to daily lives.”Launched this May, INM will “help create a transformation of manufacturing through new technology, through development of talent, and through an understanding of how to scale manufacturing in a way that enables imparts higher productivity and resilience, drives adoption of new technologies, and creates good jobs,” Hart says.INM is one of MIT’s strategic initiatives and builds on the successful three-year-old Manufacturing@MIT program. “It’s a recognition by MIT that manufacturing is an Institute-wide theme and an Institute-wide priority, and that manufacturing connects faculty and students across campus,” says Hart. Alongside Hart, INM’s faculty co-directors are Institute Professor Suzanne Berger and Chris Love, professor of chemical engineering.The initiative is pursuing four main themes: reimagining manufacturing technologies and systems, elevating the productivity and human experience of manufacturing, scaling up new manufacturing, and transforming the manufacturing base.Breaking manufacturing barriers for corporationsAmgen, Autodesk, Flex, GE Vernova, PTC, Sanofi, and Siemens are founding members of INM’s industry consortium. These industry partners will work closely with MIT faculty, researchers, and students across many aspects of manufacturing-related research, both in broad-scale initiatives and in particular areas of shared interests. Membership requires a minimum three-year commitment of $500,000 a year to manufacturing-related activities at MIT, including the INM membership fee of $275,000 per year, which supports several core activities that engage the industry members.One major thrust for INM industry collaboration is the deployment and adoption of AI and automation in manufacturing. This effort will include seed research projects at MIT, collaborative case studies, and shared strategy development.INM also offers companies participation in the MIT-wide New Manufacturing Research effort, which is studying the trajectories of specific manufacturing industries and examining cross-cutting themes such as technology and financing.Additionally, INM will concentrate on education for all professions in manufacturing, with alliances bringing together corporations, community colleges, government agencies, and other partners. “We’ll scale our curriculum to broader audiences, from aspiring manufacturing workers and aspiring production line supervisors all the way up to engineers and executives,” says Hart.In workforce training, INM will collaborate with companies broadly to help understand the challenges and frame its overall workforce agenda, and with individual firms on specific challenges, such as acquiring suitably prepared employees for a new factory.Importantly, industry partners will also engage directly with students. Founding member Flex, for instance, hosted MIT researchers and students at the Flex Institute of Technology in Sorocaba, Brazil, developing new solutions for electronics manufacturing.“History shows that you need to innovate in manufacturing alongside the innovation in products,” Hart comments. “At MIT, as more students take classes in manufacturing, they’ll think more about key manufacturing issues as they decide what research problems they want to solve, or what choices they make as they prototype their devices. The same is true for industry — companies that operate at the frontier of manufacturing, whether through internal capabilities or their supply chains, are positioned to be on the frontier of product innovation and overall growth.”“We’ll have an opportunity to bring manufacturing upstream to the early stage of research, designing new processes and new devices with scalability in mind,” he says.Additionally, MIT expects to open new manufacturing-related labs and to further broaden cooperation with industry at existing shared facilities, such as MIT.nano. Hart says that facilities will also invite tighter collaborations with corporations — not just providing advanced equipment, but working jointly on, say, new technologies for weaving textiles, or speeding up battery manufacturing.Homing in on the United StatesINM is a global project that brings a particular focus on the United States, which remains the world’s second-largest manufacturing economy, but has suffered a significant decline in manufacturing employment and innovation.One key to reversing this trend and reinvigorating the U.S. manufacturing base is advocacy for manufacturing’s critical role in society and the career opportunities it offers.“No one really disputes the importance of manufacturing,” Hart says. “But we need to elevate interest in manufacturing as a rewarding career, from the production workers to manufacturing engineers and leaders, through advocacy, education programs, and buy-in from industry, government, and academia.”MIT is in a unique position to convene industry, academic, and government stakeholders in manufacturing to work together on this vital issue, he points out.Moreover, in times of radical and rapid changes in manufacturing, “we need to focus on deploying new technologies into factories and supply chains,” Hart says. “Technology is not all of the solution, but for the U.S. to expand our manufacturing base, we need to do it with technology as a key enabler, embracing companies of all sizes, including small and medium enterprises.”