in

Aggressiveness, ADHD-like behaviour, and environment influence repetitive behaviour in dogs

  • Mason, G. J. Stereotypies: A critical review. Anim. Behav. 41, 1015–1037 (1991).

    Google Scholar 

  • Cussen, V. A. & Mench, J. A. The relationship between personality dimensions and resiliency to environmental stress in orange-winged Amazon parrots (Amazona amazonica), as indicated by the development of abnormal behaviors. PLoS ONE 10, 1–11 (2015).

    Google Scholar 

  • Clubb, R. & Mason, G. Captivity effects on wide-ranging carnivores. Nature 425, 473–474 (2003).

    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Shepherdson, D., Lewis, K. D., Carlstead, K., Bauman, J. & Perrin, N. Individual and environmental factors associated with stereotypic behavior and fecal glucocorticoid metabolite levels in zoo housed polar bears. Appl. Anim. Behav. Sci. 147, 268–277 (2013).

    Google Scholar 

  • Miller, L. J., Bettinger, T. & Mellen, J. The reduction of stereotypic pacing in tigers (Panthera tigris) by obstructing the view of neighbouring individuals. Anim. Welf. 17, 255–258 (2008).

    CAS 

    Google Scholar 

  • Bachmann, I., Bernasconi, P., Herrmann, R., Weishaupt, M. A. & Stauffacher, M. Behavioural and physiological responses to an acute stressor in crib-biting and control horses. Appl. Anim. Behav. Sci. 82, 297–311 (2003).

    Google Scholar 

  • Ahola, M. K., Vapalahti, K. & Lohi, H. Early weaning increases aggression and stereotypic behaviour in cats. Sci. Rep. 7, 10412 (2017).

    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Salonen, M. et al. Prevalence, comorbidity, and breed differences in canine anxiety in 13,700 Finnish pet dogs. Sci. Rep. 10, 2962 (2020).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Garner, J. P. Stereotypies and other abnormal repetitive behaviors: Potential impact on validity, reliability, and replicability of scientific outcomes. ILAR J. 46, 106–117 (2005).

    CAS 
    PubMed 

    Google Scholar 

  • Tynes, V. V. & Sinn, L. Abnormal repetitive behaviors in dogs and cats. A guide for practitioners. Vet. Clin. North Am. Small Anim. Pract. 44, 543–564 (2014).

    PubMed 

    Google Scholar 

  • Luescher, A. U. Diagnosis and management of compulsive disorders in dogs and cats. Vet. Clin. North Am. Small Anim. Pract. 33, 253–267 (2003).

    PubMed 

    Google Scholar 

  • Mason, G., Clubb, R., Latham, N. & Vickery, S. Why and how should we use environmental enrichment to tackle stereotypic behaviour?. Appl. Anim. Behav. Sci. 102, 163–188 (2007).

    Google Scholar 

  • Overall, K. L. & Dunham, A. E. Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 Cases (1989–2000). J. Am. Vet. Med. Assoc. 221, 1445–1452 (2002).

    PubMed 

    Google Scholar 

  • Tiira, K. et al. Environmental effects on compulsive tail chasing in dogs. PLoS One 7, e41684 (2012).

  • Mason, G. & Rushen, J. Stereotypic Animal Behaviour: Fundamentals and Applications to Welfare 2nd edn. (CABI Publishing, 2006).

    Google Scholar 

  • Moon-Fanelli, A. A., Dodman, N. H., Famula, T. R. & Cottam, N. Characteristics of compulsive tail chasing and associated risk factors in Bull Terriers. J. Am. Vet. Med. Assoc. 238, 883–889 (2011).

    PubMed 

    Google Scholar 

  • Hewson, C. J., Luescher, U. A. & Ball, R. O. Measuring change in the behavioural severity of canine compulsive disorder: The construct validity of categories of change derived from two rating scales. Appl. Anim. Behav. Sci. 60, 55–68 (1998).

