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      Angela Belcher delivers 2023 Dresselhaus Lecture on evolving organisms for new nanomaterials

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      “How do we get to making nanomaterials that haven’t been evolved before?” asked Angela Belcher at the 2023 Mildred S. Dresselhaus Lecture at MIT on Nov. 20. “We can use elements that biology has already given us.”

      The combined in-person and virtual audience of over 300 was treated to a light-up, 3D model of M13 bacteriophage, a virus that only infects bacteria, complete with a pull-out strand of DNA. Belcher used the feather-boa-like model to show how her research group modifies the M13’s genes to add new DNA and peptide sequences to template inorganic materials.

      “I love controlling materials at the nanoscale using biology,” said Belcher, the James Mason Crafts Professor of Biological Engineering, materials science professor, and of the Koch Institute of Integrative Cancer Research at MIT. “We all know if you control materials at the nanoscale and you can start to tune them, then you can have all kinds of different applications.” And the opportunities are indeed vast — from building batteries, fuel cells, and solar cells to carbon sequestration and storage, environmental remediation, catalysis, and medical diagnostics and imaging.

      Belcher sprinkled her talk with models and props, lined up on a table at the front of the 10-250 lecture hall, to demonstrate a wide variety of concepts and projects made possible by the intersection of biology and nanotechnology.

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      2023 Mildred S. Dresselhaus Lecture: Angela BelcherVideo: MIT.nano

      Energy storage and environment

      “How do you go from a DNA sequence to a functioning battery?” posed Belcher. Grabbing a model of a large carbon nanotube, she explained how her group engineered a phage to pick up carbon nanotubes that would wind all the way around the virus and then fill in with different cathode or anode materials to make nanowires for battery electrodes.

      How about using the M13 bacteriophage to improve the environment? Belcher referred to a project by former student Geran Zhang PhD ’19 that proved the virus can be modified for this context, too. He used the phage to template high-surface-area, carbon-based materials that can grab small molecules and break them down, Belcher said, opening a realm of possibilities from cleaning up rivers to developing chemical warfare agents to combating smog.

      Belcher’s lab worked with the U.S. Army to produce protective clothing and masks made of these carbon-based virus nanofibers. “We went from five liters in our lab to a thousand liters, then 10,000 liters in the army labs where we’re able to make kilograms of the material,” Belcher said, stressing the importance of being able to test and prototype at scale.

      Imaging tools and therapeutics in cancer

      In the area of biomedical imaging, Belcher explained, a lot less is known in near-infrared imaging — imaging in wavelengths above 1,000 nanometers — than other imaging techniques, yet with near-infrared scientists can see much deeper inside the body. Belcher’s lab built their own systems to image at these wavelengths. The third generation of this system provides real-time, sub-millimeter optical imaging for guided surgery.

      Working with Sangeeta Bhatia, the John J. and Dorothy Wilson Professor of Engineering, Belcher used carbon nanotubes to build imaging tools that find tiny tumors during surgery that doctors otherwise would not be able to see. The tool is actually a virus engineered to carry with it a fluorescent, single-walled carbon nanotube as it seeks out the tumors.

      Nearing the end of her talk, Belcher presented a goal: to develop an accessible detection and diagnostic technology for ovarian cancer in five to 10 years.

      “We think that we can do it,” Belcher said. She described her students’ work developing a way to scan an entire fallopian tube, as opposed to just one small portion, to find pre-cancer lesions, and talked about the team of MIT faculty, doctors, and researchers working collectively toward this goal.

      “Part of the secret of life and the meaning of life is helping other people enjoy the passage of time,” said Belcher in her closing remarks. “I think that we can all do that by working to solve some of the biggest issues on the planet, including helping to diagnose and treat ovarian cancer early so people have more time to spend with their family.”

      Honoring Mildred S. Dresselhaus

      Belcher was the fifth speaker to deliver the Dresselhaus Lecture, an annual event organized by MIT.nano to honor the late MIT physics and electrical engineering Institute Professor Mildred Dresselhaus. The lecture features a speaker from anywhere in the world whose leadership and impact echo Dresselhaus’s life, accomplishments, and values.

      “Millie was and is a huge hero of mine,” said Belcher. “Giving a lecture in Millie’s name is just the greatest honor.”

      Belcher dedicated the talk to Dresselhaus, whom she described with an array of accolades — a trailblazer, a genius, an amazing mentor, teacher, and inventor. “Just knowing her was such a privilege,” she said.

      Belcher also dedicated her talk to her own grandmother and mother, both of whom passed away from cancer, as well as late MIT professors Susan Lindquist and Angelika Amon, who both died of ovarian cancer.

      “I’ve been so fortunate to work with just the most talented and dedicated graduate students, undergraduate students, postdocs, and researchers,” concluded Belcher. “It has been a pure joy to be in partnership with all of you to solve these very daunting problems.” More

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      Making nuclear energy facilities easier to build and transport

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      For the United States to meet its net zero goals, nuclear energy needs to be on the smorgasbord of options. The problem: Its production still suffers from a lack of scale. To increase access rapidly, we need to stand up reactors quickly, says Isabel Naranjo De Candido, a third-year doctoral student advised by Professor Koroush Shirvan.

      One option is to work with microreactors, transportable units that can be wheeled to areas that need clean electricity. Naranjo De Candido’s master’s thesis at MIT, supervised by Professor Jacopo Buongiorno, focused on such reactors.

