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      Scientists chart how exercise affects the body

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      Exercise is well-known to help people lose weight and avoid gaining it. However, identifying the cellular mechanisms that underlie this process has proven difficult because so many cells and tissues are involved.

      In a new study in mice that expands researchers’ understanding of how exercise and diet affect the body, MIT and Harvard Medical School researchers have mapped out many of the cells, genes, and cellular pathways that are modified by exercise or high-fat diet. The findings could offer potential targets for drugs that could help to enhance or mimic the benefits of exercise, the researchers say.

      “It is extremely important to understand the molecular mechanisms that are drivers of the beneficial effects of exercise and the detrimental effects of a high-fat diet, so that we can understand how we can intervene, and develop drugs that mimic the impact of exercise across multiple tissues,” says Manolis Kellis, a professor of computer science in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and a member of the Broad Institute of MIT and Harvard.

      The researchers studied mice with high-fat or normal diets, who were either sedentary or given the opportunity to exercise whenever they wanted. Using single-cell RNA sequencing, the researchers cataloged the responses of 53 types of cells found in skeletal muscle and two types of fatty tissue.

      “One of the general points that we found in our study, which is overwhelmingly clear, is how high-fat diets push all of these cells and systems in one way, and exercise seems to be pushing them nearly all in the opposite way,” Kellis says. “It says that exercise can really have a major effect throughout the body.”

      Kellis and Laurie Goodyear, a professor of medicine at Harvard Medical School and senior investigator at the Joslin Diabetes Center, are the senior authors of the study, which appears today in the journal Cell Metabolism. Jiekun Yang, a research scientist in MIT CSAIL; Maria Vamvini, an instructor of medicine at the Joslin Diabetes Center; and Pasquale Nigro, an instructor of medicine at the Joslin Diabetes Center, are the lead authors of the paper.

      The risks of obesity

      Obesity is a growing health problem around the world. In the United States, more than 40 percent of the population is considered obese, and nearly 75 percent is overweight. Being overweight is a risk factor for many diseases, including heart disease, cancer, Alzheimer’s disease, and even infectious diseases such as Covid-19.

      “Obesity, along with aging, is a global factor that contributes to every aspect of human health,” Kellis says.

      Several years ago, his lab performed a study on the FTO gene region, which has been strongly linked to obesity risk. In that 2015 study, the research team found that genes in this region control a pathway that prompts immature fat cells called progenitor adipocytes to either become fat-burning cells or fat-storing cells.

      That finding, which demonstrated a clear genetic component to obesity, motivated Kellis to begin looking at how exercise, a well-known behavioral intervention that can prevent obesity, might act on progenitor adipocytes at the cellular level.

      To explore that question, Kellis and his colleagues decided to perform single-cell RNA sequencing of three types of tissue — skeletal muscle, visceral white adipose tissue (found packed around internal organs, where it stores fat), and subcutaneous white adipose tissue (which is found under the skin and primarily burns fat).

      These tissues came from mice from four different experimental groups. For three weeks, two groups of mice were fed either a normal diet or a high-fat diet. For the next three weeks, each of those two groups were further divided into a sedentary group and an exercise group, which had continuous access to a treadmill.

      By analyzing tissues from those mice, the researchers were able to comprehensively catalog the genes that were activated or suppressed by exercise in 53 different cell types.

      The researchers found that in all three tissue types, mesenchymal stem cells (MSCs) appeared to control many of the diet and exercise-induced effects that they observed. MSCs are stem cells that can differentiate into other cell types, including fat cells and fibroblasts. In adipose tissue, the researchers found that a high-fat diet modulated MSCs’ capacity to differentiate into fat-storing cells, while exercise reversed this effect.

      In addition to promoting fat storage, the researchers found that a high-fat diet also stimulated MSCs to secrete factors that remodel the extracellular matrix (ECM) — a network of proteins and other molecules that surround and support cells and tissues in the body. This ECM remodeling helps provide structure for enlarged fat-storing cells and also creates a more inflammatory environment.

      “As the adipocytes become overloaded with lipids, there’s an extreme amount of stress, and that causes low-grade inflammation, which is systemic and preserved for a long time,” Kellis says. “That is one of the factors that is contributing to many of the adverse effects of obesity.”

      Circadian effects

      The researchers also found that high-fat diets and exercise had opposing effects on cellular pathways that control circadian rhythms — the 24-hour cycles that govern many functions, from sleep to body temperature, hormone release, and digestion. The study revealed that exercise boosts the expression of genes that regulate these rhythms, while a high-fat diet suppresses them.

      “There have been a lot of studies showing that when you eat during the day is extremely important in how you absorb the calories,” Kellis says. “The circadian rhythm connection is a very important one, and shows how obesity and exercise are in fact directly impacting that circadian rhythm in peripheral organs, which could act systemically on distal clocks and regulate stem cell functions and immunity.”

      The researchers then compared their results to a database of human genes that have been linked with metabolic traits. They found that two of the circadian rhythm genes they identified in this study, known as DBP and CDKN1A, have genetic variants that have been associated with a higher risk of obesity in humans.

      “These results help us see the translational values of these targets, and how we could potentially target specific biological processes in specific cell types,” Yang says.

      The researchers are now analyzing samples of small intestine, liver, and brain tissue from the mice in this study, to explore the effects of exercise and high-fat diets on those tissues. They are also conducting work with human volunteers to sample blood and biopsies and study similarities and differences between human and mouse physiology. They hope that their findings will help guide drug developers in designing drugs that might mimic some of the beneficial effects of exercise.

      “The message for everyone should be, eat a healthy diet and exercise if possible,” Kellis says. “For those for whom this is not possible, due to low access to healthy foods, or due to disabilities or other factors that prevent exercise, or simply lack of time to have a healthy diet or a healthy lifestyle, what this study says is that we now have a better handle on the pathways, the specific genes, and the specific molecular and cellular processes that we should be manipulating therapeutically.”

