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      Translating MIT research into real-world results

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      Inventive solutions to some of the world’s most critical problems are being discovered in labs, classrooms, and centers across MIT every day. Many of these solutions move from the lab to the commercial world with the help of over 85 Institute resources that comprise MIT’s robust innovation and entrepreneurship (I&E) ecosystem. The Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) draws on MIT’s wealth of I&E knowledge and experience to help researchers commercialize their breakthrough technologies through the J-WAFS Solutions grant program. By collaborating with I&E programs on campus, J-WAFS prepares MIT researchers for the commercial world, where their novel innovations aim to improve productivity, accessibility, and sustainability of water and food systems, creating economic, environmental, and societal benefits along the way.The J-WAFS Solutions program launched in 2015 with support from Community Jameel, an international organization that advances science and learning for communities to thrive. Since 2015, J-WAFS Solutions has supported 19 projects with one-year grants of up to $150,000, with some projects receiving renewal grants for a second year of support. Solutions projects all address challenges related to water or food. Modeled after the esteemed grant program of MIT’s Deshpande Center for Technological Innovation, and initially administered by Deshpande Center staff, the J-WAFS Solutions program follows a similar approach by supporting projects that have already completed the basic research and proof-of-concept phases. With technologies that are one to three years away from commercialization, grantees work on identifying their potential markets and learn to focus on how their technology can meet the needs of future customers.“Ingenuity thrives at MIT, driving inventions that can be translated into real-world applications for widespread adoption, implantation, and use,” says J-WAFS Director Professor John H. Lienhard V. “But successful commercialization of MIT technology requires engineers to focus on many challenges beyond making the technology work. MIT’s I&E network offers a variety of programs that help researchers develop technology readiness, investigate markets, conduct customer discovery, and initiate product design and development,” Lienhard adds. “With this strong I&E framework, many J-WAFS Solutions teams have established startup companies by the completion of the grant. J-WAFS-supported technologies have had powerful, positive effects on human welfare. Together, the J-WAFS Solutions program and MIT’s I&E ecosystem demonstrate how academic research can evolve into business innovations that make a better world,” Lienhard says.Creating I&E collaborationsIn addition to support for furthering research, J-WAFS Solutions grants allow faculty, students, postdocs, and research staff to learn the fundamentals of how to transform their work into commercial products and companies. As part of the grant requirements, researchers must interact with mentors through MIT Venture Mentoring Service (VMS). VMS connects MIT entrepreneurs with teams of carefully selected professionals who provide free and confidential mentorship, guidance, and other services to help advance ideas into for-profit, for-benefit, or nonprofit ventures. Since 2000, VMS has mentored over 4,600 MIT entrepreneurs across all industries, through a dynamic and accomplished group of nearly 200 mentors who volunteer their time so that others may succeed. The mentors provide impartial and unbiased advice to members of the MIT community, including MIT alumni in the Boston area. J-WAFS Solutions teams have been guided by 21 mentors from numerous companies and nonprofits. Mentors often attend project events and progress meetings throughout the grant period.“Working with VMS has provided me and my organization with a valuable sounding board for a range of topics, big and small,” says Eric Verploegen PhD ’08, former research engineer in MIT’s D-Lab and founder of J-WAFS spinout CoolVeg. Along with professors Leon Glicksman and Daniel Frey, Verploegen received a J-WAFS Solutions grant in 2021 to commercialize cold-storage chambers that use evaporative cooling to help farmers preserve fruits and vegetables in rural off-grid communities. Verploegen started CoolVeg in 2022 to increase access and adoption of open-source, evaporative cooling technologies through collaborations with businesses, research institutions, nongovernmental organizations, and government agencies. “Working as a solo founder at my nonprofit venture, it is always great to have avenues to get feedback on communications approaches, overall strategy, and operational issues that my mentors have experience with,” Verploegen says. Three years after the initial Solutions grant, one of the VMS mentors assigned to the evaporative cooling team still acts as a mentor to Verploegen today.Another Solutions grant requirement is for teams to participate in the Spark program — a free, three-week course that provides an entry point for researchers to explore the potential value of their innovation. Spark is part of the National Science Foundation’s (NSF) Innovation Corps (I-Corps), which is an “immersive, entrepreneurial training program that facilitates the transformation of invention to impact.” In 2018, MIT received an award from the NSF, establishing the New England Regional Innovation Corps Node (NE I-Corps) to deliver I-Corps training to participants across New England. Trainings are open to researchers, engineers, scientists, and others who want to engage in a customer discovery process for their technology. Offered regularly throughout the year, the Spark course helps participants identify markets and explore customer needs in order to understand how their technologies can be positioned competitively in their target markets. They learn to assess barriers to adoption, as well as potential regulatory issues or other challenges to commercialization. NE-I-Corps reports that since its start, over 1,200 researchers from MIT have completed the program and have gone on to launch 175 ventures, raising over $3.3 billion in funding from grants and investors, and creating over 1,800 jobs.Constantinos Katsimpouras, a research scientist in the Department of Chemical Engineering, went through the NE I-Corps Spark program to better understand the customer base for a technology he developed with professors Gregory Stephanopoulos and Anthony Sinskey. The group received a J-WAFS Solutions grant in 2021 for their microbial platform that converts food waste from the dairy industry into valuable products. “As a scientist with no prior experience in entrepreneurship, the program introduced me to important concepts and tools for conducting customer interviews and adopting a new mindset,” notes Katsimpouras. “Most importantly, it encouraged me to get out of the building and engage in interviews with potential customers and stakeholders, providing me with invaluable insights and a deeper understanding of my industry,” he adds. These interviews also helped connect the team with companies willing to provide resources to test and improve their technology — a critical step to the scale-up of any lab invention.In the case of Professor Cem Tasan’s research group in the Department of Materials Science and Engineering, the I-Corps program led them to the J-WAFS Solutions grant, instead of the other way around. Tasan is currently working with postdoc Onur Guvenc on a J-WAFS Solutions project to manufacture formable sheet metal by consolidating steel scrap without melting, thereby reducing water use compared to traditional steel processing. Before applying for the Solutions grant, Guvenc took part in NE I-Corps. Like Katsimpouras, Guvenc benefited from the interaction with industry. “This program required me to step out of the lab and engage with potential customers, allowing me to learn about their immediate challenges and test my initial assumptions about the market,” Guvenc recalls. “My interviews with industry professionals also made me aware of the connection between water consumption and steelmaking processes, which ultimately led to the J-WAFS 2023 Solutions Grant,” says Guvenc.After completing the Spark program, participants may be eligible to apply for the Fusion program, which provides microgrants of up to $1,500 to conduct further customer discovery. The Fusion program is self-paced, requiring teams to conduct 12 additional customer interviews and craft a final presentation summarizing their key learnings. Professor Patrick Doyle’s J-WAFS Solutions team completed the Spark and Fusion programs at MIT. Most recently, their team was accepted to join the NSF I-Corps National program with a $50,000 award. The intensive program requires teams to complete an additional 100 customer discovery interviews over seven weeks. Located in the Department of Chemical Engineering, the Doyle lab is working on a sustainable microparticle hydrogel system to rapidly remove micropollutants from water. The team’s focus has expanded to higher value purifications in amino acid and biopharmaceutical manufacturing applications. Devashish Gokhale PhD ’24 worked with Doyle on much of the underlying science.