Honey: market value worldwide 2007–2016. https://www.statista.com/statistics/933928/global-market-value-of-honey/. Accessed Nov 2020.
Highfield AC, El Nagar A, Mackinder LCM, Noël LM-LJ, Hall MJ, Martin SJ, et al. Deformed wing virus implicated in overwintering honeybee colony losses. Appl Environ Microbiol. 2009;75:7212–20.
Google Scholar
Ongus JR, Peters D, Bonmatin JM, Bengsch E, Vlak JM, van Oers MM. Complete sequence of a picorna-like virus of the genus Iflavirus replicating in the mite Varroa destructor. J Gen Virol. 2004;85:3747–55.
Google Scholar
Lanzi G, Miranda JRD, Boniotti MB, Cameron CE, Lavazza A, Capucci L, et al. Molecular and biological characterization of Deformed wing virus of honeybees (Apis mellifera L.). J Virol. 2006;80:4998–5009.
Google Scholar
Fujiyuki T, Takeuchi H, Ono M, Ohka S, Sasaki T, Nomoto A, et al. Kakugo virus from brains of aggressive worker honeybees. Adv Virus Res. 2005;65:1–27.
Google Scholar
Dalmon A, Desbiez C, Coulon M, Thomasson M, Le Conte Y, Alaux C, et al. Evidence for positive selection and recombination hotspots in Deformed wing virus (DWV). Sci Rep. 2017;7:41045.
Google Scholar
Zioni N, Soroker V, Chejanovsky N. Replication of Varroa destructor virus 1 (VDV-1) and a Varroa destructor virus 1–deformed wing virus recombinant (VDV-1–DWV) in the head of the honey bee. Virology. 2011;417:106–12.
Google Scholar
Ryabov EV, Childers AK, Chen Y, Madella S, Nessa A, Vanengelsdorp D, et al. Recent spread of Varroa destructor virus – 1, a honey bee pathogen, in the United States. Sci Rep. 2017;7:17447.
Google Scholar
Moore J, Jironkin A, Chandler D, Burroughs N, Evans DJ, Ryabov EV. Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies. J Gen Virol. 2011;92:156–61.
Google Scholar
Mordecai GJ, Brettell LE, Martin SJ, Dixon D, Jones IM, Schroeder DC. Superinfection exclusion and the long-term survival of honey bees in Varroa-infested colonies. ISME J. 2015;10:1182–91.
Google Scholar
Woodford L, Evans DJ. Deformed wing virus: using reverse genetics to tackle unanswered questions about the most important viral pathogen of honey bees. FEMS Microbiol Rev. 2020; fuaa070, https://doi.org/10.1093/femsre/fuaa070.
Mordecai GJ, Wilfert L, Martin SJ, Jones IM, Schroeder DC. Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies. ISME J. 2016;10:1264–73.
Google Scholar
McMahon DP, Natsopoulou ME, Doublet V, Fürst M, Weging S, Brown MJF, et al. Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Proc Biol Sci. 2016;283:443–9.
Wilfert L, Long G, Leggett HC, Schmid-Hempel P, Butlin R, Martin SJM, et al. Deformed wing virus is a recent global epidemic in honeybees driven by Varroa mites. Science. 2016;351:594–7.
Google Scholar
de Miranda JR, Genersch E. Deformed wing virus. J Invertebr Pathol. 2010;103:S48–S61.
Google Scholar
Roberts JMK, Anderson DL, Durr PA. Absence of deformed wing virus and Varroa destructor in Australia provides unique perspectives on honeybee viral landscapes and colony losses. Sci Rep. 2017;7:6925.
Google Scholar
Yue C, Schröder M, Gisder S, Genersch E. Vertical-transmission routes for deformed wing virus of honeybees (Apis mellifera). J Gen Virol. 2007;88:2329–36.
Google Scholar
Ryabov EV, Childers AK, Lopez D, Grubbs K, Posada-Florez F, Weaver D, et al. Dynamic evolution in the key honey bee pathogen deformed wing virus: novel insights into virulence and competition using reverse genetics. PLoS Biol. 2019; 17; https://doi.org/10.1371/journal.pbio.3000502.
Martin SJ, Highfield AC, Brettell L, Villalobos EM, Budge GE, Powell M, et al. Global honey bee viral landscape altered by a parasitic mite. Science. 2012;336:1304–6.
Google Scholar
Loope KJ, Baty JW, Lester PJ, Wilson Rankin EE. Pathogen shifts in a honeybee predator following the arrival of the Varroa mite. Proc Biol Sci. 2019;286:20182499.
Google Scholar
Ryabov EV, Wood GR, Fannon JM, Moore JD, Bull JC, Chandler D, et al. A virulent strain of deformed wing virus (DWV) of honeybees (Apis mellifera) prevails after Varroa destructor-mediated, or in vitro, transmission. PLoS Pathog. 2014;10:e1004230.