      Another way to improve access to nuclear energy is to develop reactors that are modular so their component units can be manufactured quickly while still maintaining quality. “The idea is that you apply the industrialization techniques of manufacturing so companies produce more [nuclear] vessels, with a more predictable supply chain,” she says. The assumption is that working with standardized recipes to manufacture just a few designed components over and over again improves speed and reliability and decreases cost.

      As part of her doctoral studies, Naranjo De Candido is working on optimizing the operations and management of these small, modular reactors so they can be efficient in all stages of their lifecycle: building; operations and maintenance; and decommissioning. The motivation for her research is simple: “We need nuclear for climate change because we need a reliable and stable source of energy to fight climate change,” she says.

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      A childhood in Italy

      Despite her passion for nuclear energy and engineering today, Naranjo De Candido was unsure what she wanted to pursue after high school in Padua, Italy. The daughter of a physician Italian mother and an architect Spanish father, she enrolled in a science-based high school shortly after middle school, as she knew that was the track she enjoyed best.

      Having earned very high marks in school, she won a full scholarship to study in Pisa, at the special Sant’Anna School of Advanced Studies. Housed in a centuries-old convent, the school granted only masters and doctoral degrees. “I had to select what to study but I was unsure. I knew I was interested in engineering,” she recalls, “so I selected mechanical engineering because it’s more generic.”

      It turns out Sant’Anna was a perfect fit for Naranjo De Candido to explore her passions. An inspirational nuclear engineering course during her studies set her on the path toward studying the field as part of her master’s studies in Pisa. During her time there, she traveled around the world — to China as part of a student exchange program and to Switzerland and the United States for internships. “I formed a good background and curriculum and that allowed me to [gain admission] to MIT,” she says.

      At an internship at NASA’s Jet Propulsion Lab, she met an MIT mechanical engineering student who encouraged her to apply to the school for doctoral studies. Yet another mentor in the Italian nuclear sector had also suggested she apply to MIT to pursue nuclear engineering, so she decided to take the leap.

      And she is glad she did.

      Improving access to nuclear energy

      At MIT, Naranjo De Candido is working on improving access to nuclear energy by scaling down reactor size and, in the case of microreactors, making them mobile enough to travel to places where they’re needed. “The idea with a microreactor is that when the fuel is exhausted, you replace the entire microreactor onsite with a freshly fueled unit and take the old one back to a central facility where it’s going to be refueled,” she says. One of the early use cases for such microreactors has been remote mining sites which need reliable power 24/7.

      Modular reactors, about 10 times the size of microreactors, ensure access differently: The components can be manufactured and installed at scale. These reactors don’t just deliver electricity but also cater to the market for industrial heat, she says. “You can locate them close to industrial facilities and use the heat directly to power ammonia or hydrogen production or water desalinization for example,” she adds.

      As more of these modular reactors are installed, the industry is expected to expand to include enterprises that choose to simply build them and hand off operations to other companies. Whereas traditional nuclear energy reactors might have a full suite of staff on board, smaller-scale reactors such as modular ones cannot afford to staff in large numbers, so talent needs to be optimized and staff shared among many units. “Many of these companies are very interested in knowing exactly how many people and how much money to allocate, and how to organize resources to serve more than one reactor at the same time,” she says.

      Naranjo De Candido is working on a complex software program that factors in a large range of variables — from raw materials cost and worker training, reactor size, megawatt output and more — and leans on historical data to predict what resources newer plants might need. The program also informs operators about the tradeoffs they need to accept. For example, she explains, “if you reduce people below the typical level assigned, how does that impact the reliability of the plant, that is, the number of hours that it is able to operate without malfunctions and failures?”

      And managing and operating a nuclear reactor is particularly complex because safety standards limit how much time workers can work in certain areas and how safe zones need to be handled.

      “There’s a shortage of [qualified talent] in the industry so this is not just about reducing costs but also about making it possible to have plants out there,” Naranjo De Candido says. Different types of talent are needed, from professionals who specialize in mechanical components to electronic controls. The model that she is working on considers the need for such specialized skillsets as well as making room for cross-training talent in multiple fields as needed.

      In keeping with her goal of making nuclear energy more accessible, the optimization software will be open-source, available for all to use. “We want this to be a common ground for utilities and vendors and other players to be able to communicate better,” Naranjo De Candido says, Doing so will accelerate the operation of nuclear energy plants at scale, she hopes — an achievement that will come not a moment too soon. More

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      Accelerated climate action needed to sharply reduce current risks to life and life-support systems

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      Hottest day on record. Hottest month on record. Extreme marine heatwaves. Record-low Antarctic sea-ice.

      While El Niño is a short-term factor in this year’s record-breaking heat, human-caused climate change is the long-term driver. And as global warming edges closer to 1.5 degrees Celsius — the aspirational upper limit set in the Paris Agreement in 2015 — ushering in more intense and frequent heatwaves, floods, wildfires, and other climate extremes much sooner than many expected, current greenhouse gas emissions-reduction policies are far too weak to keep the planet from exceeding that threshold. In fact, on roughly one-third of days in 2023, the average global temperature was at least 1.5 C higher than pre-industrial levels. Faster and bolder action will be needed — from the in-progress United Nations Climate Change Conference (COP28) and beyond — to stabilize the climate and minimize risks to human (and nonhuman) lives and the life-support systems (e.g., food, water, shelter, and more) upon which they depend.

      Quantifying the risks posed by simply maintaining existing climate policies — and the benefits (i.e., avoided damages and costs) of accelerated climate action aligned with the 1.5 C goal — is the central task of the 2023 Global Change Outlook, recently released by the MIT Joint Program on the Science and Policy of Global Change.

