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    MIT scholars will take commercial break with entrepreneurial scholarship

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    Two MIT scholars, each with a strong entrepreneurial drive, have received 2024 Kavanaugh Fellowship awards, advancing their quest to turn pioneering research into profitable commercial enterprises.The Kavanaugh Translational Fellows Program gives scholars training to lead organizations that will bring their research to market. PhD candidates Grant Knappe and Arjav Shah are this year’s recipients. Knappe is developing a drug delivery platform for an emerging class of medicines called nucleic acid therapeutics. Shah is using hydrogel microparticles to clean up water polluted by heavy metals and other contaminants.Knappe and Shah will begin their fellowship with years of entrepreneurial expertise under their belts. They’ve developed and refined their business plans through MIT’s innovation ecosystem, including the Sandbox, the Legatum Center, the Venture Mentoring Service, the National Science Foundation’s I-Corps Program, and Blueprint by The Engine. Now, the yearlong Kavanaugh Fellowship will give the scholars time to focus exclusively on testing their business plans and exercising decision-making skills — critical to startup success — with the guidance of MIT mentors.“It’s a testament to the support and direction they’ve received from the MIT community that their entrepreneurial aspirations have evolved and matured over time,” says Michael J. Cima, program director for the Kavanaugh program and the David H. Koch Professor of Engineering in the Department of Materials Science and Engineering.Founded in 2016, the Kavanaugh program was instrumental in helping past fellows launch several robust startups, including low-carbon cement manufacturer Sublime Systems and SiTration, which is using a new type of filtration membrane to extract critical materials such as lithium.A safer way to deliver breakthrough medicinesNucleic acid therapeutics, including mRNA and CRISPR, are disrupting today’s clinical landscape thanks to their promise of targeting disease treatment according to genetic blueprints. But the first methods of delivering these molecules to the body used viruses as their transport, raising patient safety concerns.“Humans have figured out how to engineer certain viruses found in nature to deliver specific cargoes [for disease treatment],” says Knappe. “But because they look like viruses, the human immune system sees them as a danger signal and creates an immune reaction that can be harmful to patients.”Given the safety profile issues of viral delivery, researchers turned to non-viral technologies that use lipid nanoparticle technology, a mixture of different lipid-like materials, assembled into particles to protect the mRNA therapeutic from getting degraded before it reaches a cell of interest. “Because they don’t look like viruses there, the immune system generally tolerates them,” adds Knappe.Recent data show lipid nanoparticles can now target the lung, opening the potential for novel treatments of deadly cancers and other diseases.Knappe’s work in MIT’s Bathe BioNanoLab focused on building such a non-viral delivery platform based on a different technology: nucleic acid nanoparticles, which combine the attractive components of both viral and non-viral systems. Knappe will spend his Kavanaugh Fellowship year developing proof-of-concept data for his drug delivery method and building the team and funding needed to commercialize the technology.A PhD candidate in the Department of Chemical Engineering (ChemE), Knappe was initially attracted to MIT because of its intellectual openness. “You can work with any faculty member in other departments. I wasn’t restricted to the chemical engineering faculty,” says Knappe, whose supervisor, Professor Mark Bathe, is in the Department of Biological Engineering.Knappe, who is from New Jersey, welcomes the challenges that will come in his Kavanaugh year, including the need to pinpoint the right story that will convince venture capitalists and other funders to bet on his technology. Attracting talent is also top of mind. “How do you convince really talented people that have a lot of opportunities to work on what you work on? Building the first team is going to be critical,” he says. The network Knappe has been building in his years at MIT is paying dividends now.Targeting “forever chemicals” in waterThat network includes Shah. The two fellows met when they worked on the MIT Science Policy Review, a student-run journal concerned with the intersection of science, technology, and policy. Knappe and Shah did not compete directly academically but used their biweekly coffee walks as a welcome sounding board. Naturally, they were pleased when they found out they had both been chosen for the Kavanaugh Fellowship. So far, they have been too busy to celebrate over a beer.“We are good collaborators with research, as well,” says Shah. “Now we’re going on this entrepreneurial journey together. It’s been exciting.”Shah is a PhD candidate in ChemE’s Chemical Engineering Practice program. He got interested in the global imperative for cleaner water at a young age. His hometown of Surat is the heart of India’s textile industry. “Growing up, it wasn’t hard to see the dye-colored water flowing into your rivers and streams,” Shah says. “Playing a role in fostering positive change in water treatment fills me with a profound sense of purpose.”Shah’s work, broadly, is to clean toxic chemicals called micropollutants from water in an efficient and sustainable manner. “It’s humanly impossible to turn a blind eye to our water problems,” he says, which can be categorized as accessibility, availability, and quality. Water problems are global and complex, not just because of the technological challenges but also sociopolitical ones, he adds.Manufactured chemicals called per- and polyfluoroalkyl substances (PFAS), or “forever chemicals,” are in the news these days. PFAS, which go into making nonstick cookware and waterproof clothing, are just one of more than 10,000 such emerging contaminants that have leached into water streams. “These are extremely difficult to remove using existing systems because of their chemical diversity and low concentrations,” Shah says. “The concentrations are akin to dropping an aspirin tablet in an Olympic-sized swimming pool.” But no less toxic for that.In the lab at MIT, Shah is working with Devashish Gokhale, a fellow PhD student, and Patrick S. Doyle, the Robert T. Haslam (1911) Professor of Chemical Engineering, to commercialize an innovative microparticle technology, hydroGel, to remove these micropollutants in an effective, facile, and sustainable manner. Hydrogels are a broad class of polymer materials that can hold large quantities of water.“Our materials are like Boba beads. We are trying to save the world with our Boba beads,” says Shah with a laugh. “And we have functionalized these particles with tunable chemistries to target different micropollutants in a single unit operation.”Due to its outsized environmental impact, industrial water is the first application Shah is targeting. Today, wastewater treatment emits more than 3 percent of global carbon dioxide emissions, which is more than the shipping industry’s emissions, for example. The current state of the art for removing micropollutants in the industry is to use activated carbon filters. “[This technology] comes from coal, so it’s unsustainable,” Shah says. And the activated carbon filters are hard to reuse. “Our particles are reusable, theoretically infinitely.”“I’m very excited to be able to take advantage of the mentorship we have from the Kavanaugh team to take this technology to its next inflection point, so that we are ready to go out in the market and start making a huge impact,” he says.A dream communityShah and Knappe have become adept at navigating the array of support and mentorship opportunities MIT has to offer. Shah worked with a small team of seasoned professionals in the water space from the MIT Venture Mentoring Service. “They’ve helped us every step of the way as we think about commercializing the technology,” he says.Shah worked with MIT Sandbox, which provides a seed grant to help find the right product-market fit. He is also a fellow with the Legatum Center for Development and Entrepreneurship, which focuses on entrepreneurship in emerging countries in growth markets.“We’re exploring the potential for this technology and its application in a lot of different markets, including India. Because that’s close to my heart,” Shah says. “The Legatum community has been unique, where you can have those extremely hard conversations, confront yourself with those fears, and then talk it out with the group of fellows.”The Abdul Latif Jameel Water and Food Systems Lab, or J-WAFS, has been an integral part of Shah’s journey with research and commercialization support through its Solutions Grant and a travel award to the Stockholm World Water Week in August 2023.Knappe has also taken advantage of many innovation programs, including MIT’s Blueprint by the Engine, which helps researchers explore commercial opportunities of their work, plus programs outside of MIT but with strong on-campus ties such as Nucleate Activator and Frequency Bio.It was during one of these programs that he was inspired by two postdocs working in Bathe’s lab and spinning out biotech startups from their research, Floris Engelhardt and James Banal. Engelhardt helped spearhead Kano Therapeutics, and Banal launched Cache DNA.“I was passively absorbing and watching everything that they were going through and what they were excited about and challenged with. I still talk to them pretty regularly to this day,” Knappe says. “It’s been really great to have them as continual mentors, throughout my PhD and as I transition out of the lab.”Shah says he is grateful not only for being selected for the Kavanaugh Fellowship but to MIT as a community. “MIT has been more than a dream come true,” he says. He will have the opportunity to explore a different side of the institution as he enters the MBA program at MIT Sloan School of Management this fall. Shah expects this program, along with his Kavanaugh training, will supply the skills he needs to scale the business so it can make a difference in the world.“I always keep coming back to the question ‘How does what I do matter to the person on the street?’ This guides me to look at the bigger picture, to contextualize my research to solving important problems,” Shah says. “So many great technologies are being worked on each day, but only a minuscule fraction make it to the market.”Knappe is equally dedicated to serving a larger purpose. “With the right infrastructure, between basic fundamental science, conducted in academia, funded by government, and then translated by companies, we can make products that could improve everyone’s life across the world,” he says.Past Kavanaugh Fellows are credited with spearheading commercial outfits that have indeed made a difference. This year’s fellows are poised to follow their lead. But first they will have that beer together to celebrate. More

