Wibbelt, G., Moore, M. S., Schountz, T. & Voigt, C. C. Emerging diseases in Chiroptera: Why bats?. Biol. Let. 6, 438–440 (2010).
Google Scholar
Gonzalez, V. & Banerjee, A. Molecular, ecological, and behavioural drivers of the bat-virus relationship. iScience 25, 104779 (2022).
Google Scholar
Brook, C. E. & Dobson, A. P. Bats as ‘special’reservoirs for emerging zoonotic pathogens. Trends Microbiol. 23, 172–180 (2015).
Google Scholar
Kosoy, M. et al. Bartonella spp. in bats, Kenya. Emerg. Infect. Dis. 16, 1875–1881 (2010).
Google Scholar
Becker, D. J. et al. Livestock abundance predicts vampire bat demography, immune profiles and bacterial infection risk. Philos. Trans. R. Soc. Biol. Sci. 373, 20170089 (2018).
Google Scholar
Muehldorfer, K. Bats and bacterial pathogens: A review. Zoonoses Public Health 60, 93–103 (2013).
Google Scholar
Taylor, M. L. et al. Geographical distribution of genetic polymorphism of the pathogen Histoplasma capsulatum isolated from infected bats, captured in a central zone of Mexico. FEMS Immunol. Med. Microbiol. 45, 451–458 (2005).
Google Scholar
Schaer, J. et al. High diversity of West African bat malaria parasites and a tight link with rodent Plasmodium taxa. Proc. Natl. Acad. Sci. 110, 17415–17419 (2013).
Google Scholar
Evans, N., Bown, K., Timofte, D., Simpson, V. & Birtles, R. Fatal borreliosis in bat caused by relapsing fever spirochete, United Kingdom. Emerg. Infect. Dis. 15, 1331–1333 (2009).
Google Scholar
Muehldorfer, K., Speck, S. & Wibbelt, G. Diseases in free-ranging bats from Germany. BMC Vet. Res. 7, 61 (2011).
Google Scholar
Muehldorfer, K., Wibbelt, G., Haensel, J., Riehm, J. & Speck, S. Yersinia species isolated from bats, Germany. Emerg. Infect. Dis. 16, 578–581 (2010).
Google Scholar
Blehert, D. S. et al. Bat white-nose syndrome: An emerging fungal pathogen?. Science 323, 227–227 (2009).
Google Scholar
Barlow, A., Jolliffe, T., Tomlin, M., Worledge, L. & Miller, H. Mycotic dermatitis in a vagrant parti-coloured bat (Vespertilio murinus) in Great Britain. Vet. Rec. 169, 614–614 (2011).
Google Scholar
Simpson, V. R., Borman, A. M., Fox, R. I. & Mathews, F. Cutaneous mycosis in a Barbastelle bat (Barbastella barbastellus) caused by Hyphopichia burtonii. J. Vet. Diagn. Invest. 25, 551–554 (2013).
Google Scholar
Frick, W. F. et al. An emerging disease causes regional population collapse of a common North American bat species. Science 329, 679–682 (2010).
Google Scholar
Hecht-Höger, A. et al. Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans. Mol. Ecol. 29, 1745–1755 (2020).
Google Scholar
Baker, M., Schountz, T. & Wang, L. F. Antiviral immune responses of bats: A review. Zoonoses Public Health 60, 104–116 (2013).
Google Scholar
Baker, M. L. & Zhou, P. in Bats and Viruses Vol. 1 (eds Lin-Fa Wang & Christopher Cowled) Ch. 14, 327–348 (John Wiley & Sons, Inc., 2015).
Wang, L.-F., Walker, P. J. & Poon, L. L. M. Mass extinctions, biodiversity and mitochondrial function: Are bats ‘special’ as reservoirs for emerging viruses?. Curr. Opin. Virol. 1, 649–657 (2011).
Google Scholar
Lee, K. A. Linking immune defenses and life history at the levels of the individual and the species. Integr. Comp. Biol. 46, 1000–1015 (2006).
Google Scholar
Murphy, K. Janeway’s Immunobiology 8th edn. (Garland Science, 2012).
Gruys, E., Toussaint, M., Niewold, T. & Koopmans, S. Acute phase reaction and acute phase proteins. J. Zhejiang Univ. Sci. B Biomed. Biotechnol. 6, 1045–1056 (2005).
Google Scholar
Cray, C., Zaias, J. & Altman, N. H. Acute phase response in animals: A review. Comp. Med. 59, 517–526 (2009).
Google Scholar
Hart, B. L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12, 123–137 (1988).