      Based on a rigorous, integrated analysis of population and economic growth, technological change, Paris Agreement emissions-reduction pledges (Nationally Determined Contributions, or NDCs), geopolitical tensions, and other factors, the report presents the MIT Joint Program’s latest projections for the future of the earth’s energy, food, water, and climate systems, as well as prospects for achieving the Paris Agreement’s short- and long-term climate goals.

      The 2023 Global Change Outlook performs its risk-benefit analysis by focusing on two scenarios. The first, Current Trends, assumes that Paris Agreement NDCs are implemented through the year 2030, and maintained thereafter. While this scenario represents an unprecedented global commitment to limit greenhouse gas emissions, it neither stabilizes climate nor limits climate change. The second scenario, Accelerated Actions, extends from the Paris Agreement’s initial NDCs and aligns with its long-term goals. This scenario aims to limit and stabilize human-induced global climate warming to 1.5 C by the end of this century with at least a 50 percent probability. Uncertainty is quantified using 400-member ensembles of projections for each scenario.

      This year’s report also includes a visualization tool that enables a higher-resolution exploration of both scenarios.

      Energy

      Between 2020 and 2050, population and economic growth are projected to drive continued increases in energy needs and electrification. Successful achievement of current Paris Agreement pledges will reinforce a shift away from fossil fuels, but additional actions will be required to accelerate the energy transition needed to cap global warming at 1.5 C by 2100.

      During this 30-year period under the Current Trends scenario, the share of fossil fuels in the global energy mix drops from 80 percent to 70 percent. Variable renewable energy (wind and solar) is the fastest growing energy source with more than an 8.6-fold increase. In the Accelerated Actions scenario, the share of low-carbon energy sources grows from 20 percent to slightly more than 60 percent, a much faster growth rate than in the Current Trends scenario; wind and solar energy undergo more than a 13.3-fold increase.

      While the electric power sector is expected to successfully scale up (with electricity production increasing by 73 percent under Current Trends, and 87 percent under Accelerated Actions) to accommodate increased demand (particularly for variable renewables), other sectors face stiffer challenges in their efforts to decarbonize.

      “Due to a sizeable need for hydrocarbons in the form of liquid and gaseous fuels for sectors such as heavy-duty long-distance transport, high-temperature industrial heat, agriculture, and chemical production, hydrogen-based fuels and renewable natural gas remain attractive options, but the challenges related to their scaling opportunities and costs must be resolved,” says MIT Joint Program Deputy Director Sergey Paltsev, a lead author of the 2023 Global Change Outlook.

      Water, food, and land

      With a global population projected to reach 9.9 billion by 2050, the Current Trends scenario indicates that more than half of the world’s population will experience pressures to its water supply, and that three of every 10 people will live in water basins where compounding societal and environmental pressures on water resources will be experienced. Population projections under combined water stress in all scenarios reveal that the Accelerated Actions scenario can reduce approximately 40 million of the additional 570 million people living in water-stressed basins at mid-century.

      Under the Current Trends scenario, agriculture and food production will keep growing. This will increase pressure for land-use change, water use, and use of energy-intensive inputs, which will also lead to higher greenhouse gas emissions. Under the Accelerated Actions scenario, less agricultural and food output is observed by 2050 compared to the Current Trends scenario, since this scenario affects economic growth and increases production costs. Livestock production is more greenhouse gas emissions-intensive than crop and food production, which, under carbon-pricing policies, drives demand downward and increases costs and prices. Such impacts are transmitted to the food sector and imply lower consumption of livestock-based products.

      Land-use changes in the Accelerated Actions scenario are similar to those in the Current Trends scenario by 2050, except for land dedicated to bioenergy production. At the world level, the Accelerated Actions scenario requires cropland area to increase by 1 percent and pastureland to decrease by 4.2 percent, but land use for bioenergy must increase by 44 percent.

      Climate trends

      Under the Current Trends scenario, the world is likely (more than 50 percent probability) to exceed 2 C global climate warming by 2060, 2.8 C by 2100, and 3.8 C by 2150. Our latest climate-model information indicates that maximum temperatures will likely outpace mean temperature trends over much of North and South America, Europe, northern and southeast Asia, and southern parts of Africa and Australasia. So as human-forced climate warming intensifies, these regions are expected to experience more pronounced record-breaking extreme heat events.

      Under the Accelerated Actions scenario, global temperature will continue to rise through the next two decades. But by 2050, global temperature will stabilize, and then slightly decline through the latter half of the century.

      “By 2100, the Accelerated Actions scenario indicates that the world can be virtually assured of remaining below 2 C of global warming,” says MIT Joint Program Deputy Director C. Adam Schlosser, a lead author of the report. “Nevertheless, additional policy mechanisms must be designed with more comprehensive targets that also support a cleaner environment, sustainable resources, as well as improved and equitable human health.”

      The Accelerated Actions scenario not only stabilizes global precipitation increase (by 2060), but substantially reduces the magnitude and potential range of increases to almost one-third of Current Trends global precipitation changes. Any global increase in precipitation heightens flood risk worldwide, so policies aligned with the Accelerated Actions scenario would considerably reduce that risk.

      Prospects for meeting Paris Agreement climate goals

      Numerous countries and regions are progressing in fulfilling their Paris Agreement pledges. Many have declared more ambitious greenhouse gas emissions-mitigation goals, while financing to assist the least-developed countries in sustainable development is not forthcoming at the levels needed. In this year’s Global Stocktake Synthesis Report, the U.N. Framework Convention on Climate Change evaluated emissions reductions communicated by the parties of the Paris Agreement and concluded that global emissions are not on track to fulfill the most ambitious long-term global temperature goals of the Paris Agreement (to keep warming well below 2 C — and, ideally, 1.5 C — above pre-industrial levels), and there is a rapidly narrowing window to raise ambition and implement existing commitments in order to achieve those targets. The Current Trends scenario arrives at the same conclusion.