      The research was funded by the National Institutes of Health and the Novo Nordisk Research Center in Seattle. More

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      MIT students contribute to success of historic fusion experiment

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      For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition in a laboratory, a grand challenge of the 21st century. The High-Energy-Density Physics (HEDP) group at MIT’s Plasma Science and Fusion Center has focused on an approach called inertial confinement fusion (ICF), which uses lasers to implode a pellet of fuel in a quest for ignition. This group, including nine former and current MIT students, was crucial to an historic ICF ignition experiment performed in 2021; the results were published on the anniversary of that success.

      On Aug. 8, 2021, researchers at the National Ignition Facility (NIF), Lawrence Livermore National Laboratory (LLNL), used 192 laser beams to illuminate the inside of a tiny gold cylinder encapsulating a spherical capsule filled with deuterium-tritium fuel in their quest to produce significant fusion energy. Although researchers had followed this process many times before, using different parameters, this time the ensuing implosion produced an historic fusion yield of 1.37 megaJoules, as measured by a suite of neutron diagnostics. These included the MIT-developed and analyzed Magnetic Recoil Spectrometer (MRS). This result was published in Physical Review Letters on Aug. 8, the one-year anniversary of the ground-breaking development, unequivocally indicating that the first controlled fusion experiment reached ignition.

      Governed by the Lawson criterion, a plasma ignites when the internal fusion heating power is high enough to overcome the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop that very rapidly increases the plasma temperature. In the case of ICF, ignition is a state where the fusion plasma can initiate a “fuel burn propagation” into the surrounding dense and cold fuel, enabling the possibility of high fusion-energy gain.

      “This historic result certainly demonstrates that the ignition threshold is a real concept, with well-predicted theoretical calculations, and that a fusion plasma can be ignited in a laboratory” says HEDP Division Head Johan Frenje.

      The HEDP division has contributed to the success of the ignition program at the NIF for more than a decade by providing and using a dozen diagnostics, implemented by MIT PhD students and staff, which have been critical for assessing the performance of an implosion. The hundreds of co-authors on the paper attest to the collaborative effort that went into this milestone. MIT’s contributors included the only student co-authors.

      “The students are responsible for implementing and using a diagnostic to obtain data important to the ICF program at the NIF, says Frenje. “Being responsible for running a diagnostic at the NIF has allowed them to actively participate in the scientific dialog and thus get directly exposed to cutting-edge science.”

      Students involved from the MIT Department of Physics were Neel Kabadi, Graeme Sutcliffe, Tim Johnson, Jacob Pearcy, and Ben Reichelt; students from the Department of Nuclear Science and Engineering included Brandon Lahmann, Patrick Adrian, and Justin Kunimune.

      In addition, former student Alex Zylstra PhD ’15, now a physicist at LLNL, was the experimental lead of this record implosion experiment. More

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      in Energy

      Taking a magnifying glass to data center operations

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      When the MIT Lincoln Laboratory Supercomputing Center (LLSC) unveiled its TX-GAIA supercomputer in 2019, it provided the MIT community a powerful new resource for applying artificial intelligence to their research. Anyone at MIT can submit a job to the system, which churns through trillions of operations per second to train models for diverse applications, such as spotting tumors in medical images, discovering new drugs, or modeling climate effects. But with this great power comes the great responsibility of managing and operating it in a sustainable manner — and the team is looking for ways to improve.

      “We have these powerful computational tools that let researchers build intricate models to solve problems, but they can essentially be used as black boxes. What gets lost in there is whether we are actually using the hardware as effectively as we can,” says Siddharth Samsi, a research scientist in the LLSC. 

      To gain insight into this challenge, the LLSC has been collecting detailed data on TX-GAIA usage over the past year. More than a million user jobs later, the team has released the dataset open source to the computing community.

      Their goal is to empower computer scientists and data center operators to better understand avenues for data center optimization — an important task as processing needs continue to grow. They also see potential for leveraging AI in the data center itself, by using the data to develop models for predicting failure points, optimizing job scheduling, and improving energy efficiency. While cloud providers are actively working on optimizing their data centers, they do not often make their data or models available for the broader high-performance computing (HPC) community to leverage. The release of this dataset and associated code seeks to fill this space.

      “Data centers are changing. We have an explosion of hardware platforms, the types of workloads are evolving, and the types of people who are using data centers is changing,” says Vijay Gadepally, a senior researcher at the LLSC. “Until now, there hasn’t been a great way to analyze the impact to data centers. We see this research and dataset as a big step toward coming up with a principled approach to understanding how these variables interact with each other and then applying AI for insights and improvements.”

      Papers describing the dataset and potential applications have been accepted to a number of venues, including the IEEE International Symposium on High-Performance Computer Architecture, the IEEE International Parallel and Distributed Processing Symposium, the Annual Conference of the North American Chapter of the Association for Computational Linguistics, the IEEE High-Performance and Embedded Computing Conference, and International Conference for High Performance Computing, Networking, Storage and Analysis. 

      Workload classification

      Among the world’s TOP500 supercomputers, TX-GAIA combines traditional computing hardware (central processing units, or CPUs) with nearly 900 graphics processing unit (GPU) accelerators. These NVIDIA GPUs are specialized for deep learning, the class of AI that has given rise to speech recognition and computer vision.

      The dataset covers CPU, GPU, and memory usage by job; scheduling logs; and physical monitoring data. Compared to similar datasets, such as those from Google and Microsoft, the LLSC dataset offers “labeled data, a variety of known AI workloads, and more detailed time series data compared with prior datasets. To our knowledge, it’s one of the most comprehensive and fine-grained datasets available,” Gadepally says. 

