Aurelia Butler

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Study shows a link between obesity and what’s on local restaurant menus

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For many years, health experts have been concerned about “food deserts,” places where residents lack good nutritional options. Now, an MIT-led study of three major global cities uses a new, granular method to examine the issue, and concludes that having fewer and less nutritional eating options nearby correlates with obesity and other health outcomes.Rather than just mapping geographic areas, the researchers examined the dietary value of millions of food items on roughly 30,000 restaurant menus and derived a more precise assessment of the connection between neighborhoods and nutrition.“We show that what is sold in a restaurant has a direct correlation to people’s health,” says MIT researcher Fabio Duarte, co-author of a newly published paper outlining the study’s results. “The food landscape matters.”The open-access paper, “Data-driven nutritional assessment of urban food landscapes: insights from Boston, London, Dubai,” was published this week in Nature: Scientific Reports.The co-authors are Michael Tufano, a PhD student at Wageningen University, in the Netherlands; Duarte, associate director of MIT’s Senseable City Lab, which uses data to study cities as dynamic systems; Martina Mazzarello, a postdoc at the Senseable City Lab; Javad Eshtiyagh, a research fellow at the Senseable City Lab; Carlo Ratti, professor of the practice and director of the Senseable City Lab; and Guido Camps, a senior researcher at Wageningen University.Scanning the menuTo conduct the study, the researchers examined menus from Boston, Dubai, and London, in the summer of 2023, compiling a database of millions of items available through popular food-delivery platforms. The team then evaluated the food items as rated by the USDA’s FoodData Central database, an information bank with 375,000 kinds of food products listed. The study deployed two main metrics, the Meal Balance Index, and the Nutrient-Rich Foods Index.The researchers examined about 222,000 menu items from over 2,000 restaurants in Boston, about 1.6 million menu items from roughly 9,000 restaurants in Dubai, and about 3.1 million menu items from about 18,000 restaurants in London. In Boston, about 71 percent of the items were in the USDA database; in Dubai and London, that figure was 42 percent and 56 percent, respectively.The team then rated the nutritional value of the items appearing on menus, and correlated the food data with health-outcome data from Boston and London. In London, they found a clear correlation between neighborhood menu offerings and obesity, or the lack thereof; with a slightly less firm correlation in Boston. Areas with food options that include a lot of dietary fibers, sometimes along with fruits and vegetables, tend to have better health data.In Dubai, the researchers did not have the same types of health data available but did observe a strong correlation between rental prices and the nutritional value of neighborhood-level food, suggesting that wealthier residents have better nourishment options.“At the item level, when we have less nutritional food, we see more cases of obsesity,” Tufano says. “It’s true that not only do we have more fast food in poor neighborhoods, but the nutritional value is not the same.”Re-mapping the food landscapeBy conducting the study in this fashion, the scholars added a layer of analysis to past studies of food deserts. While past work has broken ground by identifying neighborhoods and areas lacking good food access, this research makes a more comprehensive assessment of what people consume. The research moves toward evaluating the complex mix of food available in any given area, which can be true even of areas with more limited options.“We were not satisfied with this idea that if you only have fast food, it’s a food desert, but if you have a Whole Foods, it’s not,” Duarte says. “It’s not necessarily like that.”For the Senseable City Lab researchers, the study is a new technique further enabling them to understand city dynamics and the effects of the urban environment on health. Past lab studies have often focused on issues such as urban mobility, while extending to matters such as mobility and air pollution, among other topics.Being able to study food and health at the neighborhood level, though, is still another example of the ways that data-rich spheres of life can be studied in close detail.“When we started working on cities and data, the data resolution was so low,” Ratti says. “Today the amount of data is so immense we see this great opportunity to look at cities and see the influence of the urban environment as a big determinant of health. We see this as one of the new frontiers of our lab. It’s amazing how we can now look at this very precisely in cities.” More

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    Study shows a link between obesity and what’s on local restaurant menus

    For many years, health experts have been concerned about “food deserts,” places where residents lack good nutritional options. Now, an MIT-led study of three major global cities uses a new, granular method to examine the issue, and concludes that having fewer and less nutritional eating options nearby correlates with obesity and other health outcomes.Rather than just mapping geographic areas, the researchers examined the dietary value of millions of food items on roughly 30,000 restaurant menus and derived a more precise assessment of the connection between neighborhoods and nutrition.“We show that what is sold in a restaurant has a direct correlation to people’s health,” says MIT researcher Fabio Duarte, co-author of a newly published paper outlining the study’s results. “The food landscape matters.”The open-access paper, “Data-driven nutritional assessment of urban food landscapes: insights from Boston, London, Dubai,” was published this week in Nature: Scientific Reports.The co-authors are Michael Tufano, a PhD student at Wageningen University, in the Netherlands; Duarte, associate director of MIT’s Senseable City Lab, which uses data to study cities as dynamic systems; Martina Mazzarello, a postdoc at the Senseable City Lab; Javad Eshtiyagh, a research fellow at the Senseable City Lab; Carlo Ratti, professor of the practice and director of the Senseable City Lab; and Guido Camps, a senior researcher at Wageningen University.Scanning the menuTo conduct the study, the researchers examined menus from Boston, Dubai, and London, in the summer of 2023, compiling a database of millions of items available through popular food-delivery platforms. The team then evaluated the food items as rated by the USDA’s FoodData Central database, an information bank with 375,000 kinds of food products listed. The study deployed two main metrics, the Meal Balance Index, and the Nutrient-Rich Foods Index.The researchers examined about 222,000 menu items from over 2,000 restaurants in Boston, about 1.6 million menu items from roughly 9,000 restaurants in Dubai, and about 3.1 million menu items from about 18,000 restaurants in London. In Boston, about 71 percent of the items were in the USDA database; in Dubai and London, that figure was 42 percent and 56 percent, respectively.The team then rated the nutritional value of the items appearing on menus, and correlated the food data with health-outcome data from Boston and London. In London, they found a clear correlation between neighborhood menu offerings and obesity, or the lack thereof; with a slightly less firm correlation in Boston. Areas with food options that include a lot of dietary fibers, sometimes along with fruits and vegetables, tend to have better health data.In Dubai, the researchers did not have the same types of health data available but did observe a strong correlation between rental prices and the nutritional value of neighborhood-level food, suggesting that wealthier residents have better nourishment options.“At the item level, when we have less nutritional food, we see more cases of obsesity,” Tufano says. “It’s true that not only do we have more fast food in poor neighborhoods, but the nutritional value is not the same.”Re-mapping the food landscapeBy conducting the study in this fashion, the scholars added a layer of analysis to past studies of food deserts. While past work has broken ground by identifying neighborhoods and areas lacking good food access, this research makes a more comprehensive assessment of what people consume. The research moves toward evaluating the complex mix of food available in any given area, which can be true even of areas with more limited options.“We were not satisfied with this idea that if you only have fast food, it’s a food desert, but if you have a Whole Foods, it’s not,” Duarte says. “It’s not necessarily like that.”For the Senseable City Lab researchers, the study is a new technique further enabling them to understand city dynamics and the effects of the urban environment on health. Past lab studies have often focused on issues such as urban mobility, while extending to matters such as mobility and air pollution, among other topics.Being able to study food and health at the neighborhood level, though, is still another example of the ways that data-rich spheres of life can be studied in close detail.“When we started working on cities and data, the data resolution was so low,” Ratti says. “Today the amount of data is so immense we see this great opportunity to look at cities and see the influence of the urban environment as a big determinant of health. We see this as one of the new frontiers of our lab. It’s amazing how we can now look at this very precisely in cities.” More

