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    Linzixuan (Rhoda) Zhang wins 2024 Collegiate Inventors Competition

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    Linzixuan (Rhoda) Zhang, a doctoral candidate in the MIT Department of Chemical Engineering, recently won the 2024 Collegiate Inventors Competition, medaling in both the Graduate and People’s Choice categories for developing materials to stabilize nutrients in food with the goal of improving global health.  The annual competition, organized by the National Inventors Hall of Fame and United States Patent and Trademark Office (USPTO), celebrates college and university student inventors. The finalists present their inventions to a panel of final-round judges composed of National Inventors Hall of Fame inductees and USPTO officials. No stranger to having her work in the limelight, Zhang is a three-time winner of the Koch Institute Image Awards in 2022, 2023, and 2024, as well as a 2022 fellow at the MIT Abdul Latif Jameel Water and Food Systems Lab.  “Rhoda is an exceptionally dedicated and creative student. Her well-deserved award recognizes the potential of her research on nutrient stabilization, which could have a significant impact on society,” says Ana Jaklenec, one of Zhang’s advisors and a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. Zhang is also advised by David H. Koch (1962) Institute Professor Robert Langer. Frameworks for global healthIn a world where nearly 2 billion people suffer from micronutrient deficiencies, particularly iron, the urgency for effective solutions has never been greater. Iron deficiency is especially harmful for vulnerable populations such as children and pregnant women, since it can lead to weakened immune systems and developmental delays. The World Health Organization has highlighted food fortification as a cost-effective strategy, yet many current methods fall short. Iron and other nutrients can break down during processing or cooking, and synthetic additives often come with high costs and environmental drawbacks. Zhang, along with her teammate, Xin Yang, a postdoc associate at Koch Institute, set out to innovate new technologies for nutrient fortification that are effective, accessible, and sustainable, leading to the invention nutritional metal-organic frameworks (NuMOFs) and the subsequent launch of MOFe Coffee, the world’s first iron-fortified coffee. NuMOFs not only protect essential nutrients such as iron while in food for long periods of time, but also make them more easily absorbed and used once consumed.The inspiration for the coffee came from the success of iodized salt, which significantly reduced iodine deficiency worldwide. Because coffee and tea are associated with low iron absorption, iron fortification would directly address the challenge.However, replicating the success of iodized salt for iron fortification has been extremely challenging due to the micronutrient’s high reactivity and the instability of iron(II) salts. As researchers with backgrounds in material science, chemistry, and food technology, Zhang and Yang leveraged their expertise to develop a solution that could overcome these technical barriers. The fortified coffee serves as a practical example of how NuMOFs can help people increase their iron intake by engaging in a habit that’s already part of their daily routine, with significant potential benefits for women, who are disproportionately affected by iron deficiency. The team plans to expand the technology to incorporate additional nutrients to address a wider array of nutritional deficiencies and improve health equity globally.Fast-track to addressing global health improvementsLooking ahead, Zhang and Yang in the Jaklenec Group are focused on both product commercialization and ongoing research, refining MOFe Coffee to enhance nutrient stability and ensuring the product remains palatable while maximizing iron absorption.Winning the CIC competition means that Zhang, Yang, and the team can fast-track their patent application with the USPTO. The team hopes that their fast-tracked patent will allow them to attract more potential investors and partners, which is crucial for scaling their efforts. A quicker patent process also means that the team can bring the technology to market faster, helping improve global nutrition and health for those who need it most. “Our goal is to make a real difference in addressing micronutrient deficiencies around the world,” says Zhang.   More

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      in Energy

      Aligning economic and regulatory frameworks for today’s nuclear reactor technology

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      Liam Hines ’22 didn’t move to Sarasota, Florida, until high school, but he’s a Floridian through and through. He jokes that he’s even got a floral shirt, what he calls a “Florida formal,” for every occasion.Which is why it broke his heart when toxic red algae used to devastate the Sunshine State’s coastline, including at his favorite beach, Caspersen. The outbreak made headline news during his high school years, with the blooms destroying marine wildlife and adversely impacting the state’s tourism-driven economy.In Florida, Hines says, environmental awareness is pretty high because everyday citizens are being directly impacted by climate change. After all, it’s hard not to worry when beautiful white sand beaches are covered in dead fish. Ongoing concerns about the climate cemented Hines’ resolve to pick a career that would have a strong “positive environmental impact.” He chose nuclear, as he saw it as “a green, low-carbon-emissions energy source with a pretty straightforward path to implementation.”

      Liam Hines: Ensuring that nuclear policy keeps up with nuclear technology.

