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      Pesticide innovation takes top prize at Collegiate Inventors Competition

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      On Oct. 12, MIT mechanical engineering alumnus Vishnu Jayaprakash SM ’19, PhD ’22 was named the first-place winner in the graduate category of the Collegiate Inventors Competition. The annual competition, which is organized by the National Inventors Hall of Fame, celebrates college and university student inventors. Jayaprakash won for his pesticide innovation AgZen-Cloak, which he developed while he was a student in the lab of Kripa Varanasi, a professor of mechanical engineering.

      Currently, only 2 percent of pesticide spray is retained by crops. Many crops are naturally water-repellent, causing pesticide-laden water to bounce off of them. Farmers are forced to over-spray significantly to ensure proper spray coverage on their crops. Not only does this waste expensive pesticides, but it also comes at an environmental cost.

      Runoff from pesticide treatment pollutes soil and nearby streams. Droplets can travel in the air, leading to illness and death in nearby populations. It is estimated that each year, pesticide pollution causes between 20,000 and 200,000 deaths, and up to 385 million acute illnesses like cancer, birth defects, and neurological conditions.   

      With his invention AgZen-Cloak, Jayaprakash has found a way to keep droplets of water containing pesticide from bouncing off crops by “cloaking” the droplets in a small amount of plant-derived oil. As a result, farmers could use just one-fifth the amount of spray, minimizing water waste and cost for farmers and eliminating airborne pollution and toxic runoff. It also improves pesticide retention, which can lead to higher crop yield.

      “By cloaking each droplet with a minute quantity of a plant-based oil, we promote water retention on even the most water-repellent plant surfaces,” says Jayaprakash. “AgZen-Cloak presents a universal, inexpensive, and environmentally sustainable way to prevent pesticide overuse and waste.”

      Farming is in Jayaprakash’s DNA. His family operates a 10-acre farm near Chennai, India, where they grow rice and mangoes. Upon joining the Varanasi Research Group as a graduate student, Jayaprakash was instantly drawn to Varanasi’s work on pesticides in agriculture.

      “Growing up, I would spray crops on my family farm wearing a backpack sprayer. So, I’ve always wanted to work on research that made farmer’s lives easier,” says Jayaprakash, who serves as CEO of the startup AgZen.

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      2022 World Food Day First Prize Winner – AgZen Cloak: Reducing Pesticide Pollution and Waste

      Helping droplets stick

      Varanasi and his lab at MIT work on what is known as interfacial phenomena — or the study of what happens when different phases come into contact and interact with one another. Understanding how a liquid interacts with a solid or how a liquid reacts to a certain gas has endless applications, which explains the diversity of the research Varanasi has conducted over the years. He and his team have developed solutions for everything from consumer product packaging to power plant emissions.

      In 2009, Varanasi gave a talk at the U.S. Department of Agriculture (USDA). There, he learned from the USDA just how big of a problem runoff from pesticide spray was for farmers around the world.
      A green cabbage leaf is treated with pesticide-laden water using conventional spraying. Image courtesy of AgZen.A green cabbage leaf is treated with pesticide-laden water using AgZen’s technology. By cloaking droplets in a tiny amount of plant-derived oil, the droplets stick to the leaf, minimizing over-spraying, waste, and pollution. Image courtesy of AgZen.He enlisted the help of then-graduate student Maher Damak SM ’15, PhD ’18 to apply their work in interfacial phenomena to pesticide sprays. Over the next several years, the Varanasi Research Group developed a technology that utilized electrically charged polymers to keep droplets from bouncing off hydrophobic surfaces. When droplets containing positively and negatively charged additives meet, their surface chemistry allows them to stick to a plant’s surface.

      Using polyelectrolytes, the researchers could reduce the amount of spray needed to cover a crop by tenfold in the lab. This motivated the Varanasi Research Group to pursue three years of field trials with various commercial growers around the world, where they were able to demonstrate significant savings for farmers.

      “We got fantastic feedback on our technology from farmers. We are really excited to change the paradigm for agriculture. Not only is it good for the environment, but we’ve heard from farmers that they love it. If we can put money back into farms, it helps society as a whole,” adds Varanasi.

      In response to the positive feedback, Varanasi and Jayaprakash co-founded startup AgZen in 2020. 

      When field testing their polyelectrolyte technology, Varanasi and Jayaprakash came up with the idea to explore the use of a fully plant-based material to help farmers achieve the same savings. 

      Cloaking droplets and engineering nozzles

      Jayaprakash found that by cloaking a small amount of plant-derived oil around a water droplet, droplets stick to plant surfaces that would typically repel water. After conducting many studies in the lab, he found that the oil only needs to make up 0.1 percent of a droplet’s total volume to stick to crops and provide total, uniform coverage.

      While his cloaking solution worked in the lab, Jayaprakash knew that to have a tangible impact in the real world he needed to find an easy, low-cost way for farmers to coat pesticide spray droplets in oil.

      Jayaprakash focused on spray nozzles. He developed a proprietary nozzle that coats each droplet with a small amount of oil as they are being formed. The nozzles can easily be added to any hose or farming equipment.

      “What we’ve done is figured out a smart way to cloak these droplets by using a very small quantity of oil on the outside of each drop. Because of that, we get this drastic improvement in performance that can really be a game-changer for farmers,” says Jayaprakash.

      In addition to improving pesticide retention in crops, the AgZen-Cloak solves a second problem. Since large droplets are prone to break apart and bounce off crops, historically, farmers have sprayed pesticide in tiny, mist-like droplets. These fine droplets are often carried by the wind, increasing pesticide pollution in nearby areas. 

      When AgZen-Cloak is used, the pesticide-laden droplets can be larger and still stick to crops. These larger droplets aren’t carried by the wind, decreasing the risk of pollution and minimizing the health impacts on local populations.  

      “We’re actually solving two problems with one solution. With the cloaking technology, we can spray much larger droplets that aren’t prone to wind drift and they can stick to the plant,” Jayaprakash adds.

