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    How J-WAFS Solutions grants bring research to market

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    For the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS), 2025 marks a decade of translating groundbreaking research into tangible solutions for global challenges. Few examples illustrate that mission better than NONA Technologies. With support from a J-WAFS Solutions grant, MIT electrical engineering and biological engineering Professor Jongyoon Han and his team developed a portable desalination device that transforms seawater into clean drinking water without filters or high-pressure pumps. The device stands apart from traditional systems because conventional desalination technologies, like reverse osmosis, are energy-intensive, prone to fouling, and typically deployed at large, centralized plants. In contrast, the device developed in Han’s lab employs ion concentration polarization technology to remove salts and particles from seawater, producing potable water that exceeds World Health Organization standards. It is compact, solar-powered, and operable at the push of a button — making it an ideal solution for off-grid and disaster-stricken areas.This research laid the foundation for spinning out NONA Technologies along with co-founders Junghyo Yoon PhD ’21 from Han’s lab and Bruce Crawford MBA ’22, to commercialize the technology and address pressing water-scarcity issues worldwide. “This is really the culmination of a 10-year journey that I and my group have been on,” said Han in an earlier MIT News article. “We worked for years on the physics behind individual desalination processes, but pushing all those advances into a box, building a system, and demonstrating it in the ocean … that was a really meaningful and rewarding experience for me.” You can watch this video showcasing the device in action.Moving breakthrough research out of the lab and into the world is a well-known challenge. While traditional “seed” grants typically support early-stage research at Technology Readiness Level (TRL) 1-2, few funding sources exist to help academic teams navigate to the next phase of technology development. The J-WAFS Solutions Program is strategically designed to address this critical gap by supporting technologies in the high-risk, early-commercialization phase that is often neglected by traditional research, corporate, and venture funding. By supporting technologies at TRLs 3-5, the program increases the likelihood that promising innovations will survive beyond the university setting, advancing sufficiently to attract follow-on funding.Equally important, the program gives academic researchers the time, resources, and flexibility to de-risk their technology, explore customer need and potential real-world applications, and determine whether and how they want to pursue commercialization. For faculty-led teams like Han’s, the J-WAFS Solutions Program provided the critical financial runway and entrepreneurial guidance needed to refine the technology, test assumptions about market fit, and lay the foundation for a startup team. While still in the MIT innovation ecosystem, Nona secured over $200,000 in non-dilutive funding through competitions and accelerators, including the prestigious MIT delta v Educational Accelerator. These early wins laid the groundwork for further investment and technical advancement.Since spinning out of MIT, NONA has made major strides in both technology development and business viability. What started as a device capable of producing just over half-a-liter of clean drinking water per hour has evolved into a system that now delivers 10 times that capacity, at 5 liters per hour. The company successfully raised a $3.5 million seed round to advance its portable desalination device, and entered into a collaboration with the U.S. Army Natick Soldier Systems Center, where it co-developed early prototypes and began generating revenue while validating the technology. Most recently, NONA was awarded two SBIR Phase I grants totaling $575,000, one from the National Science Foundation and another from the National Institute of Environmental Health Sciences.Now operating out of Greentown Labs in Somerville, Massachusetts, NONA has grown to a dedicated team of five and is preparing to launch its nona5 product later this year, with a wait list of over 1,000 customers. It is also kicking off its first industrial pilot, marking a key step toward commercial scale-up. “Starting a business as a postdoc was challenging, especially with limited funding and industry knowledge,” says Yoon, who currently serves as CTO of NONA. “J-WAFS gave me the financial freedom to pursue my venture, and the mentorship pushed me to hit key milestones. Thanks to J-WAFS, I successfully transitioned from an academic researcher to an entrepreneur in the water industry.”NONA is one of several J-WAFS-funded technologies that have moved from the lab to market, part of a growing portfolio of water and food solutions advancing through MIT’s innovation pipeline. As J-WAFS marks a decade of catalyzing innovation in water and food, NONA exemplifies what is possible when mission-driven research is paired with targeted early-stage support and mentorship.To learn more or get involved in supporting startups through the J-WAFS Solutions Program, please contact jwafs@mit.edu. More

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      Workshop explores new advanced materials for a growing world