“As AI becomes more capable, and automation becomes more flexible and more available, these are key building blocks upon which you can address manufacturing challenges,” he says. “AI and automation offer new accelerated ways to develop, deploy, and monitor production processes, which present a huge opportunity and, in some cases, a necessity.”“While manufacturing is always a combination of old technology, new technology, established practice, and new ways of thinking, digital technology gives manufacturers an opportunity to leapfrog competitors,” Hart says. “That’s very, very powerful for the U.S. and any company, or country, that aims to create differentiated capabilities.”Fortunately, in recent years, investors have increasingly bought into new manufacturing in the United States. “They see the opportunity to re-industrialize, to build the factories and production systems of the future,” Hart says.“That said, building new manufacturing is capital-intensive, and takes time,” he adds. “So that’s another area where it’s important to convene stakeholders and to think about how startups and growth-stage companies build their capital portfolios, how large industry can support an ecosystem of small businesses and young companies, and how to develop talent to support those growing companies.”All these concerns and opportunities in the manufacturing ecosystem play to MIT’s strengths. “MIT’s DNA of cross-disciplinary collaboration and working with industry can let us create a lot of impact,” Hart emphasizes. “We can understand the practical challenges. We can also explore breakthrough ideas in research and cultivate successful outcomes, all the way to new companies and partnerships. Sometimes those are seen as disparate approaches, but we like to bring them together.” More

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    Would you like that coffee with iron?

    Around the world, about 2 billion people suffer from iron deficiency, which can lead to anemia, impaired brain development in children, and increased infant mortality.To combat that problem, MIT researchers have come up with a new way to fortify foods and beverages with iron, using small crystalline particles. These particles, known as metal-organic frameworks, could be sprinkled on food, added to staple foods such as bread, or incorporated into drinks like coffee and tea.“We’re creating a solution that can be seamlessly added to staple foods across different regions,” says Ana Jaklenec, a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. “What’s considered a staple in Senegal isn’t the same as in India or the U.S., so our goal was to develop something that doesn’t react with the food itself. That way, we don’t have to reformulate for every context — it can be incorporated into a wide range of foods and beverages without compromise.”The particles designed in this study can also carry iodine, another critical nutrient. The particles could also be adapted to carry important minerals such as zinc, calcium, or magnesium.“We are very excited about this new approach and what we believe is a novel application of metal-organic frameworks to potentially advance nutrition, particularly in the developing world,” says Robert Langer, the David H. Koch Institute Professor at MIT and a member of the Koch Institute.Jaklenec and Langer are the senior authors of the study, which appears today in the journal Matter. MIT postdoc Xin Yang and Linzixuan (Rhoda) Zhang PhD ’24 are the lead authors of the paper.Iron stabilizationFood fortification can be a successful way to combat nutrient deficiencies, but this approach is often challenging because many nutrients are fragile and break down during storage or cooking. When iron is added to foods, it can react with other molecules in the food, giving the food a metallic taste.In previous work, Jaklenec’s lab has shown that encapsulating nutrients in polymers can protect them from breaking down or reacting with other molecules. In a small clinical trial, the researchers found that women who ate bread fortified with encapsulated iron were able to absorb the iron from the food.However, one drawback to this approach is that the polymer adds a lot of bulk to the material, limiting the amount of iron or other nutrients that end up in the food.“Encapsulating iron in polymers significantly improves its stability and reactivity, making it easier to add to food,” Jaklenec says. “But to be effective, it requires a substantial amount of polymer. That limits how much iron you can deliver in a typical serving, making it difficult to meet daily nutritional targets through fortified foods alone.”To overcome that challenge, Yang came up with a new idea: Instead of encapsulating iron in a polymer, they could use iron itself as a building block for a crystalline particle known as a metal-organic framework, or MOF (pronounced “moff”).MOFs consist of metal atoms joined by organic molecules called ligands to create a rigid, cage-like structure. Depending on the combination of metals and ligands chosen, they can be used for a wide variety of applications.