      Undergraduate studies at MITKnowing he wanted a career in the sciences, Hines applied and got accepted to MIT for undergraduate studies in fall 2018. An orientation program hosted by the Department of Nuclear Science and Engineering (NSE) sold him on the idea of pursuing the field. “The department is just a really tight-knit community, and that really appealed to me,” Hines says.During his undergraduate years, Hines realized he needed a job to pay part of his bills. “Instead of answering calls at the dorm front desk or working in the dining halls, I decided I’m going to become a licensed nuclear operator onsite,” he says. “Reactor operations offer so much hands-on experience with real nuclear systems. It doesn’t hurt that it pays better.” Becoming a licensed nuclear reactor operator is hard work, however, involving a year-long training process studying maintenance, operations, and equipment oversight. A bonus: The job, supervising the MIT Nuclear Reactor Laboratory, taught him the fundamentals of nuclear physics and engineering.Always interested in research, Hines got an early start by exploring the regulatory challenges of advanced fusion systems. There have been questions related to licensing requirements and the safety consequences of the onsite radionuclide inventory. Hines’ undergraduate research work involved studying precedent for such fusion facilities and comparing them to experimental facilities such as the Tokamak Fusion Test Reactor at the Princeton Plasma Physics Laboratory.Doctoral focus on legal and regulatory frameworksWhen scientists want to make technologies as safe as possible, they have to do two things in concert: First they evaluate the safety of the technology, and then make sure legal and regulatory structures take into account the evolution of these advanced technologies. Hines is taking such a two-pronged approach to his doctoral work on nuclear fission systems.Under the guidance of Professor Koroush Shirvan, Hines is conducting systems modeling of various reactor cores that include graphite, and simulating operations under long time spans. He then studies radionuclide transport from low-level waste facilities — the consequences of offsite storage after 50 or 100 or even 10,000 years of storage. The work has to make sure to hit safety and engineering margins, but also tread a fine line. “You want to make sure you’re not over-engineering systems and adding undue cost, but also making sure to assess the unique hazards of these advanced technologies as accurately as possible,” Hines says.On a parallel track, under Professor Haruko Wainwright’s advisement, Hines is applying the current science on radionuclide geochemistry to track radionuclide wastes and map their profile for hazards. One of the challenges fission reactors face is that existing low-level waste regulations were fine-tuned to old reactors. Regulations have not kept up: “Now that we have new technologies with new wastes, some of the hazards of the new waste are completely missed by existing standards,” Hines says. He is working to seal these gaps.A philosophy-driven outlookHines is grateful for the dynamic learning environment at NSE. “A lot of the faculty have that go-getter attitude,” he points out, impressed by the entrepreneurial spirit on campus. “It’s made me confident to really tackle the things that I care about.”An ethics class as an undergraduate made Hines realize there were discussions in class he could apply to the nuclear realm, especially when it came to teasing apart the implications of the technology — where the devices would be built and who they would serve. He eventually went on to double-major in NSE and philosophy.The framework style of reading and reasoning involved in studying philosophy is particularly relevant in his current line of work, where he has to extract key points regarding nuclear regulatory issues. Much like philosophy discussions today that involve going over material that has been discussed for centuries and framing them through new perspectives, nuclear regulatory issues too need to take the long view.“In philosophy, we have to insert ourselves into very large conversations. Similarly, in nuclear engineering, you have to understand how to take apart the discourse that’s most relevant to your research and frame it,” Hines says. This technique is especially necessary because most of the time the nuclear regulatory issues might seem like wading in the weeds of nitty-gritty technical matters, but they can have a huge impact on the public and public perception, Hines adds.As for Florida, Hines visits every chance he can get. The red tide still surfaces but not as consistently as it once did. And since he started his job as a nuclear operator in his undergraduate days, Hines has progressed to senior reactor operator. This time around he gets to sign off on the checklists. “It’s much like when I was shift lead at Dunkin’ Donuts in high school,” Hines says, “everyone is kind of doing the same thing, but you get to be in charge for the afternoon.” More

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      in Environment

      Creating connection with science communication

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      Before completing her undergraduate studies, Sophie Hartley, a student in MIT’s Graduate Program in Science Writing, had an epiphany that was years in the making.“The classes I took in my last undergraduate semester changed my career goals, but it started with my grandfather,” she says when asked about what led her to science writing. She’d been studying comparative human development at the University of Chicago, which Hartley describes as “a combination of psychology and anthropology,” when she took courses in environmental writing and digital science communications.“What if my life could be about learning more of life’s intricacies?” she thought.Hartley’s grandfather introduced her to photography when she was younger, which helped her develop an appreciation for the natural world. Each summer, they would explore tide pools, overgrown forests, and his sprawling backyard. He gave her a camera and encouraged her to take pictures of anything interesting.“Photography was a door into science journalism,” she notes. “It lets you capture the raw beauty of a moment and return to it later.”Lasting impact through storytellingHartley spent time in Wisconsin and Vermont while growing up. That’s when she noticed a divide between rural communities and urban spaces. She wants to tell stories about communities that are less likely to be covered, and “connect them to people in cities who might not otherwise understand what’s happening and why.”People have important roles to play in arresting climate change impacts, improving land management practices and policies, and taking better care of our natural resources, according to Hartley. Challenges related to conservation, land management, and farming affect us all, which is why she believes effective science writing is so important.“We’re way more connected than we believe or understand,” Hartley says. “Climate change is creating problems throughout the entire agricultural supply chain.”For her news writing course, Hartley wrote a story about how flooding in Vermont led to hay shortages, which impacted comestibles as diverse as goat cheese and beef. “When the hay can’t dry, it’s ruined,” she says. “That means cows and goats aren’t eating, which means they can’t produce our beef, milk, and cheese.”Ultimately, Hartley believes her work can build compassion for others while also educating people about how everything we do affects nature and one another.“The connective tissues between humans persist,” she said. “People who live in cities aren’t exempt from rural concerns.”Creating connections with science writingDuring her year-long study in the MIT Graduate Program in Science Writing, Hartley is also busy producing reporting for major news outlets.Earlier this year, Hartley authored a piece for Ars Technica that explored ongoing efforts to develop technology aimed at preventing car collisions with kangaroos. As Hartley reported, given the unique and unpredictable behavior of kangaroos, vehicle animal detection systems have proven ineffective. That’s forced Australian communities to develop alternative solutions, such as virtual fencing, to keep kangaroos away from the roads.In June, Hartley co-produced a story for GBH News with Hannah Richter, a fellow student in the science writing program. They reported on how and why officials at a new Peabody power plant are backtracking on an earlier pledge to run the facility on clean fuels.The story was a collaboration between GBH News and the investigative journalism class in the science writing program. Hartley recalls wonderful experience working with Richter. “We were able to lean on each other’s strengths and learn from each other,” she says. “The piece took a long time to report and write, and it was helpful to have a friend and colleague to continuously motivate me when we would pick it back up after a while.”Co-reporting can also help evenly divide what can sometimes become a massive workload, particularly with deeply, well-researched pieces like the Peabody story. “When there is so much research to do, it’s helpful to have another person to divvy up the work,” she continued. “It felt like everything was stronger and better, from the writing to the fact-checking, because we had two eyes on it during the reporting process.”Hartley’s favorite piece in 2024 focused on beech leaf disease, a deadly pathogen devastating North American forests. Her story, which was later published in The Boston Globe Magazine, followed a team of four researchers racing to discover how the disease works. Beech leaf disease kills swiftly and en masse, leaving space for invasive species to thrive on forest floors. Her interest in land management and natural resources shines through in much of her work.Local news organizations are an endangered species as newsrooms across America shed staff and increasingly rely on aggregated news accounts from larger organizations. What can be lost, however, are opportunities to tell small-scale stories with potentially large-scale impacts. “Small and rural accountability stories are being told less and less,” Hartley notes. “I think it’s important that communities are aware of what is happening around them, especially if it impacts them.” More