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      It is clear that humankind needs increasingly more resources, from computing power to steel and concrete, to meet the growing demands associated with data centers, infrastructure, and other mainstays of society. New, cost-effective approaches for producing the advanced materials key to that growth were the focus of a two-day workshop at MIT on March 11 and 12.A theme throughout the event was the importance of collaboration between and within universities and industries. The goal is to “develop concepts that everybody can use together, instead of everybody doing something different and then trying to sort it out later at great cost,” said Lionel Kimerling, the Thomas Lord Professor of Materials Science and Engineering at MIT.The workshop was produced by MIT’s Materials Research Laboratory (MRL), which has an industry collegium, and MIT’s Industrial Liaison Program. The program included an address by Javier Sanfelix, lead of the Advanced Materials Team for the European Union. Sanfelix gave an overview of the EU’s strategy to developing advanced materials, which he said are “key enablers of the green and digital transition for European industry.”That strategy has already led to several initiatives. These include a material commons, or shared digital infrastructure for the design and development of advanced materials, and an advanced materials academy for educating new innovators and designers. Sanfelix also described an Advanced Materials Act for 2026 that aims to put in place a legislative framework that supports the entire innovation cycle.Sanfelix was visiting MIT to learn more about how the Institute is approaching the future of advanced materials. “We see MIT as a leader worldwide in technology, especially on materials, and there is a lot to learn about [your] industry collaborations and technology transfer with industry,” he said.Innovations in steel and concreteThe workshop began with talks about innovations involving two of the most common human-made materials in the world: steel and cement. We’ll need more of both but must reckon with the huge amounts of energy required to produce them and their impact on the environment due to greenhouse-gas emissions during that production.One way to address our need for more steel is to reuse what we have, said C. Cem Tasan, the POSCO Associate Professor of Metallurgy in the Department of Materials Science and Engineering (DMSE) and director of the Materials Research Laboratory.But most of the existing approaches to recycling scrap steel involve melting the metal. “And whenever you are dealing with molten metal, everything goes up, from energy use to carbon-dioxide emissions. Life is more difficult,” Tasan said.The question he and his team asked is whether they could reuse scrap steel without melting it. Could they consolidate solid scraps, then roll them together using existing equipment to create new sheet metal? From the materials-science perspective, Tasan said, that shouldn’t work, for several reasons.But it does. “We’ve demonstrated the potential in two papers and two patent applications already,” he said. Tasan noted that the approach focuses on high-quality manufacturing scrap. “This is not junkyard scrap,” he said.Tasan went on to explain how and why the new process works from a materials-science perspective, then gave examples of how the recycled steel could be used. “My favorite example is the stainless-steel countertops in restaurants. Do you really need the mechanical performance of stainless steel there?” You could use the recycled steel instead.Hessam Azarijafari addressed another common, indispensable material: concrete. This year marks the 16th anniversary of the MIT Concrete Sustainability Hub (CSHub), which began when a set of industry leaders and politicians reached out to MIT to learn more about the benefits and environmental impacts of concrete.The hub’s work now centers around three main themes: working toward a carbon-neutral concrete industry; the development of a sustainable infrastructure, with a focus on pavement; and how to make our cities more resilient to natural hazards through investment in stronger, cooler construction.Azarijafari, the deputy director of the CSHub, went on to give several examples of research results that have come out of the CSHub. These include many models to identify different pathways to decarbonize the cement and concrete sector. Other work involves pavements, which the general public thinks of as inert, Azarijafari said. “But we have [created] a state-of-the-art model that can assess interactions between pavement and vehicles.” It turns out that pavement surface characteristics and structural performance “can influence excess fuel consumption by inducing an additional rolling resistance.”Azarijafari emphasized  the importance of working closely with policymakers and industry. That engagement is key “to sharing the lessons that we have learned so far.”Toward a resource-efficient microchip industryConsider the following: In 2020 the number of cell phones, GPS units, and other devices connected to the “cloud,” or large data centers, exceeded 50 billion. And data-center traffic in turn is scaling by 1,000 times every 10 years.But all of that computation takes energy. And “all of it has to happen at a constant cost of energy, because the gross domestic product isn’t changing at that rate,” said Kimerling. The solution is to either produce much more energy, or make information technology much more energy-efficient. Several speakers at the workshop focused on the materials and components behind the latter.Key to everything they discussed: adding photonics, or using light to carry information, to the well-established electronics behind today’s microchips. “The bottom line is that integrating photonics with electronics in the same package is the transistor for the 21st century. If we can’t figure out how to do that, then we’re not going to be able to scale forward,” said Kimerling, who is director of the MIT Microphotonics Center.MIT has long been a leader in the integration of photonics with electronics. For example, Kimerling described the Integrated Photonics System Roadmap – International (IPSR-I), a global network of more than 400 industrial and R&D partners working together to define and create photonic integrated circuit technology. IPSR-I is led by the MIT Microphotonics Center and PhotonDelta. Kimerling began the organization in 1997.Last year IPSR-I released its latest roadmap for photonics-electronics integration, “which  outlines a clear way forward and specifies an innovative learning curve for scaling performance and applications for the next 15 years,” Kimerling said.Another major MIT program focused on the future of the microchip industry is FUTUR-IC, a new global alliance for sustainable microchip manufacturing. Begun last year, FUTUR-IC is funded by the National Science Foundation.“Our goal is to build a resource-efficient microchip industry value chain,” said Anuradha Murthy Agarwal, a principal research scientist at the MRL and leader of FUTUR-IC. That includes all of the elements that go into manufacturing future microchips, including workforce education and techniques to mitigate potential environmental effects.FUTUR-IC is also focused on electronic-photonic integration. “My mantra is to use electronics for computation, [and] shift to photonics for communication to bring this energy crisis in control,” Agarwal said.But integrating electronic chips with photonic chips is not easy. To that end, Agarwal described some of the challenges involved. For example, currently it is difficult to connect the optical fibers carrying communications to a microchip. That’s because the alignment between the two must be almost perfect or the light will disperse. And the dimensions involved are minuscule. An optical fiber has a diameter of only millionths of a meter. As a result, today each connection must be actively tested with a laser to ensure that the light will come through.That said, Agarwal went on to describe a new coupler between the fiber and chip that could solve the problem and allow robots to passively assemble the chips (no laser needed). The work, which was conducted by researchers including MIT graduate student Drew Wenninger, Agarwal, and Kimerling, has been patented, and is reported in two papers. A second recent breakthrough in this area involving a printed micro-reflector was described by Juejun “JJ” Hu, John F. Elliott Professor of Materials Science and Engineering.FUTUR-IC is also leading educational efforts for training a future workforce, as well as techniques for detecting — and potentially destroying — the perfluroalkyls (PFAS, or “forever chemicals”) released during microchip manufacturing. FUTUR-IC educational efforts, including virtual reality and game-based learning, were described by Sajan Saini, education director for FUTUR-IC. PFAS detection and remediation were discussed by Aristide Gumyusenge, an assistant professor in DMSE, and Jesus Castro Esteban, a postdoc in the Department of Chemistry.Other presenters at the workshop included Antoine Allanore, the Heather N. Lechtman Professor of Materials Science and Engineering; Katrin Daehn, a postdoc in the Allanore lab; Xuanhe Zhao, the Uncas (1923) and Helen Whitaker Professor in the Department of Mechanical Engineering; Richard Otte, CEO of Promex; and Carl Thompson, the Stavros V. Salapatas Professor in Materials Science and Engineering. More

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      in Energy

      Chip-based system for terahertz waves could enable more efficient, sensitive electronics