      Bringing AgZen-Cloaks to farmers around the world

      This spring, Varanasi encouraged Jayaprakash to submit AgZen-Cloak to the Collegiate Inventors Competition. Out of hundreds of applications, Jayaprakash was one of 25 student inventors to be chosen as a finalist.

      On Oct. 12, Jayaprakash presented his technology to a panel of judges composed of National Inventors Hall of Fame inductees and U.S. Patent and Trademark Office officials. Meeting with such an illustrious group of inventors and officials left an impression on Jayaprakash.

      “These are people who have invented things that have changed the world. So, to get their feedback on what we’re doing was incredibly valuable,” he says. Jayaprakash received a $10,000 prize for being named the first-place graduate winner.

      As full-time CEO of AgZen, Jayaprakash is shifting focus to field testing and commercialization. He and the AgZen team have already conducted field testing across the world at locations including a Prosecco vineyard outside of Venice, a ranch in California, and Ward’s Berry Farm in Sharon, Massachusetts. The University of Massachusetts at Amherst’s vegetable extension program, led by their program director Susan Scheufele, recently concluded a field test that validated AgZen’s on-field performance.

      Two days after his win at the Collegiate Inventors Competition, Jayaprakash was named the first prize winner of the MIT Abdul Latif Jamel Water and Food Systems Lab World Food Day student video competition. Hours later, he flew across the country to attend an agricultural tech conference in California, eager to meet with farmers and discuss plans for rolling out AgZen’s innovations to farms everywhere. More

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      MIT student club Engineers Without Borders works with local village in Tanzania

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      Four students from the MIT club Engineers Without Borders (EWB) spent part of their summer in Tanzania to begin assessment work for a health and sanitation project that will benefit the entire village, and an irrigated garden for the Mkutani Primary School.

      The club has been working with the Boston Professional Chapter of Engineers Without Borders (EWB-BPC) since 2019. The Boston chapter finds projects in underserved communities in the developing world and helped connect the MIT students with local government and school officials.

      Juniors Fiona Duong, female health and sanitation team lead, and Lai Wa Chu, irrigation team lead, spent two weeks over the summer in Mkutani conducting research for their projects. Chu was faced with finding more water supplies and a way to get water from the nearby river to the school to use in the gardens they were planting. Duong was charged with assessing the needs of the people who visit The Mkutani Dispensary, which serves as a local medical clinic. Juniors Hung Huynh, club president, and Vivian Cheng, student advisor, also made the trip to work on the projects.

      Health and sanitation project

      Duong looked into ways to help pregnant women with privacy issues as the facility they give birth in — The Mkutani Dispensary — is very small, with just two beds, and is in need of repairs and upgrades. Before leaving Cambridge, Duong led FaceTime meetings with government officials and facilities managers in the village. Once on the ground, she began collecting information and conducted focus groups with the local women and other constituents. She learned that one in three women were not giving birth in the dispensary due to privacy concerns and the lack of modern equipment needed for high-risk pregnancies.

      “The women said that the most pressing need there was water. The women were expected to bring their own water to their deliveries. The rain-catching system there was not enough to fulfill their needs and the river water wasn’t clean. When in labor, they relied on others to gather it and bring it to the dispensary by bike,” Duong says. “With broken windows, the dispensary did not allow for privacy or sanitary conditions.”

      Duong will also analyze the data she collected and share it with others before more MIT students head to Mkutani next summer.

      Farming, sustainability, and irrigation projectBefore heading to Mkutani, Chu conducted research regarding irrigation methods and water collection methods. She confirmed that the river water still contained E.coli and advised the teachers that it would need to be boiled or placed in the sun for a few hours before it could be used. Her technical background in fluid dynamics was helpful for the project.

      “We also found that there was a need for supplemental food for the school, as many children lived too far away to walk home for lunch. The headmaster reached out to us about building the garden, as the garden provides supplemental fruit and vegetables for many of the 600 students to eat. They needed water from the river that was quite far away from the school. We looked at ways to get the water to the garden,” Chu says.

      The group is considering conducting an ecological survey of the area to see if there is another source of water so they could drill another borehole. They will complete their analysis and then decide the best solution to implement.

      “Watching the whole team’s hard work pay off when the travel team got to Mkutani was so amazing,” says second-year student Maria Hernandez, club internal relations chair. “Now, we’re ready to get to work again so we can go back next year. I love being a part of Engineers Without Borders because it’s such a unique way to apply technical skills outside of the classroom and see the impact you make on the community. It’s a beautiful project that truly impacts so many people, and I can’t wait to go back to Mkutani next year.”

      Both Duong and Chu hope they’ll return to the school and the dispensary in summer 2023 to work on the implementation phase of their projects. “This project is one of the reasons I came to MIT. I wanted to work on a social impact project to help improve the world,” Chu says.

      “I hope to go back next summer and implement the project,” adds Duong. “If I do, we’ll go during the two most crucial weeks of the project — after the contractors have started the repair work on the dispensary, so we can see how things are going and then help with anything else related to the project.”

      Duong and Chu said students don’t have to be engineers to help with the EWB’s work — any MIT student interested in joining the club may do so. Both agree that fundraising is a priority, but there are numerous other roles students can help with.

      “MIT students shouldn’t be afraid to just dive right in. There’s a lot that needs to be done there, and even if you don’t have experience in a certain area, don’t let that be a barrier. It’s very rewarding work and it’s also great to get international work experience,” Duong says.

      Chu added, “The project may not seem flashy now, but the rewards are great. Students will get new technical skills and get to experience a new culture as well.” More

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      Scientists chart how exercise affects the body

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      Exercise is well-known to help people lose weight and avoid gaining it. However, identifying the cellular mechanisms that underlie this process has proven difficult because so many cells and tissues are involved.

      In a new study in mice that expands researchers’ understanding of how exercise and diet affect the body, MIT and Harvard Medical School researchers have mapped out many of the cells, genes, and cellular pathways that are modified by exercise or high-fat diet. The findings could offer potential targets for drugs that could help to enhance or mimic the benefits of exercise, the researchers say.