“We thought maybe we could synthesize a metal-organic framework with food-grade ligands and food-grade micronutrients,” Yang says. “Metal-organic frameworks have very high porosity, so they can load a lot of cargo. That’s why we thought we could leverage this platform to make a new metal-organic framework that could be used in the food industry.”In this case, the researchers designed a MOF consisting of iron bound to a ligand called fumaric acid, which is often used as a food additive to enhance flavor or help preserve food.This structure prevents iron from reacting with polyphenols — compounds commonly found in foods such as whole grains and nuts, as well as coffee and tea. When iron does react with those compounds, it forms a metal polyphenol complex that cannot be absorbed by the body.The MOFs’ structure also allows them to remain stable until they reach an acidic environment, such as the stomach, where they break down and release their iron payload.Double-fortified saltsThe researchers also decided to include iodine in their MOF particle, which they call NuMOF. Iodized salt has been very successful at preventing iodine deficiency, and many efforts are now underway to create “double-fortified salts” that would also contain iron.Delivering these nutrients together has proven difficult because iron and iodine can react with each other, making each one less likely to be absorbed by the body. In this study, the MIT team showed that once they formed their iron-containing MOF particles, they could load them with iodine, in a way that the iron and iodine do not react with each other.In tests of the particles’ stability, the researchers found that the NuMOFs could withstand long-term storage, high heat and humidity, and boiling water.Throughout these tests, the particles maintained their structure. When the researchers then fed the particles to mice, they found that both iron and iodine became available in the bloodstream within several hours of the NuMOF consumption.The researchers are now working on launching a company that is developing coffee and other beverages fortified with iron and iodine. They also hope to continue working toward a double-fortified salt that could be consumed on its own or incorporated into staple food products.The research was partially supported by J-WAFS Fellowships for Water and Food Solutions.Other authors of the paper include Fangzheng Chen, Wenhao Gao, Zhiling Zheng, Tian Wang, Erika Yan Wang, Behnaz Eshaghi, and Sydney MacDonald. More

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    Confronting the AI/energy conundrum

    The explosive growth of AI-powered computing centers is creating an unprecedented surge in electricity demand that threatens to overwhelm power grids and derail climate goals. At the same time, artificial intelligence technologies could revolutionize energy systems, accelerating the transition to clean power.“We’re at a cusp of potentially gigantic change throughout the economy,” said William H. Green, director of the MIT Energy Initiative (MITEI) and Hoyt C. Hottel Professor in the MIT Department of Chemical Engineering, at MITEI’s Spring Symposium, “AI and energy: Peril and promise,” held on May 13. The event brought together experts from industry, academia, and government to explore solutions to what Green described as both “local problems with electric supply and meeting our clean energy targets” while seeking to “reap the benefits of AI without some of the harms.” The challenge of data center energy demand and potential benefits of AI to the energy transition is a research priority for MITEI.AI’s startling energy demandsFrom the start, the symposium highlighted sobering statistics about AI’s appetite for electricity. After decades of flat electricity demand in the United States, computing centers now consume approximately 4 percent of the nation’s electricity. Although there is great uncertainty, some projections suggest this demand could rise to 12-15 percent by 2030, largely driven by artificial intelligence applications.Vijay Gadepally, senior scientist at MIT’s Lincoln Laboratory, emphasized the scale of AI’s consumption. “The power required for sustaining some of these large models is doubling almost every three months,” he noted. “A single ChatGPT conversation uses as much electricity as charging your phone, and generating an image consumes about a bottle of water for cooling.”Facilities requiring 50 to 100 megawatts of power are emerging rapidly across the United States and globally, driven both by casual and institutional research needs relying on large language programs such as ChatGPT and Gemini. Gadepally cited congressional testimony by Sam Altman, CEO of OpenAI, highlighting how fundamental this relationship has become: “The cost of intelligence, the cost of AI, will converge to the cost of energy.”