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      in Environment

      A home where world-changing innovations take flight

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      In a large, open space on the first floor of 750 Main Street in Cambridge, Massachusetts, a carbon-capture company is heating up molten salts to 600 degrees Celsius right next to a quantum computing company’s device for supercooling qubits. The difference is about 900 degrees across 15 feet.

      It doesn’t take long in the tour of The Engine Accelerator to realize this isn’t your typical co-working space. Companies here are working at the extremes to develop new technologies with world-changing impact — what The Engine Accelerator’s leaders call “tough tech.”

      Comprising four floors and 150,000 square feet next door to MIT’s campus, the new space offers startups specialized lab equipment, advanced machining, fabrication facilities, office space, and a range of startup support services.

      The goal is to give young companies merging science and engineering all of the resources they need to move ideas from the lab bench to their own mass manufacturing lines.

      “The infrastructure has always been a really important accelerant for getting these kinds of companies off and running,” The Engine Accelerator President Emily Knight says. “Now you can start a company and, on day one, start building. Real estate is such a big factor. Our thought was, let’s make this investment in the infrastructure for the founders. It’s an agile lease that enables them to be very flexible as they grow.”

      Since the new facility opened its doors in the summer of 2022, the Accelerator has welcomed around 100 companies that employ close to 1,000 people. In addition to the space, members enjoy educational workshops on topics like fundraising and hiring, events, and networking opportunities that the Accelerator team hopes foster a sense of community among people working in the tough tech space overall.

      “We’re not just advocates for the startups in the space,” Knight says. “We’re advocates for tough tech as a whole. We think it’s important for the state of Massachusetts to create a tough tech hub here, and we think it’s important for national competitiveness.”

      Tough tech gets a home

      The Engine was spun out of MIT in 2016 as a public benefit corporation with the mission of bridging the gap between discovery and commercialization. Since its inception, it has featured an investment component, now known as Engine Ventures, and a shared services component.

      From the moment The Engine opened its doors to startups in its original headquarters on Massachusetts Avenue in Cambridge, the services team got a firsthand look at the unique challenges faced by tough tech startups. After speaking with founders, they realized their converted office space would need more power, stronger floors, and full lab accommodations.

      The team rose to the challenge. They turned a closet into a bio lab. They turned an unused wellness room into a laser lab. They managed to accommodate Commonwealth Fusion Systems when the founders informed them a 5,000-pound magnet would soon arrive for testing.

      But supporting ambitious founders in their quest to build world-changing companies was always going to require a bigger boat. As early as 2017, MIT’s leaders were considering turning the old Polaroid building, which had sat empty next to MIT’s campus for nearly 20 years, into the new home for tough tech.

      Speaking of tough, construction crews began the extensive building renovations for the Accelerator at the end of 2019, a few months before the Covid-19 pandemic. The team managed to avoid the worst of the supply chain disruptions, but they quickly learned the building has its quirks. Each floor is a different ceiling height, and massive pillars known as mushroom columns punctuate each floor.

      Based on conversations with founders, The Engine’s Accelerator team outfitted the renovated building with office and co-working space, a full machine shop, labs for biology and chemistry work, an array of 3D printers, bike storage, and, perhaps most important, cold brew on tap.

      “I think of the Accelerator as a really great Airbnb host rather than a landlord, where maybe you rented a bedroom in a large house, but you feel like you rented the whole thing because you have access to all kinds of amazing equipment,” says Bernardo Cervantes PhD ’20, co-founder of Concerto Biosciences, which is developing microbes for a variety of uses in human health and agriculture.

      The Engine Accelerator’s team credits MIT leadership with helping them manage the project, noting that the MIT Environment, Health and Safety office was particularly helpful.

      A week after the Accelerator opened its doors in August 2022, on a single sweltering day, 35 companies moved in. By 2023, the Accelerator was home to 55 companies. Since then, the Accelerator’s team has done everything they could to continue to grow.

      “At one point, one of our team members came to me with her tail between her legs and sheepishly said, ‘I gave our office space to a startup,’” Knight recalls. “I said, ‘Yes! That means you get it! We don’t need an office — we can sit anywhere.’”