      “It is extremely important to understand the molecular mechanisms that are drivers of the beneficial effects of exercise and the detrimental effects of a high-fat diet, so that we can understand how we can intervene, and develop drugs that mimic the impact of exercise across multiple tissues,” says Manolis Kellis, a professor of computer science in MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and a member of the Broad Institute of MIT and Harvard.

      The researchers studied mice with high-fat or normal diets, who were either sedentary or given the opportunity to exercise whenever they wanted. Using single-cell RNA sequencing, the researchers cataloged the responses of 53 types of cells found in skeletal muscle and two types of fatty tissue.

      “One of the general points that we found in our study, which is overwhelmingly clear, is how high-fat diets push all of these cells and systems in one way, and exercise seems to be pushing them nearly all in the opposite way,” Kellis says. “It says that exercise can really have a major effect throughout the body.”

      Kellis and Laurie Goodyear, a professor of medicine at Harvard Medical School and senior investigator at the Joslin Diabetes Center, are the senior authors of the study, which appears today in the journal Cell Metabolism. Jiekun Yang, a research scientist in MIT CSAIL; Maria Vamvini, an instructor of medicine at the Joslin Diabetes Center; and Pasquale Nigro, an instructor of medicine at the Joslin Diabetes Center, are the lead authors of the paper.

      The risks of obesity

      Obesity is a growing health problem around the world. In the United States, more than 40 percent of the population is considered obese, and nearly 75 percent is overweight. Being overweight is a risk factor for many diseases, including heart disease, cancer, Alzheimer’s disease, and even infectious diseases such as Covid-19.

      “Obesity, along with aging, is a global factor that contributes to every aspect of human health,” Kellis says.

      Several years ago, his lab performed a study on the FTO gene region, which has been strongly linked to obesity risk. In that 2015 study, the research team found that genes in this region control a pathway that prompts immature fat cells called progenitor adipocytes to either become fat-burning cells or fat-storing cells.

      That finding, which demonstrated a clear genetic component to obesity, motivated Kellis to begin looking at how exercise, a well-known behavioral intervention that can prevent obesity, might act on progenitor adipocytes at the cellular level.

      To explore that question, Kellis and his colleagues decided to perform single-cell RNA sequencing of three types of tissue — skeletal muscle, visceral white adipose tissue (found packed around internal organs, where it stores fat), and subcutaneous white adipose tissue (which is found under the skin and primarily burns fat).

      These tissues came from mice from four different experimental groups. For three weeks, two groups of mice were fed either a normal diet or a high-fat diet. For the next three weeks, each of those two groups were further divided into a sedentary group and an exercise group, which had continuous access to a treadmill.

      By analyzing tissues from those mice, the researchers were able to comprehensively catalog the genes that were activated or suppressed by exercise in 53 different cell types.

      The researchers found that in all three tissue types, mesenchymal stem cells (MSCs) appeared to control many of the diet and exercise-induced effects that they observed. MSCs are stem cells that can differentiate into other cell types, including fat cells and fibroblasts. In adipose tissue, the researchers found that a high-fat diet modulated MSCs’ capacity to differentiate into fat-storing cells, while exercise reversed this effect.

      In addition to promoting fat storage, the researchers found that a high-fat diet also stimulated MSCs to secrete factors that remodel the extracellular matrix (ECM) — a network of proteins and other molecules that surround and support cells and tissues in the body. This ECM remodeling helps provide structure for enlarged fat-storing cells and also creates a more inflammatory environment.

      “As the adipocytes become overloaded with lipids, there’s an extreme amount of stress, and that causes low-grade inflammation, which is systemic and preserved for a long time,” Kellis says. “That is one of the factors that is contributing to many of the adverse effects of obesity.”

      Circadian effects

      The researchers also found that high-fat diets and exercise had opposing effects on cellular pathways that control circadian rhythms — the 24-hour cycles that govern many functions, from sleep to body temperature, hormone release, and digestion. The study revealed that exercise boosts the expression of genes that regulate these rhythms, while a high-fat diet suppresses them.

      “There have been a lot of studies showing that when you eat during the day is extremely important in how you absorb the calories,” Kellis says. “The circadian rhythm connection is a very important one, and shows how obesity and exercise are in fact directly impacting that circadian rhythm in peripheral organs, which could act systemically on distal clocks and regulate stem cell functions and immunity.”

      The researchers then compared their results to a database of human genes that have been linked with metabolic traits. They found that two of the circadian rhythm genes they identified in this study, known as DBP and CDKN1A, have genetic variants that have been associated with a higher risk of obesity in humans.

      “These results help us see the translational values of these targets, and how we could potentially target specific biological processes in specific cell types,” Yang says.

      The researchers are now analyzing samples of small intestine, liver, and brain tissue from the mice in this study, to explore the effects of exercise and high-fat diets on those tissues. They are also conducting work with human volunteers to sample blood and biopsies and study similarities and differences between human and mouse physiology. They hope that their findings will help guide drug developers in designing drugs that might mimic some of the beneficial effects of exercise.

      “The message for everyone should be, eat a healthy diet and exercise if possible,” Kellis says. “For those for whom this is not possible, due to low access to healthy foods, or due to disabilities or other factors that prevent exercise, or simply lack of time to have a healthy diet or a healthy lifestyle, what this study says is that we now have a better handle on the pathways, the specific genes, and the specific molecular and cellular processes that we should be manipulating therapeutically.”

      The research was funded by the National Institutes of Health and the Novo Nordisk Research Center in Seattle. More

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      These neurons have food on the brain

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      A gooey slice of pizza. A pile of crispy French fries. Ice cream dripping down a cone on a hot summer day. When you look at any of these foods, a specialized part of your visual cortex lights up, according to a new study from MIT neuroscientists.

      This newly discovered population of food-responsive neurons is located in the ventral visual stream, alongside populations that respond specifically to faces, bodies, places, and words. The unexpected finding may reflect the special significance of food in human culture, the researchers say. 