      Notably, the team collected time-series data at an unprecedented level of detail: 100-millisecond intervals on every GPU and 10-second intervals on every CPU, as the machines processed more than 3,000 known deep-learning jobs. One of the first goals is to use this labeled dataset to characterize the workloads that different types of deep-learning jobs place on the system. This process would extract features that reveal differences in how the hardware processes natural language models versus image classification or materials design models, for example.   

      The team has now launched the MIT Datacenter Challenge to mobilize this research. The challenge invites researchers to use AI techniques to identify with 95 percent accuracy the type of job that was run, using their labeled time-series data as ground truth.

      Such insights could enable data centers to better match a user’s job request with the hardware best suited for it, potentially conserving energy and improving system performance. Classifying workloads could also allow operators to quickly notice discrepancies resulting from hardware failures, inefficient data access patterns, or unauthorized usage.

      Too many choices

      Today, the LLSC offers tools that let users submit their job and select the processors they want to use, “but it’s a lot of guesswork on the part of users,” Samsi says. “Somebody might want to use the latest GPU, but maybe their computation doesn’t actually need it and they could get just as impressive results on CPUs, or lower-powered machines.”

      Professor Devesh Tiwari at Northeastern University is working with the LLSC team to develop techniques that can help users match their workloads to appropriate hardware. Tiwari explains that the emergence of different types of AI accelerators, GPUs, and CPUs has left users suffering from too many choices. Without the right tools to take advantage of this heterogeneity, they are missing out on the benefits: better performance, lower costs, and greater productivity.

      “We are fixing this very capability gap — making users more productive and helping users do science better and faster without worrying about managing heterogeneous hardware,” says Tiwari. “My PhD student, Baolin Li, is building new capabilities and tools to help HPC users leverage heterogeneity near-optimally without user intervention, using techniques grounded in Bayesian optimization and other learning-based optimization methods. But, this is just the beginning. We are looking into ways to introduce heterogeneity in our data centers in a principled approach to help our users achieve the maximum advantage of heterogeneity autonomously and cost-effectively.”

      Workload classification is the first of many problems to be posed through the Datacenter Challenge. Others include developing AI techniques to predict job failures, conserve energy, or create job scheduling approaches that improve data center cooling efficiencies.

      Energy conservation 

      To mobilize research into greener computing, the team is also planning to release an environmental dataset of TX-GAIA operations, containing rack temperature, power consumption, and other relevant data.

      According to the researchers, huge opportunities exist to improve the power efficiency of HPC systems being used for AI processing. As one example, recent work in the LLSC determined that simple hardware tuning, such as limiting the amount of power an individual GPU can draw, could reduce the energy cost of training an AI model by 20 percent, with only modest increases in computing time. “This reduction translates to approximately an entire week’s worth of household energy for a mere three-hour time increase,” Gadepally says.

      They have also been developing techniques to predict model accuracy, so that users can quickly terminate experiments that are unlikely to yield meaningful results, saving energy. The Datacenter Challenge will share relevant data to enable researchers to explore other opportunities to conserve energy.

      The team expects that lessons learned from this research can be applied to the thousands of data centers operated by the U.S. Department of Defense. The U.S. Air Force is a sponsor of this work, which is being conducted under the USAF-MIT AI Accelerator.

      Other collaborators include researchers at MIT Computer Science and Artificial Intelligence Laboratory (CSAIL). Professor Charles Leiserson’s Supertech Research Group is investigating performance-enhancing techniques for parallel computing, and research scientist Neil Thompson is designing studies on ways to nudge data center users toward climate-friendly behavior.

      Samsi presented this work at the inaugural AI for Datacenter Optimization (ADOPT’22) workshop last spring as part of the IEEE International Parallel and Distributed Processing Symposium. The workshop officially introduced their Datacenter Challenge to the HPC community.

      “We hope this research will allow us and others who run supercomputing centers to be more responsive to user needs while also reducing the energy consumption at the center level,” Samsi says. More

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      New hardware offers faster computation for artificial intelligence, with much less energy

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      As scientists push the boundaries of machine learning, the amount of time, energy, and money required to train increasingly complex neural network models is skyrocketing. A new area of artificial intelligence called analog deep learning promises faster computation with a fraction of the energy usage.

      Programmable resistors are the key building blocks in analog deep learning, just like transistors are the core elements for digital processors. By repeating arrays of programmable resistors in complex layers, researchers can create a network of analog artificial “neurons” and “synapses” that execute computations just like a digital neural network. This network can then be trained to achieve complex AI tasks like image recognition and natural language processing.

      A multidisciplinary team of MIT researchers set out to push the speed limits of a type of human-made analog synapse that they had previously developed. They utilized a practical inorganic material in the fabrication process that enables their devices to run 1 million times faster than previous versions, which is also about 1 million times faster than the synapses in the human brain.

      Moreover, this inorganic material also makes the resistor extremely energy-efficient. Unlike materials used in the earlier version of their device, the new material is compatible with silicon fabrication techniques. This change has enabled fabricating devices at the nanometer scale and could pave the way for integration into commercial computing hardware for deep-learning applications.

      “With that key insight, and the very powerful nanofabrication techniques we have at MIT.nano, we have been able to put these pieces together and demonstrate that these devices are intrinsically very fast and operate with reasonable voltages,” says senior author Jesús A. del Alamo, the Donner Professor in MIT’s Department of Electrical Engineering and Computer Science (EECS). “This work has really put these devices at a point where they now look really promising for future applications.”

      “The working mechanism of the device is electrochemical insertion of the smallest ion, the proton, into an insulating oxide to modulate its electronic conductivity. Because we are working with very thin devices, we could accelerate the motion of this ion by using a strong electric field, and push these ionic devices to the nanosecond operation regime,” explains senior author Bilge Yildiz, the Breene M. Kerr Professor in the departments of Nuclear Science and Engineering and Materials Science and Engineering.