      The first floor holds some of the largest machinery, including that molten salt device (developed by Mantel Capture) and the quantum computer (developed by Atlantic Quantum). On the next level, a machine shop and a fabrication space featuring every 3D printer imaginable offer ways for companies to quickly build prototype products or parts. Another floor is dubbed “the Avenue” and features a kitchen and tables for networking and serendipitous meetings. The Avenue is lined by huge garage doors that open to accommodate larger crowds for workshops and meeting spaces.

      “Even though the founders are working in different spaces, we wanted to create an area where people can connect and run into each other and get help with 3D printing or hiring or anything else,” Knight says. “It fosters those casual interactions that are very important for startups.”

      An ecosystem to change the world

      Only about one-fifth of the companies in the Accelerator space are portfolio companies of Engine Ventures. The two entities operate separately, but they pool their shared learning about supporting tough tech, and Engine Ventures has an office in the Accelerator’s space.

      Engine Ventures CEO Katie Rae sees it as a symbiotic partnership.

      “We needed to have all these robust services for everyone in tough tech, not just the portfolio companies,” Rae says. “We’ll always work together and produce the Tough Tech Summit together because of our overarching missions. It’s very much like a rising tide lifts all boats. All of these companies are working to change the world in their own verticals, so we’re just focusing on the impact they’re trying to have and making that the story.”

      Rae says MIT has helped both of The Engine’s teams think through the best way to support tough tech startups.

      “Being a partner with MIT, which understands innovation and safety better than anyone, has allowed us to say yes to more things and have more flexibility,” Rae says. “If you’re going to go at breakneck speed to solve global problems, you better have a mentality of getting things done fast and safely, and I think that’s been a core tenet of The Engine.”

      Meanwhile, Knight says her team hasn’t stopped learning from the tough tech community and will continue to adapt.

      “There’s just a waterfall of information coming from these companies,” Knight says. “It’s about iterating on our services to best support them, so we can go to people on our team and ask, ‘Can you learn to run this type of program, because we just learned these five founders need it?’ Every founder we know in the area has a badge so they can come in. We want to create a hub for tough tech within this Kendall Square area that’s already a hub in so many ways.” More

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      in Environment

      Q&A: A blueprint for sustainable innovation

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      Atacama Biomaterials is a startup combining architecture, machine learning, and chemical engineering to create eco-friendly materials with multiple applications. Passionate about sustainable innovation, its co-founder Paloma Gonzalez-Rojas SM ’15, PhD ’21 highlights here how MIT has supported the project through several of its entrepreneurship initiatives, and reflects on the role of design in building a holistic vision for an expanding business.

      Q: What role do you see your startup playing in the sustainable materials space?

      A: Atacama Biomaterials is a venture dedicated to advancing sustainable materials through state-of-the-art technology. With my co-founder Jose Tomas Dominguez, we have been working on developing our technology since 2019. We initially started the company in 2020 under another name and received Sandbox funds the next year. In 2021, we went through The Engine’s accelerator, Blueprint, and changed our name to Atacama Biomaterials in 2022 during the MITdesignX program. 

      This technology we have developed allows us to create our own data and material library using artificial intelligence and machine learning, and serves as a platform applicable to various industries horizontally — biofuels, biological drugs, and even mining. Vertically, we produce inexpensive, regionally sourced, and environmentally friendly bio-based polymers and packaging — that is, naturally compostable plastics as a flagship product, along with AI products.

      Q: What motivated you to venture into biomaterials and found Atacama?

      A: I’m from Chile, a country with a beautiful, rich geography and nature where we can see all the problems stemming from industry, waste management, and pollution. We named our company Atacama Biomaterials because the Atacama Desert in Chile — one of the places where you can best see the stars in the world — is becoming a plastic dump, as many other places on Earth. I care deeply about sustainability, and I have an emotional attachment to stop these problems. Considering that manufacturing accounts for 29 percent of global carbon emissions, it is clear that sustainability has a role in how we define technology and entrepreneurship, as well as a socio-economic dimension.

      When I first came to MIT, it was to develop software in the Department of Architecture’s Design and Computation Group, with MIT professors Svafa Gronfeldt as co-advisor and Regina Barzilay as committee member. During my PhD, I studied machine-learning methods simulating pedestrian motion to understand how people move in space. In my work, I would use lots of plastics for 3D printing and I couldn’t stop thinking about sustainability and climate change, so I reached out to material science and mechanical engineering professors to look into biopolymers and degradable bio-based materials. This is how I met my co-founder, as we were both working with MIT Professor Neil Gershenfeld. Together, we were part of one of the first teams in the world to 3D print wood fibers, which is difficult — it’s slow and expensive — and quickly pivoted to sustainable packaging. 

      I then won a fellowship from MCSC [the MIT Climate and Sustainability Consortium], which gave me freedom to explore further, and I eventually got a postdoc in MIT chemical engineering, guided by MIT Professor Gregory Rutledge, a polymer physicist. This was unexpected in my career path. Winning Nucleate Eco Track 2022 and the MITdesignX Innovation Award in 2022 profiled Atacama Biomaterials as one of the rising startups in Boston’s biotechnology and climate-tech scene.

      Q: What is your process to develop new biomaterials?

      A: My PhD research, coupled with my background in material development and molecular dynamics, sparked the realization that principles I studied simulating pedestrian motion could also apply to molecular engineering. This connection may seem unconventional, but for me, it was a natural progression. Early in my career, I developed an intuition for materials, understanding their mechanics and physics.

      Using my experience and skills, and leveraging machine learning as a technology jump, I applied a similar conceptual framework to simulate the trajectories of molecules and find potential applications in biomaterials. Making that parallel and shift was amazing. It allowed me to optimize a state-of-the-art molecular dynamic software to run twice as fast as more traditional technologies through my algorithm presented at the International Conference of Machine Learning this year. This is very important, because this kind of simulation usually takes a week, so narrowing it down to two days has major implications for scientists and industry, in material science, chemical engineering, computer science and related fields. Such work greatly influenced the foundation of Atacama Biomaterials, where we developed our own AI to deploy our materials. In an effort to mitigate the environmental impact of manufacturing, Atacama is targeting a 16.7 percent reduction in carbon dioxide emissions associated with the manufacturing process of its polymers, through the use of renewable energy. 

      Another thing is that I was trained as an architect in Chile, and my degree had a design component. I think design allows me to understand problems at a very high level, and how things interconnect. It contributed to developing a holistic vision for Atacama, because it allowed me to jump from one technology or discipline to another and understand broader applications on a conceptual level. Our design approach also meant that sustainability came to the center of our work from the very beginning, not just a plus or an added cost.

      Q: What was the role of MITdesignX in Atacama’s development?