      “Food is central to human social interactions and cultural practices. It’s not just sustenance,” says Nancy Kanwisher, the Walter A. Rosenblith Professor of Cognitive Neuroscience and a member of MIT’s McGovern Institute for Brain Research and Center for Brains, Minds, and Machines. “Food is core to so many elements of our cultural identity, religious practice, and social interactions, and many other things that humans do.”

      The findings, based on an analysis of a large public database of human brain responses to a set of 10,000 images, raise many additional questions about how and why this neural population develops. In future studies, the researchers hope to explore how people’s responses to certain foods might differ depending on their likes and dislikes, or their familiarity with certain types of food.

      MIT postdoc Meenakshi Khosla is the lead author of the paper, along with MIT research scientist N. Apurva Ratan Murty. The study appears today in the journal Current Biology.

      Visual categories

      More than 20 years ago, while studying the ventral visual stream, the part of the brain that recognizes objects, Kanwisher discovered cortical regions that respond selectively to faces. Later, she and other scientists discovered other regions that respond selectively to places, bodies, or words. Most of those areas were discovered when researchers specifically set out to look for them. However, that hypothesis-driven approach can limit what you end up finding, Kanwisher says.

      “There could be other things that we might not think to look for,” she says. “And even when we find something, how do we know that that’s actually part of the basic dominant structure of that pathway, and not something we found just because we were looking for it?”

      To try to uncover the fundamental structure of the ventral visual stream, Kanwisher and Khosla decided to analyze a large, publicly available dataset of full-brain functional magnetic resonance imaging (fMRI) responses from eight human subjects as they viewed thousands of images.

      “We wanted to see when we apply a data-driven, hypothesis-free strategy, what kinds of selectivities pop up, and whether those are consistent with what had been discovered before. A second goal was to see if we could discover novel selectivities that either haven’t been hypothesized before, or that have remained hidden due to the lower spatial resolution of fMRI data,” Khosla says.

      To do that, the researchers applied a mathematical method that allows them to discover neural populations that can’t be identified from traditional fMRI data. An fMRI image is made up of many voxels — three-dimensional units that represent a cube of brain tissue. Each voxel contains hundreds of thousands of neurons, and if some of those neurons belong to smaller populations that respond to one type of visual input, their responses may be drowned out by other populations within the same voxel.

      The new analytical method, which Kanwisher’s lab has previously used on fMRI data from the auditory cortex, can tease out responses of neural populations within each voxel of fMRI data.

      Using this approach, the researchers found four populations that corresponded to previously identified clusters that respond to faces, places, bodies, and words. “That tells us that this method works, and it tells us that the things that we found before are not just obscure properties of that pathway, but major, dominant properties,” Kanwisher says.

      Intriguingly, a fifth population also emerged, and this one appeared to be selective for images of food.

      “We were first quite puzzled by this because food is not a visually homogenous category,” Khosla says. “Things like apples and corn and pasta all look so unlike each other, yet we found a single population that responds similarly to all these diverse food items.”

      The food-specific population, which the researchers call the ventral food component (VFC), appears to be spread across two clusters of neurons, located on either side of the FFA. The fact that the food-specific populations are spread out between other category-specific populations may help explain why they have not been seen before, the researchers say.

      “We think that food selectivity had been harder to characterize before because the populations that are selective for food are intermingled with other nearby populations that have distinct responses to other stimulus attributes. The low spatial resolution of fMRI prevents us from seeing this selectivity because the responses of different neural population get mixed in a voxel,” Khosla says.

      “The technique which the researchers used to identify category-sensitive cells or areas is impressive, and it recovered known category-sensitive systems, making the food category findings most impressive,” says Paul Rozin, a professor of psychology at the University of Pennsylvania, who was not involved in the study. “I can’t imagine a way for the brain to reliably identify the diversity of foods based on sensory features. That makes this all the more fascinating, and likely to clue us in about something really new.”

      Food vs non-food

      The researchers also used the data to train a computational model of the VFC, based on previous models Murty had developed for the brain’s face and place recognition areas. This allowed the researchers to run additional experiments and predict the responses of the VFC. In one experiment, they fed the model matched images of food and non-food items that looked very similar — for example, a banana and a yellow crescent moon.

      “Those matched stimuli have very similar visual properties, but the main attribute in which they differ is edible versus inedible,” Khosla says. “We could feed those arbitrary stimuli through the predictive model and see whether it would still respond more to food than non-food, without having to collect the fMRI data.”

      They could also use the computational model to analyze much larger datasets, consisting of millions of images. Those simulations helped to confirm that the VFC is highly selective for images of food.

      From their analysis of the human fMRI data, the researchers found that in some subjects, the VFC responded slightly more to processed foods such as pizza than unprocessed foods like apples. In the future they hope to explore how factors such as familiarity and like or dislike of a particular food might affect individuals’ responses to that food.

      They also hope to study when and how this region becomes specialized during early childhood, and what other parts of the brain it communicates with. Another question is whether this food-selective population will be seen in other animals such as monkeys, who do not attach the cultural significance to food that humans do.

      The research was funded by the National Institutes of Health, the National Eye Institute, and the National Science Foundation through the MIT Center for Brains, Minds, and Machines. More

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      in Environment

      New J-WAFS-led project combats food insecurity

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      Today the Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) at MIT announced a new research project, supported by Community Jameel, to tackle one of the most urgent crises facing the planet: food insecurity. Approximately 276 million people worldwide are severely food insecure, and more than half a million face famine conditions.     To better understand and analyze food security, this three-year research project will develop a comprehensive index assessing countries’ food security vulnerability, called the Jameel Index for Food Trade and Vulnerability. Global changes spurred by social and economic transitions, energy and environmental policy, regional geopolitics, conflict, and of course climate change, can impact food demand and supply. The Jameel Index will measure countries’ dependence on global food trade and imports and how these regional-scale threats might affect the ability to trade food goods across diverse geographic regions. A main outcome of the research will be a model to project global food demand, supply balance, and bilateral trade under different likely future scenarios, with a focus on climate change. The work will help guide policymakers over the next 25 years while the global population is expected to grow, and the climate crisis is predicted to worsen.    