    Google Scholar 

  • Vandeleest, J. J., McCowan, B. & Capitanio, J. P. Early rearing interacts with temperament and housing to influence the risk for motor stereotypy in rhesus monkeys (Macaca mulatta). Appl. Anim. Behav. Sci. 132, 81–89 (2011).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Tang, R. et al. Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. Genome Biol. 15, 25 (2014).

    Google Scholar 

  • Dodman, N. H. et al. A canine chromosome 7 locus confers compulsive disorder susceptibility. Mol. Psychiatry 15, 8–10 (2010).

    CAS 
    PubMed 

    Google Scholar 

  • Jeppesen, L. L., Heller, K. E. & Bildsøe, M. Stereotypies in female farm mink (Mustela vison) may be genetically transmitted and associated with higher fertility due to effects on body weight. Appl. Anim. Behav. Sci. 86, 137–143 (2004).

    Google Scholar 

  • Noh, H. J. et al. Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder. Nat. Commun. 8, 1–13 (2017).

    CAS 

    Google Scholar 

  • Koran, L. M. Quality of life in obsessive-compulsive disorder. Psychiatr. Clin. North Am. 23, 509–517 (2000).

    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Murray, C. J. & Lopez, A. D. The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020 (Harvard School of Public Health, 1996).

    Google Scholar 

  • Calzà, J. et al. Altered cortico-striatal functional connectivity during resting state in obsessive-compulsive disorder. Front. Psychiatry 10, 319 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Brem, S., Grünblatt, E., Drechsler, R., Riederer, P. & Walitza, S. The neurobiological link between OCD and ADHD. ADHD Atten. Deficit Hyperact. Disord. 6, 175–202 (2014).

    Google Scholar 

  • Stein, D. J., Dodman, N. H., Borchelt, P. & Hollander, E. Behavioral disorders in veterinary practice: Relevance to psychiatry. Compr. Psychiatry 35, 275–285 (1994).

    CAS 
    PubMed 

    Google Scholar 

  • Overall, K. L. Natural animal models of human psychiatric conditions: Assessment of mechanism and validity. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 24, 727–776 (2000).

    CAS 

    Google Scholar 

  • Flament, M. F. et al. Obsessive compulsive disorder in adolescence: An epidemiological study. J. Am. Acad. Child Adolesc. Psychiatry 27, 764–771 (1988).

    CAS 
    PubMed 

    Google Scholar 

  • Nestadt, G. et al. A family study of obsessive-compulsive disorder. Arch. Gen. Psychiatry 57, 358–363 (2000).

    CAS 
    PubMed 

    Google Scholar 

  • Protopopova, A., Hall, N. J. & Wynne, C. D. L. Association between increased behavioral persistence and stereotypy in the pet dog. Behav. Processes 106, 77–81 (2014).

    PubMed 

    Google Scholar 

  • Valerius, G., Lumpp, A., Kuelz, A. K., Freyer, T. & Voderholzer, U. Reversal learning as a neuropsychological indicator for the neuropathology of obsessive compulsive disorder? A behavioral study. J. Neuropsychiatry Clin. Neurosci. 20, 210–218 (2008).

    PubMed 

    Google Scholar 

  • Snyder, H. R., Kaiser, R. H., Warren, S. L. & Heller, W. Obsessive-compulsive disorder is associated with broad impairments in executive function: A meta-analysis. Clin. Psychol. Sci. 3, 301–330 (2015).

    PubMed 

    Google Scholar 

  • Ogata, N. et al. Brain structural abnormalities in Doberman pinschers with canine compulsive disorder. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 45, 1–6 (2013).

    Google Scholar 

  • Norman, L. J. et al. Structural and functional brain abnormalities in attention-deficit/hyperactivity disorder and obsessive-compulsive disorder: A comparative meta-analysis. JAMA Psychiat. 73, 815–825 (2016).

    Google Scholar 

  • Yalcin, E., Ilcol, Y. O. & Batmaz, H. Serum lipid concentrations in dogs with tail chasing. J. Small Anim. Pract. 50, 133–135 (2009).