“Our platform technology could potentially be used for selective separations in very diverse market segments, ranging from individual consumers to large industries and government bodies with varied use-cases,” Gokhale explains. He goes on to say, “The I-Corps Spark program added significant value by providing me with an effective framework to approach this problem … I was assigned a mentor who provided critical feedback, teaching me how to formulate effective questions and identify promising opportunities.” Gokhale says that by the end of Spark, the team was able to identify the best target markets for their products. He also says that the program provided valuable seminars on topics like intellectual property, which was helpful in subsequent discussions the team had with MIT’s Technology Licensing Office.Another member of Doyle’s team, Arjav Shah, a recent PhD from MIT’s Department of Chemical Engineering and a current MBA candidate at the MIT Sloan School of Management, is spearheading the team’s commercialization plans. Shah attended Fusion last fall and hopes to lead efforts to incorporate a startup company called hydroGel.  “I admire the hypothesis-driven approach of the I-Corps program,” says Shah. “It has enabled us to identify our customers’ biggest pain points, which will hopefully lead us to finding a product-market fit.” He adds “based on our learnings from the program, we have been able to pivot to impact-driven, higher-value applications in the food processing and biopharmaceutical industries.” Postdoc Luca Mazzaferro will lead the technical team at hydroGel alongside Shah.In a different project, Qinmin Zheng, a postdoc in the Department of Civil and Environmental Engineering, is working with Professor Andrew Whittle and Lecturer Fábio Duarte. Zheng plans to take the Fusion course this fall to advance their J-WAFS Solutions project that aims to commercialize a novel sensor to quantify the relative abundance of major algal species and provide early detection of harmful algal blooms. After completing Spark, Zheng says he’s “excited to participate in the Fusion program, and potentially the National I-Corps program, to further explore market opportunities and minimize risks in our future product development.”Economic and societal benefitsCommercializing technologies developed at MIT is one of the ways J-WAFS helps ensure that MIT research advances will have real-world impacts in water and food systems. Since its inception, the J-WAFS Solutions program has awarded 28 grants (including renewals), which have supported 19 projects that address a wide range of global water and food challenges. The program has distributed over $4 million to 24 professors, 11 research staff, 15 postdocs, and 30 students across MIT. Nearly half of all J-WAFS Solutions projects have resulted in spinout companies or commercialized products, including eight companies to date plus two open-source technologies.Nona Technologies is an example of a J-WAFS spinout that is helping the world by developing new approaches to produce freshwater for drinking. Desalination — the process of removing salts from seawater — typically requires a large-scale technology called reverse osmosis. But Nona created a desalination device that can work in remote off-grid locations. By separating salt and bacteria from water using electric current through a process called ion concentration polarization (ICP), their technology also reduces overall energy consumption. The novel method was developed by Jongyoon Han, professor of electrical engineering and biological engineering, and research scientist Junghyo Yoon. Along with Bruce Crawford, a Sloan MBA alum, Han and Yoon created Nona Technologies to bring their lightweight, energy-efficient desalination technology to the market.“My feeling early on was that once you have technology, commercialization will take care of itself,” admits Crawford. The team completed both the Spark and Fusion programs and quickly realized that much more work would be required. “Even in our first 24 interviews, we learned that the two first markets we envisioned would not be viable in the near term, and we also got our first hints at the beachhead we ultimately selected,” says Crawford. Nona Technologies has since won MIT’s $100K Entrepreneurship Competition, received media attention from outlets like Newsweek and Fortune, and hired a team that continues to further the technology for deployment in resource-limited areas where clean drinking water may be scarce. Food-borne diseases sicken millions of people worldwide each year, but J-WAFS researchers are addressing this issue by integrating molecular engineering, nanotechnology, and artificial intelligence to revolutionize food pathogen testing. Professors Tim Swager and Alexander Klibanov, of the Department of Chemistry, were awarded one of the first J-WAFS Solutions grants for their sensor that targets food safety pathogens. The sensor uses specialized droplets that behave like a dynamic lens, changing in the presence of target bacteria in order to detect dangerous bacterial contamination in food. In 2018, Swager launched Xibus Systems Inc. to bring the sensor to market and advance food safety for greater public health, sustainability, and economic security.“Our involvement with the J-WAFS Solutions Program has been vital,” says Swager. “It has provided us with a bridge between the academic world and the business world and allowed us to perform more detailed work to create a usable application,” he adds. In 2022, Xibus developed a product called XiSafe, which enables the detection of contaminants like salmonella and listeria faster and with higher sensitivity than other food testing products. The innovation could save food processors billions of dollars worldwide and prevent thousands of food-borne fatalities annually.J-WAFS Solutions companies have raised nearly $66 million in venture capital and other funding. Just this past June, J-WAFS spinout SiTration announced that it raised an $11.8 million seed round. Jeffrey Grossman, a professor in MIT’s Department of Materials Science and Engineering, was another early J-WAFS Solutions grantee for his work on low-cost energy-efficient filters for desalination. The project enabled the development of nanoporous membranes and resulted in two spinout companies, Via Separations and SiTration. SiTration was co-founded by Brendan Smith PhD ’18, who was a part of the original J-WAFS team. Smith is CEO of the company and has overseen the advancement of the membrane technology, which has gone on to reduce cost and resource consumption in industrial wastewater treatment, advanced manufacturing, and resource extraction of materials such as lithium, cobalt, and nickel from recycled electric vehicle batteries. The company also recently announced that it is working with the mining company Rio Tinto to handle harmful wastewater generated at mines.But it’s not just J-WAFS spinout companies that are producing real-world results. Products like the ECC Vial — a portable, low-cost method for E. coli detection in water — have been brought to the market and helped thousands of people. The test kit was developed by MIT D-Lab Lecturer Susan Murcott and Professor Jeffrey Ravel of the MIT History Section. The duo received a J-WAFS Solutions grant in 2018 to promote safely managed drinking water and improved public health in Nepal, where it is difficult to identify which wells are contaminated by E. coli. By the end of their grant period, the team had manufactured approximately 3,200 units, of which 2,350 were distributed — enough to help 12,000 people in Nepal. The researchers also trained local Nepalese on best manufacturing practices.“It’s very important, in my life experience, to follow your dream and to serve others,” says Murcott. Economic success is important to the health of any venture, whether it’s a company or a product, but equally important is the social impact — a philosophy that J-WAFS research strives to uphold. “Do something because it’s worth doing and because it changes people’s lives and saves lives,” Murcott adds.As J-WAFS prepares to celebrate its 10th anniversary this year, we look forward to continued collaboration with MIT’s many I&E programs to advance knowledge and develop solutions that will have tangible effects on the world’s water and food systems.Learn more about the J-WAFS Solutions program and about innovation and entrepreneurship at MIT. More

