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      in Environment

      Unlocking the secrets of natural materials

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      Growing up in Milan, Benedetto Marelli liked figuring out how things worked. He repaired broken devices simply to have the opportunity to take them apart and put them together again. Also, from a young age, he had a strong desire to make a positive impact on the world. Enrolling at the Polytechnic University of Milan, he chose to study engineering.

      “Engineering seemed like the right fit to fulfill my passions at the intersection of discovering how the world works, together with understanding the rules of nature and harnessing this knowledge to create something new that could positively impact our society,” says Marelli, MIT’s Paul M. Cook Career Development Associate Professor of Civil and Environmental Engineering.

      Marelli decided to focus on biomedical engineering, which at the time was the closest thing available to biological engineering. “I liked the idea of pursuing studies that provided me a background to engineer life,” in order to improve human health and agriculture, he says.

      Marelli went on to earn a PhD in materials science and engineering at McGill University and then worked in Tufts University’s biomaterials Silklab as a postdoc. After his postdoc, Marelli was drawn to MIT’s Department of Civil and Environmental in large part because of the work of Markus Buehler, MIT’s McAfee Professor of Engineering, who studies how to design new materials by understanding the architecture of natural ones.

      “This resonated with my training and idea of using nature’s building blocks to build a more sustainable society,” Marelli says. “It was a big leap forward for me to go from biomedical engineering to civil and environmental engineering. It meant completely changing my community, understanding what I could teach and how to mentor students in a new engineering branch. As Markus is working with silk to study how to engineer better materials, this made me see a clear connection with what I was doing and what I could be doing. I consider him one of my mentors here at MIT and was fortunate to end up collaborating with him.”

      Marelli’s research is aimed at mitigating several pressing global problems, he says.

      “Boosting food production to provide food security to an ever-increasing population, soil restoration, decreasing the environmental impact of fertilizers, and addressing stressors coming from climate change are societal challenges that need the development of rapidly scalable and deployable technologies,” he says.

      Marelli and his fellow researchers have developed coatings derived from natural silk that extend the shelf life of food, deliver biofertilizers to seeds planted in salty, unproductive soils, and allow seeds to establish healthier plants and increase crop yield in drought-stricken lands. The technologies have performed well in field tests being conducted in Morocco in collaboration with the Mohammed VI Polytechnic University in Ben Guerir, according to Marelli, and offer much potential.

      “I believe that with this technology, together with the common efforts shared by the MIT PIs participating in the Climate Grand Challenge on Revolutionizing Agriculture, we have a  real opportunity to positively impact planetary health and find new solutions that work in both rural settings and highly modernized agricultural fields,” says Marelli, who recently earned tenure.

      As a researcher and entrepreneur with about 20 patents to his name and awards including a National Science Foundation CAREER award, the Presidential Early Career Award for Scientists and Engineers award, and the Ole Madsen Mentoring Award, Marelli says that in general his insights into structural proteins — and how to use that understanding to manufacture advanced materials at multiple scales — are among his proudest achievements.

      More specifically, Marelli cites one of his breakthroughs involving a strawberry. Having dipped the berry in an odorless, tasteless edible silk suspension as part of a cooking contest held in his postdoctoral lab, he accidentally left it on his bench, only to find a week or so later that it had been well-preserved.

      “The coating of the strawberry to increase its shelf life is difficult to beat when it comes to inspiring people that natural polymers can serve as technical materials that can positively impact our society” by lessening food waste and the need for energy-intensive refrigerated shipping, Marelli says.

      When Marelli won the BioInnovation Institute and Science Prize for Innovation in 2022, he told the journal Science that he thinks students should be encouraged to choose an entrepreneurial path. He acknowledged the steepness of the learning curve of being an entrepreneur but also pointed out how the impact of research can be exponentially increased.

      He expanded on this idea more recently.

      “I believe an increasing number of academics and graduate students should try to get their hands ‘dirty’ with entrepreneurial efforts. We live in a time where academics are called to have a tangible impact on our society, and translating what we study in our labs is clearly a good way to employ our students and enhance the global effort to develop new technology that can make our society more sustainable and equitable,” Marelli says.

      Referring to a spinoff company, Mori, that grew out of the coated strawberry discovery and that develops silk-based products to preserve a wide range of perishable foods, Marelli says he finds it very satisfying to know that Mori has a product on the market that came out of his research efforts — and that 80 people are working to translate the discovery from “lab to fork.”

      “Knowing that the technology can move the needle in crises such as food waste and food-related environmental impact is the highest reward of all,” he says.

      Marelli says he tells students who are seeking solutions to extremely complicated problems to come up with one solution, “however crazy it might be,” and then do an extensive literature review to see what other researchers have done and whether “there is any hint that points toward developing their solution.”

      “Once we understand the feasibility, I typically work with them to simplify it as much as we can, and then to break down the problem in small parts that are addressable in series and/or in parallel,” Marelli says.

      That process of discovery is ongoing. Asked which of his technologies will have the greatest impact on the world, Marelli says, “I’d like to think it’s the ones that still need to be discovered.” More

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      in Security

      Microbes could help reduce the need for chemical fertilizers

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      Production of chemical fertilizers accounts for about 1.5 percent of the world’s greenhouse gas emissions. MIT chemists hope to help reduce that carbon footprint by replacing some chemical fertilizer with a more sustainable source — bacteria.

      Bacteria that can convert nitrogen gas to ammonia could not only provide nutrients that plants need, but also help regenerate soil and protect plants from pests. However, these bacteria are sensitive to heat and humidity, so it’s difficult to scale up their manufacture and ship them to farms.

      To overcome that obstacle, MIT chemical engineers have devised a metal-organic coating that protects bacterial cells from damage without impeding their growth or function. In a new study, they found that these coated bacteria improved the germination rate of a variety of seeds, including vegetables such as corn and bok choy.

      This coating could make it much easier for farmers to deploy microbes as fertilizers, says Ariel Furst, the Paul M. Cook Career Development Assistant Professor of Chemical Engineering at MIT and the senior author of the study.

      “We can protect them from the drying process, which would allow us to distribute them much more easily and with less cost because they’re a dried powder instead of in liquid,” she says. “They can also withstand heat up to 132 degrees Fahrenheit, which means that you wouldn’t have to use cold storage for these microbes.”

      Benjamin Burke ’23 and postdoc Gang Fan are the lead authors of the open-access paper, which appears in the Journal of the American Chemical Society Au. MIT undergraduate Pris Wasuwanich and Evan Moore ’23 are also authors of the study.

      Protecting microbes

      Chemical fertilizers are manufactured using an energy-intensive process known as Haber-Bosch, which uses extremely high pressures to combine nitrogen from the air with hydrogen to make ammonia.

      In addition to the significant carbon footprint of this process, another drawback to chemical fertilizers is that long-term use eventually depletes the nutrients in the soil. To help restore soil, some farmers have turned to “regenerative agriculture,” which uses a variety of strategies, including crop rotation and composting, to keep soil healthy. Nitrogen-fixing bacteria, which convert nitrogen gas to ammonia, can aid in this approach.