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      The use of terahertz waves, which have shorter wavelengths and higher frequencies than radio waves, could enable faster data transmission, more precise medical imaging, and higher-resolution radar.But effectively generating terahertz waves using a semiconductor chip, which is essential for incorporation into electronic devices, is notoriously difficult.Many current techniques can’t generate waves with enough radiating power for useful applications unless they utilize bulky and expensive silicon lenses. Higher radiating power allows terahertz signals to travel farther. Such lenses, which are often larger than the chip itself, make it hard to integrate the terahertz source into an electronic device.To overcome these limitations, MIT researchers developed a terahertz amplifier-multiplier system that achieves higher radiating power than existing devices without the need for silicon lenses.By affixing a thin, patterned sheet of material to the back of the chip and utilizing higher-power Intel transistors, the researchers produced a more efficient, yet scalable, chip-based terahertz wave generator.This compact chip could be used to make terahertz arrays for applications like improved security scanners for detecting hidden objects or environmental monitors for pinpointing airborne pollutants.“To take full advantage of a terahertz wave source, we need it to be scalable. A terahertz array might have hundreds of chips, and there is no place to put silicon lenses because the chips are combined with such high density. We need a different package, and here we’ve demonstrated a promising approach that can be used for scalable, low-cost terahertz arrays,” says Jinchen Wang, a graduate student in the Department of Electrical Engineering and Computer Science (EECS) and lead author of a paper on the terahertz radiator.He is joined on the paper by EECS graduate students Daniel Sheen and Xibi Chen; Steven F. Nagel, managing director of the T.J. Rodgers RLE Laboratory; and senior author Ruonan Han, an associate professor in EECS, who leads the Terahertz Integrated Electronics Group. The research will be presented at the IEEE International Solid-States Circuits Conference.Making wavesTerahertz waves sit on the electromagnetic spectrum between radio waves and infrared light. Their higher frequencies enable them to carry more information per second than radio waves, while they can safely penetrate a wider range of materials than infrared light.One way to generate terahertz waves is with a CMOS chip-based amplifier-multiplier chain that increases the frequency of radio waves until they reach the terahertz range. To achieve the best performance, waves go through the silicon chip and are eventually emitted out the back into the open air.But a property known as the dielectric constant gets in the way of a smooth transmission.The dielectric constant influences how electromagnetic waves interact with a material. It affects the amount of radiation that is absorbed, reflected, or transmitted. Because the dielectric constant of silicon is much higher than that of air, most terahertz waves are reflected at the silicon-air boundary rather than being cleanly transmitted out the back.Since most signal strength is lost at this boundary, current approaches often use silicon lenses to boost the power of the remaining signal. The MIT researchers approached this problem differently.They drew on an electromechanical theory known as matching. With matching, they seek to equal out the dielectric constants of silicon and air, which will minimize the amount of signal that is reflected at the boundary.They accomplish this by sticking a thin sheet of material which has a dielectric constant between silicon and air to the back of the chip. With this matching sheet in place, most waves will be transmitted out the back rather than being reflected.A scalable approachThey chose a low-cost, commercially available substrate material with a dielectric constant very close to what they needed for matching. To improve performance, they used a laser cutter to punch tiny holes into the sheet until its dielectric constant was exactly right.“Since the dielectric constant of air is 1, if you just cut some subwavelength holes in the sheet, it is equivalent to injecting some air, which lowers the overall dielectric constant of the matching sheet,” Wang explains.In addition, they designed their chip with special transistors developed by Intel that have a higher maximum frequency and breakdown voltage than traditional CMOS transistors.“These two things taken together, the more powerful transistors and the dielectric sheet, plus a few other small innovations, enabled us to outperform several other devices,” he says.Their chip generated terahertz signals with a peak radiation power of 11.1 decibel-milliwatts, the best among state-of-the-art techniques. Moreover, since the low-cost chip can be fabricated at scale, it could be integrated into real-world electronic devices more readily.One of the biggest challenges of developing a scalable chip was determining how to manage the power and temperature when generating terahertz waves.“Because the frequency and the power are so high, many of the standard ways to design a CMOS chip are not applicable here,” Wang says.The researchers also needed to devise a technique for installing the matching sheet that could be scaled up in a manufacturing facility.Moving forward, they want to demonstrate this scalability by fabricating a phased array of CMOS terahertz sources, enabling them to steer and focus a powerful terahertz beam with a low-cost, compact device.This research is supported, in part, by NASA’s Jet Propulsion Laboratory and Strategic University Research Partnerships Program, as well as the MIT Center for Integrated Circuits and Systems. The chip was fabricated through the Intel University Shuttle Program. More

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      in Environment

      In a unique research collaboration, students make the case for less e-waste

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      Brought together as part of the Social and Ethical Responsibilities of Computing (SERC) initiative within the MIT Schwarzman College of Computing, a community of students known as SERC Scholars is collaborating to examine the most urgent problems humans face in the digital landscape.Each semester, students from all levels from across MIT are invited to join a different topical working group led by a SERC postdoctoral associate. Each group delves into a specific issue — such as surveillance or data ownership — culminating in a final project presented at the end of the term.Typically, students complete the program with hands-on experience conducting research in a new cross-disciplinary field. However, one group of undergraduate and graduate students recently had the unique opportunity to enhance their resume by becoming published authors of a case study about the environmental and climate justice implications of the electronics hardware life cycle.Although it’s not uncommon for graduate students to co-author case studies, it’s unusual for undergraduates to earn this opportunity — and for their audience to be other undergraduates around the world.“Our team was insanely interdisciplinary,” says Anastasia Dunca, a junior studying computer science and one of the co-authors. “I joined the SERC Scholars Program because I liked the idea of being part of a cohort from across MIT working on a project that utilized all of our skillsets. It also helps [undergraduates] learn the ins and outs of computing ethics research.”Case study co-author Jasmin Liu, an MBA student in the MIT Sloan School of Management, sees the program as a platform to learn about the intersection of technology, society, and ethics: “I met team members spanning computer science, urban planning, to art/culture/technology. I was excited to work with a diverse team because I know complex problems must be approached with many different perspectives. Combining my background in humanities and business with the expertise of others allowed us to be more innovative and comprehensive.”Christopher Rabe, a former SERC postdoc who facilitated the group, says, “I let the students take the lead on identifying the topic and conducting the research.” His goal for the group was to challenge students across disciplines to develop a working definition of climate justice.From mining to e-wasteThe SERC Scholars’ case study, “From Mining to E-waste: The Environmental and Climate Justice Implications of the Electronics Hardware Life Cycle,” was published by the MIT Case Studies in Social and Ethical Responsibilities of Computing.The ongoing case studies series, which releases new issues twice a year on an open-source platform, is enabling undergraduate instructors worldwide to incorporate research-based education materials on computing ethics into their existing class syllabi.This particular case study broke down the electronics life cycle from mining to manufacturing, usage, and disposal. It offered an in-depth look at how this cycle promotes inequity in the Global South. Mining for the average of 60 minerals that power everyday devices lead to illegal deforestation, compromising air quality in the Amazon, and triggering armed conflict in Congo. Manufacturing leads to proven health risks for both formal and informal workers, some of whom are child laborers.Life cycle assessment and circular economy are proposed as mechanisms for analyzing environmental and climate justice issues in the electronics life cycle. Rather than posing solutions, the case study offers readers entry points for further discussion and for assessing their own individual responsibility as producers of e-waste.Crufting and crafting a case studyDunca joined Rabe’s working group, intrigued by the invitation to conduct a rigorous literature review examining issues like data center resource and energy use, manufacturing waste, ethical issues with AI, and climate change. Rabe quickly realized that a common thread among all participants was an interest in understanding and reducing e-waste and its impact on the environment.“I came in with the idea of us co-authoring a case study,” Rabe said. However, the writing-intensive process was initially daunting to those students who were used to conducting applied research. Once Rabe created sub-groups with discrete tasks, the steps for researching, writing, and iterating a case study became more approachable.For Ellie Bultena, an undergraduate student studying linguistics and philosophy and a contributor to the study, that meant conducting field research on the loading dock of MIT’s Stata Center, where students and faculty go “crufting” through piles of clunky printers, broken computers, and used lab equipment discarded by the Institute’s labs, departments, and individual users.Although not a formally sanctioned activity on-campus, “crufting” is the act of gleaning usable parts from these junk piles to be repurposed into new equipment or art. Bultena’s respondents, who opted to be anonymous, said that MIT could do better when it comes to the amount of e-waste generated and suggested that formal strategies could be implemented to encourage community members to repair equipment more easily or recycle more formally.Rabe, now an education program director at the MIT Environmental Solutions Initiative, is hopeful that through the Zero-Carbon Campus Initiative, which commits MIT to eliminating all direct emissions by 2050, MIT will ultimately become a model for other higher education institutions.Although the group lacked the time and resources to travel to communities in the Global South that they profiled in their case study, members leaned into exhaustive secondary research, collecting data on how some countries are irresponsibly dumping e-waste. In contrast, others have developed alternative solutions that can be duplicated elsewhere and scaled.“We source materials, manufacture them, and then throw them away,” Lelia Hampton says. A PhD candidate in electrical engineering and computer science and another co-author, Hampton jumped at the opportunity to serve in a writing role, bringing together the sub-groups research findings. “I’d never written a case study, and it was exciting. Now I want to write 10 more.”The content directly informed Hampton’s dissertation research, which “looks at applying machine learning to climate justice issues such as urban heat islands.” She said that writing a case study that is accessible to general audiences upskilled her for the non-profit organization she’s determined to start. “It’s going to provide communities with free resources and data needed to understand how they are impacted by climate change and begin to advocate against injustice,” Hampton explains.Dunca, Liu, Rabe, Bultena, and Hampton are joined on the case study by fellow authors Mrinalini Singha, a graduate student in the Art, Culture, and Technology program; Sungmoon Lim, a graduate student in urban studies and planning and EECS; Lauren Higgins, an undergraduate majoring in political science; and Madeline Schlegal, a Northeastern University co-op student.Taking the case study to classrooms around the worldAlthough PhD candidates have contributed to previous case studies in the series, this publication is the first to be co-authored with MIT undergraduates. Like any other peer-reviewed journal, before publication, the SERC Scholars’ case study was anonymously reviewed by senior scholars drawn from various fields.The series editor, David Kaiser, also served as one of SERC’s inaugural associate deans and helped shape the program. “The case studies, by design, are short, easy to read, and don’t take up lots of time,” Kaiser explained. “They are gateways for students to explore, and instructors can cover a topic that has likely already been on their mind.” This semester, Kaiser, the Germeshausen Professor of the History of Science and a professor of physics, is teaching STS.004 (Intersections: Science, Technology, and the World), an undergraduate introduction to the field of science, technology, and society. The last month of the semester has been dedicated wholly to SERC case studies, one of which is: “From Mining to E-Waste.”Hampton was visibly moved to hear that the case study is being used at MIT but also by some of the 250,000 visitors to the SERC platform, many of whom are based in the Global South and directly impacted by the issues she and her cohort researched. “Many students are focused on climate, whether through computer science, data science, or mechanical engineering. I hope that this case study educates them on environmental and climate aspects of e-waste and computing.” More