      The 2023 Global Change Outlook finds that both global temperature targets remain achievable, but require much deeper near-term emissions reductions than those embodied in current NDCs.

      Reducing climate risk

      This report explores two well-known sets of risks posed by climate change. Research highlighted indicates that elevated climate-related physical risks will continue to evolve by mid-century, along with heightened transition risks that arise from shifts in the political, technological, social, and economic landscapes that are likely to occur during the transition to a low-carbon economy.

      “Our Outlook shows that without aggressive actions the world will surpass critical greenhouse gas concentration thresholds and climate targets in the coming decades,” says MIT Joint Program Director Ronald Prinn. “While the costs of inaction are getting higher, the costs of action are more manageable.” More

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      New study shows how universities are critical to emerging fusion industry

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      A new study suggests that universities have an essential role to fulfill in the continued growth and success of any modern high-tech industry, and especially the nascent fusion industry; however, the importance of that role is not reflected in the number of fusion-oriented faculty and educational channels currently available. Academia’s responsiveness to the birth of other modern scientific fields, such as aeronautics and nuclear fission, provides a template for the steps universities can take to enable a robust fusion industry.

      Authored by Dennis Whyte, the Hitachi America Professor of Engineering and director of the Plasma Science and Fusion Center at MIT; Carlos Paz-Soldan, associate professor of applied physics and applied mathematics at Columbia University; and Brian D. Wirth, the Governor’s Chair Professor of Computational Nuclear Engineering at the University of Tennessee, the paper was recently published in the journal Physics of Plasmas as part of a special collection titled “Private Fusion Research: Opportunities and Challenges in Plasma Science.”

      With contributions from authors in academia, government, and private industry, the collection outlines a framework for public-private partnerships that will be essential for the success of the fusion industry.

      Now being seen as a potential source of unlimited green energy, fusion is the same process that powers the sun — hydrogen atoms combine to form helium, releasing vast amounts of clean energy in the form of light and heat.

      The excitement surrounding fusion’s arrival has resulted in the proliferation of dozens of for-profit companies positioning themselves at the forefront of the commercial fusion energy industry. In the near future, those companies will require a significant network of fusion-fluent workers to take on varied tasks requiring a range of skills.

      While the authors acknowledge the role of private industry, especially as an increasingly dominant source of research funding, they also show that academia is and will continue to be critical to industry’s development, and it cannot be decoupled from private industry’s growth. Despite the evidence of this burgeoning interest, the size and scale of the field’s academic network at U.S.-based universities is sparse.

      According to Whyte, “Diversifying the [fusion] field by adding more tracks for master’s students and undergraduates who can transition into industry more quickly is an important step.”

      An analysis found that while there are 57 universities in the United States active in plasma and fusion research, the average number of tenured or tenure-track plasma/fusion faculty at each institution is only two. By comparison, a sampling of US News and World Report’s top 10 programs for nuclear fission and aeronautics/astronautics found an average of nearly 20 faculty devoted to fission and 32 to aero/astro.

      “University programs in fusion and their sponsors need to up their game and hire additional faculty if they want to provide the necessary workforce to support a growing U.S. fusion industry,” adds Paz-Soldan.

      The growth and proliferation of those fields and others, such as computing and biotechnology, were historically in lockstep with the creation of academic programs that helped drive the fields’ progress and widespread acceptance. Creating a similar path for fusion is essential to ensuring its sustainable growth, and as Wirth notes, “that this growth should be pursued in a way that is interdisciplinary across numerous engineering and science disciplines.”

      At MIT, an example of that path is seen at the Plasma Science and Fusion Center.

      The center has deep historical ties to government research programs, and the largest fusion company in the world, Commonwealth Fusion Systems (CFS), was spun out of the PSFC by Whyte’s former students and an MIT postdoc. Whyte also serves as the primary investigator in collaborative research with CFS on SPARC, a proof-of-concept fusion platform for advancing tokamak science that is scheduled for completion in 2025.

      “Public and private roles in the fusion community are rapidly evolving in response to the growth of privately funded commercial product development,” says Michael Segal, head of open innovation at CFS. “The fusion industry will increasingly rely on its university partners to train students, work across diverse disciplines, and execute small and midsize programs at speed.”

      According to the authors, another key reason academia will remain essential to the continued growth and development of fusion is because it is unconflicted. Whyte comments, “Our mandate is sharing information and education, which means we have no competitive conflict and innovation can flow freely.” Furthermore, fusion science is inherently multidisciplinary: “[It] requires physicists, computer scientists, engineers, chemists, etc. and it’s easy to tap into all those disciplines in an academic environment where they’re all naturally rubbing elbows and collaborating.”

      Creating a new energy industry, however, will also require a workforce skilled in disciplines other than STEM, say the authors. As fusion companies continue to grow, they will need expertise in finance, safety, licensing, and market analysis. Any successful fusion enterprise will also have major geopolitical, societal, and economic impacts, all of which must be managed.

      Ultimately, there are several steps the authors identify to help build the connections between academia and industry that will be important going forward: The first is for universities to acknowledge the rapidly changing fusion landscape and begin to adapt. “Universities need to embrace the growth of the private sector in fusion, recognize the opportunities it provides, and seek out mutually beneficial partnerships,” says Paz-Soldan.

