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    A cysteine-rich diet may promote regeneration of the intestinal lining, study suggests

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    A diet rich in the amino acid cysteine may have rejuvenating effects in the small intestine, according to a new study from MIT. This amino acid, the researchers discovered, can turn on an immune signaling pathway that helps stem cells to regrow new intestinal tissue.This enhanced regeneration may help to heal injuries from radiation, which often occur in patients undergoing radiation therapy for cancer. The research was conducted in mice, but if future research shows similar results in humans, then delivering elevated quantities of cysteine, through diet or supplements, could offer a new strategy to help damaged tissue heal faster, the researchers say.“The study suggests that if we give these patients a cysteine-rich diet or cysteine supplementation, perhaps we can dampen some of the chemotherapy or radiation-induced injury,” says Omer Yilmaz, director of the MIT Stem Cell Initiative, an associate professor of biology at MIT, and a member of MIT’s Koch Institute for Integrative Cancer Research. “The beauty here is we’re not using a synthetic molecule; we’re exploiting a natural dietary compound.”While previous research has shown that certain types of diets, including low-calorie diets, can enhance intestinal stem cell activity, the new study is the first to identify a single nutrient that can help intestinal cells to regenerate.Yilmaz is the senior author of the study, which appears today in Nature. Koch Institute postdoc Fangtao Chi is the paper’s lead author.Boosting regenerationIt is well-established that diet can affect overall health: High-fat diets can lead to obesity, diabetes, and other health problems, while low-calorie diets have been shown to extend lifespans in many species. In recent years, Yilmaz’s lab has investigated how different types of diets influence stem cell regeneration, and found that high-fat diets, as well as short periods of fasting, can enhance stem cell activity in different ways.“We know that macro diets such as high-sugar diets, high-fat diets, and low-calorie diets have a clear impact on health. But at the granular level, we know much less about how individual nutrients impact stem cell fate decisions, as well as tissue function and overall tissue health,” Yilmaz says.In their new study, the researchers began by feeding mice a diet high in one of 20 different amino acids, the building blocks of proteins. For each group, they measured how the diet affected intestinal stem cell regeneration. Among these amino acids, cysteine had the most dramatic effects on stem cells and progenitor cells (immature cells that differentiate into adult intestinal cells).Further studies revealed that cysteine initiates a chain of events leading to the activation of a population of immune cells called CD8 T cells. When cells in the lining of the intestine absorb cysteine from digested food, they convert it into CoA, a cofactor that is released into the mucosal lining of the intestine. There, CD8 T cells absorb CoA, which stimulates them to begin proliferating and producing a cytokine called IL-22.IL-22 is an important player in the regulation of intestinal stem cell regeneration, but until now, it wasn’t known that CD8 T cells can produce it to boost intestinal stem cells. Once activated, those IL-22-releasing T cells are primed to help combat any kind of injury that could occur within the intestinal lining.“What’s really exciting here is that feeding mice a cysteine-rich diet leads to the expansion of an immune cell population that we typically don’t associate with IL-22 production and the regulation of intestinal stemness,” Yilmaz says. “What happens in a cysteine-rich diet is that the pool of cells that make IL-22 increases, particularly the CD8 T-cell fraction.”These T cells tend to congregate within the lining of the intestine, so they are already in position when needed. The researchers found that the stimulation of CD8 T cells occurred primarily in the small intestine, not in any other part of the digestive tract, which they believe is because most of the protein that we consume is absorbed by the small intestine.Healing the intestineIn this study, the researchers showed that regeneration stimulated by a cysteine-rich diet could help to repair radiation damage to the intestinal lining. Also, in work that has not been published yet, they showed that a high-cysteine diet had a regenerative effect following treatment with a chemotherapy drug called 5-fluorouracil. This drug, which is used to treat colon and pancreatic cancers, can also damage the intestinal lining.Cysteine is found in many high-protein foods, including meat, dairy products, legumes, and nuts. The body can also synthesize its own cysteine, by converting the amino acid methionine to cysteine — a process that takes place in the liver. However, cysteine produced in the liver is distributed through the entire body and doesn’t lead to a buildup in the small intestine the way that consuming cysteine in the diet does.“With our high-cysteine diet, the gut is the first place that sees a high amount of cysteine,” Chi says.Cysteine has been previously shown to have antioxidant effects, which are also beneficial, but this study is the first to demonstrate its effect on intestinal stem cell regeneration. The researchers now hope to study whether it may also help other types of stem cells regenerate new tissues. In one ongoing study, they are investigating whether cysteine might stimulate hair follicle regeneration.They also plan to further investigate some of the other amino acids that appear to influence stem cell regeneration.“I think we’re going to uncover multiple new mechanisms for how these amino acids regulate cell fate decisions and gut health in the small intestine and colon,” Yilmaz says.The research was funded, in part, by the National Institutes of Health, the V Foundation, the Kathy and Curt Marble Cancer Research Award, the Koch Institute-Dana-Farber/Harvard Cancer Center Bridge Project, the American Federation for Aging Research, the MIT Stem Cell Initiative, and the Koch Institute Support (core) Grant from the National Cancer Institute. More