      “The action potential in biological cells rises and falls with a timescale of milliseconds, since the voltage difference of about 0.1 volt is constrained by the stability of water,” says senior author Ju Li, the Battelle Energy Alliance Professor of Nuclear Science and Engineering and professor of materials science and engineering, “Here we apply up to 10 volts across a special solid glass film of nanoscale thickness that conducts protons, without permanently damaging it. And the stronger the field, the faster the ionic devices.”

      These programmable resistors vastly increase the speed at which a neural network is trained, while drastically reducing the cost and energy to perform that training. This could help scientists develop deep learning models much more quickly, which could then be applied in uses like self-driving cars, fraud detection, or medical image analysis.

      “Once you have an analog processor, you will no longer be training networks everyone else is working on. You will be training networks with unprecedented complexities that no one else can afford to, and therefore vastly outperform them all. In other words, this is not a faster car, this is a spacecraft,” adds lead author and MIT postdoc Murat Onen.

      Co-authors include Frances M. Ross, the Ellen Swallow Richards Professor in the Department of Materials Science and Engineering; postdocs Nicolas Emond and Baoming Wang; and Difei Zhang, an EECS graduate student. The research is published today in Science.

      Accelerating deep learning

      Analog deep learning is faster and more energy-efficient than its digital counterpart for two main reasons. “First, computation is performed in memory, so enormous loads of data are not transferred back and forth from memory to a processor.” Analog processors also conduct operations in parallel. If the matrix size expands, an analog processor doesn’t need more time to complete new operations because all computation occurs simultaneously.

      The key element of MIT’s new analog processor technology is known as a protonic programmable resistor. These resistors, which are measured in nanometers (one nanometer is one billionth of a meter), are arranged in an array, like a chess board.

      In the human brain, learning happens due to the strengthening and weakening of connections between neurons, called synapses. Deep neural networks have long adopted this strategy, where the network weights are programmed through training algorithms. In the case of this new processor, increasing and decreasing the electrical conductance of protonic resistors enables analog machine learning.

      The conductance is controlled by the movement of protons. To increase the conductance, more protons are pushed into a channel in the resistor, while to decrease conductance protons are taken out. This is accomplished using an electrolyte (similar to that of a battery) that conducts protons but blocks electrons.

      To develop a super-fast and highly energy efficient programmable protonic resistor, the researchers looked to different materials for the electrolyte. While other devices used organic compounds, Onen focused on inorganic phosphosilicate glass (PSG).

      PSG is basically silicon dioxide, which is the powdery desiccant material found in tiny bags that come in the box with new furniture to remove moisture. It is studied as a proton conductor under humidified conditions for fuel cells. It is also the most well-known oxide used in silicon processing. To make PSG, a tiny bit of phosphorus is added to the silicon to give it special characteristics for proton conduction.

      Onen hypothesized that an optimized PSG could have a high proton conductivity at room temperature without the need for water, which would make it an ideal solid electrolyte for this application. He was right.

      Surprising speed

      PSG enables ultrafast proton movement because it contains a multitude of nanometer-sized pores whose surfaces provide paths for proton diffusion. It can also withstand very strong, pulsed electric fields. This is critical, Onen explains, because applying more voltage to the device enables protons to move at blinding speeds.

      “The speed certainly was surprising. Normally, we would not apply such extreme fields across devices, in order to not turn them into ash. But instead, protons ended up shuttling at immense speeds across the device stack, specifically a million times faster compared to what we had before. And this movement doesn’t damage anything, thanks to the small size and low mass of protons. It is almost like teleporting,” he says.

      “The nanosecond timescale means we are close to the ballistic or even quantum tunneling regime for the proton, under such an extreme field,” adds Li.

      Because the protons don’t damage the material, the resistor can run for millions of cycles without breaking down. This new electrolyte enabled a programmable protonic resistor that is a million times faster than their previous device and can operate effectively at room temperature, which is important for incorporating it into computing hardware.

      Thanks to the insulating properties of PSG, almost no electric current passes through the material as protons move. This makes the device extremely energy efficient, Onen adds.

      Now that they have demonstrated the effectiveness of these programmable resistors, the researchers plan to reengineer them for high-volume manufacturing, says del Alamo. Then they can study the properties of resistor arrays and scale them up so they can be embedded into systems.

      At the same time, they plan to study the materials to remove bottlenecks that limit the voltage that is required to efficiently transfer the protons to, through, and from the electrolyte.

      “Another exciting direction that these ionic devices can enable is energy-efficient hardware to emulate the neural circuits and synaptic plasticity rules that are deduced in neuroscience, beyond analog deep neural networks. We have already started such a collaboration with neuroscience, supported by the MIT Quest for Intelligence,” adds Yildiz.

      “The collaboration that we have is going to be essential to innovate in the future. The path forward is still going to be very challenging, but at the same time it is very exciting,” del Alamo says.

      “Intercalation reactions such as those found in lithium-ion batteries have been explored extensively for memory devices. This work demonstrates that proton-based memory devices deliver impressive and surprising switching speed and endurance,” says William Chueh, associate professor of materials science and engineering at Stanford University, who was not involved with this research. “It lays the foundation for a new class of memory devices for powering deep learning algorithms.”

      “This work demonstrates a significant breakthrough in biologically inspired resistive-memory devices. These all-solid-state protonic devices are based on exquisite atomic-scale control of protons, similar to biological synapses but at orders of magnitude faster rates,” says Elizabeth Dickey, the Teddy & Wilton Hawkins Distinguished Professor and head of the Department of Materials Science and Engineering at Carnegie Mellon University, who was not involved with this work. “I commend the interdisciplinary MIT team for this exciting development, which will enable future-generation computational devices.”