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      in Environment

      Liftoff: The Climate Project at MIT takes flight

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      The leaders of The Climate Project at MIT met with community members at a campus forum on Monday, helping to kick off the Institute’s major new effort to accelerate and scale up climate change solutions.“The Climate Project is a whole-of-MIT mobilization,” MIT President Sally Kornbluth said in her opening remarks. “It’s designed to focus the Institute’s talent and resources so that we can achieve much more, faster, in terms of real-world impact, from mitigation to adaptation.”The event, “Climate Project at MIT: Launching the Missions,” drew a capacity crowd to MIT’s Samberg Center.While the Climate Project has a number of facets, a central component of the effort consists of its six “missions,” broad areas where MIT researchers will seek to identify gaps in the global climate response that MIT can help fill, and then launch and execute research and innovation projects aimed at those areas. Each mission is led by campus faculty, and Monday’s event represented the first public conversation between the mission directors and the larger campus community.“Today’s event is an important milestone,” said Richard Lester, MIT’s interim vice president for climate and the Japan Steel Industry Professor of Nuclear Science and Engineering, who led the Climate Project’s formation. He praised Kornbluth’s sustained focus on climate change as a leading priority for MIT.“The reason we’re all here is because of her leadership and vision for MIT,” Lester said. “We’re also here because the MIT community — our faculty, our staff, our students — has made it abundantly clear that it wants to do more, much more, to help solve this great problem.”The mission directors themselves emphasized the need for deep community involvement in the project — and that the Climate Project is designed to facilitate researcher-driven enterprise across campus.“There’s a tremendous amount of urgency,” said Elsa Olivetti PhD ’07, director of the Decarbonizing Energy and Industry mission, during an onstage discussion. “We all need to do everything we can, and roll up our sleeves and get it done.” Olivetti, the Jerry McAfee Professor in Engineering, has been a professor of materials science and engineering at the Institute since 2014.“What’s exciting about this is the chance of MIT really meeting its potential,” said Jesse Kroll, co-director of the mission for Restoring the Atmosphere, Protecting the Land and Oceans. Kroll is the Peter de Florez Professor in MIT’s Department of Civil and Environmental Engineering, a professor of chemical engineering, and the director of the Ralph M. Parsons Laboratory.MIT, Kroll noted, features “so much amazing work going on in all these different aspects of the problem. Science, engineering, social science … we put it all together and there is huge potential, a huge opportunity for us to make a difference.”MIT has pledged an initial $75 million to the Climate Project, including $25 million from the MIT Sloan School of Management for a complementary effort, the MIT Climate Policy Center. However, the Institute is anticipating that it will also build new connections with outside partners, whose role in implementing and scaling Climate Project solutions will be critical.Monday’s event included a keynote talk from Brian Deese, currently the MIT Innovation and Climate Impact Fellow and the former director of the White House National Economic Council in the Biden administration.“The magnitude of the risks associated with climate change are extraordinary,” Deese said. However, he added, “these are solvable issues. In fact, the energy transition globally will be the greatest economic opportunity in human history. … It has the potential to actually lift people out of poverty, it has the potential to drive international cooperation, it has the potential to drive innovation and improve lives — if we get this right.”Deese’s remarks centered on a call for the U.S. to develop a current-day climate equivalent of the Marshall Plan, the U.S. initiative to provide aid to Western Europe after World War II. He also suggested three characteristics of successful climate projects, noting that many would be interdisciplinary in nature and would “engage with policy early in the design process” to become feasible.In addition to those features, Deese said, people need to “start and end with very high ambition” when working on climate solutions. He added: “The good thing about MIT and our community is that we, you, have done this before. We’ve got examples where MIT has taken something that seemed completely improbable and made it possible, and I believe that part of what is required of this collective effort is to keep that kind of audacious thinking at the top of our mind.” The MIT mission directors all participated in an onstage discussion moderated by Somini Sengupta, the international climate reporter on the climate team of The New York Times. Sengupta asked the group about a wide range of topics, from their roles and motivations to the political constraints on global climate progress, and more.Andrew Babbin, co-director of the mission for Restoring the Atmosphere, Protecting the Land and Oceans, defined part of the task of the MIT missions as “identifying where those gaps of knowledge are and filling them rapidly,” something he believes is “largely not doable in the conventional way,” based on small-scale research projects. Instead, suggested Babbin, who is the Cecil and Ida Green Career Development Professor in MIT’s Program in Atmospheres, Oceans, and Climate, the collective input of research and innovation communities could help zero in on undervalued approaches to climate action.Some innovative concepts, the mission directors noted, can be tried out on the MIT campus, in an effort to demonstrate how a more sustainable infrastructure and systems can operate at scale.“That is absolutely crucial,” said Christoph Reinhart, director of the Building and Adapting Healthy, Resilient Cities mission, expressing the need to have the campus reach net-zero emissions. Reinhart is the Alan and Terri Spoon Professor of Architecture and Climate and director of MIT’s Building Technology Program in the School of Architecture and Planning.In response to queries from Sengupta, the mission directors affirmed that the Climate Project needs to develop solutions that can work in different societies around the world, while acknowledging that there are many political hurdles to worldwide climate action.“Any kind of quality engaged projects that we’ve done with communities, it’s taken years to build trust. … How you scale that without compromising is the challenge I’m faced with,” said Miho Mazereeuw, director of the Empowering Frontline Communities mission, an associate professor of architecture and urbanism, and director of MIT’s Urban Risk Lab.“I think we will impact different communities in different parts of the world in different ways,” said Benedetto Marelli, an associate professor in MIT’s Department of Civil and Environmental Engineering, adding that it would be important to “work with local communities [and] engage stakeholders, and at the same time, use local brains to solve the problem.” The mission he directs, Wild Cards, is centered on identifying unconventional solutions that are high risk and also high reward.Any climate program “has to be politically feasible, it has to be in separate nations’ self-interest,” said Christopher Knittel, mission director for Inventing New Policy Approaches. In an ever-shifting political world, he added, that means people must “think about not just the policy but the resiliency of the policy.” Knittel is the George P. Shultz Professor and professor of applied economics at the MIT Sloan School of Management, director of the MIT Climate Policy Center, and associate dean for Climate and Sustainability.In all, MIT has more than 300 faculty and senior researchers who, along with their students and staff, are already working on climate issues.Kornbluth, for her part, referred to MIT’s first-year students while discussing the larger motivations for taking concerted action to address the challenges of climate change. It might be easy for younger people to despair over the world’s climate trajectory, she noted, but the best response to that includes seeking new avenues for climate progress.“I understand their anxiety and concern,” Kornbluth said. “But I have no doubt at all that together, we can make a difference. I believe that we have a special obligation to the new students and their entire generation to do everything we can to create a positive change. The most powerful antidote to defeat and despair is collection action.” More