      A: I have known Svafa Grönfeldt, MITdesignX’s faculty director, for almost six years. She was the co-advisor of my PhD, and we had a mentor-mentee relationship. I admire the fact that she created a space for people interested in business and entrepreneurship to grow within the Department of Architecture. She and Executive Director Gilad Rosenzweig gave us fantastic advice, and we received significant support from mentors. For example, Daniel Tsai helped us with intellectual property, including a crucial patent for Atacama. And we’re still in touch with the rest of the cohort. I really like this “design your company” approach, which I find quite unique, because it gives us the opportunity to reflect on who we want to be as designers, technologists, and entrepreneurs. Studying user insights also allowed us to understand the broad applicability of our research, and align our vision with market demands, ultimately shaping Atacama into a company with a holistic perspective on sustainable material development.

      Q: How does Atacama approach scaling, and what are the immediate next steps for the company?

      A: When I think about accomplishing our vision, I feel really inspired by my 3-year-old daughter. I want her to experience a world with trees and wildlife when she’s 100 years old, and I hope Atacama will contribute to such a future.

      Going back to the designer’s perspective, we designed the whole process holistically, from feedstock to material development, incorporating AI and advanced manufacturing. Having proved that there is a demand for the materials we are developing, and having tested our products, manufacturing process, and technology in critical environments, we are now ready to scale. Our level of technology-readiness is comparable to the one used by NASA (level 4).

      We have proof of concept: a biodegradable and recyclable packaging material which is cost- and energy-efficient as a clean energy enabler in large-scale manufacturing. We have received pre-seed funding, and are sustainably scaling by taking advantage of available resources around the world, like repurposing machinery from the paper industry. As presented in the MIT Industrial Liaison and STEX Program’s recent Sustainability Conference, unlike our competitors, we have cost-parity with current packaging materials, as well as low-energy processes. And we also proved the demand for our products, which was an important milestone. Our next steps involve strategically expanding our manufacturing capabilities and research facilities and we are currently evaluating building a factory in Chile and establishing an R&D lab plus a manufacturing plant in the U.S. More

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      in Energy

      How to decarbonize the world, at scale

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      The world in recent years has largely been moving on from debates about the need to curb carbon emissions and focusing more on action — the development, implementation, and deployment of the technological, economic, and policy measures to spur the scale of reductions needed by mid-century. That was the message Robert Stoner, the interim director of the MIT Energy Initiative (MITEI), gave in his opening remarks at the 2023 MITEI Annual Research Conference.

      Attendees at the two-day conference included faculty members, researchers, industry and financial leaders, government officials, and students, as well as more than 50 online participants from around the world.

      “We are at an extraordinary inflection point. We have this narrow window in time to mitigate the worst effects of climate change by transforming our entire energy system and economy,” said Jonah Wagner, the chief strategist of the U.S. Department of Energy’s (DOE) Loan Programs Office, in one of the conference’s keynote speeches.

      Yet the solutions exist, he said. “Most of the technologies that we need to deploy to stay close to the international target of 1.5 degrees Celsius warming are proven and ready to go,” he said. “We have over 80 percent of the technologies we will need through 2030, and at least half of the technologies we will need through 2050.”

      For example, Wagner pointed to the newly commissioned advanced nuclear power plant near Augusta, Georgia — the first new nuclear reactor built in the United States in a generation, partly funded through DOE loans. “It will be the largest source of clean power in America,” he said. Though implementing all the needed technologies in the United States through mid-century will cost an estimated $10 trillion, or about $300 billion a year, most of that money will come from the private sector, he said.

      As the United States faces what he describes as “a tsunami of distributed energy production,” one key example of the strategy that’s needed going forward, he said, is encouraging the development of virtual power plants (VPPs). The U.S. power grid is growing, he said, and will add 200 gigawatts of peak demand by 2030. But rather than building new, large power plants to satisfy that need, much of the increase can be accommodated by VPPs, he said — which are “aggregations of distributed energy resources like rooftop solar with batteries, like electric vehicles (EVs) and chargers, like smart appliances, commercial and industrial loads on the grid that can be used together to help balance supply and demand just like a traditional power plant.” For example, by shifting the time of demand for some applications where the timing is not critical, such as recharging EVs late at night instead of right after getting home from work when demand may be peaking, the need for extra peak power can be alleviated.

      Such programs “offer a broad range of benefits,” including affordability, reliability and resilience, decarbonization, and emissions reductions. But implementing such systems on a wide scale requires some up-front help, he explained. Payment for consumers to enroll in programs that allow such time adjustments “is the majority of the cost” of establishing VPPs, he says, “and that means most of the money spent on VPPs goes back into the pockets of American consumers.” But to make that happen, there is a need for standardization of VPP operations “so that we are not recreating the wheel every single time we deploy a pilot or an effort with a utility.”

      The conference’s other keynote speaker, Anne White, the vice provost and associate vice president for research administration at MIT, cited devastating recent floods, wildfires, and many other extreme weather-related crises around the world that have been exacerbated by climate change. “We saw in myriad ways that energy concerns and climate concerns are one and the same,” she said. “So, we must urgently develop and scale low-carbon and zero-carbon solutions to prevent future warming. And we must do this with a practical, systems-based approach that considers efficiency, affordability, equity, and sustainability for how the world will meet its energy needs.”

      White added that at MIT, “we are mobilizing everything.” People at MIT feel a strong sense of responsibility for dealing with these global issues, she said, “and I think it’s because we believe we have tools that can really make a difference.”

      Among the specific promising technologies that have sprung from MIT’s labs, she pointed out, is the rapid development of fusion technology that led to MIT spinoff company Commonwealth Fusion Systems, which aims to build a demonstration unit of a practical fusion power reactor by the decade’s end. That’s an outcome of decades of research, she emphasized — the kinds of early-stage risky work that only academic labs, with help from government grants, can carry out.

      For example, she pointed to the more than 200 projects that MITEI has provided seed funds of $150,000 each for two years, totaling over $28 million to date. Such early support is “a key part of producing the kind of transformative innovation we know we all need.” In addition, MIT’s The Engine has also helped launch not only Commonwealth Fusion Systems, but also Form Energy, a company building a plant in West Virginia to manufacture advanced iron-air batteries for renewable energy storage, and many others.