      The second step is to reconcile the mission of educational institutions — unconflicted open access — with condensed timelines and proprietary outputs that come with private partnerships. At the same time, the authors note that private fusion companies should embrace the transparency of academia by publishing and sharing the findings they can through peer-reviewed journals, which will be a necessary part of building the industry’s credibility.

      The last step, the authors say, is for universities to become more flexible and creative in their technology licensing strategies to ensure ideas and innovations find their way from the lab into industry.

      “As an industry, we’re in a unique position because everything is brand new,” Whyte says. “But we’re enough students of history that we can see what’s needed to succeed; quantifying the status of the private and academic landscape is an important strategic touchstone. By drawing attention to the current trajectory, hopefully we’ll be in a better position to work with our colleagues in the public and private sector and make better-informed choices about how to proceed.” More

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      Celebrating five years of MIT.nano

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      There is vast opportunity for nanoscale innovation to transform the world in positive ways — expressed MIT.nano Director Vladimir Bulović as he posed two questions to attendees at the start of the inaugural Nano Summit: “Where are we heading? And what is the next big thing we can develop?”

      “The answer to that puts into perspective our main purpose — and that is to change the world,” Bulović, the Fariborz Maseeh Professor of Emerging Technologies, told an audience of more than 325 in-person and 150 virtual participants gathered for an exploration of nano-related research at MIT and a celebration of MIT.nano’s fifth anniversary.

      Over a decade ago, MIT embarked on a massive project for the ultra-small — building an advanced facility to support research at the nanoscale. Construction of MIT.nano in the heart of MIT’s campus, a process compared to assembling a ship in a bottle, began in 2015, and the facility launched in October 2018.

      Fast forward five years: MIT.nano now contains nearly 170 tools and instruments serving more than 1,200 trained researchers. These individuals come from over 300 principal investigator labs, representing more than 50 MIT departments, labs, and centers. The facility also serves external users from industry, other academic institutions, and over 130 startup and multinational companies.

      A cross section of these faculty and researchers joined industry partners and MIT community members to kick off the first Nano Summit, which is expected to become an annual flagship event for MIT.nano and its industry consortium. Held on Oct. 24, the inaugural conference was co-hosted by the MIT Industrial Liaison Program.

      Six topical sessions highlighted recent developments in quantum science and engineering, materials, advanced electronics, energy, biology, and immersive data technology. The Nano Summit also featured startup ventures and an art exhibition.

      Watch the videos here.

      Seeing and manipulating at the nanoscale — and beyond

      “We need to develop new ways of building the next generation of materials,” said Frances Ross, the TDK Professor in Materials Science and Engineering (DMSE). “We need to use electron microscopy to help us understand not only what the structure is after it’s built, but how it came to be. I think the next few years in this piece of the nano realm are going to be really amazing.”

      Speakers in the session “The Next Materials Revolution,” chaired by MIT.nano co-director for Characterization.nano and associate professor in DMSE James LeBeau, highlighted areas in which cutting-edge microscopy provides insights into the behavior of functional materials at the nanoscale, from anti-ferroelectrics to thin-film photovoltaics and 2D materials. They shared images and videos collected using the instruments in MIT.nano’s characterization suites, which were specifically designed and constructed to minimize mechanical-vibrational and electro-magnetic interference.

      Later, in the “Biology and Human Health” session chaired by Boris Magasanik Professor of Biology Thomas Schwartz, biologists echoed the materials scientists, stressing the importance of the ultra-quiet, low-vibration environment in Characterization.nano to obtain high-resolution images of biological structures.

      “Why is MIT.nano important for us?” asked Schwartz. “An important element of biology is to understand the structure of biology macromolecules. We want to get to an atomic resolution of these structures. CryoEM (cryo-electron microscopy) is an excellent method for this. In order to enable the resolution revolution, we had to get these instruments to MIT. For that, MIT.nano was fantastic.”

      Seychelle Vos, the Robert A. Swanson (1969) Career Development Professor of Life Sciences, shared CryoEM images from her lab’s work, followed by biology Associate Professor Joey Davis who spoke about image processing. When asked about the next stage for CryoEM, Davis said he’s most excited about in-situ tomography, noting that there are new instruments being designed that will improve the current labor-intensive process.

      To chart the future of energy, chemistry associate professor Yogi Surendranath is also using MIT.nano to see what is happening at the nanoscale in his research to use renewable electricity to change carbon dioxide into fuel.

      “MIT.nano has played an immense role, not only in facilitating our ability to make nanostructures, but also to understand nanostructures through advanced imaging capabilities,” said Surendranath. “I see a lot of the future of MIT.nano around the question of how nanostructures evolve and change under the conditions that are relevant to their function. The tools at MIT.nano can help us sort that out.”

      Tech transfer and quantum computing

      The “Advanced Electronics” session chaired by Jesús del Alamo, the Donner Professor of Science in the Department of Electrical Engineering and Computer Science (EECS), brought together industry partners and MIT faculty for a panel discussion on the future of semiconductors and microelectronics. “Excellence in innovation is not enough, we also need to be excellent in transferring these to the marketplace,” said del Alamo. On this point, panelists spoke about strengthening the industry-university connection, as well as the importance of collaborative research environments and of access to advanced facilities, such as MIT.nano, for these environments to thrive.

      The session came on the heels of a startup exhibit in which eleven START.nano companies presented their technologies in health, energy, climate, and virtual reality, among other topics. START.nano, MIT.nano’s hard-tech accelerator, provides participants use of MIT.nano’s facilities at a discounted rate and access to MIT’s startup ecosystem. The program aims to ease hard-tech startups’ transition from the lab to the marketplace, surviving common “valleys of death” as they move from idea to prototype to scaling up.