      Some farmers have already begun deploying these “microbial fertilizers,” growing them in large onsite fermenters before applying them to the soil. However, this is cost-prohibitive for many farmers.

      Shipping these bacteria to rural areas is not currently a viable option, because they are susceptible to heat damage. The microbes are also too delicate to survive the freeze-drying process that would make them easier to transport.

      To protect the microbes from both heat and freeze-drying, Furst decided to apply a coating called a metal-phenol network (MPN), which she has previously developed to encapsulate microbes for other uses, such as protecting therapeutic bacteria delivered to the digestive tract.

      The coatings contain two components — a metal and an organic compound called a polyphenol — that can self-assemble into a protective shell. The metals used for the coatings, including iron, manganese, aluminum, and zinc, are considered safe as food additives. Polyphenols, which are often found in plants, include molecules such as tannins and other antioxidants. The FDA classifies many of these polyphenols as GRAS (generally regarded as safe).

      “We are using these natural food-grade compounds that are known to have benefits on their own, and then they form these little suits of armor that protect the microbes,” Furst says.

      For this study, the researchers created 12 different MPNs and used them to encapsulate Pseudomonas chlororaphis, a nitrogen-fixing bacterium that also protects plants against harmful fungi and other pests. They found that all of the coatings protected the bacteria from temperatures up to 50 degrees Celsius (122 degrees Fahrenheit), and also from relative humidity up to 48 percent. The coatings also kept the microbes alive during the freeze-drying process.

      A boost for seeds

      Using microbes coated with the most effective MPN — a combination of manganese and a polyphenol called epigallocatechin gallate (EGCG) — the researchers tested their ability to help seeds germinate in a lab dish. They heated the coated microbes to 50 C before placing them in the dish, and compared them to fresh uncoated microbes and freeze-dried uncoated microbes.

      The researchers found that the coated microbes improved the seeds’ germination rate by 150 percent, compared to seeds treated with fresh, uncoated microbes. This result was consistent across several different types of seeds, including dill, corn, radishes, and bok choy.

      Furst has started a company called Seia Bio to commercialize the coated bacteria for large-scale use in regenerative agriculture. She hopes that the low cost of the manufacturing process will help make microbial fertilizers accessible to small-scale farmers who don’t have the fermenters needed to grow such microbes.

      “When we think about developing technology, we need to intentionally design it to be inexpensive and accessible, and that’s what this technology is. It would help democratize regenerative agriculture,” she says.

      The research was funded by the Army Research Office, a National Institutes of Health New Innovator Award, a National Institute for Environmental Health Sciences Core Center Grant, the CIFAR Azrieli Global Scholars Program, the MIT J-WAFS Program, the MIT Climate and Sustainability Consortium, and the MIT Deshpande Center. More

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      in Security

      “Move-in day is kind of like our Superbowl”

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      The academic year has officially begun at MIT, and the halls are once again filled with the energy and excitement that only students can bring. But MIT’s campus does not come to life automatically.

      The flurry of activity happening around campus this week was preceded by a lot of hard work by thousands of staff members committed to getting the school year off to a seamless start.

      “Getting MIT ready to welcome new and returning students is a real team effort, and much of the work goes on over the summer or behind the scenes when many students are away from campus,” says Suzy Nelson, vice chancellor and dean for student life. “I’m grateful to all of the staff members in the Division of Student Life and across the Institute whose dedication to their job and exceptional efforts help to make the MIT experience so special from the moment students arrive on campus.”

      Describing all of those efforts would require a book-length article, but here we highlight a few examples of the behind-the-scenes work that ushers in the new academic year.

      Housing and Residential Services

      One might think the team responsible for housing at MIT gets a break in June and July when undergraduates leave for the summer. But the housing team stays busy year-round. Summer months offer openings for renovations, planning, and events like summer programs and conferences (some of which provide housing). In fact, team members say the planning alone is nearly a year-round job.

      “We start planning for students coming back in May because first-year students are confirming attendance and starting to indicate their preferences for where they want to live, and housing works really closely with student leaders in each of the undergrad residences because our student leaders are very involved with room assignments,” explains Rich Hilton, associate dean and director for residential services and operations. “On the graduate side, grads typically move in Aug. 1, and departing grad students move out at the end of July, or sometimes earlier, so in those early summer months there’s a lot of transitioning happening.”

      Of course, move-in day for undergraduates and the subsequent Welcome Week are an important time for the Housing and Residential Services team to help the MIT community’s newest members settle in.

      “Move-in day is kind of like our Superbowl,” Hilton says. “All the summer projects we work on are to prepare and maintain the residence halls for new and returning students to be living in the residence halls. The ramp-up involves making sure the residences are refreshed and ready, and the welcome efforts include providing moving bins, materials, and moving assistance. For students who have never been to campus before, residential staff are often the first people they meet, so we want to put a really good impression out there. We pull out all the stops to make sure that welcome efforts are top-notch.”

      Hilton says the atmosphere is always special on move in day.

      “The students are a wonderful motivation,” Hilton says. “It’s great seeing the new students come in with their families. Students are coming from all corners of the world, from different backgrounds, and more often than not the parents are just beaming with pride, so being able to greet them and even reassure them if needed is really rewarding.”

      In all, MIT Housing and Residential Services employs more than 200 people focused on assignments, maintenance, cleaning, residential security, and more, to make living on campus as enjoyable as possible.

      “Housing truly is 24/7, 365,” Hilton says. “Our team members are on campus keeping our residents safe and happy and serving them 24 hours a day. They’re here rain or shine, and it’s nice to keep them in mind.”

      Dining

      MIT Dining works with students to offer healthy, affordable, and culturally meaningful food in environments that promote social connections, sustainability, and innovation. The department oversees nine different third-party contractors to provide services across 20+ locations — and MIT’s own dining staff consists of just two people: Director of Campus Dining Mark Hayes and Assistant Director of Dining Operations Heather Ryall.

      Typical summer months provide an opportunity for the small team to look at food trends, work with dieticians and food allergy specialists, review menus, and explore ways to improve operations. This summer was even busier thanks to renovations at the Stratton Student Center and Maseeh Hall and the introduction of new food stations in CommonWealth Kitchen and at Forbes Café.

      In August, MIT Dining makes sure it has established open lines of communication with new student leaders and other groups around campus

      “We interact with a lot of student groups this time of year,” Hayes says. “It’s exciting to start with a new group of students and get feedback, collaborating and sharing ideas. It reminds us of what we’re here for: students. If things are working, that’s great! If they’re not working, let’s collaborate and figure out what can we do better — let’s make it a pset [problem set]. What are we not doing that we should be? I’ve been lucky in that students at MIT are really engaged.”

      “August is when everyone wants to get together and make sure we’re starting off on the right foot,” Hayes says. “That two-way flow of information is what it’s all about, and it’s really strong here.”