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      in Energy

      Nanoscale transistors could enable more efficient electronics

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      Silicon transistors, which are used to amplify and switch signals, are a critical component in most electronic devices, from smartphones to automobiles. But silicon semiconductor technology is held back by a fundamental physical limit that prevents transistors from operating below a certain voltage.This limit, known as “Boltzmann tyranny,” hinders the energy efficiency of computers and other electronics, especially with the rapid development of artificial intelligence technologies that demand faster computation.In an effort to overcome this fundamental limit of silicon, MIT researchers fabricated a different type of three-dimensional transistor using a unique set of ultrathin semiconductor materials.Their devices, featuring vertical nanowires only a few nanometers wide, can deliver performance comparable to state-of-the-art silicon transistors while operating efficiently at much lower voltages than conventional devices.“This is a technology with the potential to replace silicon, so you could use it with all the functions that silicon currently has, but with much better energy efficiency,” says Yanjie Shao, an MIT postdoc and lead author of a paper on the new transistors.The transistors leverage quantum mechanical properties to simultaneously achieve low-voltage operation and high performance within an area of just a few square nanometers. Their extremely small size would enable more of these 3D transistors to be packed onto a computer chip, resulting in fast, powerful electronics that are also more energy-efficient.“With conventional physics, there is only so far you can go. The work of Yanjie shows that we can do better than that, but we have to use different physics. There are many challenges yet to be overcome for this approach to be commercial in the future, but conceptually, it really is a breakthrough,” says senior author Jesús del Alamo, the Donner Professor of Engineering in the MIT Department of Electrical Engineering and Computer Science (EECS).They are joined on the paper by Ju Li, the Tokyo Electric Power Company Professor in Nuclear Engineering and professor of materials science and engineering at MIT; EECS graduate student Hao Tang; MIT postdoc Baoming Wang; and professors Marco Pala and David Esseni of the University of Udine in Italy. The research appears today in Nature Electronics.Surpassing siliconIn electronic devices, silicon transistors often operate as switches. Applying a voltage to the transistor causes electrons to move over an energy barrier from one side to the other, switching the transistor from “off” to “on.” By switching, transistors represent binary digits to perform computation.A transistor’s switching slope reflects the sharpness of the “off” to “on” transition. The steeper the slope, the less voltage is needed to turn on the transistor and the greater its energy efficiency.But because of how electrons move across an energy barrier, Boltzmann tyranny requires a certain minimum voltage to switch the transistor at room temperature.To overcome the physical limit of silicon, the MIT researchers used a different set of semiconductor materials — gallium antimonide and indium arsenide — and designed their devices to leverage a unique phenomenon in quantum mechanics called quantum tunneling.Quantum tunneling is the ability of electrons to penetrate barriers. The researchers fabricated tunneling transistors, which leverage this property to encourage electrons to push through the energy barrier rather than going over it.“Now, you can turn the device on and off very easily,” Shao says.But while tunneling transistors can enable sharp switching slopes, they typically operate with low current, which hampers the performance of an electronic device. Higher current is necessary to create powerful transistor switches for demanding applications.Fine-grained fabricationUsing tools at MIT.nano, MIT’s state-of-the-art facility for nanoscale research, the engineers were able to carefully control the 3D geometry of their transistors, creating vertical nanowire heterostructures with a diameter of only 6 nanometers. They believe these are the smallest 3D transistors reported to date.Such precise engineering enabled them to achieve a sharp switching slope and high current simultaneously. This is possible because of a phenomenon called quantum confinement.Quantum confinement occurs when an electron is confined to a space that is so small that it can’t move around. When this happens, the effective mass of the electron and the properties of the material change, enabling stronger tunneling of the electron through a barrier.Because the transistors are so small, the researchers can engineer a very strong quantum confinement effect while also fabricating an extremely thin barrier.“We have a lot of flexibility to design these material heterostructures so we can achieve a very thin tunneling barrier, which enables us to get very high current,” Shao says.Precisely fabricating devices that were small enough to accomplish this was a major challenge.“We are really into single-nanometer dimensions with this work. Very few groups in the world can make good transistors in that range. Yanjie is extraordinarily capable to craft such well-functioning transistors that are so extremely small,” says del Alamo.When the researchers tested their devices, the sharpness of the switching slope was below the fundamental limit that can be achieved with conventional silicon transistors. Their devices also performed about 20 times better than similar tunneling transistors.“This is the first time we have been able to achieve such sharp switching steepness with this design,” Shao adds.The researchers are now striving to enhance their fabrication methods to make transistors more uniform across an entire chip. With such small devices, even a 1-nanometer variance can change the behavior of the electrons and affect device operation. They are also exploring vertical fin-shaped structures, in addition to vertical nanowire transistors, which could potentially improve the uniformity of devices on a chip.“This work definitively steps in the right direction, significantly improving the broken-gap tunnel field effect transistor (TFET) performance. It demonstrates steep-slope together with a record drive-current. It highlights the importance of small dimensions, extreme confinement, and low-defectivity materials and interfaces in the fabricated broken-gap TFET. These features have been realized through a well-mastered and nanometer-size-controlled process,” says Aryan Afzalian, a principal member of the technical staff at the nanoelectronics research organization imec, who was not involved with this work.This research is funded, in part, by Intel Corporation. More