      The work will be the foundational project for the J-WAFS-led Food and Climate Systems Transformation Alliance, or FACT Alliance. Formally launched at the COP26 climate conference last November, the FACT Alliance is a global network of 20 leading research institutions and stakeholder organizations that are driving research and innovation and informing better decision-making for healthy, resilient, equitable, and sustainable food systems in a rapidly changing climate. The initiative is co-directed by Greg Sixt, research manager for climate and food systems at J-WAFS, and Professor Kenneth Strzepek, climate, water, and food specialist at J-WAFS.

      The dire state of our food systems

      The need for this project is evidenced by the hundreds of millions of people around the globe currently experiencing food shortages. While several factors contribute to food insecurity, climate change is one of the most notable. Devastating extreme weather events are increasingly crippling crop and livestock production around the globe. From Southwest Asia to the Arabian Peninsula to the Horn of Africa, communities are migrating in search of food. In the United States, extreme heat and lack of rainfall in the Southwest have drastically lowered Lake Mead’s water levels, restricting water access and drying out farmlands. 

      Social, political, and economic issues also disrupt food systems. The effects of the Covid-19 pandemic, supply chain disruptions, and inflation continue to exacerbate food insecurity. Russia’s invasion of Ukraine is dramatically worsening the situation, disrupting agricultural exports from both Russia and Ukraine — two of the world’s largest producers of wheat, sunflower seed oil, and corn. Other countries like Lebanon, Sri Lanka, and Cuba are confronting food insecurity due to domestic financial crises.

      Few countries are immune to threats to food security from sudden disruptions in food production or trade. When an enormous container ship became lodged in the Suez Canal in March 2021, the vital international trade route was blocked for three months. The resulting delays in international shipping affected food supplies around the world. These situations demonstrate the importance of food trade in achieving food security: a disaster in one part of the world can drastically affect the availability of food in another. This puts into perspective just how interconnected the earth’s food systems are and how vulnerable they remain to external shocks. 

      An index to prepare for the future of food

      Despite the need for more secure food systems, significant knowledge gaps exist when it comes to understanding how different climate scenarios may affect both agricultural productivity and global food supply chains and security. The Global Trade Analysis Project database from Purdue University, and the current IMPACT modeling system from the International Food Policy Research Institute (IFPRI), enable assessments of existing conditions but cannot project or model changes in the future.

      In 2021, Strzepek and Sixt developed an initial Food Import Vulnerability Index (FIVI) as part of a regional assessment of the threat of climate change to food security in the Gulf Cooperation Council states and West Asia. FIVI is also limited in that it can only assess current trade conditions and climate change threats to food production. Additionally, FIVI is a national aggregate index and does not address issues of hunger, poverty, or equity that stem from regional variations within a country.

      “Current models are really good at showing global food trade flows, but we don’t have systems for looking at food trade between individual countries and how different food systems stressors such as climate change and conflict disrupt that trade,” says Greg Sixt of J-WAFS and the FACT Alliance. “This timely index will be a valuable tool for policymakers to understand the vulnerabilities to their food security from different shocks in the countries they import their food from. The project will also illustrate the stakeholder-guided, transdisciplinary approach that is central to the FACT Alliance,” Sixt adds.

      Phase 1 of the project will support a collaboration between four FACT Alliance members: MIT J-WAFS, Ethiopian Institute of Agricultural Research, IFPRI (which is also part of the CGIAR network), and the Martin School at the University of Oxford. An external partner, United Arab Emirates University, will also assist with the project work. This first phase will build on Strzepek and Sixt’s previous work on FIVI by developing a comprehensive Global Food System Modeling Framework that takes into consideration climate and global changes projected out to 2050, and assesses their impacts on domestic production, world market prices, and national balance of payments and bilateral trade. The framework will also utilize a mixed-modeling approach that includes the assessment of bilateral trade and macroeconomic data associated with varying agricultural productivity under the different climate and economic policy scenarios. In this way, consistent and harmonized projections of global food demand and supply balance, and bilateral trade under climate and global change can be achieved. 

      “Just like in the global response to Covid-19, using data and modeling are critical to understanding and tackling vulnerabilities in the global supply of food,” says George Richards, director of Community Jameel. “The Jameel Index for Food Trade and Vulnerability will help inform decision-making to manage shocks and long-term disruptions to food systems, with the aim of ensuring food security for all.”

      On a national level, the researchers will enrich the Jameel Index through country-level food security analyses of regions within countries and across various socioeconomic groups, allowing for a better understanding of specific impacts on key populations. The research will present vulnerability scores for a variety of food security metrics for 126 countries. Case studies of food security and food import vulnerability in Ethiopia and Sudan will help to refine the applicability of the Jameel Index with on-the-ground information. The case studies will use an IFPRI-developed tool called the Rural Investment and Policy Analysis model, which allows for analysis of urban and rural populations and different income groups. Local capacity building and stakeholder engagement will be critical to enable the use of the tools developed by this research for national-level planning in priority countries, and ultimately to inform policy.  Phase 2 of the project will build on phase 1 and the lessons learned from the Ethiopian and Sudanese case studies. It will entail a number of deeper, country-level analyses to assess the role of food imports on future hunger, poverty, and equity across various regional and socioeconomic groups within the modeled countries. This work will link the geospatial national models with the global analysis. A scholarly paper is expected to be submitted to show findings from this work, and a website will be launched so that interested stakeholders and organizations can learn more information. More

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      Helping cassava farmers by extending crop life

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      The root vegetable cassava is a major food staple in dozens of countries across the world. Drought-resistant, nutritious, and tasty, it has also become a major source of income for small-scale, rural farmers in places like West Africa and Southeast Asia.

      But the utility of cassava has always been limited by its short postharvest shelf life of two to three days. That puts millions of farmers who rely on the crop in a difficult position. The farmers can’t plant more than they can sell quickly in local markets, and they’re often forced to sell below market prices because buyers know the harvest will spoil rapidly. As a result, cassava farmers are among the world’s poorest people.