      Some dining locations stay open through the summer to support grad students, faculty and staff, but residential dining halls shut down. By August, some international students and athletes begin moving back to campus. Then Welcome Week begins for first-year students. Then pretty much everyone else returns over Labor Day Weekend.

      “In a way, you go from almost zero to 100,” Hayes says.

      This academic year, DSL will undertake a thorough review of the residence hall dining program, gathering student and community input on enhancements. This follows a similar review of campus retail dining operations completed in December 2022.

      Student Support and Wellbeing

      The Student Support and Wellbeing team, co-led by Associate Dean and Senior Director Jimmy Doan, offers a slate of resources to make it easy for students to seek help if they need it, and to encourage students to take care of themselves throughout their time at MIT. The team also coordinates with faculty, staff, and student groups across the Institute to foster an environment where students’ sense of belonging and well-being is prioritized.

      Ahead of the new school year, team members have been sharing with faculty best practices for fostering student well-being in the classroom and labs, including presenting workshops to new faculty members to inform them of resources to use when they’re concerned about students.

      They have also been connecting with student leaders so they can help their peers prioritize well-being. “Come early August, we’re facilitating a lot of trainings and gearing up for new student orientation programs.” Doan says. “We’re working with a lot of student leaders this time of year. We know students learn as much from each other as they do from us.”

      New student orientation offers a chance to provide a week’s worth of programming to incoming first-year students. In one of those sessions, Dear Future Me, older students share their perspectives on prioritizing well-being and accessing support at MIT.

      “We try to normalize students getting help at MIT when they need it,” Doan says. “Starting from day one of orientation we tell them getting help is for everybody.”

      One office where nearly 80 percent of undergraduate students seek out help before they graduate is Student Support Services, more commonly known as “S3” or “S-Cubed.” The staff in S3 are preparing for the start of the year by revamping their virtual drop-in hours for students, which students can access from the S3 website.

      “We want the ways that students reach out for help to be as accessible as possible,” Doan says. More

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      in Security

      Tiny magnetic beads produce an optical signal that could be used to quickly detect pathogens

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      Getting results from a blood test can take anywhere from one day to a week, depending on what a test is targeting. The same goes for tests of water pollution and food contamination. And in most cases, the wait time has to do with time-consuming steps in sample processing and analysis.

      Now, MIT engineers have identified a new optical signature in a widely used class of magnetic beads, which could be used to quickly detect contaminants in a variety of diagnostic tests. For example, the team showed the signature could be used to detect signs of the food contaminant Salmonella.

      The so-called Dynabeads are microscopic magnetic beads that can be coated with antibodies that bind to target molecules, such as a specific pathogen. Dynabeads are typically used in experiments in which they are mixed into solutions to capture molecules of interest. But from there, scientists have to take additional, time-consuming steps to confirm that the molecules are indeed present and bound to the beads.

      The MIT team found a faster way to confirm the presence of Dynabead-bound pathogens, using optics, specifically, Raman spectroscopy. This optical technique identifies specific molecules based on their “Raman signature,” or the unique way in which a molecule scatters light.

      The researchers found that Dynabeads have an unusually strong Raman signature that can be easily detected, much like a fluorescent tag. This signature, they found, can act as a “reporter.” If detected, the signal can serve as a quick confirmation, within less than one second, that a target pathogen is indeed present in a given sample. The team is currently working to develop a portable device for quickly detecting a range of bacterial pathogens, and their results will appear in an Emerging Investigators special issue of the Journal of Raman Spectroscopy.

      “This technique would be useful in a situation where a doctor is trying to narrow down the source of an infection in order to better inform antibiotic prescription, as well as for the detection of known pathogens in food and water,” says study co-author Marissa McDonald, a graduate student in the Harvard-MIT Program in Health Sciences and Technology. “Additionally, we hope this approach will eventually lead to expanded access to advanced diagnostics in resource-limited environments.”

      Study co-authors at MIT include Postdoctoral Associate Jongwan Lee; Visiting Scholar Nikiwe Mhlanga; Research Scientist Jeon Woong Kang; Tata Professor Rohit Karnik, who is also the associate director of the Abdul Latif Jameel Water and Food Systems Lab; and Assistant Professor Loza Tadesse of the Department of Mechanical Engineering.

      Oil and water

      Looking for diseased cells and pathogens in fluid samples is an exercise in patience.

      “It’s kind of a needle-in-a-haystack problem,” Tadesse says.

      The numbers present are so small that they must be grown in controlled environments to sufficient numbers, and their cultures stained, then studied under a microscope. The entire process can take several days to a week to yield a confident positive or negative result.

      Both Karnik and Tadesse’s labs have independently been developing techniques to speed up various parts of the pathogen testing process and make the process portable, using Dynabeads.

      Dynabeads are commercially available microscopic beads made from a magnetic iron core and a polymer shell that can be coated with antibodies. The surface antibodies act as hooks to bind specific target molecules. When mixed with a fluid, such as a vial of blood or water, any molecules present will glom onto the Dynabeads. Using a magnet, scientists can gently coax the beads to the bottom of a vial and filter them out of a solution. Karnik’s lab is investigating ways to then further separate the beads into those that are bound to a target molecule, and those that are not. “Still, the challenge is, how do we know that we have what we’re looking for?” Tadesse says.

      The beads themselves are not visible by eye. That’s where Tadesse’s work comes in. Her lab uses Raman spectroscopy as a way to “fingerprint” pathogens. She has found that different cell types scatter light in unique ways that can be used as a signature to identify them.

      In the team’s new work, she and her colleagues found that Dynabeads also have a unique and strong Raman signature that can act as a surprisingly clear beacon.

      “We were initially seeking to identify the signatures of bacteria, but the signature of the Dynabeads was actually very strong,” Tadesse says. “We realized this signal could be a means of reporting to you whether you have that bacteria or not.”

      Testing beacon

      As a practical demonstration, the researchers mixed Dynabeads into vials of water contaminated with Salmonella. They then magnetically isolated these beads onto microscope slides and measured the way light scattered through the fluid when exposed to laser light. Within half a second, they quickly detected the Dynabeads’ Raman signature — a confirmation that bound Dynabeads, and by inference, Salmonella, were present in the fluid.

      “This is something that can be used to rapidly give a positive or negative answer: Is there a contaminant or not?” Tadesse says. “Because even a handful of pathogens can cause clinical symptoms.”

      The team’s new technique is significantly faster than conventional methods and uses elements that could be adapted into smaller, more portable forms — a goal that the researchers are currently working toward. The approach is also highly versatile.

      “Salmonella is the proof of concept,” Tadesse says. “You could purchase Dynabeads with E.coli antibodies, and the same thing would happen: It would bind to the bacteria, and we’d be able to detect the Dynabead signature because the signal is super strong.”

      The team is particularly keen to apply the test to conditions such as sepsis, where time is of the essence, and where pathogens that trigger the condition are not rapidly detected using conventional lab tests.