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      in Environment

      School of Engineering welcomes new faculty

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      The School of Engineering welcomes 15 new faculty members across six of its academic departments. This new cohort of faculty members, who have either recently started their roles at MIT or will start within the next year, conduct research across a diverse range of disciplines.Many of these new faculty specialize in research that intersects with multiple fields. In addition to positions in the School of Engineering, a number of these faculty have positions at other units across MIT. Faculty with appointments in the Department of Electrical Engineering and Computer Science (EECS) report into both the School of Engineering and the MIT Stephen A. Schwarzman College of Computing. This year, new faculty also have joint appointments between the School of Engineering and the School of Humanities, Arts, and Social Sciences and the School of Science.“I am delighted to welcome this cohort of talented new faculty to the School of Engineering,” says Anantha Chandrakasan, chief innovation and strategy officer, dean of engineering, and Vannevar Bush Professor of Electrical Engineering and Computer Science. “I am particularly struck by the interdisciplinary approach many of these new faculty take in their research. They are working in areas that are poised to have tremendous impact. I look forward to seeing them grow as researchers and educators.”The new engineering faculty include:Stephen Bates joined the Department of Electrical Engineering and Computer Science as an assistant professor in September 2023. He is also a member of the Laboratory for Information and Decision Systems (LIDS). Bates uses data and AI for reliable decision-making in the presence of uncertainty. In particular, he develops tools for statistical inference with AI models, data impacted by strategic behavior, and settings with distribution shift. Bates also works on applications in life sciences and sustainability. He previously worked as a postdoc in the Statistics and EECS departments at the University of California at Berkeley (UC Berkeley). Bates received a BS in statistics and mathematics at Harvard University and a PhD from Stanford University.Abigail Bodner joined the Department of EECS and Department of Earth, Atmospheric and Planetary Sciences as an assistant professor in January. She is also a member of the LIDS. Bodner’s research interests span climate, physical oceanography, geophysical fluid dynamics, and turbulence. Previously, she worked as a Simons Junior Fellow at the Courant Institute of Mathematical Sciences at New York University. Bodner received her BS in geophysics and mathematics and MS in geophysics from Tel Aviv University, and her SM in applied mathematics and PhD from Brown University.Andreea Bobu ’17 will join the Department of Aeronautics and Astronautics as an assistant professor in July. Her research sits at the intersection of robotics, mathematical human modeling, and deep learning. Previously, she was a research scientist at the Boston Dynamics AI Institute, focusing on how robots and humans can efficiently arrive at shared representations of their tasks for more seamless and reliable interactions. Bobu earned a BS in computer science and engineering from MIT and a PhD in electrical engineering and computer science from UC Berkeley.Suraj Cheema will join the Department of Materials Science and Engineering, with a joint appointment in the Department of EECS, as an assistant professor in July. His research explores atomic-scale engineering of electronic materials to tackle challenges related to energy consumption, storage, and generation, aiming for more sustainable microelectronics. This spans computing and energy technologies via integrated ferroelectric devices. He previously worked as a postdoc at UC Berkeley. Cheema earned a BS in applied physics and applied mathematics from Columbia University and a PhD in materials science and engineering from UC Berkeley.Samantha Coday joins the Department of EECS as an assistant professor in July. She will also be a member of the MIT Research Laboratory of Electronics. Her research interests include ultra-dense power converters enabling renewable energy integration, hybrid electric aircraft and future space exploration. To enable high-performance converters for these critical applications her research focuses on the optimization, design, and control of hybrid switched-capacitor converters. Coday earned a BS in electrical engineering and mathematics from Southern Methodist University and an MS and a PhD in electrical engineering and computer science from UC Berkeley.Mitchell Gordon will join the Department of EECS as an assistant professor in July. He will also be a member of the MIT Computer Science and Artificial Intelligence Laboratory. In his research, Gordon designs interactive systems and evaluation approaches that bridge principles of human-computer interaction with the realities of machine learning. He currently works as a postdoc at the University of Washington. Gordon received a BS from the University of Rochester, and MS and PhD from Stanford University, all in computer science.Kaiming He joined the Department of EECS as an associate professor in February. He will also be a member of the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL). His research interests cover a wide range of topics in computer vision and deep learning. He is currently focused on building computer models that can learn representations and develop intelligence from and for the complex world. Long term, he hopes to augment human intelligence with improved artificial intelligence. Before joining MIT, He was a research scientist at Facebook AI. He earned a BS from Tsinghua University and a PhD from the Chinese University of Hong Kong.Anna Huang SM ’08 will join the departments of EECS and Music and Theater Arts as assistant professor in September. She will help develop graduate programming focused on music technology. Previously, she spent eight years with Magenta at Google Brain and DeepMind, spearheading efforts in generative modeling, reinforcement learning, and human-computer interaction to support human-AI partnerships in music-making. She is the creator of Music Transformer and Coconet (which powered the Bach Google Doodle). She was a judge and organizer for the AI Song Contest. Anna holds a Canada CIFAR AI Chair at Mila, a BM in music composition, and BS in computer science from the University of Southern California, an MS from the MIT Media Lab, and a PhD from Harvard University.Yael Kalai PhD ’06 will join the Department of EECS as a professor in September. She is also a member of CSAIL. Her research interests include cryptography, the theory of computation, and security and privacy. Kalai currently focuses on both the theoretical and real-world applications of cryptography, including work on succinct and easily verifiable non-interactive proofs. She received her bachelor’s degree from the Hebrew University of Jerusalem, a master’s degree at the Weizmann Institute of Science, and a PhD from MIT.Sendhil Mullainathan will join the departments of EECS and Economics as a professor in July. His research uses machine learning to understand complex problems in human behavior, social policy, and medicine. Previously, Mullainathan spent five years at MIT before joining the faculty at Harvard in 2004, and then the University of Chicago in 2018. He received his BA in computer science, mathematics, and economics from Cornell University and his PhD from Harvard University.Alex Rives will join the Department of EECS as an assistant professor in September, with a core membership in the Broad Institute of MIT and Harvard. In his research, Rives is focused on AI for scientific understanding, discovery, and design for biology. Rives worked with Meta as a New York University graduate student, where he founded and led the Evolutionary Scale Modeling team that developed large language models for proteins. Rives received his BS in philosophy and biology from Yale University and is completing his PhD in computer science at NYU.Sungho Shin will join the Department of Chemical Engineering as an assistant professor in July. His research interests include control theory, optimization algorithms, high-performance computing, and their applications to decision-making in complex systems, such as energy infrastructures. Shin is a postdoc at the Mathematics and Computer Science Division at Argonne National Laboratory. He received a BS in mathematics and chemical engineering from Seoul National University and a PhD in chemical engineering from the University of Wisconsin-Madison.Jessica Stark joined the Department of Biological Engineering as an assistant professor in January. In her research, Stark is developing technologies to realize the largely untapped potential of cell-surface sugars, called glycans, for immunological discovery and immunotherapy. Previously, Stark was an American Cancer Society postdoc at Stanford University. She earned a BS in chemical and biomolecular engineering from Cornell University and a PhD in chemical and biological engineering at Northwestern University.Thomas John “T.J.” Wallin joined the Department of Materials Science and Engineering as an assistant professor in January. As a researcher, Wallin’s interests lay in advanced manufacturing of functional soft matter, with an emphasis on soft wearable technologies and their applications in human-computer interfaces. Previously, he was a research scientist at Meta’s Reality Labs Research working in their haptic interaction team. Wallin earned a BS in physics and chemistry from the College of William and Mary, and an MS and PhD in materials science and engineering from Cornell University.Gioele Zardini joined the Department of Civil and Environmental Engineering as an assistant professor in September. He will also join LIDS and the Institute for Data, Systems, and Society. Driven by societal challenges, Zardini’s research interests include the co-design of sociotechnical systems, compositionality in engineering, applied category theory, decision and control, optimization, and game theory, with society-critical applications to intelligent transportation systems, autonomy, and complex networks and infrastructures. He received his BS, MS, and PhD in mechanical engineering with a focus on robotics, systems, and control from ETH Zurich, and spent time at MIT, Stanford University, and Motional. More