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      Study shows a link between obesity and what’s on local restaurant menus

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      For many years, health experts have been concerned about “food deserts,” places where residents lack good nutritional options. Now, an MIT-led study of three major global cities uses a new, granular method to examine the issue, and concludes that having fewer and less nutritional eating options nearby correlates with obesity and other health outcomes.Rather than just mapping geographic areas, the researchers examined the dietary value of millions of food items on roughly 30,000 restaurant menus and derived a more precise assessment of the connection between neighborhoods and nutrition.“We show that what is sold in a restaurant has a direct correlation to people’s health,” says MIT researcher Fabio Duarte, co-author of a newly published paper outlining the study’s results. “The food landscape matters.”The open-access paper, “Data-driven nutritional assessment of urban food landscapes: insights from Boston, London, Dubai,” was published this week in Nature: Scientific Reports.The co-authors are Michael Tufano, a PhD student at Wageningen University, in the Netherlands; Duarte, associate director of MIT’s Senseable City Lab, which uses data to study cities as dynamic systems; Martina Mazzarello, a postdoc at the Senseable City Lab; Javad Eshtiyagh, a research fellow at the Senseable City Lab; Carlo Ratti, professor of the practice and director of the Senseable City Lab; and Guido Camps, a senior researcher at Wageningen University.Scanning the menuTo conduct the study, the researchers examined menus from Boston, Dubai, and London, in the summer of 2023, compiling a database of millions of items available through popular food-delivery platforms. The team then evaluated the food items as rated by the USDA’s FoodData Central database, an information bank with 375,000 kinds of food products listed. The study deployed two main metrics, the Meal Balance Index, and the Nutrient-Rich Foods Index.The researchers examined about 222,000 menu items from over 2,000 restaurants in Boston, about 1.6 million menu items from roughly 9,000 restaurants in Dubai, and about 3.1 million menu items from about 18,000 restaurants in London. In Boston, about 71 percent of the items were in the USDA database; in Dubai and London, that figure was 42 percent and 56 percent, respectively.The team then rated the nutritional value of the items appearing on menus, and correlated the food data with health-outcome data from Boston and London. In London, they found a clear correlation between neighborhood menu offerings and obesity, or the lack thereof; with a slightly less firm correlation in Boston. Areas with food options that include a lot of dietary fibers, sometimes along with fruits and vegetables, tend to have better health data.In Dubai, the researchers did not have the same types of health data available but did observe a strong correlation between rental prices and the nutritional value of neighborhood-level food, suggesting that wealthier residents have better nourishment options.“At the item level, when we have less nutritional food, we see more cases of obsesity,” Tufano says. “It’s true that not only do we have more fast food in poor neighborhoods, but the nutritional value is not the same.”Re-mapping the food landscapeBy conducting the study in this fashion, the scholars added a layer of analysis to past studies of food deserts. While past work has broken ground by identifying neighborhoods and areas lacking good food access, this research makes a more comprehensive assessment of what people consume. The research moves toward evaluating the complex mix of food available in any given area, which can be true even of areas with more limited options.“We were not satisfied with this idea that if you only have fast food, it’s a food desert, but if you have a Whole Foods, it’s not,” Duarte says. “It’s not necessarily like that.”For the Senseable City Lab researchers, the study is a new technique further enabling them to understand city dynamics and the effects of the urban environment on health. Past lab studies have often focused on issues such as urban mobility, while extending to matters such as mobility and air pollution, among other topics.Being able to study food and health at the neighborhood level, though, is still another example of the ways that data-rich spheres of life can be studied in close detail.“When we started working on cities and data, the data resolution was so low,” Ratti says. “Today the amount of data is so immense we see this great opportunity to look at cities and see the influence of the urban environment as a big determinant of health. We see this as one of the new frontiers of our lab. It’s amazing how we can now look at this very precisely in cities.” More

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      MIT Solve announces 2025 Global Challenges