      “There are a lot cases, like in sepsis, where pathogenic cells cannot always be grown on a plate,” says Lee, a member of Karnik’s lab. “In that case, our technique could rapidly detect these pathogens.”

      This research was supported, in part, by the MIT Laser Biomedical Research Center, the National Cancer Institute, and the Abdul Latif Jameel Water and Food Systems Lab at MIT. More

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      in Energy

      Addressing food insecurity in arid regions with an open-source evaporative cooling chamber design

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      Anyone who has ever perspired on a hot summer day understands the principle — and critical value — of evaporative cooling. Our bodies produce droplets of sweat when we overheat, and with a dry breeze or nearby fan those droplets will evaporate, absorbing heat in the process creating a welcome cool feeling.

      That same scientific principle, known as evaporative cooling, can be a game-changer for preserving fruits and vegetables grown on smallholder farms, where the wilting dry heat can quickly degrade freshly harvested produce. If those just-picked red peppers and leafy greens are not consumed in short order, or quickly transferred to cold — or at least cool — storage, much of it can go to waste.

      Now, MIT Professor Leon Glicksman of the Building Technology Program within the Department of Architecture, and Research Engineer Eric Verploegen of MIT D-Lab have released their open-source design for a forced-air evaporative cooling chamber that can be built in a used shipping container and powered by either grid electricity or built-in solar panels. With a capacity of 168 produce crates, the chamber offers great promise for smallholder farmers in hot, dry climates who need an affordable method for quickly bringing down the temperature of freshly harvested fruit and vegetables to ensure they stay fresh.

      “Delicate fruits and vegetables are most vulnerable to spoilage if they are picked during the day,” says Verploegen, a longtime proponent of using evaporative cooling to reduce post-harvest waste. “And if refrigerated cold rooms aren’t feasible or affordable,” he continues, “evaporative cooling can make a big difference for farmers and the communities they feed.”

      Verploegen has made evaporative cooling the focus of his work since 2016, initially focusing on small-scale evaporative cooling “Zeer” pots, typically with a capacity between 10 and 100 liters and great for household use, as well as larger double-brick-walled chambers known as zero-energy cooling chambers or ZECCs, which can store between six and 16 vegetable crates at a time. These designs rely on passive airflow. The newly released design for the forced-air evaporative cooling chamber is differentiated from these two more modest designs by the active airflow system, as well as by significantly larger capacity.

      In 2019, Verploegen turned his attention to the idea of building a larger evaporative cooling room and joined forces with Glicksman to explore using forced, instead of passive, airflow to cool fruit and vegetables. After studying existing cold storage options and conducting user research with farmers in Kenya, they came up with the idea to use active evaporative cooling with a used shipping container as the structure of the chamber. As the Covid-19 pandemic was ramping up in 2020, they procured a used 10-foot shipping container, installed it in the courtyard area outside D-Lab near Village Street, and went to work on a prototype of the forced-air evaporative cooling chamber.

      Here’s how it works: Industrial fans draw hot, dry air into the chamber, which is passed through a porous wet pad. The resulting cool and humid air is then forced through the crates of fruits and vegetables stored inside the chamber. The air is then directed through the raised floor and to a channel between the insulation and the exterior container wall, where it flows to the exhaust holes near the top of the side walls.

      Leon Glicksman, a professor of building technology and mechanical engineering, drew on his previous research in natural ventilation and airflow in buildings to come up with the vertical forced-air design pattern for the chamber. “The key to the design is the close control of the airflow strength, and its direction,” he says. “The strength of the airflow passing directly through the crates of fruits and vegetables, and the airflow pathway itself, are what makes this system work so well. The design promotes rapid cooling of a harvest taken directly from the field.”

      In addition to the novel and effective airflow system, the forced-air evaporative cooling chamber represents so much of what D-Lab is known for in its work in low-resourced and off-grid communities: developing low-cost and low-carbon-footprint technologies with partners. Evaporative cooling is no different. Whether connected to the electrical grid or run from solar panels, the forced-air chamber consumes one-quarter the power of refrigerated cold rooms. And, as the chamber is designed to be built in a used shipping container — ubiquitous the world over — the project is a great example of up-cycling.

      Piloting the design

      As with earlier investigations, Verploegen, Glicksman, and their colleagues have worked closely with farmers and community members. For the forced-air system, the team engaged with community partners who are living the need for better cooling and storage conditions for their produce in the climate conditions where evaporative cooling works best. Two partners, one in Kenya and one in India, each built a pilot chamber, testing and informing the process alongside the work being done at MIT.

      In Kenya, where smallholder farms produce 63 percent of total food consumed and over 50 percent of smallholder produce is lost post-harvest, they worked with Solar Freeze, a cold storage company located in in Kibwezi, Kenya. Solar Freeze, whose founder Dysmus Kisilu was a 2019 MIT D-Lab Scale-Ups Fellow, built an off-grid forced-air evaporative cooling chamber at a produce market between Nairobi and Mombasa at a cost of $15,000, powered by solar photovoltaic panels. “The chamber is offering a safety net against huge post-harvest losses previously experienced by local smallholder farmers,” comments Peter Mumo, an entrepreneur and local politician who oversaw the construction of the Solar Freeze chamber in Makuni County, Kenya.

      As much as 30 percent of fruits and vegetables produced in India are wasted each year due to insufficient cold storage capacity, lack of cold storage close to farms, poor transportation infrastructure, and other gaps in the cold chain. Although the climate varies across the subcontinent, the hot desert climate there, such as in Bhuj where the Hunnarshala Foundation is headquartered, is perfect for evaporative cooling. Hunnarshala signed on to build an on-grid system for $8,100, which they located at an organic farm near Bhuj. “We have really encouraging results,” says Mahavir Acharya, executive director of Hunnarshala Foundation. “In peak summer, when the temperature is 42 [Celsius] we are able to get to 26 degrees [Celsius] inside and 95 percent humidity, which is really good conditions for vegetables to remain fresh for three, four, five, six days. In winter we tested [and saw temperatures reduced from] 35 degrees to 24 degrees [Celsius], and for seven days the quality was quite good.”

      Getting the word out

      With the concept validated and pilots well established, the next step is spreading the word.

      “We’re continuing to test and optimize the system, both in Kenya and India, as well as our test chambers here at MIT,” says Verploegen. “We will continue piloting with users and deploying with farmers and vendors, gathering data on the thermal performance, the shelf life of fruits and vegetables in the chamber, and how using the technology impacts the users. And, we’re also looking to engage with cold storage providers who might want to build this or others in the horticulture value chain such as farmer cooperatives, individual farmers, and local governments.”

      To reach the widest number of potential users, Verploegen and the team chose not to pursue a patent and instead set up a website to disseminate the open-source design with detailed guidance on how to build a forced-air evaporative cooling chamber. In addition to the extensive printed documentation, well-illustrated with detailed CAD drawings and video, the team has created instructional videos.