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      in Environment

      Balancing economic development with natural resources protection

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      It’s one of the paradoxes of economic development: Many countries currently offer large subsidies to their industrial fishing fleets, even though the harms of overfishing are well-known. Governments might be willing to end this practice, if they saw that its costs outweighed its benefits. But each country, acting individually, faces an incentive to keep subsidies in place.This trap evokes the classic “tragedy of the commons” that economists have studied for generations. But despite the familiarity of the problem in theory, they don’t yet have a lot of hard evidence to offer policymakers about solutions, especially on a global scale. PhD student Aaron Berman is working on a set of projects that may change that.“Our goal is to get some empirical traction on the problem,” he says.Berman and his collaborators are combining a variety of datasets — not only economic data but also projections from ecological models — to identify how these subsidies are impacting fish stocks. They also hope to determine whether countries might benefit instead from sustainability measures to help rebuild fisheries, say through new trade arrangements or other international policy agreements.As a fourth-year doctoral candidate in MIT’s Department of Economics, Berman has a variety of other research projects underway as well, all connected by the central question of how to balance economic development with the pressure it puts on the environment and natural resources. While his study of fishing subsidies is global in scope, other projects are distinctly local: He is studying air pollution generated by road infrastructure in Pakistan, groundwater irrigation in Texas, the scallop fishing industry in New England, and industrial carbon-reduction measures in Turkey. For all of these projects, Berman and his collaborators are bringing data and models from many fields of science to bear on economic questions, from seafloor images taken by NOAA to atmospheric models of pollution dispersion.“One thing I find really exciting and joyful about the work I’m doing in environmental economics is that all of these projects involve some kind of crossover into the natural sciences,” he says.Several of Berman’s projects are so ambitious that he hopes to continue working on them even after completing his PhD. He acknowledges that keeping so many irons in the fire is a lot of work, but says he finds motivation in the knowledge that his research could shape policy and benefit society in a concrete way.“Something that MIT has really instilled in me is the value of going into the field and learning about how the research you’re doing connects to real-world issues,” he says. “You want your findings as a researcher to ultimately be useful to someone.”Testing the watersThe son of two public school teachers, Berman grew up in Maryland and then attended Yale University, where he majored in global affairs as an undergraduate, then stayed to get his master’s in public health, concentrating on global health in both programs.A pivotal moment came while taking an undergraduate class in development economics. “That class helped me realize the same questions I cared a lot about from a public health standpoint were also being studied by economists using very rigorous methods,” Berman says. “Economics has a lot to say about very pressing societal issues.”After reading the work of MIT economists and Nobel laureates Esther Duflo and Abhijit Banerjee in that same class, he decided to pivot and “test the waters of economics a little bit more seriously.” The professor teaching that class also played an important role, by encouraging Berman to pursue a predoctoral research position as a first step toward a graduate degree in economics.Following that advice, Berman landed at the Harvard Kennedy School’s Evidence for Policy Design, a research initiative seeking to foster economic development by improving the policy design process. His time with this organization included five months in Jakarta, Indonesia, where he collaborated with professors Rema Hanna and Ben Olken — of Harvard and MIT, respectively — on a portfolio of projects focused on analyzing social protection and poverty alleviation.The work, which included working closely with government partners, “required me to think creatively about how to talk about economics research to several different types of audiences,” he says. “This also gave me experience thinking about the intersection between what is academically interesting and what is a policy priority.”The experience also gave him the skills and confidence to apply to the economics PhD program at MIT.(Re)discovering teachingAs an economist, Berman is now channeling his interests in global affairs to exploring the relationship between economic development and protecting the natural environment. (He’s aided by an affinity for languages — he speaks five, with varying degrees of proficiency, in addition to English: Mandarin, Cantonese, Spanish, Portuguese, and Indonesian.) His interest in natural resource governance was piqued while co-authoring a paper on the economic drivers of climate-altering tropical deforestation.The review article, written alongside Olken and two professors from the London School of Economics, explored questions such as “What does the current state of the evidence tell us about what causes deforestation in the tropics, and what further evidence is needed?” and “What are the economic barriers to implementing policies to prevent deforestation?” — the kinds of questions he seeks to answer broadly in his ongoing dissertation work.“I gained an appreciation for the importance and complexity of natural resource governance, both in developing and developed countries,” he says. “It really was a launching point for a lot of the things that I’m doing now.”These days, when not doing research, Berman can be found playing on MIT’s club tennis team or working as a teaching assistant, which he particularly enjoys. He’s ever mindful of the Yale professor whose encouragement shaped his own path, and he hopes that he can pay that forward in his own teaching roles.“The fact that he saw I had the ability to make this transition and encouraged me to take a leap of faith is really meaningful to me. I would like to be able to do that for others,” Berman says.His interest in teaching also connects him further with his family: His father is a middle school science teacher and mother is a paraeducator for students with special needs. He says they’ve encouraged him throughout his academic journey, even though they initially didn’t know much about what a PhD in economics entailed. Berman jokes that the most common question people ask economists is what stocks they should invest in, and his family was no exception.“But they’ve always been very excited to hear about the kinds of things I’m working on and very supportive,” he says. “It’s been a really amazing learning experience thus far,” Berman says about his doctoral program. “One of the coolest parts of economics research is to have a sense that you’re tangibly doing something that’s going to have an impact in the world.” More