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      in Energy

      Propelling atomically layered magnets toward green computers

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      Globally, computation is booming at an unprecedented rate, fueled by the boons of artificial intelligence. With this, the staggering energy demand of the world’s computing infrastructure has become a major concern, and the development of computing devices that are far more energy-efficient is a leading challenge for the scientific community. 

      Use of magnetic materials to build computing devices like memories and processors has emerged as a promising avenue for creating “beyond-CMOS” computers, which would use far less energy compared to traditional computers. Magnetization switching in magnets can be used in computation the same way that a transistor switches from open or closed to represent the 0s and 1s of binary code. 

      While much of the research along this direction has focused on using bulk magnetic materials, a new class of magnetic materials — called two-dimensional van der Waals magnets — provides superior properties that can improve the scalability and energy efficiency of magnetic devices to make them commercially viable. 

      Although the benefits of shifting to 2D magnetic materials are evident, their practical induction into computers has been hindered by some fundamental challenges. Until recently, 2D magnetic materials could operate only at very low temperatures, much like superconductors. So bringing their operating temperatures above room temperature has remained a primary goal. Additionally, for use in computers, it is important that they can be controlled electrically, without the need for magnetic fields. Bridging this fundamental gap, where 2D magnetic materials can be electrically switched above room temperature without any magnetic fields, could potentially catapult the translation of 2D magnets into the next generation of “green” computers.

      A team of MIT researchers has now achieved this critical milestone by designing a “van der Waals atomically layered heterostructure” device where a 2D van der Waals magnet, iron gallium telluride, is interfaced with another 2D material, tungsten ditelluride. In an open-access paper published March 15 in Science Advances, the team shows that the magnet can be toggled between the 0 and 1 states simply by applying pulses of electrical current across their two-layer device. 

      Play video

      The Future of Spintronics: Manipulating Spins in Atomic Layers without External Magnetic FieldsVideo: Deblina Sarkar

      “Our device enables robust magnetization switching without the need for an external magnetic field, opening up unprecedented opportunities for ultra-low power and environmentally sustainable computing technology for big data and AI,” says lead author Deblina Sarkar, the AT&T Career Development Assistant Professor at the MIT Media Lab and Center for Neurobiological Engineering, and head of the Nano-Cybernetic Biotrek research group. “Moreover, the atomically layered structure of our device provides unique capabilities including improved interface and possibilities of gate voltage tunability, as well as flexible and transparent spintronic technologies.”

      Sarkar is joined on the paper by first author Shivam Kajale, a graduate student in Sarkar’s research group at the Media Lab; Thanh Nguyen, a graduate student in the Department of Nuclear Science and Engineering (NSE); Nguyen Tuan Hung, an MIT visiting scholar in NSE and an assistant professor at Tohoku University in Japan; and Mingda Li, associate professor of NSE.

      Breaking the mirror symmetries 

      When electric current flows through heavy metals like platinum or tantalum, the electrons get segregated in the materials based on their spin component, a phenomenon called the spin Hall effect, says Kajale. The way this segregation happens depends on the material, and particularly its symmetries.