      As co-principal investigator in the early stages of the project, MIT professor of mechanical engineering Dan Frey contributed to the market research phase of the project and the initial conception of chamber design. “These forced-air evaporative cooling chambers have great potential, and the open-source approach is an excellent choice for this project,” says Frey. “The design’s release is a significant milestone on the path to positive impacts.”

      The forced-air evaporative cooling chamber research and design have been supported by the Abdul Latif Jameel Water and Food Systems Lab through an India Grant, Seed Grant, and a Solutions Grant. More

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      in Security

      System tracks movement of food through global humanitarian supply chain

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      Although more than enough food is produced to feed everyone in the world, as many as 828 million people face hunger today. Poverty, social inequity, climate change, natural disasters, and political conflicts all contribute to inhibiting access to food. For decades, the U.S. Agency for International Development (USAID) Bureau for Humanitarian Assistance (BHA) has been a leader in global food assistance, supplying millions of metric tons of food to recipients worldwide. Alleviating hunger — and the conflict and instability hunger causes — is critical to U.S. national security.

      But BHA is only one player within a large, complex supply chain in which food gets handed off between more than 100 partner organizations before reaching its final destination. Traditionally, the movement of food through the supply chain has been a black-box operation, with stakeholders largely out of the loop about what happens to the food once it leaves their custody. This lack of direct visibility into operations is due to siloed data repositories, insufficient data sharing among stakeholders, and different data formats that operators must manually sort through and standardize. As a result, accurate, real-time information — such as where food shipments are at any given time, which shipments are affected by delays or food recalls, and when shipments have arrived at their final destination — is lacking. A centralized system capable of tracing food along its entire journey, from manufacture through delivery, would enable a more effective humanitarian response to food-aid needs.

      In 2020, a team from MIT Lincoln Laboratory began engaging with BHA to create an intelligent dashboard for their supply-chain operations. This dashboard brings together the expansive food-aid datasets from BHA’s existing systems into a single platform, with tools for visualizing and analyzing the data. When the team started developing the dashboard, they quickly realized the need for considerably more data than BHA had access to.

      “That’s where traceability comes in, with each handoff partner contributing key pieces of information as food moves through the supply chain,” explains Megan Richardson, a researcher in the laboratory’s Humanitarian Assistance and Disaster Relief Systems Group.

      Richardson and the rest of the team have been working with BHA and their partners to scope, build, and implement such an end-to-end traceability system. This system consists of serialized, unique identifiers (IDs) — akin to fingerprints — that are assigned to individual food items at the time they are produced. These individual IDs remain linked to items as they are aggregated along the supply chain, first domestically and then internationally. For example, individually tagged cans of vegetable oil get packaged into cartons; cartons are placed onto pallets and transported via railway and truck to warehouses; pallets are loaded onto shipping containers at U.S. ports; and pallets are unloaded and cartons are unpackaged overseas.

      With a trace

      Today, visibility at the single-item level doesn’t exist. Most suppliers mark pallets with a lot number (a lot is a batch of items produced in the same run), but this is for internal purposes (i.e., to track issues stemming back to their production supply, like over-enriched ingredients or machinery malfunction), not data sharing. So, organizations know which supplier lot a pallet and carton are associated with, but they can’t track the unique history of an individual carton or item within that pallet. As the lots move further downstream toward their final destination, they are often mixed with lots from other productions, and possibly other commodity types altogether, because of space constraints. On the international side, such mixing and the lack of granularity make it difficult to quickly pull commodities out of the supply chain if food safety concerns arise. Current response times can span several months.

      “Commodities are grouped differently at different stages of the supply chain, so it is logical to track them in those groupings where needed,” Richardson says. “Our item-level granularity serves as a form of Rosetta Stone to enable stakeholders to efficiently communicate throughout these stages. We’re trying to enable a way to track not only the movement of commodities, including through their lot information, but also any problems arising independent of lot, like exposure to high humidity levels in a warehouse. Right now, we have no way to associate commodities with histories that may have resulted in an issue.”

      “You can now track your checked luggage across the world and the fish on your dinner plate,” adds Brice MacLaren, also a researcher in the laboratory’s Humanitarian Assistance and Disaster Relief Systems Group. “So, this technology isn’t new, but it’s new to BHA as they evolve their methodology for commodity tracing. The traceability system needs to be versatile, working across a wide variety of operators who take custody of the commodity along the supply chain and fitting into their existing best practices.”

      As food products make their way through the supply chain, operators at each receiving point would be able to scan these IDs via a Lincoln Laboratory-developed mobile application (app) to indicate a product’s current location and transaction status — for example, that it is en route on a particular shipping container or stored in a certain warehouse. This information would get uploaded to a secure traceability server. By scanning a product, operators would also see its history up until that point.   

      Hitting the mark

      At the laboratory, the team tested the feasibility of their traceability technology, exploring different ways to mark and scan items. In their testing, they considered barcodes and radio-frequency identification (RFID) tags and handheld and fixed scanners. Their analysis revealed 2D barcodes (specifically data matrices) and smartphone-based scanners were the most feasible options in terms of how the technology works and how it fits into existing operations and infrastructure.

      “We needed to come up with a solution that would be practical and sustainable in the field,” MacLaren says. “While scanners can automatically read any RFID tags in close proximity as someone is walking by, they can’t discriminate exactly where the tags are coming from. RFID is expensive, and it’s hard to read commodities in bulk. On the other hand, a phone can scan a barcode on a particular box and tell you that code goes with that box. The challenge then becomes figuring out how to present the codes for people to easily scan without significantly interrupting their usual processes for handling and moving commodities.” 

      As the team learned from partner representatives in Kenya and Djibouti, offloading at the ports is a chaotic, fast operation. At manual warehouses, porters fling bags over their shoulders or stack cartons atop their heads any which way they can and run them to a drop point; at bagging terminals, commodities come down a conveyor belt and land this way or that way. With this variability comes several questions: How many barcodes do you need on an item? Where should they be placed? What size should they be? What will they cost? The laboratory team is considering these questions, keeping in mind that the answers will vary depending on the type of commodity; vegetable oil cartons will have different specifications than, say, 50-kilogram bags of wheat or peas.

      Leaving a mark

      Leveraging results from their testing and insights from international partners, the team has been running a traceability pilot evaluating how their proposed system meshes with real-world domestic and international operations. The current pilot features a domestic component in Houston, Texas, and an international component in Ethiopia, and focuses on tracking individual cartons of vegetable oil and identifying damaged cans. The Ethiopian team with Catholic Relief Services recently received a container filled with pallets of uniquely barcoded cartons of vegetable oil cans (in the next pilot, the cans will be barcoded, too). They are now scanning items and collecting data on product damage by using smartphones with the laboratory-developed mobile traceability app on which they were trained. 

      “The partners in Ethiopia are comparing a couple lid types to determine whether some are more resilient than others,” Richardson says. “With the app — which is designed to scan commodities, collect transaction data, and keep history — the partners can take pictures of damaged cans and see if a trend with the lid type emerges.”