      When asked about the state of quantum computing in the “Quantum Science and Engineering” session, physics professor Aram Harrow related his response to these startup challenges. “There are quite a few valleys to cross — there are the technical valleys, and then also the commercial valleys.” He spoke about scaling superconducting qubits and qubits made of suspended trapped ions, and the need for more scalable architectures, which we have the ingredients for, he said, but putting everything together is quite challenging.

      Throughout the session, William Oliver, professor of physics and the Henry Ellis Warren (1894) Professor of Electrical Engineering and Computer Science, asked the panelists how MIT.nano can address challenges in assembly and scalability in quantum science.

      “To harness the power of students to innovate, you really need to allow them to get their hands dirty, try new things, try all their crazy ideas, before this goes into a foundry-level process,” responded Kevin O’Brien, associate professor in EECS. “That’s what my group has been working on at MIT.nano, building these superconducting quantum processors using the state-of-the art fabrication techniques in MIT.nano.”

      Connecting the digital to the physical

      In his reflections on the semiconductor industry, Douglas Carlson, senior vice president for technology at MACOM, stressed connecting the digital world to real-world application. Later, in the “Immersive Data Technology” session, MIT.nano associate director Brian Anthony explained how, at the MIT.nano Immersion Lab, researchers are doing just that.

      “We think about and facilitate work that has the human immersed between hardware, data, and experience,” said Anthony, principal research scientist in mechanical engineering. He spoke about using the capabilities of the Immersion Lab to apply immersive technologies to different areas — health, sports, performance, manufacturing, and education, among others. Speakers in this session gave specific examples in hardware, pediatric health, and opera.

      Anthony connected this third pillar of MIT.nano to the fab and characterization facilities, highlighting how the Immersion Lab supports work conducted in other parts of the building. The Immersion Lab’s strength, he said, is taking novel work being developed inside MIT.nano and bringing it up to the human scale to think about applications and uses.

      Artworks that are scientifically inspired

      The Nano Summit closed with a reception at MIT.nano where guests could explore the facility and gaze through the cleanroom windows, where users were actively conducting research. Attendees were encouraged to visit an exhibition on MIT.nano’s first- and second-floor galleries featuring work by students from the MIT Program in Art, Culture, and Technology (ACT) who were invited to utilize MIT.nano’s tool sets and environments as inspiration for art.

      In his closing remarks, Bulović reflected on the community of people who keep MIT.nano running and who are using the tools to advance their research. “Today we are celebrating the facility and all the work that has been done over the last five years to bring it to where it is today. It is there to function not just as a space, but as an essential part of MIT’s mission in research, innovation, and education. I hope that all of us here today take away a deep appreciation and admiration for those who are leading the journey into the nano age.” More

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      Team engineers nanoparticles using ion irradiation to advance clean energy and fuel conversion

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      MIT researchers and colleagues have demonstrated a way to precisely control the size, composition, and other properties of nanoparticles key to the reactions involved in a variety of clean energy and environmental technologies. They did so by leveraging ion irradiation, a technique in which beams of charged particles bombard a material.

      They went on to show that nanoparticles created this way have superior performance over their conventionally made counterparts.

      “The materials we have worked on could advance several technologies, from fuel cells to generate CO2-free electricity to the production of clean hydrogen feedstocks for the chemical industry [through electrolysis cells],” says Bilge Yildiz, leader of the work and a professor in MIT’s departments of Nuclear Science and Engineering and Materials Science and Engineering.

      Critical catalyst

      Fuel and electrolysis cells both involve electrochemical reactions through three principal parts: two electrodes (a cathode and anode) separated by an electrolyte. The difference between the two cells is that the reactions involved run in reverse.

      The electrodes are coated with catalysts, or materials that make the reactions involved go faster. But a critical catalyst made of metal-oxide materials has been limited by challenges including low durability. “The metal catalyst particles coarsen at high temperatures, and you lose surface area and activity as a result,” says Yildiz, who is also affiliated with the Materials Research Laboratory and is an author of an open-access paper on the work published in the journal Energy & Environmental Science.

      Enter metal exsolution, which involves precipitating metal nanoparticles out of a host oxide onto the surface of the electrode. The particles embed themselves into the electrode, “and that anchoring makes them more stable,” says Yildiz. As a result, exsolution has “led to remarkable progress in clean energy conversion and energy-efficient computing devices,” the researchers write in their paper.

      However, controlling the precise properties of the resulting nanoparticles has been difficult. “We know that exsolution can give us stable and active nanoparticles, but the challenging part is really to control it. The novelty of this work is that we’ve found a tool — ion irradiation — that can give us that control,” says Jiayue Wang PhD ’22, first author of the paper. Wang, who conducted the work while earning his PhD in the MIT Department of Nuclear Science and Engineering, is now a postdoc at Stanford University.

      Sossina Haile ’86, PhD ’92, the Walter P. Murphy Professor of Materials Science and Engineering at Northwestern University, who was not involved in the current work, says:

      “Metallic nanoparticles serve as catalysts in a whole host of reactions, including the important reaction of splitting water to generate hydrogen for energy storage. In this work, Yildiz and colleagues have created an ingenious method for controlling the way that nanoparticles form.”

      Haile continues, “the community has shown that exsolution results in structurally stable nanoparticles, but the process is not easy to control, so one doesn’t necessarily get the optimal number and size of particles. Using ion irradiation, this group was able to precisely control the features of the nanoparticles, resulting in excellent catalytic activity for water splitting.”