      Now the startup CassVita is buying cassava directly from farmers and applying a patent-pending biotechnology to extend its shelf life to 18 months. The approach has the potential to transform economies in rural, impoverished regions where millions of families rely on the crop for income.

      CassVita tells farmers how much cassava the company will buy each month, and processes the cassava at a manufacturing facility in Cameroon. It currently sells the first version of its product as a powdered food to people in Cameroon and to West African immigrants in the U.S.

      But CassVita founder and CEO Pelkins Ajanoh ’18 says the future of the company will revolve around its next product: a cassava-based flour that can act as a direct substitute for wheat. The wheat substitute would dramatically broaden CassVita’s target market to include the fast-growing, trillion-dollar healthy food market.

      Ajanoh says CassVita is currently able to increase farmers’ incomes by about 400 percent through its purchases.

      “Our objective is to leverage proprietary technology to offer a healthier and better-tasting alternative to wheat while creating prosperity for local farmers,” Ajanoh says. “We’re hoping to tap into this huge market while empowering farmers, all by minimizing spoilage and incentivizing farmers to plant more.”

      Gaining confidence to help a community

      While growing up in Cameroon, Ajanoh’s parents always emphasized the importance of education for him and his three siblings. But Ajanoh lost his father when he was 13, and his mother moved to the U.S. a year later to help provide for the family. During that time, Ajanoh lived with his grandmother, a cassava farmer. For many years, Ajanoh watched his grandmother harvest cassava without making any lasting financial gains. He remembers feeling powerless as his grandmother struggled to pay for things like diabetes medication.

      Then Ajanoh earned the top marks on the national exams that Cameroonian students take before college. After high school, he joined his mother in the U.S. and came to MIT to study mechanical engineering. Once on campus, Ajanoh says he had lunch with new people all the time to learn from them.

      “I’d never had this community of intellectuals — and they were from all over the world — so I soaked up as much as I could,” Ajanoh says. “That sparked an interest in entrepreneurship, because MIT is super entrepreneurial. Everyone’s thinking of starting something cool.”

      Ajanoh also got a confidence boost during an internship in the summer after his junior year, when he created self-driving technology for General Motors that was eventually patented.

      “It made me realize I could do something really valuable for the world, and by the end of that internship I was thinking, ‘Now I want to solve a problem in my community,’” he says.

      Returning to the crop he knew well, Ajanoh received a series of grants from the MIT Sandbox Innovation Fund to experiment with ways to extend the shelf life of cassava. In the summer of 2018, the MIT-Africa program sponsored three MIT students to fly to Cameroon with him to participate in internships with the company.

      Today CassVita partners with development banks to help farmers get loans to buy the cassava sticks used for planting. Ajanoh says CassVita decided on a powdered food for its first product because it requires less marketing to sell to West Africans, who are familiar with the dish. Now the company is working on a cassava flour that it will market to all consumers looking for healthy alternatives to wheat that can be used in pastries and other baked goods.

      “Cassava makes sense as a global substitute to wheat because it’s gluten free, grain free, nut free, and it also helps with glucose regulation, to normalize blood sugar levels, to lower triglycerides, so the health benefits are exciting,” Ajanoh says. “But the farmers were still living in poverty, so if we could solve the shelf-life problem then we could empower these farmers to offer healthier wheat alternatives to the global market.”

      The project has taken on additional urgency now that the war in Ukraine is limiting that country’s wheat and grain exports, raising prices, and heightening food insecurity in regions around the globe.

      Showing the value of helping farmers

      Ajanoh says the majority of people farming cassava are women, and he says the challenges related to cassava’s shelf life have contributed to gender inequities in many communities. In fact, of the roughly 500 farmers CassVita works with in Cameroon, 95 percent are women.

      “That has always excited me because I was raised by women, so working on something that could empower women in their communities and give them authority is fulfilling,” Ajanoh says.

      Ajanoh has already heard from farmers who have been able to send their children to school for the first time because of improved financial situations. Now, as CassVita continues to scale, Ajanoh wants to stay focused on the technology that enables these new business models.

      “We’re evolving into a food technology company,” Ajanoh says. “We prefer to focus on leveraging technology to impact lives and improve outcomes in these communities. Right now, we’re going all the way to consumers because this is an opportunity the Nestles and the Unilevers of the world won’t pick up because the market doesn’t make sense to them yet. So, we have to build this company and show them the value.” More

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      MIT J-WAFS announces 2022 seed grant recipients

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      The Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) at MIT has awarded eight MIT principal investigators with 2022 J-WAFS seed grants. The grants support innovative MIT research that has the potential to have significant impact on water- and food-related challenges.

      The only program at MIT that is dedicated to water- and food-related research, J-WAFS has offered seed grant funding to MIT principal investigators and their teams for the past eight years. The grants provide up to $75,000 per year, overhead-free, for two years to support new, early-stage research in areas such as water and food security, safety, supply, and sustainability. Past projects have spanned many diverse disciplines, including engineering, science, technology, and business innovation, as well as social science and economics, architecture, and urban planning. 

      Seven new projects led by eight researchers will be supported this year. With funding going to four different MIT departments, the projects address a range of challenges by employing advanced materials, technology innovations, and new approaches to resource management. The new projects aim to remove harmful chemicals from water sources, develop drought monitoring systems for farmers, improve management of the shellfish industry, optimize water purification materials, and more.

      “Climate change, the pandemic, and most recently the war in Ukraine have exacerbated and put a spotlight on the serious challenges facing global water and food systems,” says J-WAFS director John H. Lienhard. He adds, “The proposals chosen this year have the potential to create measurable, real-world impacts in both the water and food sectors.”  

      The 2022 J-WAFS seed grant researchers and their projects are:

      Gang Chen, the Carl Richard Soderberg Professor of Power Engineering in MIT’s Department of Mechanical Engineering, is using sunlight to desalinate water. The use of solar energy for desalination is not a new idea, particularly solar thermal evaporation methods. However, the solar thermal evaporation process has an overall low efficiency because it relies on breaking hydrogen bonds among individual water molecules, which is very energy-intensive. Chen and his lab recently discovered a photomolecular effect that dramatically lowers the energy required for desalination. 