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      in Environment

      3 Questions: The past, present, and future of sustainability science

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      It was 1978, over a decade before the word “sustainable” would infiltrate environmental nomenclature, and Ronald Prinn, MIT professor of atmospheric science, had just founded the Advanced Global Atmospheric Gases Experiment (AGAGE). Today, AGAGE provides real-time measurements for well over 50 environmentally harmful trace gases, enabling us to determine emissions at the country level, a key element in verifying national adherence to the Montreal Protocol and the Paris Accord. This, Prinn says, started him thinking about doing science that informed decision making.Much like global interest in sustainability, Prinn’s interest and involvement continued to grow into what would become three decades worth of achievements in sustainability science. The Center for Global Change Science (CGCS) and Joint Program on the Science and Policy Global Change, respectively founded and co-founded by Prinn, have recently joined forces to create the MIT School of Science’s new Center for Sustainability Science and Strategy (CS3), lead by former CGCS postdoc turned MIT professor, Noelle Selin.As he prepares to pass the torch, Prinn reflects on how far sustainability has come, and where it all began.Q: Tell us about the motivation for the MIT centers you helped to found around sustainability.A: In 1990 after I founded the Center for Global Change Science, I also co-founded the Joint Program on the Science and Policy Global Change with a very important partner, [Henry] “Jake” Jacoby. He’s now retired, but at that point he was a professor in the MIT Sloan School of Management. Together, we determined that in order to answer questions related to what we now call sustainability of human activities, you need to combine the natural and social sciences involved in these processes. Based on this, we decided to make a joint program between the CGCS and a center that he directed, the Center for Energy and Environmental Policy Research (CEEPR).It was called the “joint program” and was joint for two reasons — not only were two centers joining, but two disciplines were joining. It was not about simply doing the same science. It was about bringing a team of people together that could tackle these coupled issues of environment, human development and economy. We were the first group in the world to fully integrate these elements together.Q: What has been your most impactful contribution and what effect did it have on the greater public’s overall understanding?A: Our biggest contribution is the development, and more importantly, the application of the Integrated Global System Model [IGSM] framework, looking at human development in both developing countries and developed countries that had a significant impact on the way people thought about climate issues. With IGSM, we were able to look at the interactions among human and natural components, studying the feedbacks and impacts that climate change had on human systems; like how it would alter agriculture and other land activities, how it would alter things we derive from the ocean, and so on.Policies were being developed largely by economists or climate scientists working independently, and we started showing how the real answers and analysis required a coupling of all of these components. We showed, and I think convincingly, that what people used to study independently, must be coupled together, because the impacts of climate change and air pollution affected so many things.To address the value of policy, despite the uncertainty in climate projections, we ran multiple runs of the IGSM with and without policy, with different choices for uncertain IGSM variables. For public communication, around 2005, we introduced our signature Greenhouse Gamble interactive visualization tools; these have been renewed over time as science and policies evolved.Q: What can MIT provide now at this critical juncture in understanding climate change and its impact?A: We need to further push the boundaries of integrated global system modeling to ensure full sustainability of human activity and all of its beneficial dimensions, which is the exciting focus that the CS3 is designed to address. We need to focus on sustainability as a central core element and use it to not just analyze existing policies but to propose new ones. Sustainability is not just climate or air pollution, it’s got to do with human impacts in general. Human health is central to sustainability, and equally important to equity. We need to expand the capability for credibly assessing what the impact policies have not just on developed countries, but on developing countries, taking into account that many places around the world are at artisanal levels of their economies. They cannot be blamed for anything that is changing climate and causing air pollution and other detrimental things that are currently going on. They need our help. That’s what sustainability is in its full dimensions.Our capabilities are evolving toward a modeling system so detailed that we can find out detrimental things about policies even at local levels before investing in changing infrastructure. This is going to require collaboration among even more disciplines and creating a seamless connection between research and decision making; not just for policies enacted in the public sector, but also for decisions that are made in the private sector.  More