Google Scholar
Owen-Ashley, N. T. & Wingfield, J. C. Acute phase responses of passerine birds: Characterization and seasonal variation. J. Ornithol. 148, S583–S591 (2007).
Google Scholar
Kozak, W., Conn, C. A. & Kluger, M. J. Lipopolysaccharide induces fever and depresses locomotor-activity in unrestrained mice. Am. J. Physiol. 266, R125–R135 (1994).
Google Scholar
Copeland, S. et al. Acute inflammatory response to endotoxin in mice and humans. Clin. Diagn. Lab. Immunol. 12, 60–67 (2005).
Google Scholar
Evans, S. S., Repasky, E. A. & Fisher, D. T. Fever and the thermal regulation of immunity: The immune system feels the heat. Nat. Rev. Immunol. 15, 335–349 (2015).
Google Scholar
Stockmaier, S., Dechmann, D. K. N., Page, R. A. & Teague O’Mara, M. No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat. Biol. Let. 11, 20150576 (2015).
Google Scholar
Martin, L. B., Scheuerlein, A. & Wikelski, M. Immune activity elevates energy expenditure of house sparrows: A link between direct and indirect costs?. Proc. R. Soc. Lond. B Biol. Sci. 270, 153–158 (2003).
Google Scholar
Sheldon, B. C. & Verhulst, S. Ecological immunology: Costly parasite defences and trade-offs in evolutionary ecology. Trends Ecol. Evol. 11, 317–321 (1996).
Google Scholar
Bonneaud, C. et al. Assessing the cost of mounting an immune response. Am. Nat. 161, 367–379 (2003).
Google Scholar
Audebert, H. J., Pellkofer, T. S., Wimmer, M. L. & Haberl, R. L. Progression in lacunar stroke is related to elevated acute phase parameters. Eur. Neurol. 51, 125–131 (2004).
Google Scholar
Lee, K. A., Martin, L. B. & Wikelski, M. C. Responding to inflammatory challenges is less costly for a successful avian invader, the house sparrow (Passer domesticus), than its less-invasive congener. Oecologia 145, 244–251 (2005).
Google Scholar
Owen-Ashley, N. T., Turner, M., Hahn, T. P. & Wingfield, J. C. Hormonal, behavioral, and thermoregulatory responses to bacterial lipopolysaccharide in captive and free-living white-crowned sparrows (Zonotrichia leucophrys gambelii). Horm. Behav. 49, 15–29 (2006).
Google Scholar
Coon, C. A. C., Warne, R. W. & Martin, L. B. Acute-phase responses vary with pathogen identity in house sparrows (Passer domesticus). Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R1418–R1425 (2011).
Google Scholar
Kimura, M. et al. Comparison of acute phase responses induced in rabbits by lipopolysaccharide and double-stranded RNA. Am. J. Physiol. Regul. Integr. Comp. Physiol. 267, R1596–R1605 (1994).
Google Scholar
Gomez, C. R., Goral, J., Ramirez, L., Kopf, M. & Kovacs, E. J. Aberrant acute-phase response in aged interleukin-6 knockout mice. Shock 25, 581–585 (2006).
Google Scholar
Barrientos, R. M., Watkins, L. R., Rudy, J. W. & Maier, S. F. Characterization of the sickness response in young and aging rats following E. coli infection. Brain Behav Immun. 23, 450–454 (2009).
Google Scholar
Sköld-Chiriac, S., Nord, A., Tobler, M., Nilsson, J. -Å. & Hasselquist, D. Body temperature changes during simulated bacterial infection in a songbird: Fever at night and hypothermia during the day. J. Exp. Biol. 218, 2961–2969 (2015).
Google Scholar
Sköld-Chiriac, S., Nord, A., Nilsson, J. -Å. & Hasselquist, D. Physiological and behavioral responses to an acute-phase response in zebra finches: Immediate and short-term effects. Physiol. Biochem. Zool. 87, 288–298 (2014).
Google Scholar
Fritze, M. et al. Immune response of hibernating European bats to a fungal challenge. Biol. Open 8, bio046078 (2019).
Google Scholar
Triana-Llanos, C., Guerrero-Chacón, A. L., Rivera-Ruíz, D., Rojas-Díaz, V. & Niño-Castro, A. The acute phase response elicited by a viral-like molecular pattern increases energy expenditure in Artibeus lituratus. Biologia 74, 667–673 (2019).
Google Scholar
Schneeberger, K., Czirják, G. Á. & Voigt, C. C. Inflammatory challenge increases measures of oxidative stress in a free-ranging, long-lived mammal. J. Exp. Biol. 216, 4514–4519 (2013).