      Next, the team will run a series of pilots with the World Food Program (WFP), the world’s largest humanitarian organization. The first pilot will focus on data connectivity and interoperability, and the team will engage with suppliers to directly print barcodes on individual commodities instead of applying barcode labels to packaging, as they did in the initial feasibility testing. The WFP will provide input on which of their operations are best suited for testing the traceability system, considering factors like the network bandwidth of WFP staff and local partners, the commodity types being distributed, and the country context for scanning. The BHA will likely also prioritize locations for system testing.

      “Our goal is to provide an infrastructure to enable as close to real-time data exchange as possible between all parties, given intermittent power and connectivity in these environments,” MacLaren says.

      In subsequent pilots, the team will try to integrate their approach with existing systems that partners rely on for tracking procurements, inventory, and movement of commodities under their custody so that this information is automatically pushed to the traceability server. The team also hopes to add a capability for real-time alerting of statuses, like the departure and arrival of commodities at a port or the exposure of unclaimed commodities to the elements. Real-time alerts would enable stakeholders to more efficiently respond to food-safety events. Currently, partners are forced to take a conservative approach, pulling out more commodities from the supply chain than are actually suspect, to reduce risk of harm. Both BHA and WHP are interested in testing out a food-safety event during one of the pilots to see how the traceability system works in enabling rapid communication response.

      To implement this technology at scale will require some standardization for marking different commodity types as well as give and take among the partners on best practices for handling commodities. It will also require an understanding of country regulations and partner interactions with subcontractors, government entities, and other stakeholders.

      “Within several years, I think it’s possible for BHA to use our system to mark and trace all their food procured in the United States and sent internationally,” MacLaren says.

      Once collected, the trove of traceability data could be harnessed for other purposes, among them analyzing historical trends, predicting future demand, and assessing the carbon footprint of commodity transport. In the future, a similar traceability system could scale for nonfood items, including medical supplies distributed to disaster victims, resources like generators and water trucks localized in emergency-response scenarios, and vaccines administered during pandemics. Several groups at the laboratory are also interested in such a system to track items such as tools deployed in space or equipment people carry through different operational environments.

      “When we first started this program, colleagues were asking why the laboratory was involved in simple tasks like making a dashboard, marking items with barcodes, and using hand scanners,” MacLaren says. “Our impact here isn’t about the technology; it’s about providing a strategy for coordinated food-aid response and successfully implementing that strategy. Most importantly, it’s about people getting fed.” More

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      in Security

      Exploring the links between diet and cancer

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      Every three to five days, all of the cells lining the human intestine are replaced. That constant replenishment of cells helps the intestinal lining withstand the damage caused by food passing through the digestive tract.

      This rapid turnover of cells relies on intestinal stem cells, which give rise to all of the other types of cells found in the intestine. Recent research has shown that those stem cells are heavily influenced by diet, which can help keep them healthy or stimulate them to become cancerous.

      “Low-calorie diets such as fasting and caloric restriction can have antiaging effects and antitumor effects, and we want to understand why that is. On the other hand, diets that lead to obesity can promote diseases of aging, such as cancer,” says Omer Yilmaz, the Eisen and Chang Career Development Associate Professor of Biology at MIT.

      For the past decade, Yilmaz has been studying how different diets and environmental conditions affect intestinal stem cells, and how those factors can increase the risk of cancer and other diseases. This work could help researchers develop new ways to improve gastrointestinal health, either through dietary interventions or drugs that mimic the beneficial effects of certain diets, he says. 

      “Our findings have raised the possibility that fasting interventions, or small molecules that mimic the effects of fasting, might have a role in improving intestinal regeneration,” says Yilmaz, who is also a member of MIT’s Koch Institute for Integrative Cancer Research.

      A clinical approach

      Yilmaz’s interest in disease and medicine arose at an early age. His father practiced internal medicine, and Yilmaz spent a great deal of time at his father’s office after school, or tagging along at the hospital where his father saw patients.

      “I was very interested in medicines and how medicines were used to treat diseases,” Yilmaz recalls. “He’d ask me questions, and many times I wouldn’t know the answer, but he would encourage me to figure out the answers to his questions. That really stimulated my interest in biology and in wanting to become a doctor.”

      Knowing that he wanted to go into medicine, Yilmaz applied and was accepted to an eight-year, combined bachelor’s and MD program at the University of Michigan. As an undergraduate, this gave him the freedom to explore areas of interest without worrying about applying to medical school. While majoring in biochemistry and physics, he did undergraduate research in the field of protein folding.

      During his first year of medical school, Yilmaz realized that he missed doing research, so he decided to apply to the MD/PhD program at the University of Michigan. For his PhD research, he studied blood-forming stem cells and identified new markers that allowed such cells to be more easily isolated from the bone marrow.

      “This was important because there’s a lot of interest in understanding what makes a stem cell a stem cell, and how much of it is an internal program versus signals from the microenvironment,” Yilmaz says.

      After finishing his PhD and MD, he thought about going straight into research and skipping a medical residency, but ended up doing a residency in pathology at Massachusetts General Hospital. During that time, he decided to switch his research focus from blood-forming stem cells to stem cells found in the gastrointestinal tract.

      “The GI tract seemed very interesting because in contrast to the bone marrow, we knew very little about the identity of GI stem cells,” Yilmaz says. “I knew that once GI stem cells were identified, there’d be a lot of interesting questions about how they respond to diet and how they respond to other environmental stimuli.”

      Dietary questions

      To delve into those questions, Yilmaz did postdoctoral research at the Whitehead Institute, where he began investigating the connections between stem cells, metabolism, diet, and cancer.

      Because intestinal stem cells are so long-lived, they are more likely to accumulate genetic mutations that make them susceptible to becoming cancerous. At the Whitehead Institute, Yilmaz began studying how different diets might influence this vulnerability to cancer, a topic that he carried into his lab at MIT when he joined the faculty in 2014.

      One question his lab has been exploring is why low-calorie diets often have protective effects, including a boost in longevity — a phenomenon that has been seen in many studies in animals and humans.

      In a 2018 study, his lab found that a 24-hour fast dramatically improves stem cells’ ability to regenerate. This effect was seen in both young and aged mice, suggesting that even in old age, fasting or drugs that mimic the effects of fasting could have a beneficial effect.

      On the flip side, Yilmaz is also interested in why a high-fat diet appears to promote the development of cancer, especially colorectal cancer. In a 2016 study, he found that when mice consume a high-fat diet, it triggers a significant increase in the number of intestinal stem cells. Also, some non-stem-cell populations begin to resemble stem cells in their behavior. “The upshot of these changes is that both stem cells and non-stem-cells can give rise to tumors in a high-fat diet state,” Yilmaz says.

      To help with these studies, Yilmaz’s lab has developed a way to use mouse or human intestinal stem cells to generate miniature intestines or colons in cell culture. These “organoids” can then be exposed to different nutrients in a very controlled setting, allowing researchers to analyze how different diets affect the system.