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      in Security

      Study reveals the benefits and downside of fasting

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      Low-calorie diets and intermittent fasting have been shown to have numerous health benefits: They can delay the onset of some age-related diseases and lengthen lifespan, not only in humans but many other organisms.Many complex mechanisms underlie this phenomenon. Previous work from MIT has shown that one way fasting exerts its beneficial effects is by boosting the regenerative abilities of intestinal stem cells, which helps the intestine recover from injuries or inflammation.In a study of mice, MIT researchers have now identified the pathway that enables this enhanced regeneration, which is activated once the mice begin “refeeding” after the fast. They also found a downside to this regeneration: When cancerous mutations occurred during the regenerative period, the mice were more likely to develop early-stage intestinal tumors.“Having more stem cell activity is good for regeneration, but too much of a good thing over time can have less favorable consequences,” says Omer Yilmaz, an MIT associate professor of biology, a member of MIT’s Koch Institute for Integrative Cancer Research, and the senior author of the new study.Yilmaz adds that further studies are needed before forming any conclusion as to whether fasting has a similar effect in humans.“We still have a lot to learn, but it is interesting that being in either the state of fasting or refeeding when exposure to mutagen occurs can have a profound impact on the likelihood of developing a cancer in these well-defined mouse models,” he says.MIT postdocs Shinya Imada and Saleh Khawaled are the lead authors of the paper, which appears today in Nature.Driving regenerationFor several years, Yilmaz’s lab has been investigating how fasting and low-calorie diets affect intestinal health. In a 2018 study, his team reported that during a fast, intestinal stem cells begin to use lipids as an energy source, instead of carbohydrates. They also showed that fasting led to a significant boost in stem cells’ regenerative ability.However, unanswered questions remained: How does fasting trigger this boost in regenerative ability, and when does the regeneration begin?“Since that paper, we’ve really been focused on understanding what is it about fasting that drives regeneration,” Yilmaz says. “Is it fasting itself that’s driving regeneration, or eating after the fast?”In their new study, the researchers found that stem cell regeneration is suppressed during fasting but then surges during the refeeding period. The researchers followed three groups of mice — one that fasted for 24 hours, another one that fasted for 24 hours and then was allowed to eat whatever they wanted during a 24-hour refeeding period, and a control group that ate whatever they wanted throughout the experiment.The researchers analyzed intestinal stem cells’ ability to proliferate at different time points and found that the stem cells showed the highest levels of proliferation at the end of the 24-hour refeeding period. These cells were also more proliferative than intestinal stem cells from mice that had not fasted at all.“We think that fasting and refeeding represent two distinct states,” Imada says. “In the fasted state, the ability of cells to use lipids and fatty acids as an energy source enables them to survive when nutrients are low. And then it’s the postfast refeeding state that really drives the regeneration. When nutrients become available, these stem cells and progenitor cells activate programs that enable them to build cellular mass and repopulate the intestinal lining.”Further studies revealed that these cells activate a cellular signaling pathway known as mTOR, which is involved in cell growth and metabolism. One of mTOR’s roles is to regulate the translation of messenger RNA into protein, so when it’s activated, cells produce more protein. This protein synthesis is essential for stem cells to proliferate.The researchers showed that mTOR activation in these stem cells also led to production of large quantities of polyamines — small molecules that help cells to grow and divide.“In the refed state, you’ve got more proliferation, and you need to build cellular mass. That requires more protein, to build new cells, and those stem cells go on to build more differentiated cells or specialized intestinal cell types that line the intestine,” Khawaled says.Too much of a good thingThe researchers also found that when stem cells are in this highly regenerative state, they are more prone to become cancerous. Intestinal stem cells are among the most actively dividing cells in the body, as they help the lining of the intestine completely turn over every five to 10 days. Because they divide so frequently, these stem cells are the most common source of precancerous cells in the intestine.In this study, the researchers discovered that if they turned on a cancer-causing gene in the mice during the refeeding stage, they were much more likely to develop precancerous polyps than if the gene was turned on during the fasting state. Cancer-linked mutations that occurred during the refeeding state were also much more likely to produce polyps than mutations that occurred in mice that did not undergo the cycle of fasting and refeeding.“I want to emphasize that this was all done in mice, using very well-defined cancer mutations. In humans it’s going to be a much more complex state,” Yilmaz says. “But it does lead us to the following notion: Fasting is very healthy, but if you’re unlucky and you’re refeeding after a fasting, and you get exposed to a mutagen, like a charred steak or something, you might actually be increasing your chances of developing a lesion that can go on to give rise to cancer.”Yilmaz also noted that the regenerative benefits of fasting could be significant for people who undergo radiation treatment, which can damage the intestinal lining, or other types of intestinal injury. His lab is now studying whether polyamine supplements could help to stimulate this kind of regeneration, without the need to fast.“This fascinating study provides insights into the complex interplay between food consumption, stem cell biology, and cancer risk,” says Ophir Klein, a professor of medicine at the University of California at San Francisco and Cedars-Sinai Medical Center, who was not involved in the study. “Their work lays a foundation for testing polyamines as compounds that may augment intestinal repair after injuries, and it suggests that careful consideration is needed when planning diet-based strategies for regeneration to avoid increasing cancer risk.”The research was funded, in part, by a Pew-Stewart Trust Scholar award, the Marble Center for Cancer Nanomedicine, the Koch Institute-Dana Farber/Harvard Cancer Center Bridge Project, and the MIT Stem Cell Initiative. More

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      in Environment

      Study: Rocks from Mars’ Jezero Crater, which likely predate life on Earth, contain signs of water

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      In a new study appearing today in the journal AGU Advances, scientists at MIT and NASA report that seven rock samples collected along the “fan front” of Mars’ Jezero Crater contain minerals that are typically formed in water. The findings suggest that the rocks were originally deposited by water, or may have formed in the presence of water.The seven samples were collected by NASA’s Perseverance rover in 2022 during its exploration of the crater’s western slope, where some rocks were hypothesized to have formed in what is now a dried-up ancient lake. Members of the Perseverance science team, including MIT scientists, have studied the rover’s images and chemical analyses of the samples, and confirmed that the rocks indeed contain signs of water, and that the crater was likely once a watery, habitable environment.Whether the crater was actually inhabited is yet unknown. The team found that the presence of organic matter — the starting material for life — cannot be confirmed, at least based on the rover’s measurements. But judging from the rocks’ mineral content, scientists believe the samples are their best chance of finding signs of ancient Martian life once the rocks are returned to Earth for more detailed analysis.“These rocks confirm the presence, at least temporarily, of habitable environments on Mars,” says the study’s lead author, Tanja Bosak, professor of geobiology in MIT’s Department of Earth, Atmospheric and Planetary Sciences (EAPS). “What we’ve found is that indeed there was a lot of water activity. For how long, we don’t know, but certainly for long enough to create these big sedimentary deposits.”What’s more, some of the collected samples may have originally been deposited in the ancient lake more than 3.5 billion years ago — before even the first signs of life on Earth.“These are the oldest rocks that may have been deposited by water, that we’ve ever laid hands or rover arms on,” says co-author Benjamin Weiss, the Robert R. Shrock Professor of Earth and Planetary Sciences at MIT. “That’s exciting, because it means these are the most promising rocks that may have preserved fossils, and signatures of life.”The study’s MIT co-authors include postdoc Eva Scheller, and research scientist Elias Mansbach, along with members of the Perseverance science team.At the front

      NASA’s Perseverance rover collected rock samples from two locations seen in this image of Mars’ Jezero Crater: “Wildcat Ridge” (lower left) and “Skinner Ridge” (upper right).

      Credit: NASA/JPL-Caltech/ASU/MSSS

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      The new rock samples were collected in 2022 as part of the rover’s Fan Front Campaign — an exploratory phase during which Perseverance traversed Jezero Crater’s western slope, where a fan-like region contains sedimentary, layered rocks. Scientists suspect that this “fan front” is an ancient delta that was created by sediment that flowed with a river and settled into a now bone-dry lakebed. If life existed on Mars, scientists believe that it could be preserved in the layers of sediment along the fan front.In the end, Perseverance collected seven samples from various locations along the fan front. The rover obtained each sample by drilling into the Martian bedrock and extracting a pencil-sized core, which it then sealed in a tube to one day be retrieved and returned to Earth for detailed analysis.