      Following that theme of supporting early innovation, the conference featured two panels that served to highlight the work of students and alumni and their energy-related startup companies. First, a startup showcase, moderated by Catarina Madeira, the director of MIT’s Startup Exchange, featured presentations about seven recent spinoff companies that are developing cutting-edge technologies that emerged from MIT research. These included:

      Aeroshield, developing a new kind of highly-insulated window using a unique aerogel material;
      Sublime, which is developing a low-emissions concrete;
      Found Energy, developing a way to use recycled aluminum as a fuel;
      Veir, developing superconducting power lines;
      Emvolom, developing inexpensive green fuels from waste gases;
      Boston Metal, developing low-emissions production processes for steel and other metals;
      Transaera, with a new kind of efficient air conditioning; and
      Carbon Recycling International, producing cheap hydrogen fuel and syngas.
      Later in the conference, a “student slam competition” featured presentations by 11 students who described results of energy projects they had been working on this past summer. The projects were as diverse as analyzing opposition to wind farms in Maine, how best to allocate EV charging stations, optimizing bioenergy production, recycling the lithium from batteries, encouraging adoption of heat pumps, and conflict analysis about energy project siting. Attendees voted on the quality of the student presentations, and electrical engineering and computer science student Tori Hagenlocker was declared first-place winner for her talk on heat pump adoption.

      Students were also featured in a first-time addition to the conference: a panel discussion among five current or recent students, giving their perspective on today’s energy issues and priorities, and how they are working toward trying to make a difference. Andres Alvarez, a recent graduate in nuclear engineering, described his work with a startup focused on identifying and supporting early-stage ideas that have potential. Graduate student Dyanna Jaye of urban studies and planning spoke about her work helping to launch a group called the Sunrise Movement to try to drive climate change as a top priority for the country, and her work helping to develop the Green New Deal.

      Peter Scott, a graduate student in mechanical engineering who is studying green hydrogen production, spoke of the need for a “very drastic and rapid phaseout of current, existing fossil fuels” and a halt on developing new sources. Amar Dayal, an MBA candidate at the MIT Sloan School of Management, talked about the interplay between technology and policy, and the crucial role that legislation like the Inflation Reduction Act can have in enabling new energy technology to make the climb to commercialization. And Shreyaa Raghavan, a doctoral student in the Institute of Data, Systems, and Society, talked about the importance of multidisciplinary approaches to climate issues, including the important role of computer science. She added that MIT does well on this compared to other institutions, and “sustainability and decarbonization is a pillar in a lot of the different departments and programs that exist here.”

      Some recent recipients of MITEI’s Seed Fund grants reported on their progress in a panel discussion moderated by MITEI Executive Director Martha Broad. Seed grant recipient Ariel Furst, a professor of chemical engineering, pointed out that access to electricity is very much concentrated in the global North and that, overall, one in 10 people worldwide lacks access to electricity and some 2.5 billion people “rely on dirty fuels to heat their homes and cook their food,” with impacts on both health and climate. The solution her project is developing involves using DNA molecules combined with catalysts to passively convert captured carbon dioxide into ethylene, a widely used chemical feedstock and fuel. Kerri Cahoy, a professor of aeronautics and astronautics, described her work on a system for monitoring methane emissions and power-line conditions by using satellite-based sensors. She and her team found that power lines often begin emitting detectable broadband radio frequencies long before they actually fail in a way that could spark fires.

      Admir Masic, an associate professor of civil and environmental engineering, described work on mining the ocean for minerals such as magnesium hydroxide to be used for carbon capture. The process can turn carbon dioxide into solid material that is stable over geological times and potentially usable as a construction material. Kripa Varanasi, a professor of mechanical engineering, said that over the years MITEI seed funding helped some of his projects that “went on to become startup companies, and some of them are thriving.” He described ongoing work on a new kind of electrolyzer for green hydrogen production. He developed a system using bubble-attracting surfaces to increase the efficiency of bioreactors that generate hydrogen fuel.

      A series of panel discussions over the two days covered a range of topics related to technologies and policies that could make a difference in combating climate change. On the technological side, one panel led by Randall Field, the executive director of MITEI’s Future Energy Systems Center, looked at large, hard-to-decarbonize industrial processes. Antoine Allanore, a professor of metallurgy, described progress in developing innovative processes for producing iron and steel, among the world’s most used commodities, in a way that drastically reduces greenhouse gas emissions. Greg Wilson of JERA Americas described the potential for ammonia produced from renewable sources to substitute for natural gas in power plants, greatly reducing emissions. Yet-Ming Chiang, a professor in materials science and engineering, described ways to decarbonize cement production using a novel low-temperature process. And Guiyan Zang, a research scientist at MITEI, spoke of efforts to reduce the carbon footprint of producing ethylene, a major industrial chemical, by using an electrochemical process.

      Another panel, led by Jacopo Buongiorno, professor of nuclear science and engineering, explored the brightening future for expansion of nuclear power, including new, small, modular reactors that are finally emerging into commercial demonstration. “There is for the first time truly here in the U.S. in at least a decade-and-a-half, a lot of excitement, a lot of attention towards nuclear,” Buongiorno said. Nuclear power currently produces 45 to 50 percent of the nation’s carbon-free electricity, the panelists said, and with the first new nuclear power plant in decades now in operation, the stage is set for significant growth.

      Carbon capture and sequestration was the subject of a panel led by David Babson, the executive director of MIT’s Climate Grand Challenges program. MIT professors Betar Gallant and Kripa Varanasi and industry representatives Elisabeth Birkeland from Equinor and Luc Huyse from Chevron Technology Ventures described significant progress in various approaches to recovering carbon dioxide from power plant emissions, from the air, and from the ocean, and converting it into fuels, construction materials, or other valuable commodities.

      Some panel discussions also addressed the financial and policy side of the climate issue. A panel on geopolitical implications of the energy transition was moderated by MITEI Deputy Director of Policy Christopher Knittel, who said “energy has always been synonymous with geopolitics.” He said that as concerns shift from where to find the oil and gas to where is the cobalt and nickel and other elements that will be needed, “not only are we worried about where the deposits of natural resources are, but we’re going to be more and more worried about how governments are incentivizing the transition” to developing this new mix of natural resources. Panelist Suzanne Berger, an Institute professor, said “we’re now at a moment of unique openness and opportunity for creating a new American production system,” one that is much more efficient and less carbon-producing.

      One panel dealt with the investor’s perspective on the possibilities and pitfalls of emerging energy technologies. Moderator Jacqueline Pless, an assistant professor in MIT Sloan, said “there’s a lot of momentum now in this space. It’s a really ripe time for investing,” but the risks are real. “Tons of investment is needed in some very big and uncertain technologies.”