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    Designing across cultural and geographic divides

    In addition to the typical rigors of MIT classes, Terrascope Subject 2.00C/1.016/EC.746 (Design for Complex Environmental Issues) poses some unusual hurdles for students to navigate: collaborating across time zones, bridging different cultural and institutional experiences, and trying to do hands-on work over Zoom. That’s because the class includes students from not only MIT, but also Diné College in Tsaile, Arizona, within the Navajo Nation, and the University of Puerto Rico-Ponce (UPRP).Despite being thousands of miles apart, students work in teams to tackle a real-world problem for a client, based on the Terrascope theme for the year. “Understanding how to collaborate over long distances with people who are not like themselves will be an important item in many of these students’ toolbelts going forward, in some cases just as much as — or more than — any particular design technique,” says Ari Epstein, Terrascope associate director and senior lecturer. Over the past several years, Epstein has taught the class along with Joel Grimm of MIT Beaver Works and Libby Hsu of MIT D-Lab, as well instructors from the two collaborating institutions. Undergraduate teaching fellows from all three schools are also key members of the instructional staff.Since the partnership began three years ago (initially with Diné College, with the addition of UPRP two years ago), the class themes have included food security and sustainable agriculture in Navajo Nation; access to reliable electrical power in Puerto Rico; and this year, increasing museum visitors’ engagement with artworks depicting mining and landscape alteration in Nevada.Each team — which includes students from all three colleges — meets with clients online early in the term to understand their needs; then, through an iterative process, teams work on designing prototypes. During MIT’s spring break, teams travel to meet with the clients onsite to get feedback and continue to refine their prototypes. At the end of the term, students present their final products to the clients, an expert panel, and their communities at a hybrid showcase event held simultaneously on all three campuses.Free-range design engineering“I really loved the class,” says Graciela Leon, a second-year mechanical engineering major who took the subject in 2024. “It was not at all what I was expecting,” she adds. While the learning objectives on the syllabus are fairly traditional — using an iterative engineering design process, developing teamwork skills, and deepening communication skills, to name a few — the approach is not. “Terrascope is just kind of like throwing you into a real-world problem … it feels a lot more like you are being trusted with this actual challenge,” Leon says.The 2024 challenge was to find a way to help the clients, Puerto Rican senior citizens, turn on gasoline-powered generators when the electrical power grid fails; some of them struggle with the pull cords necessary to start the generators. The students were tasked with designing solutions to make starting the generators easier.Terrascope instructors teach fundamental skills such as iterative design spirals and scrum workflow frameworks, but they also give students ample freedom to follow their ideas. Leon admits she was a bit frustrated at first, because she wasn’t sure what she was supposed to be doing. “I wanted to be building things and thought, ‘Wow, I have to do all these other things, I have to write some kind of client profile and understand my client’s needs.’ I was just like, ‘Hand me a drill! I want to design something!’”When he took the class last year, Uziel Rodriguez-Andujar was also thrown off initially by the independence teams had. Now a second-year UPRP student in mechanical engineering, he’s accustomed to lecture-based classes. “What I found so interesting is the way [they] teach the class, which is, ‘You make your own project, and we need you to find a solution to this. How it will look, and when you have it — that’s up to you,’” he says.Clearing hurdlesTeaching the course on three different campuses introduces a number of challenges for students and instructors to overcome — among them, operating in three different time zones, overcoming language barriers, navigating different cultural and institutional norms, communicating effectively, and designing and building prototypes over Zoom.“The culture span is huge,” explains Epstein. “There are different ways of speaking, different ways of listening, and each organization has different resources.”First-year MIT student EJ Rodriguez found that one of the biggest obstacles was trying to convey ideas to teammates clearly. He took the class this year, when the theme revolved around the environmental impacts of lithium mining. The client, the Nevada Museum of Art, wanted to find ways to engage visitors with its artwork collection related to mining-related landscape changes.Rodriguez and his team designed a pendulum with a light affixed to it that illuminates a painting by a Native American artist. When the pendulum swings, it changes how the visitor experiences the artwork. The team built parts for the pendulum on different campuses, and they reached a point where they realized their pieces were incompatible. “We had different visions of what we wanted for the project, and different vocabulary we were using to describe our ideas. Sometimes there would be a misunderstanding … It required a lot of honesty from each campus to be like, ‘OK, I thought we were doing exactly this,’ and obviously in a really respectful way.”It’s not uncommon for students at Diné College and UPRP to experience an initial hurdle that their MIT peers do not. Epstein notes, “There’s a tendency for some folks outside MIT to see MIT students as these brilliant people that they don’t belong in the same room with.” But the other students soon realize not only that they can hold their own intellectually, but also that their backgrounds and experiences are incredibly valuable. “Their life experiences actually put them way ahead of many MIT students in some ways, when you think about design and fabrication, like repairing farm equipment or rebuilding transmissions,” he adds.That’s how Cauy Bia felt when he took the class in 2024. Currently a first-year graduate student in biology at Diné College, Bia questioned whether he’d be on par with the MIT students. “I’ve grown up on a farm, and we do a lot of building, a lot of calculations, a lot of hands-on stuff. But going into this, I was sweating it so hard [wondering], ‘Am I smart enough to work with these students?’ And then, at the end of the day, that was never an issue,” he says.The value of reflectionEvery two weeks, Terrascope students write personal reflections about their experiences in the class, which helps them appreciate their academic and personal development. “I really felt that I had undergone a process that made me grow as an engineer,” says Leon. “I understood the importance of people and engineering more, including teamwork, working with clients, and de-centering the project away from what I wanted to build and design.”When Bia began the semester, he says, he was more of a “make-or-break-type person” and tended to see things in black and white. “But working with all three campuses, it kind of opened up my thought process so I can assess more ideas, more voices and opinions. And I can get broader perspectives and get bigger ideas from that point,” he says. It was also a powerful experience culturally for him, particularly “drawing parallels between Navajo history, Navajo culture, and seeing the similarities between that and Puerto Rican culture, seeing how close we are as two nations.”Rodriguez-Andujar gained an appreciation for the “constant struggle between simplicity and complexity” in engineering. “You have all these engineers trying to over-engineer everything,” he says. “And after you get your client feedback [halfway through the semester], it turns out, ‘Oh, that doesn’t work for me. I’m sorry — you have to scale it down like a hundred times and make it a lot simpler.’”For instructors, the students’ reflections are invaluable as they strive to make improvements every year. In many ways, you might say the class is an iterative design spiral, too. “The past three years have themselves been prototypes,” Epstein says, “and all of the instructional staff are looking forward to continuing these exciting partnerships.” More