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      in Environment

      MIT scholars will take commercial break with entrepreneurial scholarship

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      Two MIT scholars, each with a strong entrepreneurial drive, have received 2024 Kavanaugh Fellowship awards, advancing their quest to turn pioneering research into profitable commercial enterprises.The Kavanaugh Translational Fellows Program gives scholars training to lead organizations that will bring their research to market. PhD candidates Grant Knappe and Arjav Shah are this year’s recipients. Knappe is developing a drug delivery platform for an emerging class of medicines called nucleic acid therapeutics. Shah is using hydrogel microparticles to clean up water polluted by heavy metals and other contaminants.Knappe and Shah will begin their fellowship with years of entrepreneurial expertise under their belts. They’ve developed and refined their business plans through MIT’s innovation ecosystem, including the Sandbox, the Legatum Center, the Venture Mentoring Service, the National Science Foundation’s I-Corps Program, and Blueprint by The Engine. Now, the yearlong Kavanaugh Fellowship will give the scholars time to focus exclusively on testing their business plans and exercising decision-making skills — critical to startup success — with the guidance of MIT mentors.“It’s a testament to the support and direction they’ve received from the MIT community that their entrepreneurial aspirations have evolved and matured over time,” says Michael J. Cima, program director for the Kavanaugh program and the David H. Koch Professor of Engineering in the Department of Materials Science and Engineering.Founded in 2016, the Kavanaugh program was instrumental in helping past fellows launch several robust startups, including low-carbon cement manufacturer Sublime Systems and SiTration, which is using a new type of filtration membrane to extract critical materials such as lithium.A safer way to deliver breakthrough medicinesNucleic acid therapeutics, including mRNA and CRISPR, are disrupting today’s clinical landscape thanks to their promise of targeting disease treatment according to genetic blueprints. But the first methods of delivering these molecules to the body used viruses as their transport, raising patient safety concerns.“Humans have figured out how to engineer certain viruses found in nature to deliver specific cargoes [for disease treatment],” says Knappe. “But because they look like viruses, the human immune system sees them as a danger signal and creates an immune reaction that can be harmful to patients.”Given the safety profile issues of viral delivery, researchers turned to non-viral technologies that use lipid nanoparticle technology, a mixture of different lipid-like materials, assembled into particles to protect the mRNA therapeutic from getting degraded before it reaches a cell of interest. “Because they don’t look like viruses there, the immune system generally tolerates them,” adds Knappe.Recent data show lipid nanoparticles can now target the lung, opening the potential for novel treatments of deadly cancers and other diseases.Knappe’s work in MIT’s Bathe BioNanoLab focused on building such a non-viral delivery platform based on a different technology: nucleic acid nanoparticles, which combine the attractive components of both viral and non-viral systems. Knappe will spend his Kavanaugh Fellowship year developing proof-of-concept data for his drug delivery method and building the team and funding needed to commercialize the technology.A PhD candidate in the Department of Chemical Engineering (ChemE), Knappe was initially attracted to MIT because of its intellectual openness. “You can work with any faculty member in other departments. I wasn’t restricted to the chemical engineering faculty,” says Knappe, whose supervisor, Professor Mark Bathe, is in the Department of Biological Engineering.Knappe, who is from New Jersey, welcomes the challenges that will come in his Kavanaugh year, including the need to pinpoint the right story that will convince venture capitalists and other funders to bet on his technology. Attracting talent is also top of mind. “How do you convince really talented people that have a lot of opportunities to work on what you work on? Building the first team is going to be critical,” he says. The network Knappe has been building in his years at MIT is paying dividends now.Targeting “forever chemicals” in waterThat network includes Shah. The two fellows met when they worked on the MIT Science Policy Review, a student-run journal concerned with the intersection of science, technology, and policy. Knappe and Shah did not compete directly academically but used their biweekly coffee walks as a welcome sounding board. Naturally, they were pleased when they found out they had both been chosen for the Kavanaugh Fellowship. So far, they have been too busy to celebrate over a beer.“We are good collaborators with research, as well,” says Shah. “Now we’re going on this entrepreneurial journey together. It’s been exciting.”Shah is a PhD candidate in ChemE’s Chemical Engineering Practice program. He got interested in the global imperative for cleaner water at a young age. His hometown of Surat is the heart of India’s textile industry. “Growing up, it wasn’t hard to see the dye-colored water flowing into your rivers and streams,” Shah says. “Playing a role in fostering positive change in water treatment fills me with a profound sense of purpose.”Shah’s work, broadly, is to clean toxic chemicals called micropollutants from water in an efficient and sustainable manner. “It’s humanly impossible to turn a blind eye to our water problems,” he says, which can be categorized as accessibility, availability, and quality. Water problems are global and complex, not just because of the technological challenges but also sociopolitical ones, he adds.Manufactured chemicals called per- and polyfluoroalkyl substances (PFAS), or “forever chemicals,” are in the news these days. PFAS, which go into making nonstick cookware and waterproof clothing, are just one of more than 10,000 such emerging contaminants that have leached into water streams. “These are extremely difficult to remove using existing systems because of their chemical diversity and low concentrations,” Shah says. “The concentrations are akin to dropping an aspirin tablet in an Olympic-sized swimming pool.” But no less toxic for that.In the lab at MIT, Shah is working with Devashish Gokhale, a fellow PhD student, and Patrick S. Doyle, the Robert T. Haslam (1911) Professor of Chemical Engineering, to commercialize an innovative microparticle technology, hydroGel, to remove these micropollutants in an effective, facile, and sustainable manner. Hydrogels are a broad class of polymer materials that can hold large quantities of water.“Our materials are like Boba beads. We are trying to save the world with our Boba beads,” says Shah with a laugh. “And we have functionalized these particles with tunable chemistries to target different micropollutants in a single unit operation.”Due to its outsized environmental impact, industrial water is the first application Shah is targeting. Today, wastewater treatment emits more than 3 percent of global carbon dioxide emissions, which is more than the shipping industry’s emissions, for example. The current state of the art for removing micropollutants in the industry is to use activated carbon filters. “[This technology] comes from coal, so it’s unsustainable,” Shah says. And the activated carbon filters are hard to reuse. “Our particles are reusable, theoretically infinitely.”“I’m very excited to be able to take advantage of the mentorship we have from the Kavanaugh team to take this technology to its next inflection point, so that we are ready to go out in the market and start making a huge impact,” he says.A dream communityShah and Knappe have become adept at navigating the array of support and mentorship opportunities MIT has to offer. Shah worked with a small team of seasoned professionals in the water space from the MIT Venture Mentoring Service. “They’ve helped us every step of the way as we think about commercializing the technology,” he says.Shah worked with MIT Sandbox, which provides a seed grant to help find the right product-market fit. He is also a fellow with the Legatum Center for Development and Entrepreneurship, which focuses on entrepreneurship in emerging countries in growth markets.“We’re exploring the potential for this technology and its application in a lot of different markets, including India. Because that’s close to my heart,” Shah says. “The Legatum community has been unique, where you can have those extremely hard conversations, confront yourself with those fears, and then talk it out with the group of fellows.”The Abdul Latif Jameel Water and Food Systems Lab, or J-WAFS, has been an integral part of Shah’s journey with research and commercialization support through its Solutions Grant and a travel award to the Stockholm World Water Week in August 2023.Knappe has also taken advantage of many innovation programs, including MIT’s Blueprint by the Engine, which helps researchers explore commercial opportunities of their work, plus programs outside of MIT but with strong on-campus ties such as Nucleate Activator and Frequency Bio.It was during one of these programs that he was inspired by two postdocs working in Bathe’s lab and spinning out biotech startups from their research, Floris Engelhardt and James Banal. Engelhardt helped spearhead Kano Therapeutics, and Banal launched Cache DNA.“I was passively absorbing and watching everything that they were going through and what they were excited about and challenged with. I still talk to them pretty regularly to this day,” Knappe says. “It’s been really great to have them as continual mentors, throughout my PhD and as I transition out of the lab.”Shah says he is grateful not only for being selected for the Kavanaugh Fellowship but to MIT as a community. “MIT has been more than a dream come true,” he says. He will have the opportunity to explore a different side of the institution as he enters the MBA program at MIT Sloan School of Management this fall. Shah expects this program, along with his Kavanaugh training, will supply the skills he needs to scale the business so it can make a difference in the world.“I always keep coming back to the question ‘How does what I do matter to the person on the street?’ This guides me to look at the bigger picture, to contextualize my research to solving important problems,” Shah says. “So many great technologies are being worked on each day, but only a minuscule fraction make it to the market.”Knappe is equally dedicated to serving a larger purpose. “With the right infrastructure, between basic fundamental science, conducted in academia, funded by government, and then translated by companies, we can make products that could improve everyone’s life across the world,” he says.Past Kavanaugh Fellows are credited with spearheading commercial outfits that have indeed made a difference. This year’s fellows are poised to follow their lead. But first they will have that beer together to celebrate. More