      This research is funded, in part, by the MIT-IBM Watson AI Lab. More

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      in Energy

      How the universe got its magnetic field

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      When we look out into space, all of the astrophysical objects that we see are embedded in magnetic fields. This is true not only in the neighborhood of stars and planets, but also in the deep space between galaxies and galactic clusters. These fields are weak — typically much weaker than those of a refrigerator magnet — but they are dynamically significant in the sense that they have profound effects on the dynamics of the universe. Despite decades of intense interest and research, the origin of these cosmic magnetic fields remains one of the most profound mysteries in cosmology.

      In previous research, scientists came to understand how turbulence, the churning motion common to fluids of all types, could amplify preexisting magnetic fields through the so-called dynamo process. But this remarkable discovery just pushed the mystery one step deeper. If a turbulent dynamo could only amplify an existing field, where did the “seed” magnetic field come from in the first place?

      We wouldn’t have a complete and self-consistent answer to the origin of astrophysical magnetic fields until we understood how the seed fields arose. New work carried out by MIT graduate student Muni Zhou, her advisor Nuno Loureiro, a professor of nuclear science and engineering at MIT, and colleagues at Princeton University and the University of Colorado at Boulder provides an answer that shows the basic processes that generate a field from a completely unmagnetized state to the point where it is strong enough for the dynamo mechanism to take over and amplify the field to the magnitudes that we observe.

      Magnetic fields are everywhere

      Naturally occurring magnetic fields are seen everywhere in the universe. They were first observed on Earth thousands of years ago, through their interaction with magnetized minerals like lodestone, and used for navigation long before people had any understanding of their nature or origin. Magnetism on the sun was discovered at the beginning of the 20th century by its effects on the spectrum of light that the sun emitted. Since then, more powerful telescopes looking deep into space found that the fields were ubiquitous.

      And while scientists had long learned how to make and use permanent magnets and electromagnets, which had all sorts of practical applications, the natural origins of magnetic fields in the universe remained a mystery. Recent work has provided part of the answer, but many aspects of this question are still under debate.

      Amplifying magnetic fields — the dynamo effect

      Scientists started thinking about this problem by considering the way that electric and magnetic fields were produced in the laboratory. When conductors, like copper wire, move in magnetic fields, electric fields are created. These fields, or voltages, can then drive electrical currents. This is how the electricity that we use every day is produced. Through this process of induction, large generators or “dynamos” convert mechanical energy into the electromagnetic energy that powers our homes and offices. A key feature of dynamos is that they need magnetic fields in order to work.

      But out in the universe, there are no obvious wires or big steel structures, so how do the fields arise? Progress on this problem began about a century ago as scientists pondered the source of the Earth’s magnetic field. By then, studies of the propagation of seismic waves showed that much of the Earth, below the cooler surface layers of the mantle, was liquid, and that there was a core composed of molten nickel and iron. Researchers theorized that the convective motion of this hot, electrically conductive liquid and the rotation of the Earth combined in some way to generate the Earth’s field.

      Eventually, models emerged that showed how the convective motion could amplify an existing field. This is an example of “self-organization” — a feature often seen in complex dynamical systems — where large-scale structures grow spontaneously from small-scale dynamics. But just like in a power station, you needed a magnetic field to make a magnetic field.

      A similar process is at work all over the universe. However, in stars and galaxies and in the space between them, the electrically conducting fluid is not molten metal, but plasma — a state of matter that exists at extremely high temperatures where the electrons are ripped away from their atoms. On Earth, plasmas can be seen in lightning or neon lights. In such a medium, the dynamo effect can amplify an existing magnetic field, provided it starts at some minimal level.

      Making the first magnetic fields

      Where does this seed field come from? That’s where the recent work of Zhou and her colleagues, published May 5 in PNAS, comes in. Zhou developed the underlying theory and performed numerical simulations on powerful supercomputers that show how the seed field can be produced and what fundamental processes are at work. An important aspect of the plasma that exists between stars and galaxies is that it is extraordinarily diffuse — typically about one particle per cubic meter. That is a very different situation from the interior of stars, where the particle density is about 30 orders of magnitude higher. The low densities mean that the particles in cosmological plasmas never collide, which has important effects on their behavior that had to be included in the model that these researchers were developing.   

      Calculations performed by the MIT researchers followed the dynamics in these plasmas, which developed from well-ordered waves but became turbulent as the amplitude grew and the interactions became strongly nonlinear. By including detailed effects of the plasma dynamics at small scales on macroscopic astrophysical processes, they demonstrated that the first magnetic fields can be spontaneously produced through generic large-scale motions as simple as sheared flows. Just like the terrestrial examples, mechanical energy was converted into magnetic energy.

      An important output of their computation was the amplitude of the expected spontaneously generated magnetic field. What this showed was that the field amplitude could rise from zero to a level where the plasma is “magnetized” — that is, where the plasma dynamics are strongly affected by the presence of the field. At this point, the traditional dynamo mechanism can take over and raise the fields to the levels that are observed. Thus, their work represents a self-consistent model for the generation of magnetic fields at cosmological scale.

      Professor Ellen Zweibel of the University of Wisconsin at Madison notes that “despite decades of remarkable progress in cosmology, the origin of magnetic fields in the universe remains unknown. It is wonderful to see state-of-the-art plasma physics theory and numerical simulation brought to bear on this fundamental problem.”

      Zhou and co-workers will continue to refine their model and study the handoff from the generation of the seed field to the amplification phase of the dynamo. An important part of their future research will be to determine if the process can work on a time scale consistent with astronomical observations. To quote the researchers, “This work provides the first step in the building of a new paradigm for understanding magnetogenesis in the universe.”

      This work was funded by the National Science Foundation CAREER Award and the Future Investigators of NASA Earth and Space Science Technology (FINESST) grant. More

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      in Energy

      MIT expands research collaboration with Commonwealth Fusion Systems to build net energy fusion machine, SPARC

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      MIT’s Plasma Science and Fusion Center (PSFC) will substantially expand its fusion energy research and education activities under a new five-year agreement with Institute spinout Commonwealth Fusion Systems (CFS).