Google Scholar
Allen, L. C. et al. Roosting ecology and variation in adaptive and innate immune system function in the Brazilian free-tailed bat (Tadarida brasiliensis). J. Comp. Physiol. B. 179, 315–323 (2009).
Google Scholar
Otálora-Ardila, A., Herrera, M. L. G., Flores-Martínez, J. J. & Welch, K. C. Jr. Metabolic cost of the activation of immune response in the fish-eating myotis (Myotis vivesi): The effects of inflammation and the acute phase response. PLoS ONE 11, e0164938 (2016).
Google Scholar
Ohmer, M. E. B. et al. Applied ecoimmunology: Using immunological tools to improve conservation efforts in a changing world. Conserv. Physiol. 9, coab074 (2021).
Google Scholar
Becker, D. J., Seifert, S. N. & Carlson, C. J. Beyond infection: Intergrating competence into reservoir host prediction. Trends Ecol. Evol. 35, P1062–P1065 (2020).
Google Scholar
Kacprzyk, J. et al. A potent anti-inflammatory response in bat macrophages may be linked to extended longevity and viral tolerance. Acta Chiropterologica 19, 219–228 (2017).
Google Scholar
Langlois, M. R. & Delanghe, J. R. Biological and clinical significance of haptoglobin polymorphism in humans. Clin. Chem. 42, 1589–1600 (1996).
Google Scholar
Field, K. A. et al. The white-nose syndrome transcriptome: activation of anti-fungal host responses in wing tissue of hibernating little brown myotis. PLoS Pathog. 11, e1005168 (2015).
Google Scholar
Fritze, M. et al. Determinants of defence strategies of a hibernating European bat species towards the fungal pathogen Pseudogymnoascus destructans. Dev. Comp. Immunol. 119, 104017 (2021).
Google Scholar
Moreno, K. et al. Sick bats stay home alone: Fruit bats practice social distancing when faced with an immunological challenge. Ann. N. Y. Acad. Sci. 1505, 178–190 (2021).
Google Scholar
Otálora-Ardila, A., Herrera, M. L. G., Flores-Martínez, J. J. & Welch, K. C. Jr. The effect of short-term food restriction on the metabolic cost of the acute phase response in the fish-eating Myotis (Myotis vivesi). Mamm. Biol. 82, 41–47 (2017).
Google Scholar
Voigt, C. C. et al. The immune response of bats differs between pre-migration and migration seasons. Sci. Rep. 10, 17384 (2020).
Google Scholar
Guerrero-Chacón, A. L., Rivera-Ruíz, D., Rojas-Díaz, V., Triana-Llanos, C. & Niño-Castro, A. Metabolic cost of acute phase response in the frugivorous bat, Artibeus lituratus. Mamm. Res. 63, 397–404 (2018).
Google Scholar
Weise, P., Czirják, G. Á., Lindecke, O., Bumrungsri, S. & Voigt, C. C. Simulated bacterial infection disrupts the circadian fluctuation of immune cells in wrinkle-lipped bats (Chaerephon plicatus). PeerJ 5, e3570 (2017).
Google Scholar
Cabrera-Martínez, L. V., Herrera, M. L. G. & Cruz-Neto, A. P. The energetic cost of mounting an immune response for Pallas’s long-tongued bat (Glossophaga soricina). PeerJ 6, e4627 (2018).
Google Scholar
Cabrera-Martinez, L. V., Herrera, M. L. G. & Cruz-Neto, A. P. Food restriction, but not seasonality, modulates the acute phase response of a neotropical bat. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 229, 93–100 (2019).
Google Scholar
Stockmaier, S., Bolnick, D. I., Page, R. A. & Carter, G. G. An immune challenge reduces social grooming in vampire bats. Anim. Behav. 140, 141–149 (2018).
Google Scholar
Scheiermann, C., Kunisaki, Y. & Frenette, P. S. Circadian control of the immune system. Nat. Rev. Immunol. 13, 190–198 (2013).
Google Scholar
Schneeberger, K., Czirják, G. Á. & Voigt, C. C. Measures of the constitutive immune system are linked to diet and roosting habits of Neotropical bats. PLoS ONE 8, e54023 (2013).
Google Scholar
Hasselquist, D. Comparative immunoecology in birds: Hypotheses and tests. J. Ornithol. 148, 571–582 (2007).
Google Scholar
Becker, D. J. et al. Leukocyte profiles reflect geographic range limits and local food abundance in a widespread Neotropical bat. Integr. Comp. Biol. 59, 1176–1189 (2019).
Google Scholar
Vermeulen, A., Eens, M., Zaid, E. & Müller, W. Baseline innate immunity does not affect the response to an immune challenge in female great tits (Parus major). Behav. Ecol. Sociobiol. 70, 585–592 (2016).