    CAS 
    PubMed 

    Google Scholar 

  • Vermeire, S. et al. Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiatry Res. 201, 78–87 (2012).

    CAS 
    PubMed 

    Google Scholar 

  • Moon-Fanelli, A. A. & Dodman, N. H. Description and development of compulsive tail chasing in terriers and response to clomipramine treatment. J. Am. Vet. Med. Assoc. 212, 1252–1257 (1998).

    CAS 
    PubMed 

    Google Scholar 

  • Irimajiri, M. et al. Randomized, controlled clinical trial of the efficacy of fluoxetine for treatment of compulsive disorders in dogs. J. Am. Vet. Med. Assoc. 235, 705–709 (2009).

    CAS 
    PubMed 

    Google Scholar 

  • Walsh, B. R. A critical review of the evidence for the equivalence of canine and human compulsions. Appl. Anim. Behav. Sci. 234, 105166 (2021).

    Google Scholar 

  • Wright, H. F., Mills, D. S. & Pollux, P. M. J. Development and validation of a psychometric tool for assessing impulsivity in the domestic dog (Canis familiaris). Int. J. Comp. Psychol. 24, 210–225 (2011).

    Google Scholar 

  • Dinwoodie, I. R., Dwyer, B., Zottola, V., Gleason, D. & Dodman, N. H. Demographics and comorbidity of behavior problems in dogs. J. Vet. Behav. 32, 62–71 (2019).

    Google Scholar 

  • Sulkama, S. et al. Canine hyperactivity, impulsivity, and inattention share similar demographic risk factors and behavioural comorbidities with human ADHD. Transl. Psychiatry 11, 501 (2021).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kooij, J. J. S. et al. Updated European Consensus Statement on diagnosis and treatment of adult ADHD. Eur. Psychiatry 56, 14–34 (2019).

    CAS 
    PubMed 

    Google Scholar 

  • Nakao, T., Okada, K. & Kanba, S. Neurobiological model of obsessive-compulsive disorder: Evidence from recent neuropsychological and neuroimaging findings. Psychiatry Clin. Neurosci. 68, 587–605 (2014).

    PubMed 

    Google Scholar 

  • Milad, M. R. & Rauch, S. L. Obsessive-compulsive disorder: Beyond segregated cortico-striatal pathways. Trends Cogn. Sci. 16, 43–51 (2012).

    PubMed 

    Google Scholar 

  • Hollander, E. Managing aggressive behavior in patients with obsessive-compulsive disorder and borderline personality disorder. J. Clin. Psychiatry 60, 38–44 (1999).

    PubMed 

    Google Scholar 

  • Marsden, M. D. & Wood-Gush, D. G. M. The use of space by group-housed sheep. Appl. Anim. Behav. Sci. 15, 178 (1986).

    Google Scholar 

  • Burn, C. C. A vicious cycle: A cross-sectional study of canine tail-chasing and human responses to it, using a free video-sharing website. PLoS ONE 6, e26553 (2011).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Stubbs, B. et al. An examination of the anxiolytic effects of exercise for people with anxiety and stress-related disorders: A meta-analysis. Psychiatry Res. 249, 102–108 (2017).

    PubMed 

    Google Scholar 

  • Schneider, B. M., Dodman, N. H. & Maranda, L. Use of memantine in treatment of canine compulsive disorders. J. Vet. Behav. Clin. Appl. Res. 4, 118–126 (2009).

    Google Scholar 

  • Mihevc, S. P. & Majdic, G. Canine cognitive dysfunction and Alzheimer’s disease-two facets of the same disease?. Front. Neurosci. 13, 604 (2019).

    Google Scholar 

  • Delorme, R. et al. Admixture analysis of age at onset in obsessive-compulsive disorder. Psychol. Med. 35, 237–243 (2005).

    PubMed 

    Google Scholar 

  • Flaisher-Grinberg, S. et al. Ovarian hormones modulate ‘compulsive’ lever-pressing in female rats. Horm. Behav. 55, 356–365 (2009).