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      in Environment

      Two MIT PhD students awarded J-WAFS fellowships for their research on water

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      Since 2014, the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) has advanced interdisciplinary research aimed at solving the world’s most pressing water and food security challenges to meet human needs. In 2017, J-WAFS established the Rasikbhai L. Meswani Water Solutions Fellowship and the J-WAFS Graduate Student Fellowship. These fellowships provide support to outstanding MIT graduate students who are pursuing research that has the potential to improve water and food systems around the world. Recently, J-WAFS awarded the 2024-25 fellowships to Jonathan Bessette and Akash Ball, two MIT PhD students dedicated to addressing water scarcity by enhancing desalination and purification processes. This work is of important relevance since the world’s freshwater supply has been steadily depleting due to the effects of climate change. In fact, one-third of the global population lacks access to safe drinking water. Bessette and Ball are focused on designing innovative solutions to enhance the resilience and sustainability of global water systems. To support their endeavors, J-WAFS will provide each recipient with funding for one academic semester for continued research and related activities.“This year, we received many strong fellowship applications,” says J-WAFS executive director Renee J. Robins. “Bessette and Ball both stood out, even in a very competitive pool of candidates. The award of the J-WAFS fellowships to these two students underscores our confidence in their potential to bring transformative solutions to global water challenges.”2024-25 Rasikbhai L. Meswani Fellowship for Water SolutionsThe Rasikbhai L. Meswani Fellowship for Water Solutions is a doctoral fellowship for students pursuing research related to water and water supply at MIT. The fellowship is made possible by Elina and Nikhil Meswani and family. Jonathan Bessette is a doctoral student in the Global Engineering and Research (GEAR) Center within the Department of Mechanical Engineering at MIT, advised by Professor Amos Winter. His research is focused on water treatment systems for the developing world, mainly desalination, or the process in which salts are removed from water. Currently, Bessette is working on designing and constructing a low-cost, deployable, community-scale desalination system for humanitarian crises.In arid and semi-arid regions, groundwater often serves as the sole water source, despite its common salinity issues. Many remote and developing areas lack reliable centralized power and water systems, making brackish groundwater desalination a vital, sustainable solution for global water scarcity. “An overlooked need for desalination is inland groundwater aquifers, rather than in coastal areas,” says Bessette. “This is because much of the population lives far enough from a coast that seawater desalination could never reach them. My work involves designing low-cost, sustainable, renewable-powered desalination technologies for highly constrained situations, such as drinking water for remote communities,” he adds.To achieve this goal, Bessette developed a batteryless, renewable electrodialysis desalination system. The technology is energy-efficient, conserves water, and is particularly suited for challenging environments, as it is decentralized and sustainable. The system offers significant advantages over the conventional reverse osmosis method, especially in terms of reduced energy consumption for treating brackish water. Highlighting Bessette’s capacity for engineering insight, his advisor noted the “simple and elegant solution” that Bessette and a staff engineer, Shane Pratt, devised that negated the need for the system to have large batteries. Bessette is now focusing on simplifying the system’s architecture to make it more reliable and cost-effective for deployment in remote areas.Growing up in upstate New York, Bessette completed a bachelor’s degree at the State University of New York at Buffalo. As an undergrad, he taught middle and high school students in low-income areas of Buffalo about engineering and sustainability. However, he cited his junior-year travel to India and his experience there measuring water contaminants in rural sites as cementing his dedication to a career addressing food, water, and sanitation challenges. In addition to his doctoral research, his commitment to these goals is further evidenced by another project he is pursuing, funded by a J-WAFS India grant, that uses low-cost, remote sensors to better understand water fetching practices. Bessette is conducting this work with fellow MIT student Gokul Sampath in order to help families in rural India gain access to safe drinking water.2024-25 J-WAFS Graduate Student Fellowship for Water and Food SolutionsThe J-WAFS Graduate Student Fellowship is supported by the J-WAFS Research Affiliate Program, which offers companies the opportunity to engage with MIT on water and food research. Current fellowship support was provided by two J-WAFS Research Affiliates: Xylem, a leading U.S.-based provider of water treatment and infrastructure solutions, and GoAigua, a Spanish company at the forefront of digital transformation in the water industry through innovative solutions. Akash Ball is a doctoral candidate in the Department of Chemical Engineering, advised by Professor Heather Kulik. His research focuses on the computational discovery of novel functional materials for energy-efficient ion separation membranes with high selectivity. Advanced membranes like these are increasingly needed for applications such as water desalination, battery recycling, and removal of heavy metals from industrial wastewater. “Climate change, water pollution, and scarce freshwater reserves cause severe water distress for about 4 billion people annually, with 2 billion in India and China’s semiarid regions,” Ball notes. “One potential solution to this global water predicament is the desalination of seawater, since seawater accounts for 97 percent of all water on Earth.”Although several commercial reverse osmosis membranes are currently available, these membranes suffer several problems, like slow water permeation, permeability-selectivity trade-off, and high fabrication costs. Metal-organic frameworks (MOFs) are porous crystalline materials that are promising candidates for highly selective ion separation with fast water transport due to high surface area, the presence of different pore windows, and the tunability of chemical functionality.In the Kulik lab, Ball is developing a systematic understanding of how MOF chemistry and pore geometry affect water transport and ion rejection rates. By the end of his PhD, Ball plans to identify existing, best-performing MOFs with unparalleled water uptake using machine learning models, propose novel hypothetical MOFs tailored to specific ion separations from water, and discover experimental design rules that enable the synthesis of next-generation membranes.  Ball’s advisor praised the creativity he brings to his research, and his leadership skills that benefit her whole lab. Before coming to MIT, Ball obtained a master’s degree in chemical engineering from the Indian Institute of Technology (IIT) Bombay and a bachelor’s degree in chemical engineering from Jadavpur University in India. During a research internship at IIT Bombay in 2018, he worked on developing a technology for in situ arsenic detection in water. Like Bessette, he noted the impact of this prior research experience on his interest in global water challenges, along with his personal experience growing up in an area in India where access to safe drinking water was not guaranteed. More