“The energy demands of AI are a significant challenge, but we also have an opportunity to harness these vast computational capabilities to contribute to climate change solutions,” said Evelyn Wang, MIT vice president for energy and climate and the former director at the Advanced Research Projects Agency-Energy (ARPA-E) at the U.S. Department of Energy.Wang also noted that innovations developed for AI and data centers — such as efficiency, cooling technologies, and clean-power solutions — could have broad applications beyond computing facilities themselves.Strategies for clean energy solutionsThe symposium explored multiple pathways to address the AI-energy challenge. Some panelists presented models suggesting that while artificial intelligence may increase emissions in the short term, its optimization capabilities could enable substantial emissions reductions after 2030 through more efficient power systems and accelerated clean technology development.Research shows regional variations in the cost of powering computing centers with clean electricity, according to Emre Gençer, co-founder and CEO of Sesame Sustainability and former MITEI principal research scientist. Gençer’s analysis revealed that the central United States offers considerably lower costs due to complementary solar and wind resources. However, achieving zero-emission power would require massive battery deployments — five to 10 times more than moderate carbon scenarios — driving costs two to three times higher.“If we want to do zero emissions with reliable power, we need technologies other than renewables and batteries, which will be too expensive,” Gençer said. He pointed to “long-duration storage technologies, small modular reactors, geothermal, or hybrid approaches” as necessary complements.Because of data center energy demand, there is renewed interest in nuclear power, noted Kathryn Biegel, manager of R&D and corporate strategy at Constellation Energy, adding that her company is restarting the reactor at the former Three Mile Island site, now called the “Crane Clean Energy Center,” to meet this demand. “The data center space has become a major, major priority for Constellation,” she said, emphasizing how their needs for both reliability and carbon-free electricity are reshaping the power industry.Can AI accelerate the energy transition?Artificial intelligence could dramatically improve power systems, according to Priya Donti, assistant professor and the Silverman Family Career Development Professor in MIT’s Department of Electrical Engineering and Computer Science and the Laboratory for Information and Decision Systems. She showcased how AI can accelerate power grid optimization by embedding physics-based constraints into neural networks, potentially solving complex power flow problems at “10 times, or even greater, speed compared to your traditional models.”AI is already reducing carbon emissions, according to examples shared by Antonia Gawel, global director of sustainability and partnerships at Google. Google Maps’ fuel-efficient routing feature has “helped to prevent more than 2.9 million metric tons of GHG [greenhouse gas] emissions reductions since launch, which is the equivalent of taking 650,000 fuel-based cars off the road for a year,” she said. Another Google research project uses artificial intelligence to help pilots avoid creating contrails, which represent about 1 percent of global warming impact.AI’s potential to speed materials discovery for power applications was highlighted by Rafael Gómez-Bombarelli, the Paul M. Cook Career Development Associate Professor in the MIT Department of Materials Science and Engineering. “AI-supervised models can be trained to go from structure to property,” he noted, enabling the development of materials crucial for both computing and efficiency.Securing growth with sustainabilityThroughout the symposium, participants grappled with balancing rapid AI deployment against environmental impacts. While AI training receives most attention, Dustin Demetriou, senior technical staff member in sustainability and data center innovation at IBM, quoted a World Economic Forum article that suggested that “80 percent of the environmental footprint is estimated to be due to inferencing.” Demetriou emphasized the need for efficiency across all artificial intelligence applications.Jevons’ paradox, where “efficiency gains tend to increase overall resource consumption rather than decrease it” is another factor to consider, cautioned Emma Strubell, the Raj Reddy Assistant Professor in the Language Technologies Institute in the School of Computer Science at Carnegie Mellon University. Strubell advocated for viewing computing center electricity as a limited resource requiring thoughtful allocation across different applications.Several presenters discussed novel approaches for integrating renewable sources with existing grid infrastructure, including potential hybrid solutions that combine clean installations with existing natural gas plants that have valuable grid connections already in place. These approaches could provide substantial clean capacity across the United States at reasonable costs while minimizing reliability impacts.Navigating the AI-energy paradoxThe symposium highlighted MIT’s central role in developing solutions to the AI-electricity challenge.Green spoke of a new MITEI program on computing centers, power, and computation that will operate alongside the comprehensive spread