      “The conversion of electric current to spin currents in heavy metals lies at the heart of controlling magnets electrically,” Kajale notes. “The microscopic structure of conventionally used materials, like platinum, have a kind of mirror symmetry, which restricts the spin currents only to in-plane spin polarization.”

      Kajale explains that two mirror symmetries must be broken to produce an “out-of-plane” spin component that can be transferred to a magnetic layer to induce field-free switching. “Electrical current can ‘break’ the mirror symmetry along one plane in platinum, but its crystal structure prevents the mirror symmetry from being broken in a second plane.”

      In their earlier experiments, the researchers used a small magnetic field to break the second mirror plane. To get rid of the need for a magnetic nudge, Kajale and Sarkar and colleagues looked instead for a material with a structure that could break the second mirror plane without outside help. This led them to another 2D material, tungsten ditelluride. The tungsten ditelluride that the researchers used has an orthorhombic crystal structure. The material itself has one broken mirror plane. Thus, by applying current along its low-symmetry axis (parallel to the broken mirror plane), the resulting spin current has an out-of-plane spin component that can directly induce switching in the ultra-thin magnet interfaced with the tungsten ditelluride. 

      “Because it’s also a 2D van der Waals material, it can also ensure that when we stack the two materials together, we get pristine interfaces and a good flow of electron spins between the materials,” says Kajale. 

      Becoming more energy-efficient 

      Computer memory and processors built from magnetic materials use less energy than traditional silicon-based devices. And the van der Waals magnets can offer higher energy efficiency and better scalability compared to bulk magnetic material, the researchers note. 

      The electrical current density used for switching the magnet translates to how much energy is dissipated during switching. A lower density means a much more energy-efficient material. “The new design has one of the lowest current densities in van der Waals magnetic materials,” Kajale says. “This new design has an order of magnitude lower in terms of the switching current required in bulk materials. This translates to something like two orders of magnitude improvement in energy efficiency.”

      The research team is now looking at similar low-symmetry van der Waals materials to see if they can reduce current density even further. They are also hoping to collaborate with other researchers to find ways to manufacture the 2D magnetic switch devices at commercial scale. 

      This work was carried out, in part, using the facilities at MIT.nano. It was funded by the Media Lab, the U.S. National Science Foundation, and the U.S. Department of Energy. More

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      in Energy

      New MIT.nano equipment to accelerate innovation in “tough tech” sectors

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      A new set of advanced nanofabrication equipment will make MIT.nano one of the world’s most advanced research facilities in microelectronics and related technologies, unlocking new opportunities for experimentation and widening the path for promising inventions to become impactful new products.

      The equipment, provided by Applied Materials, will significantly expand MIT.nano’s nanofabrication capabilities, making them compatible with wafers — thin, round slices of semiconductor material — up to 200 millimeters, or 8 inches, in diameter, a size widely used in industry. The new tools will allow researchers to prototype a vast array of new microelectronic devices using state-of-the-art materials and fabrication processes. At the same time, the 200-millimeter compatibility will support close collaboration with industry and enable innovations to be rapidly adopted by companies and mass produced.

      MIT.nano’s leaders say the equipment, which will also be available to scientists outside of MIT, will dramatically enhance their facility’s capabilities, allowing experts in the region to more efficiently explore new approaches in “tough tech” sectors, including advanced electronics, next-generation batteries, renewable energies, optical computing, biological sensing, and a host of other areas — many likely yet to be imagined.

      “The toolsets will provide an accelerative boost to our ability to launch new technologies that can then be given to the world at scale,” says MIT.nano Director Vladimir Bulović, who is also the Fariborz Maseeh Professor of Emerging Technology. “MIT.nano is committed to its expansive mission — to build a better world. We provide toolsets and capabilities that, in the hands of brilliant researchers, can effectively move the world forward.”

      The announcement comes as part of an agreement between MIT and Applied Materials, Inc. that, together with a grant to MIT from the Northeast Microelectronics Coalition (NEMC) Hub, commits more than $40 million of estimated private and public investment to add advanced nano-fabrication equipment and capabilities at MIT.nano.

      “We don’t believe there is another space in the United States that will offer the same kind of versatility, capability, and accessibility, with 8-inch toolsets integrated right next to more fundamental toolsets for research discoveries,” Bulović says. “It will create a seamless path to accelerate the pace of innovation.”

      Pushing the boundaries of innovation

      Applied Materials is the world’s largest supplier of equipment for manufacturing semiconductors, displays, and other advanced electronics. The company will provide at MIT.nano several state-of-the-art process tools capable of supporting 150- and 200-millimeter wafers and will enhance and upgrade an existing tool owned by MIT. In addition to assisting MIT.nano in the day-to-day operation and maintenance of the equipment, Applied Materials engineers will develop new process capabilities to benefit researchers and students from MIT and beyond.

      “This investment will significantly accelerate the pace of innovation and discovery in microelectronics and microsystems,” says Tomás Palacios, director of MIT’s Microsystems Technology Laboratories and the Clarence J. Lebel Professor in Electrical Engineering. “It’s wonderful news for our community, wonderful news for the state, and, in my view, a tremendous step forward toward implementing the national vision for the future of innovation in microelectronics.”

      Nanoscale research at universities is traditionally conducted on machines that are less compatible with industry, which makes academic innovations more difficult to turn into impactful, mass-produced products. Jorg Scholvin, associate director for MIT.nano’s shared fabrication facility, says the new machines, when combined with MIT.nano’s existing equipment, represent a step-change improvement in that area: Researchers will be able to take an industry-standard wafer and build their technology on top of it to prove to companies it works on existing devices, or to co-fabricate new ideas in close collaboration with industry partners.

      “In the journey from an idea to a fully working device, the ability to begin on a small scale, figure out what you want to do, rapidly debug your designs, and then scale it up to an industry-scale wafer is critical,” Scholvin says. “It means a student can test out their idea on wafer-scale quickly and directly incorporate insights into their project so that their processes are scalable. Providing such proof-of-principle early on will accelerate the idea out of the academic environment, potentially reducing years of added effort. Other tools at MIT.nano can supplement work on the 200-millimeter wafer scale, but the higher throughput and higher precision of the Applied equipment will provide researchers with repeatability and accuracy that is unprecedented for academic research environments. Essentially what you have is a sharper, faster, more precise tool to do your work.”

      Scholvin predicts the equipment will lead to exponential growth in research opportunities.