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      Exploring frontiers of mechanical engineering

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      From cutting-edge robotics, design, and bioengineering to sustainable energy solutions, ocean engineering, nanotechnology, and innovative materials science, MechE students and their advisors are doing incredibly innovative work. The graduate students highlighted here represent a snapshot of the great work in progress this spring across the Department of Mechanical Engineering, and demonstrate the ways the future of this field is as limitless as the imaginations of its practitioners.Democratizing design through AILyle RegenwetterHometown: Champaign, IllinoisAdvisor: Assistant Professor Faez AhmedInterests: Food, climbing, skiing, soccer, tennis, cookingLyle Regenwetter finds excitement in the prospect of generative AI to “democratize” design and enable inexperienced designers to tackle complex design problems. His research explores new training methods through which generative AI models can be taught to implicitly obey design constraints and synthesize higher-performing designs. Knowing that prospective designers often have an intimate knowledge of the needs of users, but may otherwise lack the technical training to create solutions, Regenwetter also develops human-AI collaborative tools that allow AI models to interact and support designers in popular CAD software and real design problems. Solving a whale of a problem Loïcka BailleHometown: L’Escale, FranceAdvisor: Daniel ZitterbartInterests: Being outdoors — scuba diving, spelunking, or climbing. Sailing on the Charles River, martial arts classes, and playing volleyballLoïcka Baille’s research focuses on developing remote sensing technologies to study and protect marine life. Her main project revolves around improving onboard whale detection technology to prevent vessel strikes, with a special focus on protecting North Atlantic right whales. Baille is also involved in an ongoing study of Emperor penguins. Her team visits Antarctica annually to tag penguins and gather data to enhance their understanding of penguin population dynamics and draw conclusions regarding the overall health of the ecosystem.Water, water anywhereCarlos Díaz-MarínHometown: San José, Costa RicaAdvisor: Professor Gang Chen | Former Advisor: Professor Evelyn WangInterests: New England hiking, biking, and dancingCarlos Díaz-Marín designs and synthesizes inexpensive salt-polymer materials that can capture large amounts of humidity from the air. He aims to change the way we generate potable water from the air, even in arid conditions. In addition to water generation, these salt-polymer materials can also be used as thermal batteries, capable of storing and reusing heat. Beyond the scientific applications, Díaz-Marín is excited to continue doing research that can have big social impacts, and that finds and explains new physical phenomena. As a LatinX person, Díaz-Marín is also driven to help increase diversity in STEM.Scalable fabrication of nano-architected materialsSomayajulu DhulipalaHometown: Hyderabad, IndiaAdvisor: Assistant Professor Carlos PortelaInterests: Space exploration, taekwondo, meditation.Somayajulu Dhulipala works on developing lightweight materials with tunable mechanical properties. He is currently working on methods for the scalable fabrication of nano-architected materials and predicting their mechanical properties. The ability to fine-tune the mechanical properties of specific materials brings versatility and adaptability, making these materials suitable for a wide range of applications across multiple industries. While the research applications are quite diverse, Dhulipala is passionate about making space habitable for humanity, a crucial step toward becoming a spacefaring civilization.Ingestible health-care devicesJimmy McRaeHometown: Woburn, MassachusettsAdvisor: Associate Professor Giovani TraversoInterests: Anything basketball-related: playing, watching, going to games, organizing hometown tournaments Jimmy McRae aims to drastically improve diagnostic and therapeutic capabilities through noninvasive health-care technologies. His research focuses on leveraging materials, mechanics, embedded systems, and microfabrication to develop novel ingestible electronic and mechatronic devices. This ranges from ingestible electroceutical capsules that modulate hunger-regulating hormones to devices capable of continuous ultralong monitoring and remotely triggerable actuations from within the stomach. The principles that guide McRae’s work to develop devices that function in extreme environments can be applied far beyond the gastrointestinal tract, with applications for outer space, the ocean, and more.Freestyle BMX meets machine learningEva NatesHometown: Narberth, Pennsylvania Advisor: Professor Peko HosoiInterests: Rowing, running, biking, hiking, bakingEva Nates is working with the Australian Cycling Team to create a tool to classify Bicycle Motocross Freestyle (BMX FS) tricks. She uses a singular value decomposition method to conduct a principal component analysis of the time-dependent point-tracking data of an athlete and their bike during a run to classify each trick. The 2024 Olympic team hopes to incorporate this tool in their training workflow, and Nates worked alongside the team at their facilities on the Gold Coast of Australia during MIT’s Independent Activities Period in January.Augmenting Astronauts with Wearable Limbs Erik BallesterosHometown: Spring, TexasAdvisor: Professor Harry AsadaInterests: Cosplay, Star Wars, Lego bricksErik Ballesteros’s research seeks to support astronauts who are conducting planetary extravehicular activities through the use of supernumerary robotic limbs (SuperLimbs). His work is tailored toward design and control manifestation to assist astronauts with post-fall recovery, human-leader/robot-follower quadruped locomotion, and coordinated manipulation between the SuperLimbs and the astronaut to perform tasks like excavation and sample handling.This article appeared in the Spring 2024 edition of the Department of Mechanical Engineering’s magazine, MechE Connects.  More