Google Scholar
Kevill JL, de Souza FS, Sharples C, Oliver R, Schroeder DC, Martin SJ. DWV-A lethal to honey bees (Apis mellifera): a colony level survey of DWV variants (A, B, and C) in England, Wales, and 32 States across the US. Viruses. 2019;11:426.
Google Scholar
Tehel A, Vu Q, Bigot D, Gogol-Döring A, Koch P, Jenkins C, et al. The two prevalent genotypes of an emerging infectious disease, Deformed wing virus, cause equally low pupal mortality and equally high wing deformities in host honey bees. Viruses. 2019;11:114.
Google Scholar
Norton AM, Remnant EJ, Buchmann G, Beekman M. Accumulation and competition amongst Deformed wing virus genotypes in naïve Australian honeybees provides insight Into the increasing global prevalence of genotype B. Front Microbiol. 2020;11:620.
Google Scholar
Gusachenko ON, Woodford L, Balbirnie-Cumming K, Campbell EM, Christie CR, Bowman AS, et al. Green bees: reverse genetic analysis of Deformed wing virus transmission, replication, and tropism. Viruses. 2020;12:532.
Google Scholar
Steck FT, Rubin H. The mechanism of interference between an avian leukosis virus and Rous sarcoma virus. II. Early steps of infection by RSV of cells under conditions of interference. Virology. 1966;29:642–53.
Google Scholar
Adams RH, Brown DT. BHK cells expressing Sindbis virus-induced homologous interference allow the translation of nonstructural genes of superinfecting virus. J Virol. 1985;54:351–7.
Google Scholar
Strauss JH, Strauss EG. The alphaviruses: gene expression, replication, and evolution. Microbiol Rev. 1994;58:491–562.
Google Scholar
Karpf AR, Lenches E, Strauss EG, Strauss JH, Brown DT. Superinfection exclusion of alphaviruses in three mosquito cell lines persistently infected with Sindbis virus. J Virol. 1997;71:7119–23.
Google Scholar
Singh IR, Suomalainen M, Varadarajan S, Garoff H, Helenius A. Multiple mechanisms for the inhibition of entry and uncoating of superinfecting Semliki Forest virus. Virology. 1997;231:59–71.
Google Scholar
Geib T, Sauder C, Venturelli S, Hässler C, Staeheli P, Schwemmle M. Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components. J Virol. 2003;77:4283–90.
Google Scholar
Edwards MC, Bragg J, Jackson AO. Natural resistance mechanisms to viruses in barley. In: Loebenstein G and Carr JP, editors. Natural Resistance Mechanisms of Plants to Viruses. Dordrecht, The Netherlands: Springer; 2006. p. 465–501.
Bergua M, Zwart MP, El-Mohtar C, Shilts T, Elena SF, Folimonova SY. A viral protein mediates superinfection exclusion at the whole-organism level but Is not required for exclusion at the cellular Level. J Virol. 2014;88:11327–38.
Google Scholar
Michel N, Allespach I, Venzke S, Fackler OT, Keppler OT. The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4. Curr Biol. 2005;15:714–23.
Google Scholar
Tscherne DM, Evans MJ, von Hahn T, Jones CT, Stamataki Z, McKeating JA, et al. Superinfection exclusion in cells infected with hepatitis C virus. J Virol. 2007;81:3693–703.
Google Scholar
Leonard SP, Powell JE, Perutka J, Geng P, Heckmann LC, Horak RD, et al. Engineered symbionts activate honey bee immunity and limit pathogens. Science. 2020;367:573–6.
Google Scholar
Lamp B, Url A, Seitz K, Rgen Eichhorn J, Riedel C, Sinn LJ, et al. Construction and rescue of a molecular clone of Deformed wing virus (DWV). PLoS ONE. 2016;11:e0164639.
Gusachenko ON, Woodford L, Balbirnie-Cumming K, Ryabov EV, Evans DJ. Evidence for and against deformed wing virus spillover from honey bees to bumble bees: a reverse genetic analysis. Sci Rep. 2020;10:16847.
Google Scholar
Routh A, Johnson JE. Discovery of functional genomic motifs in viruses with ViReMa – a Virus Recombination Mapper – for analysis of next-generation sequencing data. Nucleic Acids Res. 2014;42:e11.
Google Scholar
Ryabov EV, Christmon K, Heerman MC, Posada-Florez F, Harrison RL, Chen Y, et al. Development of a honey bee RNA virus vector based on the genome of a Deformed wing virus. Viruses. 2020;12:374.
Google Scholar
Mueller S, Wimmer E. Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames. J Virol. 1998;72:20–31.