      “This expanded relationship puts MIT and PSFC in a prime position to be an even stronger academic leader that can help deliver the research and education needs of the burgeoning fusion energy industry, in part by utilizing the world’s first burning plasma and net energy fusion machine, SPARC,” says PSFC director Dennis Whyte. “CFS will build SPARC and develop a commercial fusion product, while MIT PSFC will focus on its core mission of cutting-edge research and education.”

      Commercial fusion energy has the potential to play a significant role in combating climate change, and there is a concurrent increase in interest from the energy sector, governments, and foundations. The new agreement, administered by the MIT Energy Initiative (MITEI), where CFS is a startup member, will help PSFC expand its fusion technology efforts with a wider variety of sponsors. The collaboration enables rapid execution at scale and technology transfer into the commercial sector as soon as possible.

      This new agreement doubles CFS’ financial commitment to PSFC, enabling greater recruitment and support of students, staff, and faculty. “We’ll significantly increase the number of graduate students and postdocs, and just as important they will be working on a more diverse set of fusion science and technology topics,” notes Whyte. It extends the collaboration between PSFC and CFS that resulted in numerous advances toward fusion power plants, including last fall’s demonstration of a high-temperature superconducting (HTS) fusion electromagnet with record-setting field strength of 20 tesla.

      The combined magnetic fusion efforts at PSFC will surpass those in place during the operations of the pioneering Alcator C-Mod tokamak device that operated from 1993 to 2016. This increase in activity reflects a moment when multiple fusion energy technologies are seeing rapidly accelerating development worldwide, and the emergence of a new fusion energy industry that would require thousands of trained people.

      MITEI director Robert Armstrong adds, “Our goal from the beginning was to create a membership model that would allow startups who have specific research challenges to leverage the MITEI ecosystem, including MIT faculty, students, and other MITEI members. The team at the PSFC and MITEI have worked seamlessly to support CFS, and we are excited for this next phase of the relationship.”

      PSFC is supporting CFS’ efforts toward realizing the SPARC fusion platform, which facilitates rapid development and refinement of elements (including HTS magnets) needed to build ARC, a compact, modular, high-field fusion power plant that would set the stage for commercial fusion energy production. The concepts originated in Whyte’s nuclear science and engineering class 22.63 (Principles of Fusion Engineering) and have been carried forward by students and PSFC staff, many of whom helped found CFS; the new activity will expand research into advanced technologies for the envisioned pilot plant.

      “This has been an incredibly effective collaboration that has resulted in a major breakthrough for commercial fusion with the successful demonstration of revolutionary fusion magnet technology that will enable the world’s first commercially relevant net energy fusion device, SPARC, currently under construction,” says Bob Mumgaard SM ’15, PhD ’15, CEO of Commonwealth Fusion Systems. “We look forward to this next phase in the collaboration with MIT as we tackle the critical research challenges ahead for the next steps toward fusion power plant development.”

      In the push for commercial fusion energy, the next five years are critical, requiring intensive work on materials longevity, heat transfer, fuel recycling, maintenance, and other crucial aspects of power plant development. It will need innovation from almost every engineering discipline. “Having great teams working now, it will cut the time needed to move from SPARC to ARC, and really unleash the creativity. And the thing MIT does so well is cut across disciplines,” says Whyte.

      “To address the climate crisis, the world needs to deploy existing clean energy solutions as widely and as quickly as possible, while at the same time developing new technologies — and our goal is that those new technologies will include fusion power,” says Maria T. Zuber, MIT’s vice president for research. “To make new climate solutions a reality, we need focused, sustained collaborations like the one between MIT and Commonwealth Fusion Systems. Delivering fusion power onto the grid is a monumental challenge, and the combined capabilities of these two organizations are what the challenge demands.”

      On a strategic level, climate change and the imperative need for widely implementable carbon-free energy have helped orient the PSFC team toward scalability. “Building one or 10 fusion plants doesn’t make a difference — we have to build thousands,” says Whyte. “The design decisions we make will impact the ability to do that down the road. The real enemy here is time, and we want to remove as many impediments as possible and commit to funding a new generation of scientific leaders. Those are critically important in a field with as much interdisciplinary integration as fusion.” More

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      in Energy

      How can we reduce the carbon footprint of global computing?

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      The voracious appetite for energy from the world’s computers and communications technology presents a clear threat for the globe’s warming climate. That was the blunt assessment from presenters in the intensive two-day Climate Implications of Computing and Communications workshop held on March 3 and 4, hosted by MIT’s Climate and Sustainability Consortium (MCSC), MIT-IBM Watson AI Lab, and the Schwarzman College of Computing.

      The virtual event featured rich discussions and highlighted opportunities for collaboration among an interdisciplinary group of MIT faculty and researchers and industry leaders across multiple sectors — underscoring the power of academia and industry coming together.

      “If we continue with the existing trajectory of compute energy, by 2040, we are supposed to hit the world’s energy production capacity. The increase in compute energy and demand has been increasing at a much faster rate than the world energy production capacity increase,” said Bilge Yildiz, the Breene M. Kerr Professor in the MIT departments of Nuclear Science and Engineering and Materials Science and Engineering, one of the workshop’s 18 presenters. This computing energy projection draws from the Semiconductor Research Corporations’s decadal report.To cite just one example: Information and communications technology already account for more than 2 percent of global energy demand, which is on a par with the aviation industries emissions from fuel.“We are the very beginning of this data-driven world. We really need to start thinking about this and act now,” said presenter Evgeni Gousev, senior director at Qualcomm.  Innovative energy-efficiency optionsTo that end, the workshop presentations explored a host of energy-efficiency options, including specialized chip design, data center architecture, better algorithms, hardware modifications, and changes in consumer behavior. Industry leaders from AMD, Ericsson, Google, IBM, iRobot, NVIDIA, Qualcomm, Tertill, Texas Instruments, and Verizon outlined their companies’ energy-saving programs, while experts from across MIT provided insight into current research that could yield more efficient computing.Panel topics ranged from “Custom hardware for efficient computing” to “Hardware for new architectures” to “Algorithms for efficient computing,” among others.