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    MIT chemists boost the efficiency of a key enzyme in photosynthesis

    During photosynthesis, an enzyme called rubisco catalyzes a key reaction — the incorporation of carbon dioxide into organic compounds to create sugars. However, rubisco, which is believed to be the most abundant enzyme on Earth, is very inefficient compared to the other enzymes involved in photosynthesis.MIT chemists have now shown that they can greatly enhance a version of rubisco found in bacteria from a low-oxygen environment. Using a process known as directed evolution, they identified mutations that could boost rubisco’s catalytic efficiency by up to 25 percent.The researchers now plan to apply their technique to forms of rubisco that could be used in plants to help boost their rates of photosynthesis, which could potentially improve crop yields.“This is, I think, a compelling demonstration of successful improvement of a rubisco’s enzymatic properties, holding out a lot of hope for engineering other forms of rubisco,” says Matthew Shoulders, the Class of 1942 Professor of Chemistry at MIT.Shoulders and Robert Wilson, a research scientist in the Department of Chemistry, are the senior authors of the new study, which appears this week in the Proceedings of the National Academy of Sciences. MIT graduate student Julie McDonald is the paper’s lead author.Evolution of efficiencyWhen plants or photosynthetic bacteria absorb energy from the sun, they first convert it into energy-storing molecules such as ATP. In the next phase of photosynthesis, cells use that energy to transform a molecule known as ribulose bisphosphate into glucose, which requires several additional reactions. Rubisco catalyzes the first of those reactions, known as carboxylation. During that reaction, carbon from CO2 is added to ribulose bisphosphate.Compared to the other enzymes involved in photosynthesis, rubisco is very slow, catalyzing only one to 10 reactions per second. Additionally, rubisco can also interact with oxygen, leading to a competing reaction that incorporates oxygen instead of carbon — a process that wastes some of the energy absorbed from sunlight.“For protein engineers, that’s a really attractive set of problems because those traits seem like things that you could hopefully make better by making changes to the enzyme’s amino acid sequence,” McDonald says.Previous research has led to improvement in rubisco’s stability and solubility, which resulted in small gains in enzyme efficiency. Most of those studies used directed evolution — a technique in which a naturally occurring protein is randomly mutated and then screened for the emergence of new, desirable features.This process is usually done using error-prone PCR, a technique that first generates mutations in vitro (outside of the cell), typically introducing only one or two mutations in the target gene. In past studies on rubisco, this library of mutations was then introduced into bacteria that grow at a rate relative to rubisco activity. Limitations in error-prone PCR and in the efficiency of introducing new genes restrict the total number of mutations that can be generated and screened using this approach. Manual mutagenesis and selection steps also add more time to the process over multiple rounds of evolution.The MIT team instead used a newer mutagenesis technique that the Shoulders Lab previously developed, called MutaT7. This technique allows the researchers to perform both mutagenesis and screening in living cells, which dramatically speeds up the process. Their technique also enables them to mutate the target gene at a higher rate.“Our continuous directed evolution technique allows you to look at a lot more mutations in the enzyme than has been done in the past,” McDonald says.Better rubiscoFor this study, the researchers began with a version of rubisco, isolated from a family of semi-anaerobic bacteria known as Gallionellaceae, that is one of the fastest rubisco found in nature. During the directed evolution experiments, which were conducted in E. coli, the researchers kept the microbes in an environment with atmospheric levels of oxygen, creating evolutionary pressure to adapt to oxygen.After six rounds of directed evolution, the researchers identified three different mutations that improved the rubisco’s resistance to oxygen. Each of these mutations are located near the enzyme’s active site (where it performs carboxylation or oxygenation). The researchers believe that these mutations improve the enzyme’s ability to preferentially interact with carbon dioxide over oxygen, which leads to an overall increase in carboxylation efficiency.“The underlying question here is: Can you alter and improve the kinetic properties of rubisco to operate better in environments where you want it to operate better?” Shoulders says. “What changed through the directed evolution process was that rubisco began to like to react with oxygen less. That allows this rubisco to function well in an oxygen-rich environment, where normally it would constantly get distracted and react with oxygen, which you don’t want it to do.”In ongoing work, the researchers are applying this approach to other forms of rubisco, including rubisco from plants. Plants are believed to lose about 30 percent of the energy from the sunlight they absorb through a process called photorespiration, which occurs when rubisco acts on oxygen instead of carbon dioxide.“This really opens the door to a lot of exciting new research, and it’s a step beyond the types of engineering that have dominated rubisco engineering in the past,” Wilson says. “There are definite benefits to agricultural productivity that could be leveraged through a better rubisco.”The research was funded, in part, by the National Science Foundation, the National Institutes of Health, an Abdul Latif Jameel Water and Food Systems Lab Grand Challenge grant, and a Martin Family Society Fellowship for Sustainability. More