Google Scholar
Kirkegaard K, Baltimore D. The mechanism of RNA recombination in poliovirus. Cell. 1986;47:433–43.
Google Scholar
Egger D, Bienz K. Recombination of poliovirus RNA proceeds in mixed replication complexes originating from distinct replication start sites. J Virol. 2002;76:10960–71.
Google Scholar
Lowry K, Woodman A, Cook J, Evans DJ. Recombination in enteroviruses is a biphasic replicative process involving the generation of greater-than genome length ‘imprecise’ Intermediates. PLoS Pathog. 2014;10; https://doi.org/10.1371/journal.ppat.1004191.
de Miranda JR, Fries I. Venereal and vertical transmission of deformed wing virus in honeybees (Apis mellifera L.). J Invertebr Pathol. 2008;98:184–9.
Google Scholar
Yañez O, Jaffé R, Jarosch A, Fries I, Robin FAM, Robert JP, et al. Deformed wing virus and drone mating flights in the honey bee (Apis mellifera): Implications for sexual transmission of a major honey bee virus. Apidologie. 2012;43:17–30.
Simon KO, Cardamone JJ Jr, Whitaker-Dowling PA, Youngner JS, Widnell CC. Cellular mechanisms in the superinfection exclusion of vesicular stomatitis virus. Virology. 1990;177:375–9.
Google Scholar
Stevenson M, Meier C, Mann AM, Chapman N, Wasiak A. Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: mechanism for persistence in AIDS. Cell. 1988;53:483–96.
Google Scholar
Bratt MA, Rubin H.Specific interference among strains of Newcastle disease virus. II. Comparison of interference by active and inactive virus.Virology. 1968;35:381–94.
Google Scholar
Zou G, Zhang B, Lim P-Y, Yuan Z, Bernard KA, Shi P-Y. Exclusion of West Nile virus superinfection through RNA replication. J Virol. 2009;83:11765–76.
Google Scholar
Ziebell H, Carr JP. Cross-protection: a century of mystery. Adv Virus Res. 2010;76:211–64.
Google Scholar
Folimonova SY. Developing an understanding of cross-protection by Citrus tristeza virus. Front Microbiol. 2013;4; https://doi.org/10.3389/fmicb.2013.00076.
Gisder S, Genersch E. Direct evidence for infection of mites with the bee-pathogenic Deformed wing virus variant B – but not variant A – via fluorescence-hybridization analysis. J Virol. 2021;95:e01786–20.
Google Scholar
Posada-Florez F, Childers AK, Heerman MC, Egekwu NI, Cook SC, Chen Y, et al. Deformed wing virus type A, a major honey bee pathogen, is vectored by the mite Varroa destructor in a non-propagative manner. Sci Rep. 2019;9:12445.
Google Scholar
Barr JN, Fearns R. How RNA viruses maintain their genome integrity. J Gen Virol. 2010;91:1373–87.
Google Scholar
Bentley K, Evans DJ. Mechanisms and consequences of positive-strand RNA virus recombination. J Gen Virol. 2018;99:1345–56.
Google Scholar
Muslin C, Mac Kain A, Bessaud M, Blondel B, Delpeyroux F. Recombination in enteroviruses, a multi-step modular evolutionary process. Viruses. 2019;11:859.
Google Scholar
Alnaji FG, Bentley K, Pearson A, Woodman A, Moore JD, Fox H, et al. Recombination in enteroviruses is a ubiquitous event independent of sequence homology and RNA structure. 2020; preprint at bioRxiv; https://doi.org/10.1101/2020.09.29.319285.
Brutscher LM, Flenniken ML. RNAi and antiviral defense in the honey bee. J Immunol Res. 2015;2015:941897.
Google Scholar
Chejanovsky N, Ophir R, Schwager MS, Slabezki Y, Grossman S, Cox-Foster D. Characterization of viral siRNA populations in honey bee colony collapse disorder. Virology. 2014;454-5:176–83.
Desai SD, Eu YJ, Whyard S, Currie RW. Reduction in deformed wing virus infection in larval and adult honey bees (Apis mellifera L.) by double-stranded RNA ingestion. Insect Mol Biol. 2012;21:446–55.
Google Scholar
Hunter W, Ellis J, Vanengelsdorp D, Hayes J, Westervelt D, Glick E, et al. Large-scale field application of RNAi technology reducing Israeli acute paralysis virus disease in honey bees (Apis mellifera, hymenoptera: Apidae). PLoS Pathog. 2010;6:e1001160.
Google Scholar
Maori E, Paldi N, Shafir S, Kalev H, Tsur E, Glick E, et al. IAPV, a bee-affecting virus associated with colony collapse disorder can be silenced by dsRNA ingestion. Insect Mol Biol. 2009;18:55–60.
Google Scholar
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