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      in Environment

      Bringing an investigator’s eye to complex social challenges

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      Anna Russo likes puzzles. They require patience, organization, and a view of the big picture. She brings an investigator’s eye to big institutional and societal challenges whose solutions can have wide-ranging, long-term impacts.

      Russo’s path to MIT began with questions. She didn’t have the whole picture yet. “I had no idea what I wanted to do with my life,” says Russo, who is completing her PhD in economics in 2024. “I was good at math and science and thought I wanted to be a doctor.”

      While completing her undergraduate studies at Yale University, where she double majored in economics and applied math, Russo discovered a passion for problem-solving, where she could apply an analytical lens to answering the kinds of thorny questions whose solutions could improve policy. “Empirical research is fun and exciting,” Russo says.

      After Yale, Russo considered what to do next. She worked as a full-time research assistant with MIT economist Amy Finkelstein. Russo’s work with Finkelstein led her toward identifying, studying, and developing answers to complex questions. 

      “My research combines ideas from two fields of economic inquiry — public finance and industrial organization — and applies them to questions about the design of environmental and health care policy,” Russo says. “I like the way economists think analytically about social problems.”

      Narrowing her focus

      Studying with and being advised by renowned economists as both an undergraduate and a doctoral student helped Russo narrow her research focus, fitting more pieces into the puzzle. “What drew me to MIT was its investment in its graduate students,” Russo says.

      Economic research meant digging into policy questions, identifying market failures, and proposing solutions. Doctoral study allowed Russo to assemble data to rigorously follow each line of inquiry.

      “Doctoral study means you get to write about something you’re really interested in,” Russo notes. This led her to study policy responses to climate change adaptation and mitigation. 

      “In my first year, I worked on a project exploring the notion that floodplain regulation design doesn’t do a good job of incentivizing the right level of development in flood-prone areas,” she says. “How can economists help governments convince people to act in society’s best interest?”

      It’s important to understand institutional details, Russo adds, which can help investigators identify and implement solutions. 

      “Feedback, advice, and support from faculty were crucial as I grew as a researcher at MIT,” she says. Beyond her two main MIT advisors, Finkelstein and economist Nikhil Agarwal — educators she describes as “phenomenal, dedicated advisors and mentors” — Russo interacted regularly with faculty across the department. 

      Russo later discovered another challenge she hoped to solve: inefficiencies in conservation and carbon offset programs. She set her sights on the United States Department of Agriculture’s Conservation Reserve Program because she believes it and programs like it can be improved. 

      The CRP is a land conservation plan administered by USDA’s Farm Service Agency. In exchange for a yearly rental payment, farmers enrolled in the program agree to remove environmentally sensitive land from agricultural production and plant species that will improve environmental health and quality.

      “I think we can tweak the program’s design to improve cost-effectiveness,” Russo says. “There’s a trove of data available.” The data include information like auction participants’ bids in response to well-specified auction rules, which Russo links to satellite data measuring land use outcomes. Understanding how landowners bid in CRP auctions can help identify and improve the program’s function. 

      “We may be able to improve targeting and achieve more cost-effective conservation by adjusting the CRP’s scoring system,” Russo argues. Opportunities may exist to scale the incremental changes under study for other conservation programs and carbon offset markets more generally.  

      Economics, Russo believes, can help us conceptualize problems and recommend effective alternative solutions.

      The next puzzle

      Russo wants to find her next challenge while continuing her research. She plans to continue her work as a junior fellow at the Harvard Society of Fellows, after which she’ll join the Harvard Department of Economics as an assistant professor. Russo also plans to continue helping other budding economists since she believes in the importance of supporting other students.   

      Russo’s advisors are some of her biggest supporters. 

      Finklestein emphasizes Russo’s curiosity, enthusiasm, and energy as key drivers in her success. “Her genuine curiosity and interest in getting to the bottom of a problem with the data — with an econometric analysis, with a modeling issue — is the best antidote for [the stress that can be associated with research],” Finklestein says. “It’s a key ingredient in her ability to produce important and credible work.”

      “She’s also incredibly generous with her time and advice,” Finklestein continues, “whether it’s helping an undergraduate research assistant with her senior thesis, or helping an advisor such as myself navigate a data access process she’s previously been through.”

      “Instead of an advisor-advisee relationship, working with her on a thesis felt more like a collaboration between equals,” Agarwal adds. “[She] has the maturity and smarts to produce pathbreaking research.

      “Doctoral study is an opportunity for students to find their paths collaboratively,” Russo says. “If I can help someone else solve a small piece of their puzzle, that’s a huge positive. Research is a series of many, many small steps forward.” 

      Identifying important causes for further investigation and study will always be important to Russo. “I also want to dig into some other market that’s not working well and figure out how to make it better,” she says. “Right now I’m really excited about understanding California wildfire mitigation.” 