      Visual representation of the conversation during the workshop session entitled “Energy Efficient Systems.”

      Image: Haley McDevitt

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      The goal, said Yildiz, is to improve energy efficiency associated with computing by more than a million-fold.“I think part of the answer of how we make computing much more sustainable has to do with specialized architectures that have very high level of utilization,” said Darío Gil, IBM senior vice president and director of research, who stressed that solutions should be as “elegant” as possible.  For example, Gil illustrated an innovative chip design that uses vertical stacking to reduce the distance data has to travel, and thus reduces energy consumption. Surprisingly, more effective use of tape — a traditional medium for primary data storage — combined with specialized hard drives (HDD), can yield a dramatic savings in carbon dioxide emissions.Gil and presenters Bill Dally, chief scientist and senior vice president of research of NVIDIA; Ahmad Bahai, CTO of Texas Instruments; and others zeroed in on storage. Gil compared data to a floating iceberg in which we can have fast access to the “hot data” of the smaller visible part while the “cold data,” the large underwater mass, represents data that tolerates higher latency. Think about digital photo storage, Gil said. “Honestly, are you really retrieving all of those photographs on a continuous basis?” Storage systems should provide an optimized mix of of HDD for hot data and tape for cold data based on data access patterns.Bahai stressed the significant energy saving gained from segmenting standby and full processing. “We need to learn how to do nothing better,” he said. Dally spoke of mimicking the way our brain wakes up from a deep sleep, “We can wake [computers] up much faster, so we don’t need to keep them running in full speed.”Several workshop presenters spoke of a focus on “sparsity,” a matrix in which most of the elements are zero, as a way to improve efficiency in neural networks. Or as Dally said, “Never put off till tomorrow, where you could put off forever,” explaining efficiency is not “getting the most information with the fewest bits. It’s doing the most with the least energy.”Holistic and multidisciplinary approaches“We need both efficient algorithms and efficient hardware, and sometimes we need to co-design both the algorithm and the hardware for efficient computing,” said Song Han, a panel moderator and assistant professor in the Department of Electrical Engineering and Computer Science (EECS) at MIT.Some presenters were optimistic about innovations already underway. According to Ericsson’s research, as much as 15 percent of the carbon emissions globally can be reduced through the use of existing solutions, noted Mats Pellbäck Scharp, head of sustainability at Ericsson. For example, GPUs are more efficient than CPUs for AI, and the progression from 3G to 5G networks boosts energy savings.“5G is the most energy efficient standard ever,” said Scharp. “We can build 5G without increasing energy consumption.”Companies such as Google are optimizing energy use at their data centers through improved design, technology, and renewable energy. “Five of our data centers around the globe are operating near or above 90 percent carbon-free energy,” said Jeff Dean, Google’s senior fellow and senior vice president of Google Research.Yet, pointing to the possible slowdown in the doubling of transistors in an integrated circuit — or Moore’s Law — “We need new approaches to meet this compute demand,” said Sam Naffziger, AMD senior vice president, corporate fellow, and product technology architect. Naffziger spoke of addressing performance “overkill.” For example, “we’re finding in the gaming and machine learning space we can make use of lower-precision math to deliver an image that looks just as good with 16-bit computations as with 32-bit computations, and instead of legacy 32b math to train AI networks, we can use lower-energy 8b or 16b computations.”

      Visual representation of the conversation during the workshop session entitled “Wireless, networked, and distributed systems.”

      Image: Haley McDevitt

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      Other presenters singled out compute at the edge as a prime energy hog.“We also have to change the devices that are put in our customers’ hands,” said Heidi Hemmer, senior vice president of engineering at Verizon. As we think about how we use energy, it is common to jump to data centers — but it really starts at the device itself, and the energy that the devices use. Then, we can think about home web routers, distributed networks, the data centers, and the hubs. “The devices are actually the least energy-efficient out of that,” concluded Hemmer.Some presenters had different perspectives. Several called for developing dedicated silicon chipsets for efficiency. However, panel moderator Muriel Medard, the Cecil H. Green Professor in EECS, described research at MIT, Boston University, and Maynooth University on the GRAND (Guessing Random Additive Noise Decoding) chip, saying, “rather than having obsolescence of chips as the new codes come in and in different standards, you can use one chip for all codes.”Whatever the chip or new algorithm, Helen Greiner, CEO of Tertill (a weeding robot) and co-founder of iRobot, emphasized that to get products to market, “We have to learn to go away from wanting to get the absolute latest and greatest, the most advanced processor that usually is more expensive.” She added, “I like to say robot demos are a dime a dozen, but robot products are very infrequent.”Greiner emphasized consumers can play a role in pushing for more energy-efficient products — just as drivers began to demand electric cars.Dean also sees an environmental role for the end user.“We have enabled our cloud customers to select which cloud region they want to run their computation in, and they can decide how important it is that they have a low carbon footprint,” he said, also citing other interfaces that might allow consumers to decide which air flights are more efficient or what impact installing a solar panel on their home would have.However, Scharp said, “Prolonging the life of your smartphone or tablet is really the best climate action you can do if you want to reduce your digital carbon footprint.”Facing increasing demandsDespite their optimism, the presenters acknowledged the world faces increasing compute demand from machine learning, AI, gaming, and especially, blockchain. Panel moderator Vivienne Sze, associate professor in EECS, noted the conundrum.“We can do a great job in making computing and communication really efficient. But there is this tendency that once things are very efficient, people use more of it, and this might result in an overall increase in the usage of these technologies, which will then increase our overall carbon footprint,” Sze said.Presenters saw great potential in academic/industry partnerships, particularly from research efforts on the academic side. “By combining these two forces together, you can really amplify the impact,” concluded Gousev.Presenters at the Climate Implications of Computing and Communications workshop also included: Joel Emer, professor of the practice in EECS at MIT; David Perreault, the Joseph F. and Nancy P. Keithley Professor of EECS at MIT; Jesús del Alamo, MIT Donner Professor and professor of electrical engineering in EECS at MIT; Heike Riel, IBM Fellow and head science and technology at IBM; and Takashi Ando, principal research staff member at IBM Research. The recorded workshop sessions are available on YouTube. More

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      in Security

      From seawater to drinking water, with the push of a button

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      MIT researchers have developed a portable desalination unit, weighing less than 10 kilograms, that can remove particles and salts to generate drinking water.