      Recently, his lab adapted the system to allow them to expand their studies to include the role of immune cells, fibroblasts, and other supportive cells found in the microenvironment of stem cells. “It would be remiss of us to focus on just one cell type,” Yilmaz says. “We’re looking at how these different dietary interventions impact the entire stem cell neighborhood.”

      While Yilmaz spends most of his time running his lab at MIT, he also devotes six to eight weeks per year to his work at MGH, where he is an associate pathologist focusing on gastrointestinal pathology.

      “I enjoy my clinical work, and it always reminds me about the importance of the research we do,” he says. “Seeing colon cancer and other GI cancers under the microscope, and seeing their complexity, reminds me of the importance of our mission to figure out how we can prevent these cancers from forming.” More

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      in Environment

      J-WAFS announces 2023 seed grant recipients

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      Today, the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) announced its ninth round of seed grants to support innovative research projects at MIT. The grants are designed to fund research efforts that tackle challenges related to water and food for human use, with the ultimate goal of creating meaningful impact as the world population continues to grow and the planet undergoes significant climate and environmental changes.Ten new projects led by 15 researchers from seven different departments will be supported this year. The projects address a range of challenges by employing advanced materials, technology innovations, and new approaches to resource management. The new projects aim to remove harmful chemicals from water sources, develop monitoring and other systems to help manage various aquaculture industries, optimize water purification materials, and more.“The seed grant program is J-WAFS’ flagship grant initiative,” says J-WAFS executive director Renee J. Robins. “The funding is intended to spur groundbreaking MIT research addressing complex issues that are challenging our water and food systems. The 10 projects selected this year show great promise, and we look forward to the progress and accomplishments these talented researchers will make,” she adds.The 2023 J-WAFS seed grant researchers and their projects are:Sara Beery, an assistant professor in the Department of Electrical Engineering and Computer Science (EECS), is building the first completely automated system to estimate the size of salmon populations in the Pacific Northwest (PNW).Salmon are a keystone species in the PNW, feeding human populations for the last 7,500 years at least. However, overfishing, habitat loss, and climate change threaten extinction of salmon populations across the region. Accurate salmon counts during their seasonal migration to their natal river to spawn are essential for fisheries’ regulation and management but are limited by human capacity. Fish population monitoring is a widespread challenge in the United States and worldwide. Beery and her team are working to build a system that will provide a detailed picture of the state of salmon populations in unprecedented, spatial, and temporal resolution by combining sonar sensors and computer vision and machine learning (CVML) techniques. The sonar will capture individual fish as they swim upstream and CVML will train accurate algorithms to interpret the sonar video for detecting, tracking, and counting fish automatically while adapting to changing river conditions and fish densities.Another aquaculture project is being led by Michael Triantafyllou, the Henry L. and Grace Doherty Professor in Ocean Science and Engineering in the Department of Mechanical Engineering, and Robert Vincent, the assistant director at MIT’s Sea Grant Program. They are working with Otto Cordero, an associate professor in the Department of Civil and Environmental Engineering, to control harmful bacteria blooms in aquaculture algae feed production.

      Aquaculture in the United States represents a $1.5 billion industry annually and helps support 1.7 million jobs, yet many American hatcheries are not able to keep up with demand. One barrier to aquaculture production is the high degree of variability in survival rates, most likely caused by a poorly controlled microbiome that leads to bacterial infections and sub-optimal feed efficiency. Triantafyllou, Vincent, and Cordero plan to monitor the microbiome composition of a shellfish hatchery in order to identify possible causing agents of mortality, as well as beneficial microbes. They hope to pair microbe data with detail phenotypic information about the animal population to generate rapid diagnostic tests and explore the potential for microbiome therapies to protect larvae and prevent future outbreaks. The researchers plan to transfer their findings and technology to the local and regional aquaculture community to ensure healthy aquaculture production that will support the expansion of the U.S. aquaculture industry.