      Composed of multiple images from NASA’s Perseverance Mars rover, this mosaic shows a rocky outcrop called “Wildcat Ridge,” where the rover extracted two rock cores and abraded a circular patch to investigate the rock’s composition.

      Credit: NASA/JPL-Caltech/ASU/MSSS

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      Prior to extracting the cores, the rover took images of the surrounding sediments at each of the seven locations. The science team then processed the imaging data to estimate a sediment’s average grain size and mineral composition. This analysis showed that all seven collected samples likely contain signs of water, suggesting that they were initially deposited by water.Specifically, Bosak and her colleagues found evidence of certain minerals in the sediments that are known to precipitate out of water.“We found lots of minerals like carbonates, which are what make reefs on Earth,” Bosak says. “And it’s really an ideal material that can preserve fossils of microbial life.”Interestingly, the researchers also identified sulfates in some samples that were collected at the base of the fan front. Sulfates are minerals that form in very salty water — another sign that water was present in the crater at one time — though very salty water, Bosak notes, “is not necessarily the best thing for life.” If the entire crater was once filled with very salty water, then it would be difficult for any form of life to thrive. But if only the bottom of the lake were briny, that could be an advantage, at least for preserving any signs of life that may have lived further up, in less salty layers, that eventually died and drifted down to the bottom.“However salty it was, if there were any organics present, it’s like pickling something in salt,” Bosak says. “If there was life that fell into the salty layer, it would be very well-preserved.”Fuzzy fingerprintsBut the team emphasizes that organic matter has not been confidently detected by the rover’s instruments. Organic matter can be signs of life, but can also be produced by certain geological processes that have nothing to do with living matter. Perseverance’s predecessor, the Curiosity rover, had detected organic matter throughout Mars’ Gale Crater, which scientists suspect may have come from asteroids that made impact with Mars in the past.And in a previous campaign, Perseverance detected what appeared to be organic molecules at multiple locations along Jezero Crater’s floor. These observations were taken by the rover’s Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) instrument, which uses ultraviolet light to scan the Martian surface. If organics are present, they can glow, similar to material under a blacklight. The wavelengths at which the material glows act as a sort of fingerprint for the kind of organic molecules that are present.In Perseverance’s previous exploration of the crater floor, SHERLOC appeared to pick up signs of organic molecules throughout the region, and later, at some locations along the fan front. But a careful analysis, led by MIT’s Eva Scheller, has found that while the particular wavelengths observed could be signs of organic matter, they could just as well be signatures of substances that have nothing to do with organic matter.“It turns out that cerium metals incorporated in minerals actually produce very similar signals as the organic matter,” Scheller says. “When investigated, the potential organic signals were strongly correlated with phosphate minerals, which always contain some cerium.”Scheller’s work shows that the rover’s measurements cannot be interpreted definitively as organic matter.“This is not bad news,” Bosak says. “It just tells us there is not very abundant organic matter. It’s still possible that it’s there. It’s just below the rover’s detection limit.”When the collected samples are finally sent back to Earth, Bosak says laboratory instruments will have more than enough sensitivity to detect any organic matter that might lie within.“On Earth, once we have microscopes with nanometer-scale resolution, and various types of instruments that we cannot staff on one rover, then we can actually attempt to look for life,” she says.This work was supported, in part, by NASA. More

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      in Environment

      MIT School of Science launches Center for Sustainability Science and Strategy

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      The MIT School of Science is launching a center to advance knowledge and computational capabilities in the field of sustainability science, and support decision-makers in government, industry, and civil society to achieve sustainable development goals. Aligned with the Climate Project at MIT, researchers at the MIT Center for Sustainability Science and Strategy will develop and apply expertise from across the Institute to improve understanding of sustainability challenges, and thereby provide actionable knowledge and insight to inform strategies for improving human well-being for current and future generations.Noelle Selin, professor at MIT’s Institute for Data, Systems and Society and the Department of Earth, Atmospheric and Planetary Sciences, will serve as the center’s inaugural faculty director. C. Adam Schlosser and Sergey Paltsev, senior research scientists at MIT, will serve as deputy directors, with Anne Slinn as executive director.Incorporating and succeeding both the Center for Global Change Science and Joint Program on the Science and Policy of Global Change while adding new capabilities, the center aims to produce leading-edge research to help guide societal transitions toward a more sustainable future. Drawing on the long history of MIT’s efforts to address global change and its integrated environmental and human dimensions, the center is well-positioned to lead burgeoning global efforts to advance the field of sustainability science, which seeks to understand nature-society systems in their full complexity. This understanding is designed to be relevant and actionable for decision-makers in government, industry, and civil society in their efforts to develop viable pathways to improve quality of life for multiple stakeholders.“As critical challenges such as climate, health, energy, and food security increasingly affect people’s lives around the world, decision-makers need a better understanding of the earth in its full complexity — and that includes people, technologies, and institutions as well as environmental processes,” says Selin. “Better knowledge of these systems and how they interact can lead to more effective strategies that avoid unintended consequences and ensure an improved quality of life for all.”    Advancing knowledge, computational capability, and decision supportTo produce more precise and comprehensive knowledge of sustainability challenges and guide decision-makers to formulate more effective strategies, the center has set the following goals:Advance fundamental understanding of the complex interconnected physical and socio-economic systems that affect human well-being. As new policies and technologies are developed amid climate and other global changes, they interact with environmental processes and institutions in ways that can alter the earth’s critical life-support systems. Fundamental mechanisms that determine many of these systems’ behaviors, including those related to interacting climate, water, food, and socio-economic systems, remain largely unknown and poorly quantified. Better understanding can help society mitigate the risks of abrupt changes and “tipping points” in these systems.Develop, establish and disseminate new computational tools toward better understanding earth systems, including both environmental and human dimensions. The center’s work will integrate modeling and data analysis across disciplines in an era of increasing volumes of observational data. MIT multi-system models and data products will provide robust information to inform decision-making and shape the next generation of sustainability science and strategy.Produce actionable science that supports equity and justice within and across generations. The center’s research will be designed to inform action associated with measurable outcomes aligned with supporting human well-being across generations. This requires engaging a broad range of stakeholders, including not only nations and companies, but also nongovernmental organizations and communities that take action to promote sustainable development — with special attention to those who have historically borne the brunt of environmental injustice.“The center’s work will advance fundamental understanding in sustainability science, leverage leading-edge computing and data, and promote engagement and impact,” says Selin. “Our researchers will help lead scientists and strategists across the globe who share MIT’s commitment to mobilizing knowledge to inform action toward a more sustainable world.”Building a better world at MITBuilding on existing MIT capabilities in sustainability, science, and strategy, the center aims to: focus research, education, and outreach under a theme that reflects a comprehensive state of the field and international research directions, fostering a dynamic community of students, researchers, and faculty;raise the visibility of sustainability science at MIT, emphasizing links between science and action, in the context of existing Institute goals and other efforts on climate and sustainability, and in a way that reflects the vital contributions of a range of natural and social science disciplines to understanding human-environment systems; andre-emphasize MIT’s long-standing expertise in integrated systems modeling while leveraging the Institute’s concurrent leading-edge strengths in data and computing, establishing leadership that harnesses recent innovations, including those in machine learning and artificial intelligence, toward addressing the science challenges of global change and sustainability.“The Center for Sustainability Science and Strategy will provide the necessary synergy for our MIT researchers to develop, deploy, and scale up serious solutions to climate change and other critical sustainability challenges,” says Nergis Mavalvala, the Curtis and Kathleen Marble Professor of Astrophysics and dean of the MIT School of Science. “With Professor Selin at its helm, the center will also ensure that these solutions are created in concert with the people who are directly affected now and in the future.”The center builds on more than three decades of achievements by the Center for Global Change Science and the Joint Program on the Science and Policy of Global Change, both of which were directed or co-directed by professor of atmospheric science Ronald Prinn. 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      in Environment