    CAS 
    PubMed 

    Google Scholar 

  • Fernández-Guasti, A., Agrati, D., Reyes, R. & Ferreira, A. Ovarian steroids counteract serotonergic drugs actions in an animal model of obsessive-compulsive disorder. Psychoneuroendocrinology 31, 924–934 (2006).

    PubMed 

    Google Scholar 

  • Col, R., Day, C. & Phillips, C. J. C. An epidemiological analysis of dog behavior problems presented to an Australian behavior clinic, with associated risk factors. J. Vet. Behav. Clin. Appl. Res. 15, 1–11 (2016).

    Google Scholar 

  • Rusbridge, C. Neurological diseases of the Cavalier King Charles spaniel. J. Small Anim. Pract. 46, 265–272 (2005).

    CAS 
    PubMed 

    Google Scholar 

  • Wrzosek, M., Płonek, M., Nicpoń, J., Cizinauskas, S. & Pakozdy, A. Retrospective multicenter evaluation of the ‘fly-catching syndrome’ in 24 dogs: EEG, BAER, MRI, CSF findings and response to antiepileptic and antidepressant treatment. Epilepsy Behav. 53, 184–189 (2015).

    PubMed 

    Google Scholar 

  • Cao, X. et al. Balancing selection on CDH2 may be related to the behavioral features of the Belgian malinois. PLoS ONE 9, e110075 (2014).

    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Moon-Fanelli, A. A., Dodman, N. H. & Cottam, N. Blanket and flank sucking in Doberman Pinschers. J. Am. Vet. Med. Assoc. 231, 907–912 (2007).

    PubMed 

    Google Scholar 

  • Tiira, K. & Lohi, H. Reliability and validity of a questionnaire survey in canine anxiety research. Appl. Anim. Behav. Sci. 155, 82–92 (2014).

    Google Scholar 

  • Puurunen, J. et al. Inadequate socialisation, inactivity, and urban living environment are associated with social fearfulness in pet dogs. Sci. Rep. 10, 3527 (2020).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hakanen, E. et al. Active and social life is associated with lower non-social fearfulness in pet dogs. Sci. Rep. 10, 1–13 (2020).

    Google Scholar 

  • Mikkola, S. et al. Aggressive behaviour is affected by demographic, environmental and behavioural factors in purebred dogs. Sci. Rep. 11, 9433 (2021).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hejjas, K. et al. Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs. Anim. Genet. 38, 629–633 (2007).

    CAS 
    PubMed 

    Google Scholar 

  • R Core Team. R: A language and environment for statistical computing. (2019).

  • Hastie, T. gam: Generalized Additive Models. (2018).

  • Robinson, D. & Hayes, A. broom: Convert Statistical Analysis Objects into Tidy Tibbles. https://cran.r-project.org/package=broom (2018).

  • Wickham, H., François, R., Lionel, H. & Müller, K. dplyr: A Grammar of Data Manipulation. https://cran.r-project.org/package=dplyr (2019).

  • Wickham, H. ggplot2: Elegant Graphics for Data Analysis (Springer-Verlag, 2016).

    MATH 

    Google Scholar 

  • Fox, J. & Weisberg, S. An R Companion to Applied Regression (Sage Publications, 2011).

    Google Scholar 

  • Robin, X. et al. pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform. 12, 77 (2011).

    Google Scholar 

  • Lenth, R. emmeans: Estimated Marginal Means, aka Least-Squares Means. https://cran.r-project.org/package=emmeans (2019).

  • Fox, J. Effect Displays in R for Generalised Linear Models. J. Stat. Softw. 8, 1–27 (2003).

    Google Scholar 

  • Goto, A., Arata, S., Kiyokawa, Y., Takeuchi, Y. & Mori, Y. Risk factors for canine tail chasing behaviour in Japan. Vet. J. 192, 445–448 (2012).

    PubMed 

    Google Scholar 


  • Source: Ecology - nature.com

    Genetic variation in released gametes produces genetic diversity in the offspring of the broadcast spawning coral Acropora tenuis

    A better way to separate gases