Google Scholar
Melhado, G., Herrera, M. L. G. & Cruz-Neto, A. P. Bats respond to simulated bacterial infection during the active phase by reducing food intake. J. Exp. Zool. A 333, 536–542 (2020).
Google Scholar
Costantini, D. et al. Induced bacterial sickness causes inflammation but not blood oxidative stress in Egyptian fruit bats (Rousettus aegyptiacus). Conserv. Physiol. 10, coac028 (2022).
Google Scholar
Viljoen, H., Bennett, N. C. & Lutermann, H. Life-history traits, but not season, affect the febrile response to a lipopolysaccharide challenge in highveld mole-rats. J. Zool. 285, 222–229 (2011).
Google Scholar
Ahn, M., Cui, J., Irving, A. T. & Wang, L. F. Unique loss of the PYHIN gene family in bats amongst mammals: Implications for inflammasome sensing. Sci. Rep. 6, 21722 (2016).
Google Scholar
Lilley, T. et al. Immune responses in hibernating little brown myotis (Myotis lucifugus) with white-nose syndrome. Proc. R. Soc. Lond. B Biol. Sci. 284, 20162232 (2017).
Mayberry, H. W., McGuire, L. P. & Willis, C. K. Body temperatures of hibernating little brown bats reveal pronounced behavioural activity during deep torpor and suggest a fever response during white-nose syndrome. J. Comp. Physiol. B. 188, 333–343 (2018).
Google Scholar
Watkins, L. R., Maier, S. F. & Goehler, L. E. Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 63, 289–302 (1995).
Google Scholar
Grimble, R. F. Interaction between nutrients, pro-inflammatory cytokines and inflammation. Clin. Sci. 91, 121–130 (1996).
Google Scholar
Schultz, E. M., Hahn, T. P. & Klasing, K. C. Photoperiod but not food restriction modulates innate immunity in an opportunistic breeder, Loxia curvirostra. J. Exp. Biol. 220, 722–730 (2016).
Google Scholar
Brinkmann, V. & Zychlinsky, A. Neutrophil extracellular traps: Is immunity the second function of chromatin?. J. Cell Biol. 198, 773–783 (2012).
Google Scholar
Davis, A. K., Maney, D. L. & Maerz, J. C. The use of leukocyte profiles to measure stress in vertebrates: A review for ecologists. Funct. Ecol. 22, 760–772 (2008).
Google Scholar
Bouma, H. R., Carey, H. V. & Kroese, F. G. Hibernation: The immune system at rest?. J. Leukoc. Biol. 88, 619–624 (2010).
Google Scholar
Crameri, G. et al. Establishment, immortalisation and characterisation of pteropid bat cell lines. PLoS ONE 4, e8266 (2009).
Google Scholar
Neely, B. A. et al. Surveying the vampire bat (Desmodus rotundus) serum proteome: A resource for identifying immunological proteins and detecting pathogens. J. Proteome Res. 20, 2547–2559 (2021).
Google Scholar
Hecht, A. M. et al. Plasma proteomic analysis of active and torpid greater mouse-eared bats (Myotis myotis). Sci. Rep. 5, 16604 (2015).
Google Scholar
Barclay, R. M. R. et al. Can external radiotransmitters be used to assess body temperature and torpor in bats?. J. Mammal. 77, 1102–1106 (1996).
Google Scholar
Pap, P. L., Czirják, G. Á., Vágási, C. I., Barta, Z. & Hasselquist, D. Sexual dimorphism in immune function changes during the annual cycle in house sparrows. Naturwissenschaften 97, 891–901 (2010).
Google Scholar
Heinrich, S. K. et al. Feliform carnivores have a distinguished constitutive innate immune response. Biol. Open 5, 550–555 (2016).
Google Scholar
Heinrich, S. K. et al. Cheetahs have a stronger constitutive innate immunity than leopards. Sci. Rep. 7, 44837 (2017).
Google Scholar
Morell, V., Lundgren, E. & Gillott, A. Predicting severity of trauma by admission white blood cell count, serum potassium level, and arterial pH. South. Med. J. 86, 658–659 (1993).
Google Scholar
R Core Team. A Language and Environment for Statistical Computing. (R foundation for statistical computing, 2018).
Pinheiro, J., Bates, D., DebRoy, S. & Sarkar, D. Linear and nonlinear mixed effects models. R Package Version 3, 57 (2007).
Fox, J. & Weisberg, S. An R Companion to Applied Regression (SAGE, 2011).
Hothorn, T., Bretz, F. & Westfall, P. Simultaneous inference in general parametric models. Biom. J. 50, 346–363 (2008).
Google Scholar
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