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    Study shows how a common fertilizer ingredient benefits plants

    Lanthanides are a class of rare earth elements that in many countries are added to fertilizer as micronutrients to stimulate plant growth. But little is known about how they are absorbed by plants or influence photosynthesis, potentially leaving their benefits untapped.Now, researchers from MIT have shed light on how lanthanides move through and operate within plants. These insights could help farmers optimize their use to grow some of the world’s most popular crops.Published today in the Journal of the American Chemical Society, the study shows that a single nanoscale dose of lanthanides applied to seeds can make some of the world’s most common crops more resilient to UV stress. The researchers also uncovered the chemical processes by which lanthanides interact with the chlorophyll pigments that drive photosynthesis, showing that different lanthanide elements strengthen chlorophyll by replacing the magnesium at its center.“This is a first step to better understand how these elements work in plants, and to provide an example of how they could be better delivered to plants, compared to simply applying them in the soil,” says Associate Professor Benedetto Marelli, who conducted the research with postdoc Giorgio Rizzo. “This is the first example of a thorough study showing the effects of lanthanides on chlorophyll, and their beneficial effects to protect plants from UV stress.”Inside plant connectionsCertain lanthanides are used as contrast agents in MRI and for applications including light-emitting diodes, solar cells, and lasers. Over the last 50 years, lanthanides have become increasingly used in agriculture to enhance crop yields, with China alone applying lanthanide-based fertilizers to nearly 4 million hectares of land each year.“Lanthanides have been considered for a long time to be biologically irrelevant, but that’s changed in agriculture, especially in China,” says Rizzo, the paper’s first author. “But we largely don’t know how lanthanides work to benefit plants — nor do we understand their uptake mechanisms from plant tissues.”Recent studies have shown that low concentrations of lanthanides can promote plant growth, root elongation, hormone synthesis, and stress tolerance, but higher doses can cause harm to plants. Striking the right balance has been hard because of our lack of understanding around how lanthanides are absorbed by plants or how they interact with root soil.For the study, the researchers leveraged seed coating and treatment technologies they previously developed to investigate the way the plant pigment chlorophyll interacts with lanthanides, both inside and outside of plants. Up until now, researchers haven’t been sure whether chlorophyll interacts with lanthanide ions at all.Chlorophyll drives photosynthesis, but the pigments lose their ability to efficiently absorb light when the magnesium ion at their core is removed. The researchers discovered that lanthanides can fill that void, helping chlorophyll pigments partially recover some of their optical properties in a process known as re-greening.“We found that lanthanides can boost several parameters of plant health,” Marelli says. “They mostly accumulate in the roots, but a small amount also makes its way to the leaves, and some of the new chlorophyll molecules made in leaves have lanthanides incorporated in their structure.”This study also offers the first experimental evidence that lanthanides can increase plant resilience to UV stress, something the researchers say was completely unexpected.“Chlorophylls are very sensitive pigments,” Rizzo says. “They can convert light to energy in plants, but when they are isolated from the cell structure, they rapidly hydrolyze and degrade. However, in the form with lanthanides at their center, they are pretty stable, even after extracting them from plant cells.”The researchers, using different spectroscopic techniques, found the benefits held across a range of staple crops, including chickpea, barley, corn, and soybeans.The findings could be used to boost crop yield and increase the resilience of some of the world’s most popular crops to extreme weather.“As we move into an environment where extreme heat and extreme climate events are more common, and particularly where we can have prolonged periods of sun in the field, we want to provide new ways to protect our plants,” Marelli says. “There are existing agrochemicals that can be applied to leaves for protecting plants from stressors such as UV, but they can be toxic, increase microplastics, and can require multiple applications. This could be a complementary way to protect plants from UV stress.”Identifying new applicationsThe researchers also found that larger lanthanide elements like lanthanum were more effective at strengthening chlorophyll pigments than smaller ones. Lanthanum is considered a low-value byproduct of rare earths mining, and can become a burden to the rare earth element (REE) supply chain due to the need to separate it from more desirable rare earths. Increasing the demand for lanthanum could diversify the economics of REEs and improve the stability of their supply chain, the scientists suggest.“This study shows what we could do with these lower-value metals,” Marelli says. “We know lanthanides are extremely useful in electronics, magnets, and energy. In the U.S., there’s a big push to recycle them. That’s why for the plant studies, we focused on lanthanum, being the most abundant, cheapest lanthanide ion.”Moving forward, the team plans to explore how lanthanides work with other biological molecules, including proteins in the human body.In agriculture, the team hopes to scale up its research to include field and greenhouse studies to continue testing the results of UV resilience on different crop types and in experimental farm conditions.“Lanthanides are already widely used in agriculture,” Rizzo says. “We hope this study provides evidence that allows more conscious use of them and also a new way to apply them through seed treatments.”The research was supported by the MIT Climate Grand Challenge and the Office for Naval Research. More

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    VAMO proposes an alternative to architectural permanence