      The role that large, established companies can play in leading a transition to cleaner energy was addressed by another panel. Moderator J.J. Laukatis, MITEI’s director of member services, said that “the scale of this transformation is massive, and it will also be very different from anything we’ve seen in the past. We’re going to have to scale up complex new technologies and systems across the board, from hydrogen to EVs to the electrical grid, at rates we haven’t done before.” And doing so will require a concerted effort that includes industry as well as government and academia. More

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      Manufacturing a cleaner future

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      Manufacturing had a big summer. The CHIPS and Science Act, signed into law in August, represents a massive investment in U.S. domestic manufacturing. The act aims to drastically expand the U.S. semiconductor industry, strengthen supply chains, and invest in R&D for new technological breakthroughs. According to John Hart, professor of mechanical engineering and director of the Laboratory for Manufacturing and Productivity at MIT, the CHIPS Act is just the latest example of significantly increased interest in manufacturing in recent years.

      “You have multiple forces working together: reflections from the pandemic’s impact on supply chains, the geopolitical situation around the world, and the urgency and importance of sustainability,” says Hart. “This has now aligned incentives among government, industry, and the investment community to accelerate innovation in manufacturing and industrial technology.”

      Hand-in-hand with this increased focus on manufacturing is a need to prioritize sustainability.

      Roughly one-quarter of greenhouse gas emissions came from industry and manufacturing in 2020. Factories and plants can also deplete local water reserves and generate vast amounts of waste, some of which can be toxic.

      To address these issues and drive the transition to a low-carbon economy, new products and industrial processes must be developed alongside sustainable manufacturing technologies. Hart sees mechanical engineers as playing a crucial role in this transition.

      “Mechanical engineers can uniquely solve critical problems that require next-generation hardware technologies, and know how to bring their solutions to scale,” says Hart.

      Several fast-growing companies founded by faculty and alumni from MIT’s Department of Mechanical Engineering offer solutions for manufacturing’s environmental problem, paving the path for a more sustainable future.

      Gradiant: Cleantech water solutions

      Manufacturing requires water, and lots of it. A medium-sized semiconductor fabrication plant uses upward of 10 million gallons of water a day. In a world increasingly plagued by droughts, this dependence on water poses a major challenge.

      Gradiant offers a solution to this water problem. Co-founded by Anurag Bajpayee SM ’08, PhD ’12 and Prakash Govindan PhD ’12, the company is a pioneer in sustainable — or “cleantech” — water projects.

      As doctoral students in the Rohsenow Kendall Heat Transfer Laboratory, Bajpayee and Govindan shared a pragmatism and penchant for action. They both worked on desalination research — Bajpayee with Professor Gang Chen and Govindan with Professor John Lienhard.

      Inspired by a childhood spent during a severe drought in Chennai, India, Govindan developed for his PhD a humidification-dehumidification technology that mimicked natural rainfall cycles. It was with this piece of technology, which they named Carrier Gas Extraction (CGE), that the duo founded Gradiant in 2013.

      The key to CGE lies in a proprietary algorithm that accounts for variability in the quality and quantity in wastewater feed. At the heart of the algorithm is a nondimensional number, which Govindan proposes one day be called the “Lienhard Number,” after his doctoral advisor.

      “When the water quality varies in the system, our technology automatically sends a signal to motors within the plant to adjust the flow rates to bring back the nondimensional number to a value of one. Once it’s brought back to a value of one, you’re running in optimal condition,” explains Govindan, who serves as chief operating officer of Gradiant.

      This system can treat and clean the wastewater produced by a manufacturing plant for reuse, ultimately conserving millions of gallons of water each year.

      As the company has grown, the Gradiant team has added new technologies to their arsenal, including Selective Contaminant Extraction, a cost-efficient method that removes only specific contaminants, and a brine-concentration method called Counter-Flow Reverse Osmosis. They now offer a full technology stack of water and wastewater treatment solutions to clients in industries including pharmaceuticals, energy, mining, food and beverage, and the ever-growing semiconductor industry.

      “We are an end-to-end water solutions provider. We have a portfolio of proprietary technologies and will pick and choose from our ‘quiver’ depending on a customer’s needs,” says Bajpayee, who serves as CEO of Gradiant. “Customers look at us as their water partner. We can take care of their water problem end-to-end so they can focus on their core business.”

      Gradiant has seen explosive growth over the past decade. With 450 water and wastewater treatment plants built to date, they treat the equivalent of 5 million households’ worth of water each day. Recent acquisitions saw their total employees rise to above 500.

      The diversity of Gradiant’s solutions is reflected in their clients, who include Pfizer, AB InBev, and Coca-Cola. They also count semiconductor giants like Micron Technology, GlobalFoundries, Intel, and TSMC among their customers.

      “Over the last few years, we have really developed our capabilities and reputation serving semiconductor wastewater and semiconductor ultrapure water,” says Bajpayee.

      Semiconductor manufacturers require ultrapure water for fabrication. Unlike drinking water, which has a total dissolved solids range in the parts per million, water used to manufacture microchips has a range in the parts per billion or quadrillion.

      Currently, the average recycling rate at semiconductor fabrication plants — or fabs — in Singapore is only 43 percent. Using Gradiant’s technologies, these fabs can recycle 98-99 percent of the 10 million gallons of water they require daily. This reused water is pure enough to be put back into the manufacturing process.

      “What we’ve done is eliminated the discharge of this contaminated water and nearly eliminated the dependence of the semiconductor fab on the public water supply,” adds Bajpayee.

      With new regulations being introduced, pressure is increasing for fabs to improve their water use, making sustainability even more important to brand owners and their stakeholders.

      As the domestic semiconductor industry expands in light of the CHIPS and Science Act, Gradiant sees an opportunity to bring their semiconductor water treatment technologies to more factories in the United States.

      Via Separations: Efficient chemical filtration

      Like Bajpayee and Govindan, Shreya Dave ’09, SM ’12, PhD ’16 focused on desalination for her doctoral thesis. Under the guidance of her advisor Jeffrey Grossman, professor of materials science and engineering, Dave built a membrane that could enable more efficient and cheaper desalination.

      A thorough cost and market analysis brought Dave to the conclusion that the desalination membrane she developed would not make it to commercialization.

      “The current technologies are just really good at what they do. They’re low-cost, mass produced, and they worked. There was no room in the market for our technology,” says Dave.

      Shortly after defending her thesis, she read a commentary article in the journal Nature that changed everything. The article outlined a problem. Chemical separations that are central to many manufacturing processes require a huge amount of energy. Industry needed more efficient and cheaper membranes. Dave thought she might have a solution.

      After determining there was an economic opportunity, Dave, Grossman, and Brent Keller PhD ’16 founded Via Separations in 2017. Shortly thereafter, they were chosen as one of the first companies to receive funding from MIT’s venture firm, The Engine.

      Currently, industrial filtration is done by heating chemicals at very high temperatures to separate compounds. Dave likens it to making pasta by boiling all of the water off until it evaporates and all you are left with is the pasta noodles. In manufacturing, this method of chemical separation is extremely energy-intensive and inefficient.