of MIT Climate Project research. “We’re going to try to tackle a very complicated problem all the way from the power sources through the actual algorithms that deliver value to the customers — in a way that’s going to be acceptable to all the stakeholders and really meet all the needs,” Green said.Participants in the symposium were polled about priorities for MIT’s research by Randall Field, MITEI director of research. The real-time results ranked “data center and grid integration issues” as the top priority, followed by “AI for accelerated discovery of advanced materials for energy.”In addition, attendees revealed that most view AI’s potential regarding power as a “promise,” rather than a “peril,” although a considerable portion remain uncertain about the ultimate impact. When asked about priorities in power supply for computing facilities, half of the respondents selected carbon intensity as their top concern, with reliability and cost following. More

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    “Each of us holds a piece of the solution”

    MIT has an unparalleled history of bringing together interdisciplinary teams to solve pressing problems — think of the development of radar during World War II, or leading the international coalition that cracked the code of the human genome — but the challenge of climate change could demand a scale of collaboration unlike any that’s come before at MIT.“Solving climate change is not just about new technologies or better models. It’s about forging new partnerships across campus and beyond — between scientists and economists, between architects and data scientists, between policymakers and physicists, between anthropologists and engineers, and more,” MIT Vice President for Energy and Climate Evelyn Wang told an energetic crowd of faculty, students, and staff on May 6. “Each of us holds a piece of the solution — but only together can we see the whole.”Undeterred by heavy rain, approximately 300 campus community members filled the atrium in the Tina and Hamid Moghadam Building (Building 55) for a spring gathering hosted by Wang and the Climate Project at MIT. The initiative seeks to direct the full strength of MIT to address climate change, which Wang described as one of the defining challenges of this moment in history — and one of its greatest opportunities.“It calls on us to rethink how we power our world, how we build, how we live — and how we work together,” Wang said. “And there is no better place than MIT to lead this kind of bold, integrated effort. Our culture of curiosity, rigor, and relentless experimentation makes us uniquely suited to cross boundaries — to break down silos and build something new.”The Climate Project is organized around six missions, thematic areas in which MIT aims to make significant impact, ranging from decarbonizing industry to new policy approaches to designing resilient cities. The faculty leaders of these missions posed challenges to the crowd before circulating among the crowd to share their perspectives and to discuss community questions and ideas.Wang and the Climate Project team were joined by a number of research groups, startups, and MIT offices conducting relevant work today on issues related to energy and climate. For example, the MIT Office of Sustainability showcased efforts to use the MIT campus as a living laboratory; MIT spinouts such as Forma Systems, which is developing high-performance, low-carbon building systems, and Addis Energy, which envisions using the earth as a reactor to produce clean ammonia, presented their technologies; and visitors learned about current projects in MIT labs, including DebunkBot, an artificial intelligence-powered chatbot that can persuade people to shift their attitudes about conspiracies, developed by David Rand, the Erwin H. Schell Professor at the MIT Sloan School of Management.Benedetto Marelli, an associate professor in the Department of Civil and Environmental Engineering who leads the Wild Cards Mission, said the energy and enthusiasm that filled the room was inspiring — but that the individual conversations were equally valuable.“I was especially pleased to see so many students come out. I also spoke with other faculty, talked to staff from across the Institute, and met representatives of external companies interested in collaborating with MIT,” Marelli said. “You could see connections being made all around the room, which is exactly what we need as we build momentum for the Climate Project.” More

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    Universal nanosensor unlocks the secrets to plant growth