      What they did

      The researchers found that aiming a beam of ions at the electrode while simultaneously exsolving metal nanoparticles onto the electrode’s surface allowed them to control several properties of the resulting nanoparticles.

      “Through ion-matter interactions, we have successfully engineered the size, composition, density, and location of the exsolved nanoparticles,” the team writes in Energy & Environmental Science.

      For example, they could make the particles much smaller — down to 2 billionths of a meter in diameter — than those made using conventional thermal exsolution methods alone. Further, they were able to change the composition of the nanoparticles by irradiating with specific elements. They demonstrated this with a beam of nickel ions that implanted nickel into the exsolved metal nanoparticle. As a result, they demonstrated a direct and convenient way to engineer the composition of exsolved nanoparticles.

      “We want to have multi-element nanoparticles, or alloys, because they usually have higher catalytic activity,” Yildiz says. “With our approach, the exsolution target does not have to be dependent on the substrate oxide itself.” Irradiation opens the door to many more compositions. “We can pretty much choose any oxide and any ion that we can irradiate with and exsolve that,” says Yildiz.

      The team also found that ion irradiation forms defects in the electrode itself. And these defects provide additional nucleation sites, or places for the exsolved nanoparticles to grow from, increasing the density of the resulting nanoparticles.

      Irradiation could also allow extreme spatial control over the nanoparticles. “Because you can focus the ion beam, you can imagine that you could ‘write’ with it to form specific nanostructures,” says Wang. “We did a preliminary demonstration [of that], but we believe it has potential to realize well-controlled micro- and nano-structures.”

      The team also showed that the nanoparticles they created with ion irradiation had superior catalytic activity over those created by conventional thermal exsolution alone.

      Additional MIT authors of the paper are Kevin B. Woller, a principal research scientist at the Plasma Science and Fusion Center (PSFC), home to the equipment used for ion irradiation; Abinash Kumar PhD ’22, who received his PhD from the Department of Materials Science and Engineering (DMSE) and is now at Oak Ridge National Laboratory; and James M. LeBeau, an associate professor in DMSE. Other authors are Zhan Zhang and Hua Zhou of Argonne National Laboratory, and Iradwikanari Waluyo and Adrian Hunt of Brookhaven National Laboratory.

      This work was funded by the OxEon Corp. and MIT’s PSFC. The research also used resources supported by the U.S. Department of Energy Office of Science, MIT’s Materials Research Laboratory, and MIT.nano. The work was performed, in part, at Harvard University through a network funded by the National Science Foundation. More

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      A green hydrogen innovation for clean energy

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      Renewable energy today — mainly derived from the sun or wind — depends on batteries for storage. While costs have dropped in recent years, the pursuit of more efficient means of storing renewable power continues.

      “All of these technologies, unfortunately, have a long way to go,” said Sossina Haile SB ’86, PhD ’92, the Walter P. Murphy Professor of Materials Science and Engineering at Northwestern University, at recent talk at MIT. She was the speaker of the fall 2023 Wulff Lecture, an event hosted by the Department of Materials Science and Engineering (DMSE) to ignite enthusiasm for the discipline.

      To add to the renewable energy mix — and help quicken the pace to a sustainable future — Haile is working on an approach based on hydrogen in fuel cells, particularly for eco-friendly fuel in cars. Fuel cells, like batteries, produce electricity from chemical reactions but don’t lose their charge so long as fuel is supplied.

      To generate power, the hydrogen must be pure — not attached to another molecule. Most methods of producing hydrogen today require burning fossil fuel, which generates planet-heating carbon emissions. Haile proposes a “green” process using renewable electricity to extract the hydrogen from steam.

      When hydrogen is used in a fuel cell, “you have water as the product, and that’s the beautiful zero emissions,” Haile said, referring to the renewable energy production cycle that is set in motion.

      Ammonia fuels hydrogen’s potential

      Hydrogen is not yet widely used as a fuel because it’s difficult to transport. For one, it has low energy density, meaning a large volume of hydrogen gas is needed to store a large amount of energy. And storing it is challenging because hydrogen’s tiny molecules can infiltrate metal tanks or pipes, causing cracks and gas leakage.

      Haile’s solution for transporting hydrogen is using ammonia to “carry” it. Ammonia is three parts hydrogen and one part nitrogen, so the hydrogen needs to be separated from the nitrogen before it can be used in the kind of fuel cells that can power cars.

      Ammonia has some advantages, including using existing pipelines and a high transmission capacity, Haile said — so more power can be transmitted at any given time.

      To extract the hydrogen from ammonia, Haile has built devices that look a lot like fuel cells, with cesium dihydrogen phosphate as an electrolyte. The “superprotonic” material displays high proton conductivity — it allows protons, or positively charged particles, to move through it. This is important for hydrogen, which has just a proton and an electron. By letting only protons through the electrolyte, the device strips hydrogen from the ammonia, leaving behind the nitrogen.

      The material has other benefits, too, Haile said: “It’s inexpensive, nontoxic, earth-abundant — all these good things that you want to have when you think about a sustainable energy technology.”

      Play video

      2023 Fall Wulff LectureVideo: Department of Materials Science and Engineering

      Sparking interest — and hope

      Haile’s talk piqued interest in the audience, which nearly filled the 6-120 auditorium at MIT, which seats about 150 people.

      Materials science and engineering major Nikhita Law heard hope in Haile’s talk for a more sustainable future.

      “A major problem in making our energy system sustainable is finding ways to store energy from renewables,” Law says. Even if hydrogen-powered cars are not as wide-scale as lithium-battery-powered electric cars, “a permanent energy storage station where we convert electricity into hydrogen and convert it back seems like it makes more sense than mining more lithium.”