      Scientists find a human “fingerprint” in the upper troposphere’s increasing ozone

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      Ozone can be an agent of good or harm, depending on where you find it in the atmosphere. Way up in the stratosphere, the colorless gas shields the Earth from the sun’s harsh ultraviolet rays. But closer to the ground, ozone is a harmful air pollutant that can trigger chronic health problems including chest pain, difficulty breathing, and impaired lung function.And somewhere in between, in the upper troposphere — the layer of the atmosphere just below the stratosphere, where most aircraft cruise — ozone contributes to warming the planet as a potent greenhouse gas.There are signs that ozone is continuing to rise in the upper troposphere despite efforts to reduce its sources at the surface in many nations. Now, MIT scientists confirm that much of ozone’s increase in the upper troposphere is likely due to humans.In a paper appearing today in the journal Environmental Science and Technology, the team reports that they detected a clear signal of human influence on upper tropospheric ozone trends in a 17-year satellite record starting in 2005.“We confirm that there’s a clear and increasing trend in upper tropospheric ozone in the northern midlatitudes due to human beings rather than climate noise,” says study lead author Xinyuan Yu, a graduate student in MIT’s Department of Earth, Atmospheric and Planetary Sciences (EAPS).“Now we can do more detective work and try to understand what specific human activities are leading to this ozone trend,” adds co-author Arlene Fiore, the Peter H. Stone and Paola Malanotte Stone Professor in Earth, Atmospheric and Planetary Sciences.The study’s MIT authors include Sebastian Eastham and Qindan Zhu, along with Benjamin Santer at the University of California at Los Angeles, Gustavo Correa of Columbia University, Jean-François Lamarque at the National Center for Atmospheric Research, and Jerald Zimeke at NASA Goddard Space Flight Center.Ozone’s tangled webUnderstanding ozone’s causes and influences is a challenging exercise. Ozone is not emitted directly, but instead is a product of “precursors” — starting ingredients, such as nitrogen oxides and volatile organic compounds (VOCs), that react in the presence of sunlight to form ozone. These precursors are generated from vehicle exhaust, power plants, chemical solvents, industrial processes, aircraft emissions, and other human-induced activities.Whether and how long ozone lingers in the atmosphere depends on a tangle of variables, including the type and extent of human activities in a given area, as well as natural climate variability. For instance, a strong El Niño year could nudge the atmosphere’s circulation in a way that affects ozone’s concentrations, regardless of how much ozone humans are contributing to the atmosphere that year.Disentangling the human- versus climate-driven causes of ozone trend, particularly in the upper troposphere, is especially tricky. Complicating matters is the fact that in the lower troposphere — the lowest layer of the atmosphere, closest to ground level — ozone has stopped rising, and has even fallen in some regions at northern midlatitudes in the last few decades. This decrease in lower tropospheric ozone is mainly a result of efforts in North America and Europe to reduce industrial sources of air pollution.“Near the surface, ozone has been observed to decrease in some regions, and its variations are more closely linked to human emissions,” Yu notes. “In the upper troposphere, the ozone trends are less well-monitored but seem to decouple with those near the surface, and ozone is more easily influenced by climate variability. So, we don’t know whether and how much of that increase in observed ozone in the upper troposphere is attributed to humans.”A human signal amid climate noiseYu and Fiore wondered whether a human “fingerprint” in ozone levels, caused directly by human activities, could be strong enough to be detectable in satellite observations in the upper troposphere. To see such a signal, the researchers would first have to know what to look for.For this, they looked to simulations of the Earth’s climate and atmospheric chemistry. Following approaches developed in climate science, they reasoned that if they could simulate a number of possible climate variations in recent decades, all with identical human-derived sources of ozone precursor emissions, but each starting with a slightly different climate condition, then any differences among these scenarios should be due to climate noise. By inference, any common signal that emerged when averaging over the simulated scenarios should be due to human-driven causes. Such a signal, then, would be a “fingerprint” revealing human-caused ozone, which the team could look for in actual satellite observations.With this strategy in mind, the team ran simulations using a state-of-the-art chemistry climate model. They ran multiple climate scenarios, each starting from the year 1950 and running through 2014.From their simulations, the team saw a clear and common signal across scenarios, which they identified as a human fingerprint. They then looked to tropospheric ozone products derived from multiple instruments aboard NASA’s Aura satellite.“Quite honestly, I thought the satellite data were just going to be too noisy,” Fiore admits. “I didn’t expect that the pattern would be robust enough.”But the satellite observations they used gave them a good enough shot. The team looked through the upper tropospheric ozone data derived from the satellite products, from the years 2005 to 2021, and found that, indeed, they could see the signal of human-caused ozone that their simulations predicted. The signal is especially pronounced over Asia, where industrial activity has risen significantly in recent decades and where abundant sunlight and frequent weather events loft pollution, including ozone and its precursors, to the upper troposphere.Yu and Fiore are now looking to identify the specific human activities that are leading to ozone’s increase in the upper troposphere.“Where is this increasing trend coming from? Is it the near-surface emissions from combusting fossil fuels in vehicle engines and power plants? Is it the aircraft that are flying in the upper troposphere? Is it the influence of wildland fires? Or some combination of all of the above?” Fiore says. “Being able to separate human-caused impacts from natural climate variations can help to inform strategies to address climate change and air pollution.”This research was funded, in part, by NASA. More