      Via Separations has created the chemical equivalent of a “pasta strainer.” Rather than using heat to separate, their membranes “strain” chemical compounds. This method of chemical filtration uses 90 percent less energy than standard methods.

      While most membranes are made of polymers, Via Separations’ membranes are made with graphene oxide, which can withstand high temperatures and harsh conditions. The membrane is calibrated to the customer’s needs by altering the pore size and tuning the surface chemistry.

      Currently, Dave and her team are focusing on the pulp and paper industry as their beachhead market. They have developed a system that makes the recovery of a substance known as “black liquor” more energy efficient.

      “When tree becomes paper, only one-third of the biomass is used for the paper. Currently the most valuable use for the remaining two-thirds not needed for paper is to take it from a pretty dilute stream to a pretty concentrated stream using evaporators by boiling off the water,” says Dave.

      This black liquor is then burned. Most of the resulting energy is used to power the filtration process.

      “This closed-loop system accounts for an enormous amount of energy consumption in the U.S. We can make that process 84 percent more efficient by putting the ‘pasta strainer’ in front of the boiler,” adds Dave.

      VulcanForms: Additive manufacturing at industrial scale

      The first semester John Hart taught at MIT was a fruitful one. He taught a course on 3D printing, broadly known as additive manufacturing (AM). While it wasn’t his main research focus at the time, he found the topic fascinating. So did many of the students in the class, including Martin Feldmann MEng ’14.

      After graduating with his MEng in advanced manufacturing, Feldmann joined Hart’s research group full time. There, they bonded over their shared interest in AM. They saw an opportunity to innovate with an established metal AM technology, known as laser powder bed fusion, and came up with a concept to realize metal AM at an industrial scale.

      The pair co-founded VulcanForms in 2015.

      “We have developed a machine architecture for metal AM that can build parts with exceptional quality and productivity,” says Hart. “And, we have integrated our machines in a fully digital production system, combining AM, postprocessing, and precision machining.”

      Unlike other companies that sell 3D printers for others to produce parts, VulcanForms makes and sells parts for their customers using their fleet of industrial machines. VulcanForms has grown to nearly 400 employees. Last year, the team opened their first production factory, known as “VulcanOne,” in Devens, Massachusetts.

      The quality and precision with which VulcanForms produces parts is critical for products like medical implants, heat exchangers, and aircraft engines. Their machines can print layers of metal thinner than a human hair.

      “We’re producing components that are difficult, or in some cases impossible to manufacture otherwise,” adds Hart, who sits on the company’s board of directors.

      The technologies developed at VulcanForms may help lead to a more sustainable way to manufacture parts and products, both directly through the additive process and indirectly through more efficient, agile supply chains.

      One way that VulcanForms, and AM in general, promotes sustainability is through material savings.

      Many of the materials VulcanForms uses, such as titanium alloys, require a great deal of energy to produce. When titanium parts are 3D-printed, substantially less of the material is used than in a traditional machining process. This material efficiency is where Hart sees AM making a large impact in terms of energy savings.

      Hart also points out that AM can accelerate innovation in clean energy technologies, ranging from more efficient jet engines to future fusion reactors.

      “Companies seeking to de-risk and scale clean energy technologies require know-how and access to advanced manufacturing capability, and industrial additive manufacturing is transformative in this regard,” Hart adds.

      LiquiGlide: Reducing waste by removing friction

      There is an unlikely culprit when it comes to waste in manufacturing and consumer products: friction. Kripa Varanasi, professor of mechanical engineering, and the team at LiquiGlide are on a mission to create a frictionless future, and substantially reduce waste in the process.

      Founded in 2012 by Varanasi and alum David Smith SM ’11, LiquiGlide designs custom coatings that enable liquids to “glide” on surfaces. Every last drop of a product can be used, whether it’s being squeezed out of a tube of toothpaste or drained from a 500-liter tank at a manufacturing plant. Making containers frictionless substantially minimizes wasted product, and eliminates the need to clean a container before recycling or reusing.

      Since launching, the company has found great success in consumer products. Customer Colgate utilized LiquiGlide’s technologies in the design of the Colgate Elixir toothpaste bottle, which has been honored with several industry awards for design. In a collaboration with world- renowned designer Yves Béhar, LiquiGlide is applying their technology to beauty and personal care product packaging. Meanwhile, the U.S. Food and Drug Administration has granted them a Device Master Filing, opening up opportunities for the technology to be used in medical devices, drug delivery, and biopharmaceuticals.

      In 2016, the company developed a system to make manufacturing containers frictionless. Called CleanTanX, the technology is used to treat the surfaces of tanks, funnels, and hoppers, preventing materials from sticking to the side. The system can reduce material waste by up to 99 percent.

      “This could really change the game. It saves wasted product, reduces wastewater generated from cleaning tanks, and can help make the manufacturing process zero-waste,” says Varanasi, who serves as chair at LiquiGlide.

      LiquiGlide works by creating a coating made of a textured solid and liquid lubricant on the container surface. When applied to a container, the lubricant remains infused within the texture. Capillary forces stabilize and allow the liquid to spread on the surface, creating a continuously lubricated surface that any viscous material can slide right down. The company uses a thermodynamic algorithm to determine the combinations of safe solids and liquids depending on the product, whether it’s toothpaste or paint.

      The company has built a robotic spraying system that can treat large vats and tanks at manufacturing plants on site. In addition to saving companies millions of dollars in wasted product, LiquiGlide drastically reduces the amount of water needed to regularly clean these containers, which normally have product stuck to the sides.

      “Normally when you empty everything out of a tank, you still have residue that needs to be cleaned with a tremendous amount of water. In agrochemicals, for example, there are strict regulations about how to deal with the resulting wastewater, which is toxic. All of that can be eliminated with LiquiGlide,” says Varanasi.

      While the closure of many manufacturing facilities early in the pandemic slowed down the rollout of CleanTanX pilots at plants, things have picked up in recent months. As manufacturing ramps up both globally and domestically, Varanasi sees a growing need for LiquiGlide’s technologies, especially for liquids like semiconductor slurry.

      Companies like Gradiant, Via Separations, VulcanForms, and LiquiGlide demonstrate that an expansion in manufacturing industries does not need to come at a steep environmental cost. It is possible for manufacturing to be scaled up in a sustainable way.

      “Manufacturing has always been the backbone of what we do as mechanical engineers. At MIT in particular, there is always a drive to make manufacturing sustainable,” says Evelyn Wang, Ford Professor of Engineering and former head of the Department of Mechanical Engineering. “It’s amazing to see how startups that have an origin in our department are looking at every aspect of the manufacturing process and figuring out how to improve it for the health of our planet.”