      The bonds among water molecules inside a water cluster in liquid water are mostly hydrogen bonds. Chen discovered that a photon with energy larger than the bonding energy between the water cluster and the remaining water liquids can cleave off the water cluster at the water-air interface, colliding with air molecules and disintegrating into 60 or even more individual water molecules. This effect has the potential to significantly boost clean water production via new desalination technology that produces a photomolecular evaporation rate that exceeds pure solar thermal evaporation by at least ten-fold. 

      John E. Fernández is the director of the MIT Environmental Solutions Initiative (ESI) and a professor in the Department of Architecture, and also affiliated with the Department of Urban Studies and Planning. Fernández is working with Scott D. Odell, a postdoc in the ESI, to better understand the impacts of mining and climate change in water-stressed regions of Chile.

      The country of Chile is one of the world’s largest exporters of both agricultural and mineral products; however, little research has been done on climate change effects at the intersection of these two sectors. Fernández and Odell will explore how desalination is being deployed by the mining industry to relieve pressure on continental water supplies in Chile, and with what effect. They will also research how climate change and mining intersect to affect Andean glaciers and agricultural communities dependent upon them. The researchers intend for this work to inform policies to reduce social and environmental harms from mining, desalination, and climate change.

      Ariel L. Furst is the Raymond (1921) and Helen St. Laurent Career Development Professor of Chemical Engineering at MIT. Her 2022 J-WAFS seed grant project seeks to effectively remove dangerous and long-lasting chemicals from water supplies and other environmental areas. 

      Perfluorooctanoic acid (PFOA), a component of Teflon, is a member of a group of chemicals known as per- and polyfluoroalkyl substances (PFAS). These human-made chemicals have been extensively used in consumer products like nonstick cooking pans. Exceptionally high levels of PFOA have been measured in water sources near manufacturing sites, which is problematic as these chemicals do not readily degrade in our bodies or the environment. The majority of humans have detectable levels of PFAS in their blood, which can lead to significant health issues including cancer, liver damage, and thyroid effects, as well as developmental effects in infants. Current remediation methods are limited to inefficient capture and are mostly confined to laboratory settings. Furst’s proposed method utilizes low-energy, scaffolded enzyme materials to move beyond simple capture to degrade these hazardous pollutants.

      Heather J. Kulik is an associate professor in the Department of Chemical Engineering at MIT who is developing novel computational strategies to identify optimal materials for purifying water. Water treatment requires purification by selectively separating small ions from water. However, human-made, scalable materials for water purification and desalination are often not stable in typical operating conditions and lack precision pores for good separation. 

      Metal-organic frameworks (MOFs) are promising materials for water purification because their pores can be tailored to have precise shapes and chemical makeup for selective ion affinity. Yet few MOFs have been assessed for their properties relevant to water purification. Kulik plans to use virtual high-throughput screening accelerated by machine learning models and molecular simulation to accelerate discovery of MOFs. Specifically, Kulik will be looking for MOFs with ultra-stable structures in water that do not break down at certain temperatures. 

      Gregory C. Rutledge is the Lammot du Pont Professor of Chemical Engineering at MIT. He is leading a project that will explore how to better separate oils from water. This is an important problem to solve given that industry-generated oil-contaminated water is a major source of pollution to the environment.

      Emulsified oils are particularly challenging to remove from water due to their small droplet sizes and long settling times. Microfiltration is an attractive technology for the removal of emulsified oils, but its major drawback is fouling, or the accumulation of unwanted material on solid surfaces. Rutledge will examine the mechanism of separation behind liquid-infused membranes (LIMs) in which an infused liquid coats the surface and pores of the membrane, preventing fouling. Robustness of the LIM technology for removal of different types of emulsified oils and oil mixtures will be evaluated. César Terrer is an assistant professor in the Department of Civil and Environmental Engineering whose J-WAFS project seeks to answer the question: How can satellite images be used to provide a high-resolution drought monitoring system for farmers? 

      Drought is recognized as one of the world’s most pressing issues, with direct impacts on vegetation that threaten water resources and food production globally. However, assessing and monitoring the impact of droughts on vegetation is extremely challenging as plants’ sensitivity to lack of water varies across species and ecosystems. Terrer will leverage a new generation of remote sensing satellites to provide high-resolution assessments of plant water stress at regional to global scales. The aim is to provide a plant drought monitoring product with farmland-specific services for water and socioeconomic management.

      Michael Triantafyllou is the Henry L. and Grace Doherty Professor in Ocean Science and Engineering in the Department of Mechanical Engineering. He is developing a web-based system for natural resources management that will deploy geospatial analysis, visualization, and reporting to better manage and facilitate aquaculture data.  By providing value to commercial fisheries’ permit holders who employ significant numbers of people and also to recreational shellfish permit holders who contribute to local economies, the project has attracted support from the Massachusetts Division of Marine Fisheries as well as a number of local resource management departments.

      Massachusetts shell fisheries generated roughly $339 million in 2020, accounting for 17 percent of U.S. East Coast production. Managing such a large industry is a time-consuming process, given there are thousands of acres of coastal areas grouped within over 800 classified shellfish growing areas. Extreme climate events present additional challenges. Triantafyllou’s research will help efforts to enforce environmental regulations, support habitat restoration efforts, and prevent shellfish-related food safety issues. More

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      Five MIT PhD students awarded 2022 J-WAFS fellowships for water and food solutions

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      The Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) recently announced the selection of its 2022-23 cohort of graduate fellows. Two students were named Rasikbhai L. Meswani Fellows for Water Solutions and three students were named J-WAFS Graduate Student Fellows. All five fellows will receive full tuition and a stipend for one semester, and J-WAFS will support the students throughout the 2022-23 academic year by providing networking, mentorship, and opportunities to showcase their research.