    The International Architecture Exhibition of La Biennale di Venezia holds up a mirror to the industry — not only reflecting current priorities and preoccupations, but also projecting an agenda for what might be possible. Curated by Carlo Ratti, MIT professor of practice of urban technologies and planning, this year’s exhibition (“Intelligens. Natural. Artificial. Collective”) proposes a “Circular Economy Manifesto” with the goal to support the “development and production of projects that utilize natural, artificial, and collective intelligence to combat the climate crisis.” Designers and architects will quickly recognize the paradox of this year’s theme. Global architecture festivals have historically had a high carbon footprint, using vast amounts of energy, resources, and materials to build and transport temporary structures that are later discarded. This year’s unprecedented emphasis on waste elimination and carbon neutrality challenges participants to reframe apparent limitations into creative constraints. In this way, the Biennale acts as a microcosm of current planetary conditions — a staging ground to envision and practice adaptive strategies.VAMO (Vegetal, Animal, Mineral, Other)When Ratti approached John Ochsendorf, MIT professor and founding director of MIT Morningside Academy of Design (MAD), with the invitation to interpret the theme of circularity, the project became the premise for a convergence of ideas, tools, and know-how from multiple teams at MIT and the wider MIT community. The Digital Structures research group, directed by Professor Caitlin Mueller, applied expertise in designing efficient structures of tension and compression. The Circular Engineering for Architecture research group, led by MIT alumna Catherine De Wolf at ETH Zurich, explored how digital technologies and traditional woodworking techniques could make optimal use of reclaimed timber. Early-stage startups — including companies launched by the venture accelerator MITdesignX — contributed innovative materials harnessing natural byproducts from vegetal, animal, mineral, and other sources. The result is VAMO (Vegetal, Animal, Mineral, Other), an ultra-lightweight, biodegradable, and transportable canopy designed to circle around a brick column in the Corderie of the Venice Arsenale — a historic space originally used to manufacture ropes for the city’s naval fleet. “This year’s Biennale marks a new radicalism in approaches to architecture,” says Ochsendorf. “It’s no longer sufficient to propose an exciting idea or present a stylish installation. The conversation on material reuse must have relevance beyond the exhibition space, and we’re seeing a hunger among students and emerging practices to have a tangible impact. VAMO isn’t just a temporary shelter for new thinking. It’s a material and structural prototype that will evolve into multiple different forms after the Biennale.”Tension and compressionThe choice to build the support structure from reclaimed timber and hemp rope called for a highly efficient design to maximize the inherent potential of comparatively humble materials. Working purely in tension (the spliced cable net) or compression (the oblique timber rings), the structure appears to float — yet is capable of supporting substantial loads across large distances. The canopy weighs less than 200 kilograms and covers over 6 meters in diameter, highlighting the incredible lightness that equilibrium forms can achieve. VAMO simultaneously showcases a series of sustainable claddings and finishes made from surprising upcycled materials — from coconut husks, spent coffee grounds, and pineapple peel to wool, glass, and scraps of leather. The Digital Structures research group led the design of structural geometries conditioned by materiality and gravity. “We knew we wanted to make a very large canopy,” says Mueller. “We wanted it to have anticlastic curvature suggestive of naturalistic forms. We wanted it to tilt up to one side to welcome people walking from the central corridor into the space. However, these effects are almost impossible to achieve with today’s computational tools that are mostly focused on drawing rigid materials.”In response, the team applied two custom digital tools, Ariadne and Theseus, developed in-house to enable a process of inverse form-finding: a way of discovering forms that achieve the experiential qualities of an architectural project based on the mechanical properties of the materials. These tools allowed the team to model three-dimensional design concepts and automatically adjust geometries to ensure that all elements were held in pure tension or compression.“Using digital tools enhances our creativity by allowing us to choose between multiple different options and short-circuit a process that would have otherwise taken months,” says Mueller. “However, our process is also generative of conceptual thinking that extends beyond the tool — we’re constantly thinking about the natural and historic precedents that demonstrate the potential of these equilibrium structures.”Digital efficiency and human creativity Lightweight enough to be carried as standard luggage, the hemp rope structure was spliced by hand and transported from Massachusetts to Venice. Meanwhile, the heavier timber structure was constructed in Zurich, where it could be transported by train — thereby significantly reducing the project’s overall carbon footprint. The wooden rings were fabricated using salvaged beams and boards from two temporary buildings in Switzerland — the Huber and Music Pavilions — following a pedagogical approach that De Wolf has developed for the Digital Creativity for Circular Construction course at ETH Zurich. Each year, her students are tasked with disassembling a building due for demolition and using the materials to design a new structure. In the case of VAMO, the goal was to upcycle the wood while avoiding the use of chemicals, high-energy methods, or non-biodegradable components (such as metal screws or plastics). “Our process embraces all three types of intelligence celebrated by the exhibition,” says De Wolf. “The natural intelligence of the materials selected for the structure and cladding; the artificial intelligence of digital tools empowering us to upcycle, design, and fabricate with these natural materials; and the crucial collective intelligence that unlocks possibilities of newly developed reused materials, made possible by the contributions of many hands and minds.”For De Wolf, true creativity in digital design and construction requires a context-sensitive approach to identifying when and how such tools are best applied in relation to hands-on craftsmanship. Through a process of collective evaluation, it was decided that the 20-foot lower ring would be assembled with eight scarf joints using wedges and wooden pegs, thereby removing the need for metal screws. The scarf joints were crafted through five-axis CNC milling; the smaller, dual-jointed upper ring was shaped and assembled by hand by Nicolas Petit-Barreau, founder of the Swiss woodwork company Anku, who applied his expertise in designing and building yurts, domes, and furniture to the VAMO project. “While digital tools suited the repetitive joints of the lower ring, the upper ring’s two unique joints were more efficiently crafted by hand,” says Petit-Barreau. “When it comes to designing for circularity, we can learn a lot from time-honored building traditions. These methods were refined long before we had access to energy-intensive technologies — they also allow for the level of subtlety and responsiveness necessary when adapting to the irregularities of reused wood.”A material palette for circularityThe structural system of a building is often the most energy-intensive; an impact dramatically mitigated by the collaborative design and fabrication process developed by MIT Digital Structures and ETH Circular Engineering for Architecture. The structure also serves to showcase panels made of biodegradable and low-energy materials — many of which were advanced through ventures supported by MITdesignX, a program dedicated to design innovation and entrepreneurship at MAD. “In recent years, several MITdesignX teams have proposed ideas for new sustainable materials that might at first seem far-fetched,” says Gilad Rosenzweig, executive director of MITdesignX. “For instance, using spent coffee grounds to create a leather-like material (Cortado), or creating compostable acoustic panels from coconut husks and reclaimed wool (Kokus). This reflects a major cultural shift in the architecture profession toward rethinking the way we build, but it’s not enough just to have an inventive idea. To achieve impact — to convert invention into innovation — teams have to prove that their concept is cost-effective, viable as a business, and scalable.”Aligned with the ethos of MAD, MITdesignX assesses profit and productivity in terms of environmental and social sustainability. In addition to presenting the work of R&D teams involved in MITdesignX, VAMO also exhibits materials produced by collaborating teams at University of Pennsylvania’s Stuart Weitzman School of Design, Politecnico di Milano, and other partners, such as Manteco. The result is a composite structure that encapsulates multiple life spans within a diverse material palette of waste materials from vegetal, animal, and mineral forms. Panels of Ananasse, a material made from pineapple peels developed by Vérabuccia, preserve the fruit’s natural texture as a surface pattern, while rehub repurposes fragments of multicolored Murano glass into a flexible terrazzo-like material; COBI creates breathable shingles from coarse wool and beeswax, and DumoLab produces fuel-free 3D-printable wood panels. A purpose beyond permanence Adriana Giorgis, a designer and teaching fellow in architecture at MIT, played a crucial role in bringing the parts of the project together. Her research explores the diverse network of factors that influence whether a building stands the test of time, and her insights helped to shape the collective understanding of long-term design thinking.“As a point of connection between all the teams, helping to guide the design as well as serving as a project manager, I had the chance to see how my research applied at each level of the project,” Giorgis reflects. “Braiding these different strands of thinking and ultimately helping to install the canopy on site brought forth a stronger idea about what it really means for a structure to have longevity. VAMO isn’t limited to its current form — it’s a way of carrying forward a powerful idea into contemporary and future practice.”What’s next for VAMO? Neither the attempt at architectural permanence associated with built projects, nor the relegation to waste common to temporary installations. After the Biennale, VAMO will be disassembled, possibly reused for further exhibitions, and finally relocated to a natural reserve in Switzerland, where the parts will be researched as they biodegrade. In this way, the lifespan of the project is extended beyond its initial purpose for human habitation and architectural experimentation, revealing the gradual material transformations constantly taking place in our built environment.To quote Carlo Ratti’s Circular Economy Manifesto, the “lasting legacy” of VAMO is to “harness nature’s intelligence, where nothing is wasted.” Through a regenerative symbiosis of natural, artificial, and collective intelligence, could architectural thinking and practice expand to planetary proportions? More