      As legislation like the CHIPS and Science Act fuels growth in manufacturing, there will be an increased need for startups and companies that develop solutions to mitigate the environmental impact, bringing us closer to a more sustainable future. More

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      Cleaning up industrial filtration

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      If you wanted to get pasta out of a pot of water, would you boil off the water, or use a strainer? While home cooks would choose the strainer, many industries continue to use energy-intensive thermal methods of separating out liquids. In some cases, that’s because it’s difficult to make a filtration system for chemical separation, which requires pores small enough to separate atoms.

      In other cases, membranes exist to separate liquids, but they are made of fragile polymers, which can break down or gum up in industrial use.

      Via Separations, a startup that emerged from MIT in 2017, has set out to address these challenges with a membrane that is cost-effective and robust. Made of graphene oxide (a “cousin” of pencil lead), the membrane can reduce the amount of energy used in industrial separations by 90 percent, according to Shreya Dave PhD ’16, company co-founder and CEO.

      This is valuable because separation processes account for about 22 percent of all in-plant energy use in the United States, according to Oak Ridge National Laboratory. By making such processes significantly more efficient, Via Separations plans to both save energy and address the significant emissions produced by thermal processes. “Our goal is eliminating 500 megatons of carbon dioxide emissions by 2050,” Dave says.

      Play video

      What do our passions for pasta and decarbonizing the Earth have in common? MIT alumna Shreya Dave PhD ’16 explains how she and her team at Via Separations are building the equivalent of a pasta strainer to separate chemical compounds for industry.

      Via Separations began piloting its technology this year at a U.S. paper company and expects to deploy a full commercial system there in the spring of 2022. “Our vision is to help manufacturers slow carbon dioxide emissions next year,” Dave says.

      MITEI Seed Grant

      The story of Via Separations begins in 2012, when the MIT Energy Initiative (MITEI) awarded a Seed Fund grant to Professor Jeffrey Grossman, who is now the Morton and Claire Goulder and Family Professor in Environmental Systems and head of MIT’s Department of Materials Science and Engineering. Grossman was pursuing research into nanoporous membranes for water desalination. “We thought we could bring down the cost of desalination and improve access to clean water,” says Dave, who worked on the project as a graduate student in Grossman’s lab.

      There, she teamed up with Brent Keller PhD ’16, another Grossman graduate student and a 2016-17 ExxonMobil-MIT Energy Fellow, who was developing lab experiments to fabricate and test new materials. “We were early comrades in figuring out how to debug experiments or fix equipment,” says Keller, Via Separations’ co-founder and chief technology officer. “We were fast friends who spent a lot of time talking about science over burritos.”

      Dave went on to write her doctoral thesis on using graphene oxide for water desalination, but that turned out to be the wrong application of the technology from a business perspective, she says. “The cost of desalination doesn’t lie in the membrane materials,” she explains.

      So, after Dave and Keller graduated from MIT in 2016, they spent a lot of time talking to customers to learn more about the needs and opportunities for their new separation technology. This research led them to target the paper industry, because the environmental benefits of improving paper processing are enormous, Dave says. “The paper industry is particularly exciting because separation processes just in that industry account for more than 2 percent of U.S. energy consumption,” she says. “It’s a very concentrated, high-energy-use industry.”

      Most paper today is made by breaking down the chemical bonds in wood to create wood pulp, the primary ingredient of paper. This process generates a byproduct called black liquor, a toxic solution that was once simply dumped into waterways. To clean up this process, paper mills turned to boiling off the water from black liquor and recovering both water and chemicals for reuse in the pulping process. (Today, the most valuable way to use the liquor is as biomass feedstock to generate energy.) Via Separations plans to accomplish this same separation work by filtering black liquor through its graphene oxide membrane.

      “The advantage of graphene oxide is that it’s very robust,” Dave says. “It’s got carbon double bonds that hold together in a lot of environments, including at different pH levels and temperatures that are typically unfriendly to materials.”

      Such properties should also make the company’s membranes attractive to other industries that use membrane separation, Keller says, because today’s polymer membranes have drawbacks. “For most of the things we make — from plastics to paper and gasoline — those polymers will swell or react or degrade,” he says.

      Graphene oxide is significantly more durable, and Via Separations can customize the pores in the material to suit each industry’s application. “That’s our secret sauce,” Dave says, “modulating pore size while retaining robustness to operate in challenging environments.”

      “We’re building a catalog of products to serve different applications,” Keller says, noting that the next target market could be the food and beverage industry. “In that industry, instead of separating different corrosive paper chemicals from water, we’re trying to separate particular sugars and food ingredients from other things.”

      Future target customers include pharmaceutical companies, oil refineries, and semiconductor manufacturers, or even carbon capture businesses.

      Scaling up

      Dave, Keller, and Grossman launched Via Separations in 2017 — with a lot of help from MIT. After the seed grant, in 2015, the founders received a year of funding and support from the J-WAFS Solutions program to explore markets and to develop their business plans. The company’s first capital investment came from The Engine, a venture firm founded by MIT to support “tough tech” companies (tech businesses with transformative potential but long and challenging paths to success). They also received advice and support from MIT’s Deshpande Center for Technological Innovation, Venture Mentoring Service, and Technology Licensing Office. In addition, Grossman continues to serve the company as chief scientist.

      “We were incredibly fortunate to be starting a company in the MIT entrepreneurial ecosystem,” Keller says, noting that The Engine support alone “probably shaved years off our progress.”

      Already, Via Separations has grown to employ 17 people, while significantly scaling up its product. “Our customers are producing thousands of gallons per minute,” Keller explains. “To process that much liquid, we need huge areas of membrane.”

      Via Separations’ manufacturing process, which is now capable of making more than 10,000 square feet of membrane in one production run, is a key competitive advantage, Dave says. The company rolls 300-400 square feet of membrane into a module, and modules can be combined as needed to increase filtration capacity.

      The goal, Dave says, is to contribute to a more sustainable world by making an environmentally beneficial product that makes good business sense. “What we do is make manufacturing things more energy-efficient,” she says. “We allow a paper mill or chemical facility to make more product using less energy and with lower costs. So, there is a bottom-line benefit that’s significant on an industrial scale.”

      Keller says he shares Dave’s goal of building a more sustainable future. “Climate change and energy are central challenges of our time,” he says. “Working on something that has a chance to make a meaningful impact on something so important to everyone is really fulfilling.”

      This article appears in the Spring 2021 issue of Energy Futures, the magazine of the MIT Energy Initiative.  More