      Another DMSE student, senior Daniel Tong, learned about the challenges involved in transporting hydrogen at another seminar and was curious to learn more. “This was something I hadn’t thought of: Can you carry hydrogen more effectively in a different form? That’s really cool.”

      He adds that talks like the Wulff Lecture are helpful in keeping people up to date in a wide-ranging, interdisciplinary field such as materials science and engineering, which spans chemistry, physics, engineering, and other disciplines. “This is a really good way to get exposed to different parts of materials science. There are so many more facets than you know of.”

      In her talk, Haile encouraged audience members to get involved in sustainability research.

      “There’s lots of room for further insight and materials discovery,” she said.

      Haile concluded by underscoring the challenges faced by developing countries in dealing with climate change impacts, particularly those near the equator where there isn’t adequate infrastructure to deal with big swings in precipitation and temperature. For the people who aren’t driven to solve problems that affect people on the other side of the world, Haile offered some extra motivation.

      “I’m sure many of you enjoy coffee. This is going to put the coffee crops in jeopardy as well,” she said. More

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      in Energy

      A civil discourse on climate change

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      A new MIT initiative designed to encourage open dialogue on campus kicked off with a conversation focused on how to address challenges related to climate change.

      “Climate Change: Existential Threat or Bump in the Road” featured Steve Koonin, theoretical physicist and former U.S. undersecretary for science during the Obama administration, and Kerry Emanuel, professor emeritus of atmospheric science at MIT. A crowd of roughly 130 students, staff, and faculty gathered in an MIT lecture hall for the discussion on Tuesday, Oct. 24. 

      “The bump is strongly favored,” Koonin said when the talk began, referring to his contention that climate change was a “bump in the road” rather than an existential threat. After proposing a future in which we could potentially expect continued growth in America’s gross domestic product despite transportation and infrastructure challenges related to climate change, he concluded that investments in nuclear energy and capacity increases related to storing wind- and solar-generated energy could help mitigate climate-related phenomena. 

      Emanuel, while mostly agreeing with Koonin’s assessment of climate challenges and potential solutions, cautioned against underselling the threat of human-aided climate change.

      “Humanity’s adaptation to climate stability hasn’t prepared us to effectively manage massive increases in temperature and associated effects,” he argued. “We’re poorly adapted to less-frequent events like those we’re observing now.”

      Decarbonization, Emanuel noted, can help mitigate global conflicts related to fossil fuel usage. “Carbonization kills between 8 and 9 million people annually,” he said.

      The conversation on climate change is one of several planned on campus this academic year. The speaker series is one part of “Civil Discourse in the Classroom and Beyond,” an initiative being led by MIT philosophers Alex Byrne and Brad Skow. The two-year project is meant to encourage the open exchange of ideas inside and outside college and university classrooms. 

      The speaker series pairs external thought leaders with MIT faculty to encourage the interrogation and debate of all kinds of ideas.

      Finding common ground

      At the talk on climate change, both Koonin and Emanuel recommended a slow and steady approach to mitigation efforts, reminding attendees that, for example, developing nations can’t afford to take a developed world approach to climate change. 

      “These people have immediate needs to meet,” Koonin reminded the audience, “which can include fossil fuel use.”

      Both Koonin and Emanuel recommended a series of steps to assist with both climate change mitigation and effective messaging:

      Sustain and improve climate science — continue to investigate and report findings.
      Improve climate communications for non-experts — tell an easy-to-understand and cohesive story.
      Focus on reliability and affordability before mitigation — don’t undertake massive efforts that may disrupt existing energy transmission infrastructure.
      Adopt a “graceful” approach to decarbonization — consider impacts as broadly as possible.
      Don’t constrain energy supply in the developing world.
      Increase focus on developing and delivering alternative responses  — consider the potential ability to scale power generation, and delivery methods like nuclear energy.
      Mitigating climate risk requires political will, careful consideration, and an improved technical approach to energy policy, both concluded.

      “We have to learn to deal rationally with climate risk in a polarized society,” Koonin offered.

      The audience asked both speakers questions about impacts on nonhuman species (“We don’t know but we should,” both shared); nuclear fusion (“There isn’t enough tritium to effectively scale the widespread development of fusion-based energy; perhaps in 30 to 40 years,” Koonin suggested); and the planetary boundaries framework (“There’s good science underway in this space and I’m curious to see where it’s headed,” said Emanuel.) 

      “The event was a great success,” said Byrne, afterward. “The audience was engaged, and there was a good mix of faculty and students.”

      “One surprising thing,” Skow added, “was both Koonin and Emanuel were down on wind and solar power, [especially since] the idea that we need to transition to both is certainly in the air.”

      More conversations

      A second speaker series event, held earlier this month, was “Has Feminism Made Progress?” with Mary Harrington, author of “Feminism Against Progress,” and Anne McCants, MIT professor of history. An additional discussion planned for spring 2024 will cover the public health response to Covid-19.

      Discussions from the speaker series will appear as special episodes on “The Good Fight,” a podcast hosted by Johns Hopkins University political scientist Yascha Mounk.

      The Civil Discourse project is made possible due, in part, to funding from the Arthur Vining Davis Foundations and a collaboration between the MIT History Section and Concourse, a program featuring an integrated, cross-disciplinary approach to investigating some of humanity’s most interesting questions.

      The Civil Discourse initiative includes two components: the speaker series open to the MIT community, and seminars where students can discuss freedom of expression and develop skills for successfully engaging in civil discourse. More