      The suitcase-sized device, which requires less power to operate than a cell phone charger, can also be driven by a small, portable solar panel, which can be purchased online for around $50. It automatically generates drinking water that exceeds World Health Organization quality standards. The technology is packaged into a user-friendly device that runs with the push of one button.

      Unlike other portable desalination units that require water to pass through filters, this device utilizes electrical power to remove particles from drinking water. Eliminating the need for replacement filters greatly reduces the long-term maintenance requirements.

      This could enable the unit to be deployed in remote and severely resource-limited areas, such as communities on small islands or aboard seafaring cargo ships. It could also be used to aid refugees fleeing natural disasters or by soldiers carrying out long-term military operations.

      “This is really the culmination of a 10-year journey that I and my group have been on. We worked for years on the physics behind individual desalination processes, but pushing all those advances into a box, building a system, and demonstrating it in the ocean, that was a really meaningful and rewarding experience for me,” says senior author Jongyoon Han, a professor of electrical engineering and computer science and of biological engineering, and a member of the Research Laboratory of Electronics (RLE).

      Joining Han on the paper are first author Junghyo Yoon, a research scientist in RLE; Hyukjin J. Kwon, a former postdoc; SungKu Kang, a postdoc at Northeastern University; and Eric Brack of the U.S. Army Combat Capabilities Development Command (DEVCOM). The research has been published online in Environmental Science and Technology.

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      Filter-free technology

      Commercially available portable desalination units typically require high-pressure pumps to push water through filters, which are very difficult to miniaturize without compromising the energy-efficiency of the device, explains Yoon.

      Instead, their unit relies on a technique called ion concentration polarization (ICP), which was pioneered by Han’s group more than 10 years ago. Rather than filtering water, the ICP process applies an electrical field to membranes placed above and below a channel of water. The membranes repel positively or negatively charged particles — including salt molecules, bacteria, and viruses — as they flow past. The charged particles are funneled into a second stream of water that is eventually discharged.

      The process removes both dissolved and suspended solids, allowing clean water to pass through the channel. Since it only requires a low-pressure pump, ICP uses less energy than other techniques.

      But ICP does not always remove all the salts floating in the middle of the channel. So the researchers incorporated a second process, known as electrodialysis, to remove remaining salt ions.

      Yoon and Kang used machine learning to find the ideal combination of ICP and electrodialysis modules. The optimal setup includes a two-stage ICP process, with water flowing through six modules in the first stage then through three in the second stage, followed by a single electrodialysis process. This minimized energy usage while ensuring the process remains self-cleaning.

      “While it is true that some charged particles could be captured on the ion exchange membrane, if they get trapped, we just reverse the polarity of the electric field and the charged particles can be easily removed,” Yoon explains.

      They shrunk and stacked the ICP and electrodialysis modules to improve their energy efficiency and enable them to fit inside a portable device. The researchers designed the device for nonexperts, with just one button to launch the automatic desalination and purification process. Once the salinity level and the number of particles decrease to specific thresholds, the device notifies the user that the water is drinkable.

      The researchers also created a smartphone app that can control the unit wirelessly and report real-time data on power consumption and water salinity.

      Beach tests

      After running lab experiments using water with different salinity and turbidity (cloudiness) levels, they field-tested the device at Boston’s Carson Beach.

      Yoon and Kwon set the box near the shore and tossed the feed tube into the water. In about half an hour, the device had filled a plastic drinking cup with clear, drinkable water.

      “It was successful even in its first run, which was quite exciting and surprising. But I think the main reason we were successful is the accumulation of all these little advances that we made along the way,” Han says.

      The resulting water exceeded World Health Organization quality guidelines, and the unit reduced the amount of suspended solids by at least a factor of 10. Their prototype generates drinking water at a rate of 0.3 liters per hour, and requires only 20 watts of power per liter.

      “Right now, we are pushing our research to scale up that production rate,” Yoon says.

      One of the biggest challenges of designing the portable system was engineering an intuitive device that could be used by anyone, Han says.

      Yoon hopes to make the device more user-friendly and improve its energy efficiency and production rate through a startup he plans to launch to commercialize the technology.

      In the lab, Han wants to apply the lessons he’s learned over the past decade to water-quality issues that go beyond desalination, such as rapidly detecting contaminants in drinking water.

      “This is definitely an exciting project, and I am proud of the progress we have made so far, but there is still a lot of work to do,” he says.

      For example, while “development of portable systems using electro-membrane processes is an original and exciting direction in off-grid, small-scale desalination,” the effects of fouling, especially if the water has high turbidity, could significantly increase maintenance requirements and energy costs, notes Nidal Hilal, professor of engineering and director of the New York University Abu Dhabi Water research center, who was not involved with this research.

      “Another limitation is the use of expensive materials,” he adds. “It would be interesting to see similar systems with low-cost materials in place.”

      The research was funded, in part, by the DEVCOM Soldier Center, the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS), the Experimental AI Postdoc Fellowship Program of Northeastern University, and the Roux AI Institute. More