      “I think a key benefit of these tools is they allow us to push the boundary of research in a variety of different ways that we can predict today,” Scholvin says. “But then there are also unpredictable benefits, which are hiding in the shadows waiting to be discovered by the creativity of the researchers at MIT. With each new application, more ideas and paths usually come to mind — so that over time, more and more opportunities are discovered.”

      Because the equipment is available for use by people outside of the MIT community, including regional researchers, industry partners, nonprofit organizations, and local startups, they will also enable new collaborations.

      “The tools themselves will be an incredible meeting place — a place that can, I think, transpose the best of our ideas in a much more effective way than before,” Bulović says. “I’m extremely excited about that.”

      Palacios notes that while microelectronics is best known for work making transistors smaller to fit on microprocessors, it’s a vast field that enables virtually all the technology around us, from wireless communications and high-speed internet to energy management, personalized health care, and more.

      He says he’s personally excited to use the new machines to do research around power electronics and semiconductors, including exploring promising new materials like gallium nitride, which could dramatically improve the efficiency of electronic devices.

      Fulfilling a mission

      MIT.nano’s leaders say a key driver of commercialization will be startups, both from MIT and beyond.

      “This is not only going to help the MIT research community innovate faster, it’s also going to enable a new wave of entrepreneurship,” Palacios says. “We’re reducing the barriers for students, faculty, and other entrepreneurs to be able to take innovation and get it to market. That fits nicely with MIT’s mission of making the world a better place through technology. I cannot wait to see the amazing new inventions that our colleagues and students will come out with.”

      Bulović says the announcement aligns with the mission laid out by MIT’s leaders at MIT.nano’s inception.

      “We have the space in MIT.nano to accommodate these tools, we have the capabilities inside MIT.nano to manage their operation, and as a shared and open facility, we have methodologies by which we can welcome anyone from the region to use the tools,” Bulović says. “That is the vision MIT laid out as we were designing MIT.nano, and this announcement helps to fulfill that vision.” More

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      in Security

      Engineers develop a vibrating, ingestible capsule that might help treat obesity

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      When you eat a large meal, your stomach sends signals to your brain that create a feeling of fullness, which helps you realize it’s time to stop eating. A stomach full of liquid can also send these messages, which is why dieters are often advised to drink a glass of water before eating.

      MIT engineers have now come up with a new way to take advantage of that phenomenon, using an ingestible capsule that vibrates within the stomach. These vibrations activate the same stretch receptors that sense when the stomach is distended, creating an illusory sense of fullness.

      In animals who were given this pill 20 minutes before eating, the researchers found that this treatment not only stimulated the release of hormones that signal satiety, but also reduced the animals’ food intake by about 40 percent. Scientists have much more to learn about the mechanisms that influence human body weight, but if further research suggests this technology could be safely used in humans, such a pill might offer a minimally invasive way to treat obesity, the researchers say.

      “For somebody who wants to lose weight or control their appetite, it could be taken before each meal,” says Shriya Srinivasan PhD ’20, a former MIT graduate student and postdoc who is now an assistant professor of bioengineering at Harvard University. “This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there.”

      Srinivasan is the lead author of the new study, which appears today in Science Advances. Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital, is the senior author of the paper.

      A sense of fullness

      When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates production of insulin, as well as hormones such as C-peptide, Pyy, and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down.

      While a graduate student at MIT, Srinivasan became interested in the idea of controlling this process by artificially stretching the mechanoreceptors that line the stomach, through vibration. Previous research had shown that vibration applied to a muscle can induce a sense that the muscle has stretched farther than it actually has.

      “I wondered if we could activate stretch receptors in the stomach by vibrating them and having them perceive that the entire stomach has been expanded, to create an illusory sense of distension that could modulate hormones and eating patterns,” Srinivasan says.

      As a postdoc in MIT’s Koch Institute for Integrative Cancer Research, Srinivasan worked closely with Traverso’s lab, which has developed many novel approaches to oral delivery of drugs and electronic devices. For this study, Srinivasan, Traverso, and a team of researchers designed a capsule about the size of a multivitamin, that includes a vibrating element. When the pill, which is powered by a small silver oxide battery, reaches the stomach, acidic gastric fluids dissolve a gelatinous membrane that covers the capsule, completing the electronic circuit that activates the vibrating motor.

      In a study in animals, the researchers showed that once the pill begins vibrating, it activates mechanoreceptors, which send signals to the brain through stimulation of the vagus nerve. The researchers tracked hormone levels during the periods when the device was vibrating and found that they mirrored the hormone release patterns seen following a meal, even when the animals had fasted.

      The researchers then tested the effects of this stimulation on the animals’ appetite. They found that when the pill was activated for about 20 minutes, before the animals were offered food, they consumed 40 percent less, on average, than they did when the pill was not activated. The animals also gained weight more slowly during periods when they were treated with the vibrating pill.

      “The behavioral change is profound, and that’s using the endogenous system rather than any exogenous therapeutic. We have the potential to overcome some of the challenges and costs associated with delivery of biologic drugs by modulating the enteric nervous system,” Traverso says.

      The current version of the pill is designed to vibrate for about 30 minutes after arriving in the stomach, but the researchers plan to explore the possibility of adapting it to remain in the stomach for longer periods of time, where it could be turned on and off wirelessly as needed. In the animal studies, the pills passed through the digestive tract within four or five days.

      The study also found that the animals did not show any signs of obstruction, perforation, or other negative impacts while the pill was in their digestive tract.

      An alternative approach

      This type of pill could offer an alternative to the current approaches to treating obesity, the researchers say. Nonmedical interventions such as diet exercise don’t always work, and many of the existing medical interventions are fairly invasive. These include gastric bypass surgery, as well as gastric balloons, which are no longer used widely in the United States due to safety concerns.

      Drugs such as GLP-1 agonists can also aid weight loss, but most of them have to be injected, and they are unaffordable for many people. According to Srinivasan, the MIT capsules could be manufactured at a cost that would make them available to people who don’t have access to more expensive treatment options.

      “For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point,” she says. “I’d love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today.”

      The researchers now plan to explore ways to scale up the manufacturing of the capsules, which could enable clinical trials in humans. Such studies would be important to learn more about the devices’ safety, as well as determine the best time to swallow the capsule before to a meal and how often it would need to be administered.

      Other authors of the paper include Amro Alshareef, Alexandria Hwang, Ceara Byrne, Johannes Kuosmann, Keiko Ishida, Joshua Jenkins, Sabrina Liu, Wiam Abdalla Mohammed Madani, Alison Hayward, and Niora Fabian.

      The research was funded by the National Institutes of Health, Novo Nordisk, the Department of Mechanical Engineering at MIT, a Schmidt Science Fellowship, and the National Science Foundation. More