      David Des Marais is the Cecil and Ida Green Career Development Professor in the Department of Civil and Environmental Engineering. His 2023 J-WAFS project seeks to understand plant growth responses to elevated carbon dioxide (CO2) in the atmosphere, in the hopes of identifying breeding strategies that maximize crop yield under future CO2 scenarios.Today’s crop plants experience higher atmospheric CO2 than 20 or 30 years ago. Crops such as wheat, oat, barley, and rice typically increase their growth rate and biomass when grown at experimentally elevated atmospheric CO2. This is known as the so-called “CO2 fertilization effect.” However, not all plant species respond to rising atmospheric CO2 with increased growth, and for the ones that do, increased growth doesn’t necessarily correspond to increased crop yield. Using specially built plant growth chambers that can control the concentration of CO2, Des Marais will explore how CO2 availability impacts the development of tillers (branches) in the grass species Brachypodium. He will study how gene expression controls tiller development, and whether this is affected by the growing environment. The tillering response refers to how many branches a plant produces, which sets a limit on how much grain it can yield. Therefore, optimizing the tillering response to elevated CO2 could greatly increase yield. Des Marais will also look at the complete genome sequence of Brachypodium, wheat, oat, and barley to help identify genes relevant for branch growth.Darcy McRose, an assistant professor in the Department of Civil and Environmental Engineering, is researching whether a combination of plant metabolites and soil bacteria can be used to make mineral-associated phosphorus more bioavailable.The nutrient phosphorus is essential for agricultural plant growth, but when added as a fertilizer, phosphorus sticks to the surface of soil minerals, decreasing bioavailability, limiting plant growth, and accumulating residual phosphorus. Heavily fertilized agricultural soils often harbor large reservoirs of this type of mineral-associated “legacy” phosphorus. Redox transformations are one chemical process that can liberate mineral-associated phosphorus. However, this needs to be carefully controlled, as overly mobile phosphorus can lead to runoff and pollution of natural waters. Ideally, phosphorus would be made bioavailable when plants need it and immobile when they don’t. Many plants make small metabolites called coumarins that might be able to solubilize mineral-adsorbed phosphorus and be activated and inactivated under different conditions. McRose will use laboratory experiments to determine whether a combination of plant metabolites and soil bacteria can be used as a highly efficient and tunable system for phosphorus solubilization. She also aims to develop an imaging platform to investigate exchanges of phosphorus between plants and soil microbes.Many of the 2023 seed grants will support innovative technologies to monitor, quantify, and remediate various kinds of pollutants found in water. Two of the new projects address the problem of per- and polyfluoroalkyl substances (PFAS), human-made chemicals that have recently emerged as a global health threat. Known as “forever chemicals,” PFAS are used in many manufacturing processes. These chemicals are known to cause significant health issues including cancer, and they have become pervasive in soil, dust, air, groundwater, and drinking water. Unfortunately, the physical and chemical properties of PFAS render them difficult to detect and remove.Aristide Gumyusenge, the Merton C. Assistant Professor of Materials Science and Engineering, is using metal-organic frameworks for low-cost sensing and capture of PFAS. Most metal-organic frameworks (MOFs) are synthesized as particles, which complicates their high accuracy sensing performance due to defects such as intergranular boundaries. Thin, film-based electronic devices could enable the use of MOFs for many applications, especially chemical sensing. Gumyusenge’s project aims to design test kits based on two-dimensional conductive MOF films for detecting PFAS in drinking water. In early demonstrations, Gumyusenge and his team showed that these MOF films can sense PFAS at low concentrations. They will continue to iterate using a computation-guided approach to tune sensitivity and selectivity of the kits with the goal of deploying them in real-world scenarios.Carlos Portela, the Brit (1961) and Alex (1949) d’Arbeloff Career Development Professor in the Department of Mechanical Engineering, and Ariel Furst, the Cook Career Development Professor in the Department of Chemical Engineering, are building novel architected materials to act as filters for the removal of PFAS from water. Portela and Furst will design and fabricate nanoscale materials that use activated carbon and porous polymers to create a physical adsorption system. They will engineer the materials to have tunable porosities and morphologies that can maximize interactions between contaminated water and functionalized surfaces, while providing a mechanically robust system.Rohit Karnik is a Tata Professor and interim co-department head of the Department of Mechanical Engineering. He is working on another technology, his based on microbead sensors, to rapidly measure and monitor trace contaminants in water.Water pollution from both biological and chemical contaminants contributes to an estimated 1.36 million deaths annually. Chemical contaminants include pesticides and herbicides, heavy metals like lead, and compounds used in manufacturing. These emerging contaminants can be found throughout the environment, including in water supplies. The Environmental Protection Agency (EPA) in the United States sets recommended water quality standards, but states are responsible for developing their own monitoring criteria and systems, which must be approved by the EPA every three years. However, the availability of data on regulated chemicals and on candidate pollutants is limited by current testing methods that are either insensitive or expensive and laboratory-based, requiring trained scientists and technicians. Karnik’s project proposes a simple, self-contained, portable system for monitoring trace and emerging pollutants in water, making it suitable for field studies. The concept is based on multiplexed microbead-based sensors that use thermal or gravitational actuation to generate a signal. His proposed sandwich assay, a testing format that is appealing for environmental sensing, will enable both single-use and continuous monitoring. The hope is that the bead-based assays will increase the ease and reach of detecting and quantifying trace contaminants in water for both personal and industrial scale applications.Alexander Radosevich, a professor in the Department of Chemistry, and Timothy Swager, the John D. MacArthur Professor of Chemistry, are teaming up to create rapid, cost-effective, and reliable techniques for on-site arsenic detection in water.Arsenic contamination of groundwater is a problem that affects as many as 500 million people worldwide. Arsenic poisoning can lead to a range of severe health problems from cancer to cardiovascular and neurological impacts. Both the EPA and the World Health Organization have established that 10 parts per billion is a practical threshold for arsenic in drinking water, but measuring arsenic in water at such low levels is challenging, especially in resource-limited environments where access to sensitive laboratory equipment may not be readily accessible. Radosevich and Swager plan to develop reaction-based chemical sensors that bind and extract electrons from aqueous arsenic. In this way, they will exploit the inherent reactivity of aqueous arsenic to selectively detect and quantify it. This work will establish the chemical basis for a new method of detecting trace arsenic in drinking water.Rajeev Ram is a professor in the Department of Electrical Engineering and Computer Science. His J-WAFS research will advance a robust technology for monitoring nitrogen-containing pollutants, which threaten over 15,000 bodies of water in the United States alone.Nitrogen in the form of nitrate, nitrite, ammonia, and urea can run off from agricultural fertilizer and lead to harmful algal blooms that jeopardize human health. Unfortunately, monitoring these contaminants in the environment is challenging, as sensors are difficult to maintain and expensive to deploy. Ram and his students will work to establish limits of detection for nitrate, nitrite, ammonia, and urea in environmental, industrial, and agricultural samples using swept-source Raman spectroscopy. Swept-source Raman spectroscopy is a method of detecting the presence of a chemical by using a tunable, single mode laser that illuminates a sample. This method does not require costly, high-power lasers or a spectrometer. Ram will then develop and demonstrate a portable system that is capable of achieving chemical specificity in complex, natural environments. Data generated by such a system should help regulate polluters and guide remediation.Kripa Varanasi, a professor in the Department of Mechanical Engineering, and Angela Belcher, the James Mason Crafts Professor and head of the Department of Biological Engineering, will join forces to develop an affordable water disinfection technology that selectively identifies, adsorbs, and kills “superbugs” in domestic and industrial wastewater.Recent research predicts that antibiotic-resistance bacteria (superbugs) will result in $100 trillion in health care expenses and 10 million deaths annually by 2050. The prevalence of superbugs in our water systems has increased due to corroded pipes, contamination, and climate change. Current drinking water disinfection technologies are designed to kill all types of bacteria before human consumption. However, for certain domestic and industrial applications there is a need to protect the good bacteria required for ecological processes that contribute to soil and plant health. Varanasi and Belcher will combine material, biological, process, and system engineering principles to design a sponge-based water disinfection technology that can identify and destroy harmful bacteria while leaving the good bacteria unharmed. By modifying the sponge surface with specialized nanomaterials, their approach will be able to kill superbugs faster and more efficiently. The sponge filters can be deployed under very low pressure, making them an affordable technology, especially in resource-constrained communities.In addition to the 10 seed grant projects, J-WAFS will also fund a research initiative led by Greg Sixt. Sixt is the research manager for climate and food systems at J-WAFS, and the director of the J-WAFS-led Food and Climate Systems Transformation (FACT) Alliance. His project focuses on the Lake Victoria Basin (LVB) of East Africa. The second-largest freshwater lake in the world, Lake Victoria straddles three countries (Uganda, Tanzania, and Kenya) and has a catchment area that encompasses two more (Rwanda and Burundi). Sixt will collaborate with Michael Hauser of the University of Natural Resources and Life Sciences, Vienna, and Paul Kariuki, of the Lake Victoria Basin Commission.The group will study how to adapt food systems to climate change in the Lake Victoria Basin. The basin is facing a range of climate threats that could significantly impact livelihoods and food systems in the expansive region. For example, extreme weather events like droughts and floods are negatively affecting agricultural production and freshwater resources. Across the LVB, current approaches to land and water management are unsustainable and threaten future food and water security. The Lake Victoria Basin Commission (LVBC), a specialized institution of the East African Community, wants to play a more vital role in coordinating transboundary land and water management to support transitions toward more resilient, sustainable, and equitable food systems. The primary goal of this research will be to support the LVBC’s transboundary land and water management efforts, specifically as they relate to sustainability and climate change adaptation in food systems. The research team will work with key stakeholders in Kenya, Uganda, and Tanzania to identify specific capacity needs to facilitate land and water management transitions. The two-year project will produce actionable recommendations to the LVBC. More