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      in Environment

      A bright and airy hub for climate at MIT

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      Seen from a distance, MIT’s Cecil and Ida Green Building (Building 54) — designed by renowned architect and MIT alumnus I.M. Pei ’40 — is one of the most iconic buildings on the Cambridge, Massachusetts, skyline. Home to the MIT Department of Earth, Atmospheric and Planetary Sciences (EAPS), the 21-story concrete structure soars over campus, topped with its distinctive spherical radar dome. Close up, however, it was a different story.A sunless, two-story, open-air plaza beneath the tower previously served as a nondescript gateway to the department’s offices, labs, and classrooms above. “It was cold and windy — probably the windiest place on campus,” EAPS department head Robert van der Hilst, the Schlumberger Professor of Earth and Planetary Sciences, told a packed auditorium inside the building in March. “You would pass through the elevators and disappear into the corridors, never to be seen again until the end of the day.”Van der Hilst was speaking at a dedication event to celebrate the opening of the renovated and expanded space, 60 years after the Green Building’s original dedication in 1964. In a dramatic transformation, the perpetually-shaded expanse beneath the tower has been filled with an airy, glassed-in structure that is as inviting as the previous space was forbidding.Designed to meet LEED-platinum certification, the newly-constructed Tina and Hamid Moghadam Building (Building 55) seems to float next to the Brutalist tower, its glass façade both opening up the interior and reflecting the sunlight and green space outside. The 300-seat auditorium within the original tower has been similarly transformed, bringing light and space to the newly dubbed Dixie Lee Bryant (1891) Lecture Hall, named after the first person to earn a geology degree at MIT.Catalyzing collaborationThe project is about more than updating an overlooked space. “The building we’re here to celebrate today does something else,” MIT President Sally Kornbluth said at the dedication.“In its lightness, in its transparency, it calls attention not to itself, but to the people gathered inside it. In its warmth, its openness, it makes room for culture and community. And it welcomes in those who don’t yet belong … as we take on the immense challenges of climate together,” she continued, referencing the recent launch of The Climate Project at MIT — a whole-of-MIT initiative to innovate bold solutions to climate change. In MIT’s famously decentralized structure, the Moghadam Building provides a new physical hub for students, scientists, and engineers interested in climate and the environment to congregate and share ideas.From the start, fostering this kind of multidisciplinary collaboration was part of Van der Hilst’s vision. In addition to serving as the flagship location for EAPS, Building 54 has long been the administrative home of the MIT-WHOI Joint Program in Oceanography/Applied Ocean Science and Engineering — a graduate program in partnership with Woods Hole Oceanographic Institute. With the addition of Building 55, EAPS has now been joined by the MIT Environmental Solutions Initiative (ESI) — a campus-wide program fostering education, outreach, and innovation in earth system science, urban infrastructure, and sustainability — and will welcome closer collaboration with Terrascope — a first-year learning community which invites its students to take on real-world environmental challenges.A shared vision comes to lifeThe building project dovetailed with the long-overdue refurbishment of the Green Building. After a multi-year fundraising campaign where Van der Hilst spearheaded the department’s efforts, the project received a major boost from lead donors Tina and Hamid Moghadam ’77, SM ’78, allowing the department to break ground in November 2021.In Moghadam, chair and CEO of Prologis, which owns 1.2 billion square feet of warehouses and other logistics infrastructure worldwide, EAPS found a fellow champion for climate and environmental innovation. By putting solar panels on the roofs of Prologis buildings, the company is now the second largest on-site producer of solar energy in the United States. “I don’t think there needs to be a trade-off between good sound economics and return on investment and solving climate change problems,” Moghadam said at the dedication. “The solutions that really work are the ones that actually make sense in a market economy.”Architectural firm AW-ARCH designed the Moghadam Building with a light touch, emphasizing spaciousness in contrast to the heavy concrete buildings that surround it. “The kind of delicacy and fragility of the thing is in some ways a depiction of what happens here,” said architect and co-founding partner Alex Anmahian at the dedication reception, giving a nod to the study of the delicate balance of the earth system itself. The sense is further illustrated by the responsiveness of the façade to the surrounding environment, which, depending on the time of day and quality of light, makes the glass alternately reflective and transparent.Inside, the 11,900-square foot pavilion is highly flexible and serves as a showcase for the science that happens in the labs and offices above. Central to the space is a 16-foot by 9-foot video wall featuring vivid footage of field work, lab research, data visualizations, and natural phenomena — visible even to passers-by outside. The video wall is counterposed to an unpretentious set of stair-step bleachers leading to the second floor that could play host to anything from a scientific lecture to a community pizza-and-movie night.Van der Hilst has referred to his vision for the atrium as a “campus living room,” and the furniture throughout is intentionally chosen to allow for impromptu rearrangements, providing a valuable public space on campus for students to work and socialize.The second level is similarly adaptable, featuring three classrooms with state-of-the-art teaching technologies that can be transformed from a single large space for a hackathon to intimate rooms for discussion.“The space is really meant for a yet unforeseen experience,” Anmahian says. “The reason it is so open is to allow for any possibility.”The inviting, dynamic design of the pavilion has also become an instant point of pride for the building’s inhabitants. At the dedication, School of Science dean Nergis Mavalvala quipped that anyone walking into the space “gains two inches in height.”Van der Hilst quoted a colleague with a similar observation: “Now, when I come into this space, I feel respected by it.”The perfect complementAnother significant feature of the project is the List Visual Arts Center Percent-for-Art Program installation by conceptual artist Julian Charrière, entitled “Everything Was Forever Until It Was No More.”Consisting of three interrelated works, the commission includes: “Not All Who Wander Are Lost,” three glacial erratic boulders which sit atop their own core samples in the surrounding green space; “We Are All Astronauts,” a trio of glass pillars containing vintage globes with distinctions between nations, land, and sea removed; and “Pure Waste,” a synthetic diamond embedded in the foundation, created from carbon captured from the air and the breath of researchers who work in the building.Known for themes that explore the transformation of the natural world over time and humanity’s complex relationship with our environment, Charrière was a perfect fit to complement the new Building 55 — offering a thought-provoking perspective on our current environmental challenges while underscoring the value of the research that happens within its walls. 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