      New this year, fellowship nominations were open not only to students pursuing water research, but food-related research as well. The five students selected were chosen for their commitment to solutions-based research that aims to alleviate problems such as water supply or purification, food security, or agriculture. Their projects exemplify the wide range of research that J-WAFS supports, from enhancing nutrition through improved methods to deliver micronutrients to developing high-performance drip irrigation technology. The strong applicant pool reflects the passion MIT students have to address the water and food crises currently facing the planet.

      “This year’s fellows are drawn from a dynamic and engaged community across the Institute whose creativity and ingenuity are pushing forward transformational water and food solutions,” says J-WAFS executive director Renee J. Robins. “We congratulate these students as we recognize their outstanding achievements and their promise as up-and-coming leaders in global water and food sectors.”

      2022-23 Rasikbhai L. Meswani Fellows for Water SolutionsThe Rasikbhai L. Meswani Fellowship for Water Solutions is a fellowship for students pursuing water-related research at MIT. The Rasikbhai L. Meswani Fellowship for Water Solutions was made possible by a generous gift from Elina and Nikhil Meswani and family.

      Aditya Ghodgaonkar is a PhD candidate in the Department of Mechanical Engineering at MIT, where he works in the Global Engineering and Research (GEAR) Lab under Professor Amos Winter. Ghodgaonkar received a bachelor’s degree in mechanical engineering from the RV College of Engineering in India. He then moved to the United States and received a master’s degree in mechanical engineering from Purdue University.Ghodgaonkar is currently designing hydraulic components for drip irrigation that could support the development of water-efficient irrigation systems that are off-grid, inexpensive, and low-maintenance. He has focused on designing drip irrigation emitters that are resistant to clogging, seeking inspiration about flow regulation from marine fauna such as manta rays, as well as turbomachinery concepts. Ghodgaonkar notes that clogging is currently an expensive technical challenge to diagnose, mitigate, and resolve. With an eye on hundreds of millions of farms in developing countries, he aims to bring the benefits of irrigation technology to even the poorest farmers.Outside of his research, Ghodgaonkar is a mentor in MIT Makerworks and has been a teaching assistant for classes such as 2.007 (Design and Manufacturing I). He also helped organize the annual MIT Water Summit last fall.

      Devashish Gokhale is a PhD candidate advised by Professor Patrick Doyle in the Department of Chemical Engineering. He received a bachelor’s degree in chemical engineering from the Indian Institute of Technology Madras, where he researched fluid flow in energy-efficient pumps. Gokhale’s commitment to global water security stemmed from his experience growing up in India, where water sources are threatened by population growth, industrialization, and climate change.As a researcher in the Doyle group, Devashish is developing sustainable and reusable materials for water treatment, with a focus on the elimination of emerging contaminants and other micropollutants from water through cost-effective processes. Many of these contaminants are carcinogens or endocrine disruptors, posing significant threats to both humans and animals. His advisor notes that Devashish was the first researcher in the Doyle group to work on water purification, bringing his passion for the topic to the lab.Gokhale’s research won an award for potential scalability in last year’s J-WAFS World Water Day competition. He also serves as the lecture series chair in the MIT Water Club.

      2022-23 J-WAFS Graduate Student FellowsThe J-WAFS Fellowship for Water and Food Solutions is funded by the J-WAFS Research Affiliate Program, which offers companies the opportunity to collaborate with MIT on water and food research. A portion of each research affiliate’s fees supports this fellowship. The program is central to J-WAFS’ efforts to engage across sector and disciplinary boundaries in solving real-world problems. Currently, there are two J-WAFS Research Affiliates: Xylem, Inc., a water technology company, and GoAigua, a company leading the digital transformation of the water industry.

      James Zhang is a PhD candidate in the Department of Mechanical Engineering at MIT, where he has worked in the NanoEngineering Laboratory with Professor Gang Chen since 2019. As an undergraduate at Carnegie Mellon University, he double majored in mechanical engineering and engineering public policy. He then received a master’s degree in mechanical engineering from MIT. In addition to working in the NanoEngineering Laboratory, James has also worked in the Zhao Laboratory and in the Boriskina Research Group at MIT.Zhang is developing a technology that uses light-induced evaporation to clean water. He is currently investigating the fundamental properties of how light interacts with brackish water surfaces. With strong theoretical as well as experimental components, his research could lead to innovations in desalinating brackish water at high energy efficiencies. Outside of his research, Zhang has served as a student moderator for the MIT International Colloquia on Thermal Innovations.

      Katharina Fransen is a PhD candidate advised by Professor Bradley Olsen in the Department of Chemical Engineering at MIT. She received a bachelor’s degree in chemical engineering from the University of Minnesota, where she was involved in the Society of Women Engineers. Fransen is motivated by the challenge of protecting the most vulnerable global communities from the large quantities of plastic waste associated with traditional food packaging materials. As a researcher in the Olsen Lab, Fransen is developing new plastics that are biologically-based and biodegradable, so they can degrade in the environment instead of polluting communities with plastic waste. These polymers are also optimized for food packaging applications to keep food fresher for longer, preventing food waste.Outside of her research, Fransen is involved in Diversity in Chemical Engineering as the coordinator for the graduate application mentorship program for underrepresented groups. She is also an active member of Graduate Womxn in ChemE and mentors an Undergraduate Research Opportunities Program student.

      Linzixuan (Rhoda) Zhang is a PhD candidate advised by Professor Robert Langer and Ana Jaklenec in the Department of Chemical Engineering at MIT. She received a bachelor’s degree in chemical engineering from the University of Illinois at Urbana-Champaign, where she researched how to genetically engineer microorganisms for the efficient production of advanced biofuels and chemicals.Zhang is currently developing a micronutrient delivery platform that fortifies foods with essential vitamins and nutrients. She has helped develop a group of biodegradable polymers that can stabilize micronutrients under harsh conditions, enabling local food companies to fortify food with essential vitamins. This work aims to tackle a hidden crisis in low- and middle-income countries, where a chronic lack of essential micronutrients affects an estimated 2 billion people.Zhang is also working on the development of self-boosting vaccines to promote more widespread vaccine access and serves as a research mentor in the Langer Lab. More