      Puzzles are made to be solved, after all. More

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      Letting the Earth answer back: Designing better planetary conversations

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      For Chen Chu MArch ’21, the invitation to join the 2023-24 cohort of Morningside Academy for Design Design Fellows has been an unparalleled opportunity to investigate the potential of design as an alternative method of problem-solving.

      After earning a master’s degree in architecture at MIT and gaining professional experience as a researcher at an environmental nongovernmental organization, Chu decided to pursue a PhD in the Department of Urban Studies and Planning. “I discovered that I needed to engage in a deeper way with the most difficult ethical challenges of our time, especially those arising from the fact of climate change,” he explains. “For me, MIT has always represented this wonderful place where people are inherently intellectually curious — it’s a very rewarding community to be part of.”

      Chu’s PhD research, guided by his doctoral advisor Delia Wendel, assistant professor of urban studies and international development, focuses on how traditional practices of floodplain agriculture can inform local and global strategies for sustainable food production and distribution in response to climate change. 

      Typically located alongside a river or stream, floodplains arise from seasonal flooding patterns that distribute nutrient-rich silt and create connectivity between species. This results in exceptionally high levels of biodiversity and microbial richness, generating the ideal conditions for agriculture. It’s no accident that the first human civilizations were founded on floodplains, including Mesopotamia (named for its location poised between two rivers, the Euphrates and Tigris), the Indus River Civilization, and the cultures of Ancient Egypt based around the Nile. Riverine transportation networks and predictable flooding rhythms provide a framework for trade and cultivation; nonetheless, floodplain communities must learn to live with risk, subject to the sudden disruptions of high waters, drought, and ecological disequilibrium. 

      For Chu, the “unstable and ungovernable” status of floodplains makes them fertile ground for thinking about. “I’m drawn to these so-called ‘wet landscapes’ — edge conditions that act as transitional spaces between land and water, between humans and nature, between city and river,” he reflects. “The development of extensively irrigated agricultural sites is typically a collective effort, which raises intriguing questions about how communities establish social organizations that simultaneously negotiate top-down state control and adapt to the uncertainty of nature.”

      Chu is in the process of honing the focus of his dissertation and refining his data collection methods, which will include archival research and fieldwork, as well as interviews with floodplain inhabitants to gain an understanding of sociopolitical nuances. Meanwhile, his role as a design fellow gives him the space to address the big questions that fire his imagination. How can we live well on shared land? How can we take responsibility for the lives of future generations? What types of political structures are required to get everyone on board? 

      These are just a few of the questions that Chu recently put to his cohort in a presentation. During the weekly seminars for the fellowship, he has the chance to converse with peers and mentors of multiple disciplines — from researchers rethinking the pedagogy of design to entrepreneurs applying design thinking to new business models to architects and engineers developing new habitats to heal our relationship with the natural world. 

      “I’ll admit — I’m wary of the human instinct to problem-solve,” says Chu. “When it comes to the material conditions and lived experience of people and planet, there’s a limit to our economic and political reasoning, and to conventional architectural practice. That said, I do believe that the mindset of a designer can open up new ways of thinking. At its core, design is an interdisciplinary practice based on the understanding that a problem can’t be solved from a narrow, singular perspective.” 

      The stimulating structure of a MAD Fellowship — free from immediate obligations to publish or produce, fellows learn from one another and engage with visiting speakers via regular seminars and events — has prompted Chu to consider what truly makes for generative conversation in the contexts of academia and the private and public sectors. In his opinion, discussions around climate change often fail to take account of one important voice; an absence he describes as “that silent being, the Earth.”

      “You can’t ask the Earth, ‘What does justice mean to you?’ Nature will not respond,” he reflects. To bridge the gap, Chu believes it’s important to combine the study of specific political and social conditions with broader existential questions raised by the environmental humanities. His own research draws upon the perspectives of thinkers including Dipesh Chakrabarty, Donna Haraway, Peter Singer,  Anna Tsing, and Michael Watts, among others. He cites James C. Scott’s lecture “In Praise of Floods” as one of his most important influences.

      In addition to his instinctive appreciation for theory, Chu’s outlook is grounded by an attention to innovation at the local level. He is currently establishing the parameters of his research, examining case studies of agricultural systems and flood mitigation strategies that have been sustained for centuries. 

      “One example is the polder system that is practiced in the Netherlands, China, Bangladesh, and many parts of the world: small, low-lying tracts of land submerged in water and surrounded by dykes and canals,” he explains. “You’ll find a different but comparable strategy in the colder regions of Japan. Crops are protected from the winter winds by constructing a spatial unit with the house at the center; trees behind the house serve as windbreakers and paddy fields for rice are located in front of the house, providing an integrated system of food and livelihood security.”

      Chu observes that there is a tendency for international policymakers to overlook local solutions in favor of grander visions and ambitious climate pledges — but he is equally keen not to romanticize vernacular practices. “Realistically, it’s always a two-way interaction. Unless you already have a workable local system in place, it’s difficult to implement a solution without top-down support. On the other hand, the large-scale technocratic dreams are empty if ignorant of local traditions and histories.” 

      By navigating between the global and the local, the theoretical and the practical, the visionary and the cautionary, Chu has hope in the possibility of gradually finding a way toward long-term solutions that adapt to specific conditions over time. It’s a model of ambition and criticality that Chu sees played out during dialogue at MAD and within his department; at root, he’s aware that the outcome of these conversations depends on the ethical context that shapes them.

      “I’ve been fortunate to have many mentors who have taught me the power of humility; a respect for the finitude, fragility,  and uncertainty of life,” he recalls. “It’s a mindset that’s barely apparent in today’s push for economic growth.” The flip-side of hubristic growth is an assumption that technological ingenuity will be enough to solve the climate crisis, but Chu’s optimism arises from a different source: “When I feel overwhelmed by the weight of the problems we’re facing, I just need to look around me,” he says. “Here on campus — at MAD, in my home department, and increasingly among the new generations of students — there’s a powerful ethos of political sensitivity, ethical compassion, and an attention to clear and critical judgment. That always gives me hope for the planet.” More