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    in Security

    MIT Open Learning bootcamp supports effort to bring invention for long-term fentanyl recovery to market

    Evan Kharasch, professor of anesthesiology and vice chair for innovation at Duke University, has developed two approaches that may aid in fentanyl addiction recovery. After attending MIT’s Substance Use Disorders (SUD) Ventures Bootcamp, he’s committed to bringing them to market.Illicit fentanyl addiction is still a national emergency in the United States, fueled by years of opioid misuse. As opioid prescriptions fell by 50 percent over 15 years, many turned to street drugs. Among those drugs, fentanyl stands out for its potency — just 2 milligrams can be fatal — and its low production cost. Often mixed with other drugs, it contributed to a large portion of over 80,000 overdose deaths in 2024. It has been particularly challenging to treat with currently available medications for opioid use disorder.  ​​As an anesthesiologist, Kharasch is highly experienced with opioids, including methadone, one of only three drugs approved in the United States for treating opioid use disorder. Methadone is a key option for managing fentanyl use. It’s employed to transition patients off fentanyl and to support ongoing maintenance, but access is limited, with only 20 percent of eligible patients receiving it. Initiating and adjusting methadone treatment can take weeks due to its clinical characteristics, often causing withdrawal and requiring longer hospital stays. Maintenance demands daily visits to one of just over 2,000 clinics, disrupting work or study and leading most patients to drop out after a few months.To tackle these challenges, Kharasch developed two novel methadone formulations: one for faster absorption to cut initiation time from weeks to days — or even hours — and one to slow elimination, thereby potentially requiring only weekly, rather than daily, dosing. As a clinician, scientist, and entrepreneur, he sees the science as demanding, but bringing these treatments to patients presents an even greater challenge. Kharasch learned about the SUD Ventures Bootcamp, part of MIT Open Learning, as a recipient of research funding from the National Institute on Drug Abuse (NIDA). He decided to apply to bridge the gap in his expertise and was selected to attend as a fellow.Each year, the SUD Ventures Bootcamp unites innovators — including scientists, entrepreneurs, and medical professionals — to develop bold, cross-disciplinary solutions to substance use disorders. Through online learning and an intensive one-week in-person bootcamp, teams tackle challenges in different “high priority” areas. Guided by experts in science, entrepreneurship, and policy, they build and pitch ventures aimed at real-world impact. Beyond the multidisciplinary curriculum, the program connects people deeply committed to this space and equipped to drive progress.Throughout the program, Kharasch’s concepts were validated by the invited industry experts, who highlighted the potential impact of a longer-acting methadone formulation, particularly in correctional settings. Encouragement from MIT professors, coaches, and peers energized Kharasch to fully pursue commercialization. He has already begun securing intellectual property rights, validating the regulatory pathway through the U.S Food and Drug Administration, and gathering market and patient feedback.The SUD Ventures Bootcamp, he says, both activated and validated his passion for bringing these innovations to patients. “After many years of basic, translational and clinical research on methadone all — supported by NIDA — I experienced that a ha moment of recognizing a potential opportunity to apply the findings to benefit patients at scale,” Kharasch says. “The NIDA-sponsored participation in the MIT SUD Ventures Bootcamp was the critical catalyst which ignited the inspiration and commitment to pursue commercializing our research findings into better treatments for opioid use disorder.”As next steps, Kharasch is seeking an experienced co-founder and finalizing IP protections. He remains engaged with the SUD Ventures network as mentors, industry experts, and peers offer help with advancing this needed solution to market. For example, the program’s mentor, Nat Sims, the Newbower/Eitan Endowed Chair in Biomedical Technology Innovation at Massachusetts General Hospital (MGH) and a fellow anesthesiologist, has helped Kharasch arrange technology validation conversations within the MGH ecosystem and the drug development community.“Evan’s collaboration with the MGH ecosystem can help define an optimum process for commercializing these innovations — identifying who would benefit, how they would benefit, and who is willing to pilot the product once it’s available,” says Sims.Kharasch has also presented his project in the program’s webinar series. Looking ahead, Kharasch hopes to involve MIT Sloan School of Management students in advancing his project through health care entrepreneurship classes, continuing the momentum that began with the SUD Ventures Bootcamp.The program and its research are supported by the NIDA of the National Institutes of Health. Cynthia Breazeal, a professor of media arts and sciences at the MIT Media Lab and dean for digital learning at MIT Open Learning, serves as the principal investigator on the grant. More