    Researchers from the Disruptive and Sustainable Technologies for Agricultural Precision (DiSTAP) interdisciplinary research group within the Singapore-MIT Alliance for Research and Technology have developed the world’s first near-infrared fluorescent nanosensor capable of real-time, nondestructive, and species-agnostic detection of indole-3-acetic acid (IAA) — the primary bioactive auxin hormone that controls the way plants develop, grow, and respond to stress.Auxins, particularly IAA, play a central role in regulating key plant processes such as cell division, elongation, root and shoot development, and response to environmental cues like light, heat, and drought. External factors like light affect how auxin moves within the plant, temperature influences how much is produced, and a lack of water can disrupt hormone balance. When plants cannot effectively regulate auxins, they may not grow well, adapt to changing conditions, or produce as much food. Existing IAA detection methods, such as liquid chromatography, require taking plant samples from the plant — which harms or removes part of it. Conventional methods also measure the effects of IAA rather than detecting it directly, and cannot be used universally across different plant types. In addition, since IAA are small molecules that cannot be easily tracked in real time, biosensors that contain fluorescent proteins need to be inserted into the plant’s genome to measure auxin, making it emit a fluorescent signal for live imaging.SMART’s newly developed nanosensor enables direct, real-time tracking of auxin levels in living plants with high precision. The sensor uses near infrared imaging to monitor IAA fluctuations non-invasively across tissues like leaves, roots, and cotyledons, and it is capable of bypassing chlorophyll interference to ensure highly reliable readings even in densely pigmented tissues. The technology does not require genetic modification and can be integrated with existing agricultural systems — offering a scalable precision tool to advance both crop optimization and fundamental plant physiology research. By providing real-time, precise measurements of auxin, the sensor empowers farmers with earlier and more accurate insights into plant health. With these insights and comprehensive data, farmers can make smarter, data-driven decisions on irrigation, nutrient delivery, and pruning, tailored to the plant’s actual needs — ultimately improving crop growth, boosting stress resilience, and increasing yields.“We need new technologies to address the problems of food insecurity and climate change worldwide. Auxin is a central growth signal within living plants, and this work gives us a way to tap it to give new information to farmers and researchers,” says Michael Strano, co-lead principal investigator at DiSTAP, Carbon P. Dubbs Professor of Chemical Engineering at MIT, and co-corresponding author of the paper. “The applications are many, including early detection of plant stress, allowing for timely interventions to safeguard crops. For urban and indoor farms, where light, water, and nutrients are already tightly controlled, this sensor can be a valuable tool in fine-tuning growth conditions with even greater precision to optimize yield and sustainability.”The research team documented the nanosensor’s development in a paper titled, “A Near-Infrared Fluorescent Nanosensor for Direct and Real-Time Measurement of Indole-3-Acetic Acid in Plants,” published in the journal ACS Nano. The sensor comprises single-walled carbon nanotubes wrapped in a specially designed polymer, which enables it to detect IAA through changes in near infrared fluorescence intensity. Successfully tested across multiple species, including Arabidopsis, Nicotiana benthamiana, choy sum, and spinach, the nanosensor can map IAA responses under various environmental conditions such as shade, low light, and heat stress. “This sensor builds on DiSTAP’s ongoing work in nanotechnology and the CoPhMoRe technique, which has already been used to develop other sensors that can detect important plant compounds such as gibberellins and hydrogen peroxide. By adapting this approach for IAA, we’re adding to our inventory of novel, precise, and nondestructive tools for monitoring plant health. Eventually, these sensors can be multiplexed, or combined, to monitor a spectrum of plant growth markers for more complete insights into plant physiology,” says Duc Thinh Khong, research scientist at DiSTAP and co-first author of the paper.“This small but mighty nanosensor tackles a long-standing challenge in agriculture: the need for a universal, real-time, and noninvasive tool to monitor plant health across various species. Our collaborative achievement not only empowers researchers and farmers to optimize growth conditions and improve crop yield and resilience, but also advances our scientific understanding of hormone pathways and plant-environment interactions,” says In-Cheol Jang, senior principal investigator at TLL, principal investigator at DiSTAP, and co-corresponding author of the paper.Looking ahead, the research team is looking to combine multiple sensing platforms to simultaneously detect IAA and its related metabolites to create a comprehensive hormone signaling profile, offering deeper insights into plant stress responses and enhancing precision agriculture. They are also working on using microneedles for highly localized, tissue-specific sensing, and collaborating with industrial urban farming partners to translate the technology into practical, field-ready solutions. The research was carried out by SMART, and supported by the National Research Foundation of Singapore under its Campus for Research Excellence And Technological Enterprise program. More