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    in Environment

    Merging AI and underwater photography to reveal hidden ocean worlds

    In the Northeastern United States, the Gulf of Maine represents one of the most biologically diverse marine ecosystems on the planet — home to whales, sharks, jellyfish, herring, plankton, and hundreds of other species. But even as this ecosystem supports rich biodiversity, it is undergoing rapid environmental change. The Gulf of Maine is warming faster than 99 percent of the world’s oceans, with consequences that are still unfolding.A new research initiative developing at MIT Sea Grant, called LOBSTgER — short for Learning Oceanic Bioecological Systems Through Generative Representations — brings together artificial intelligence and underwater photography to document the ocean life left vulnerable to these changes and share them with the public in new visual ways. Co-led by underwater photographer and visiting artist at MIT Sea Grant Keith Ellenbogen and MIT mechanical engineering PhD student Andreas Mentzelopoulos, the project explores how generative AI can expand scientific storytelling by building on field-based photographic data.Just as the 19th-century camera transformed our ability to document and reveal the natural world — capturing life with unprecedented detail and bringing distant or hidden environments into view — generative AI marks a new frontier in visual storytelling. Like early photography, AI opens a creative and conceptual space, challenging how we define authenticity and how we communicate scientific and artistic perspectives. In the LOBSTgER project, generative models are trained exclusively on a curated library of Ellenbogen’s original underwater photographs — each image crafted with artistic intent, technical precision, accurate species identification, and clear geographic context. By building a high-quality dataset grounded in real-world observations, the project ensures that the resulting imagery maintains both visual integrity and ecological relevance. In addition, LOBSTgER’s models are built using custom code developed by Mentzelopoulos to protect the process and outputs from any potential biases from external data or models. LOBSTgER’s generative AI builds upon real photography, expanding the researchers’ visual vocabulary to deepen the public’s connection to the natural world.

    This ocean sunfish (Mola mola) image was generated by LOBSTgER’s unconditional models.

    AI-generated image: Keith Ellenbogen, Andreas Mentzelopoulos, and LOBSTgER.

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    At its heart, LOBSTgER operates at the intersection of art, science, and technology. The project draws from the visual language of photography, the observational rigor of marine science, and the computational power of generative AI. By uniting these disciplines, the team is not only developing new ways to visualize ocean life — they are also reimagining how environmental stories can be told. This integrative approach makes LOBSTgER both a research tool and a creative experiment — one that reflects MIT’s long-standing tradition of interdisciplinary innovation.Underwater photography in New England’s coastal waters is notoriously difficult. Limited visibility, swirling sediment, bubbles, and the unpredictable movement of marine life all pose constant challenges. For the past several years, Ellenbogen has navigated these challenges and is building a comprehensive record of the region’s biodiversity through the project, Space to Sea: Visualizing New England’s Ocean Wilderness. This large dataset of underwater images provides the foundation for training LOBSTgER’s generative AI models. The images span diverse angles, lighting conditions, and animal behaviors, resulting in a visual archive that is both artistically striking and biologically accurate.

    Image synthesis via reverse diffusion: This short video shows the de-noising trajectory from Gaussian latent noise to photorealistic output using LOBSTgER’s unconditional models. Iterative de-noising requires 1,000 forward passes through the trained neural network.Video: Keith Ellenbogen and Andreas Mentzelopoulos / MIT Sea Grant

    LOBSTgER’s custom diffusion models are trained to replicate not only the biodiversity Ellenbogen documents, but also the artistic style he uses to capture it. By learning from thousands of real underwater images, the models internalize fine-grained details such as natural lighting gradients, species-specific coloration, and even the atmospheric texture created by suspended particles and refracted sunlight. The result is imagery that not only appears visually accurate, but also feels immersive and moving.The models can both generate new, synthetic, but scientifically accurate images unconditionally (i.e., requiring no user input/guidance), and enhance real photographs conditionally (i.e., image-to-image generation). By integrating AI into the photographic workflow, Ellenbogen will be able to use these tools to recover detail in turbid water, adjust lighting to emphasize key subjects, or even simulate scenes that would be nearly impossible to capture in the field. The team also believes this approach may benefit other underwater photographers and image editors facing similar challenges. This hybrid method is designed to accelerate the curation process and enable storytellers to construct a more complete and coherent visual narrative of life beneath the surface.

    Left: Enhanced image of an American lobster using LOBSTgER’s image-to-image models. Right: Original image.

    Left: AI genertated image by Keith Ellenbogen, Andreas Mentzelopoulos, and LOBSTgER. Right: Keith Ellenbogen

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    In one key series, Ellenbogen captured high-resolution images of lion’s mane jellyfish, blue sharks, American lobsters, and ocean sunfish (Mola mola) while free diving in coastal waters. “Getting a high-quality dataset is not easy,” Ellenbogen says. “It requires multiple dives, missed opportunities, and unpredictable conditions. But these challenges are part of what makes underwater documentation both difficult and rewarding.”Mentzelopoulos has developed original code to train a family of latent diffusion models for LOBSTgER grounded on Ellenbogen’s images. Developing such models requires a high level of technical expertise, and training models from scratch is a complex process demanding hundreds of hours of computation and meticulous hyperparameter tuning.The project reflects a parallel process: field documentation through photography and model development through iterative training. Ellenbogen works in the field, capturing rare and fleeting encounters with marine animals; Mentzelopoulos works in the lab, translating those moments into machine-learning contexts that can extend and reinterpret the visual language of the ocean.“The goal isn’t to replace photography,” Mentzelopoulos says. “It’s to build on and complement it — making the invisible visible, and helping people see environmental complexity in a way that resonates both emotionally and intellectually. Our models aim to capture not just biological realism, but the emotional charge that can drive real-world engagement and action.”LOBSTgER points to a hybrid future that merges direct observation with technological interpretation. The team’s long-term goal is to develop a comprehensive model that can visualize a wide range of species found in the Gulf of Maine and, eventually, apply similar methods to marine ecosystems around the world.The researchers suggest that photography and generative AI form a continuum, rather than a conflict. Photography captures what is — the texture, light, and animal behavior during actual encounters — while AI extends that vision beyond what is seen, toward what could be understood, inferred, or imagined based on scientific data and artistic vision. Together, they offer a powerful framework for communicating science through image-making.In a region where ecosystems are changing rapidly, the act of visualizing becomes more than just documentation. It becomes a tool for awareness, engagement, and, ultimately, conservation. LOBSTgER is still in its infancy, and the team looks forward to sharing more discoveries, images, and insights as the project evolves.Answer from the lead image: The left image was generated using using LOBSTgER’s unconditional models and the right image is real.For more information, contact Keith Ellenbogen and Andreas Mentzelopoulos. More

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    in Environment

    Island rivers carve passageways through coral reefs

    Volcanic islands, such as the islands of Hawaii and the Caribbean, are surrounded by coral reefs that encircle an island in a labyrinthine, living ring. A coral reef is punctured at points by reef passes — wide channels that cut through the coral and serve as conduits for ocean water and nutrients to filter in and out. These watery passageways provide circulation throughout a reef, helping to maintain the health of corals by flushing out freshwater and transporting key nutrients.Now, MIT scientists have found that reef passes are shaped by island rivers. In a study appearing today in the journal Geophysical Research Letters, the team shows that the locations of reef passes along coral reefs line up with where rivers funnel out from an island’s coast.Their findings provide the first quantitative evidence of rivers forming reef passes.  Scientists and explorers had speculated that this may be the case: Where a river on a volcanic island meets the coast, the freshwater and sediment it carries flows toward the reef, where a strong enough flow can tunnel into the surrounding coral. This idea has been proposed from time to time but never quantitatively tested, until now.“The results of this study help us to understand how the health of coral reefs depends on the islands they surround,” says study author Taylor Perron, the Cecil and Ida Green Professor of Earth, Atmospheric and Planetary Sciences at MIT.“A lot of discussion around rivers and their impact on reefs today has been negative because of human impact and the effects of agricultural practices,” adds lead author Megan Gillen, a graduate student in the MIT-WHOI Joint Program in Oceanography. “This study shows the potential long-term benefits rivers can have on reefs, which I hope reshapes the paradigm and highlights the natural state of rivers interacting with reefs.”The study’s other co-author is Andrew Ashton of the Woods Hole Oceanographic Institution.Drawing the linesThe new study is based on the team’s analysis of the Society Islands, a chain of islands in the South Pacific Ocean that includes Tahiti and Bora Bora. Gillen, who joined the MIT-WHOI program in 2020, was interested in exploring connections between coral reefs and the islands they surround. With limited options for on-site work during the Covid-19 pandemic, she and Perron looked to see what they could learn through satellite images and maps of island topography. They did a quick search using Google Earth and zeroed in on the Society Islands for their uniquely visible reef and island features.“The islands in this chain have these iconic, beautiful reefs, and we kept noticing these reef passes that seemed to align with deeply embayed portions of the coastline,” Gillen says. “We started asking ourselves, is there a correlation here?”Viewed from above, the coral reefs that circle some islands bear what look to be notches, like cracks that run straight through a ring. These breaks in the coral are reef passes — large channels that run tens of meters deep and can be wide enough for some boats to pass through. On first look, Gillen noticed that the most obvious reef passes seemed to line up with flooded river valleys — depressions in the coastline that have been eroded over time by island rivers that flow toward the ocean. She wondered whether and to what extent island rivers might shape reef passes.“People have examined the flow through reef passes to understand how ocean waves and seawater circulate in and out of lagoons, but there have been no claims of how these passes are formed,” Gillen says. “Reef pass formation has been mentioned infrequently in the literature, and people haven’t explored it in depth.”Reefs unraveledTo get a detailed view of the topography in and around the Society Islands, the team used data from the NASA Shuttle Radar Topography Mission — two radar antennae that flew aboard the space shuttle in 1999 and measured the topography across 80 percent of the Earth’s surface.The researchers used the mission’s topographic data in the Society Islands to create a map of every drainage basin along the coast of each island, to get an idea of where major rivers flow or once flowed. They also marked the locations of every reef pass in the surrounding coral reefs. They then essentially “unraveled” each island’s coastline and reef into a straight line, and compared the locations of basins versus reef passes.“Looking at the unwrapped shorelines, we find a significant correlation in the spatial relationship between these big river basins and where the passes line up,” Gillen says. “So we can say that statistically, the alignment of reef passes and large rivers does not seem random. The big rivers have a role in forming passes.”As for how rivers shape the coral conduits, the team has two ideas, which they call, respectively, reef incision and reef encroachment. In reef incision, they propose that reef passes can form in times when the sea level is relatively low, such that the reef is exposed above the sea surface and a river can flow directly over the reef. The water and sediment carried by the river can then erode the coral, progressively carving a path through the reef.When sea level is relatively higher, the team suspects a reef pass can still form, through reef encroachment. Coral reefs naturally live close to the water surface, where there is light and opportunity for photosynthesis. When sea levels rise, corals naturally grow upward and inward toward an island, to try to “catch up” to the water line.“Reefs migrate toward the islands as sea levels rise, trying to keep pace with changing average sea level,” Gillen says.However, part of the encroaching reef can end up in old river channels that were previously carved out by large rivers and that are lower than the rest of the island coastline. The corals in these river beds end up deeper than light can extend into the water column, and inevitably drown, leaving a gap in the form of a reef pass.“We don’t think it’s an either/or situation,” Gillen says. “Reef incision occurs when sea levels fall, and reef encroachment happens when sea levels rise. Both mechanisms, occurring over dozens of cycles of sea-level rise and island evolution, are likely responsible for the formation and maintenance of reef passes over time.”The team also looked to see whether there were differences in reef passes in older versus younger islands. They observed that younger islands were surrounded by more reef passes that were spaced closer together, versus older islands that had fewer reef passes that were farther apart.As islands age, they subside, or sink, into the ocean, which reduces the amount of land that funnels rainwater into rivers. Eventually, rivers are too weak to keep the reef passes open, at which point, the ocean likely takes over, and incoming waves could act to close up some passes.Gillen is exploring ideas for how rivers, or river-like flow, can be engineered to create paths through coral reefs in ways that would promote circulation and benefit reef health.“Part of me wonders: If you had a more persistent flow, in places where you don’t naturally have rivers interacting with the reef, could that potentially be a way to increase health, by incorporating that river component back into the reef system?” Gillen says. “That’s something we’re thinking about.”This research was supported, in part, by the WHOI Watson and Von Damm fellowships. More