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      MIT Solve has launched its 2025 Global Challenges, calling on innovators worldwide to submit transformative, tech-driven solutions to some of the planet’s most pressing and persistent problems. With over $1 million in funding available, selected innovators have a unique opportunity to scale their solutions and gain an influential network.”In an era where technology is transforming our world at breakneck speed, we’re seeing a profound shift in how innovators approach global problems,” says Hala Hanna, executive director of MIT Solve. “The unprecedented convergence of technological capabilities and social consciousness sets our current moment apart. Our Solver teams aren’t just creating solutions — they’re rewriting the rules of what’s possible in social innovation. With their solutions now reaching over 280 million lives worldwide, they’re demonstrating that human-centered technology can scale impact in ways we never imagined possible.”Over 30 winning solutions will be announced at Solve Challenge Finals during Climate Week and the United Nations General Assembly in New York City. Selected innovators join the 2025 Solver Class, gaining access to a comprehensive nine-month support program that includes connections to MIT’s innovation ecosystem, specialized mentorship, extensive pro-bono resources, and substantial funding from Solve’s growing community of supporters.2025 funding opportunities for selected Solvers exceed $1 million and include:Health Innovation Award (supported by Johnson & Johnson Foundation): All Solver teams selected for Solve’s Global Health Challenge will receive an additional prize from Global Health Anchor Supporter, Johnson & Johnson FoundationThe Seeding the Future Food Systems Prize (supported by the Seeding The Future Foundation)The GM Prize (supported by General Motors)The AI for Humanity Prize (supported by The Patrick J. McGovern Foundation)The Crescent Enterprises “AI for Social Innovation” Prize (supported by Crescent Enterprises)The Citizens Workforce Innovation Prize (supported by Citizens)The E Ink Innovation Prize (supported by E Ink)Since 2015, supporters of MIT Solve have catalyzed more than 800 partnerships and deployed more than $70 million, touching the lives of 280 million people worldwide. More

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      An inflatable gastric balloon could help people lose weight

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      Gastric balloons — silicone balloons filled with air or saline and placed in the stomach — can help people lose weight by making them feel too full to overeat. However, this effect eventually can wear off as the stomach becomes used to the sensation of fullness.To overcome that limitation, MIT engineers have designed a new type of gastric balloon that can be inflated and deflated as needed. In an animal study, they showed that inflating the balloon before a meal caused the animals to reduce their food intake by 60 percent.This type of intervention could offer an alternative for people who don’t want to undergo more invasive treatments such as gastric bypass surgery, or people who don’t respond well to weight-loss drugs, the researchers say.“The basic concept is we can have this balloon that is dynamic, so it would be inflated right before a meal and then you wouldn’t feel hungry. Then it would be deflated in between meals,” says Giovanni Traverso, an associate professor of mechanical engineering at MIT, a gastroenterologist at Brigham and Women’s Hospital, and the senior author of the study.Neil Zixun Jia, who received a PhD from MIT in 2023, is the lead author of the paper, which appears today in the journal Device.An inflatable balloonGastric balloons filled with saline are currently approved for use in the United States. These balloons stimulate a sense of fullness in the stomach, and studies have shown that they work well, but the benefits are often temporary.“Gastric balloons do work initially. Historically, what has been seen is that the balloon is associated with weight loss. But then in general, the weight gain resumes the same trajectory,” Traverso says. “What we reasoned was perhaps if we had a system that simulates that fullness in a transient way, meaning right before a meal, that could be a way of inducing weight loss.”To achieve a longer-lasting effect in patients, the researchers set out to design a device that could expand and contract on demand. They created two prototypes: One is a traditional balloon that inflates and deflates, and the other is a mechanical device with four arms that expand outward, pushing out an elastic polymer shell that presses on the stomach wall.In animal tests, the researchers found that the mechanical-arm device could effectively expand to fill the stomach, but they ended up deciding to pursue the balloon option instead.“Our sense was that the balloon probably distributed the force better, and down the line, if you have balloon that is applying the pressure, that is probably a safer approach in the long run,” Traverso says.The researchers’ new balloon is similar to a traditional gastric balloon, but it is inserted into the stomach through an incision in the abdominal wall. The balloon is connected to an external controller that can be attached to the skin and contains a pump that inflates and deflates the balloon when needed. Inserting this device would be similar to the procedure used to place a feeding tube into a patient’s stomach, which is commonly done for people who are unable to eat or drink.“If people, for example, are unable to swallow, they receive food through a tube like this. We know that we can keep tubes in for years, so there is already precedent for other systems that can stay in the body for a very long time. That gives us some confidence in the longer-term compatibility of this system,” Traverso says.Reduced food intakeIn tests in animals, the researchers found that inflating the balloon before meals led to a 60 percent reduction in the amount of food consumed. These studies were done over the course of a month, but the researchers now plan to do longer-term studies to see if this reduction leads to weight loss.“The deployment for traditional gastric balloons is usually six months, if not more, and only then you will see good amount of weight loss. We will have to evaluate our device in a similar or longer time span to prove it really works better,” Jia says.If developed for use in humans, the new gastric balloon could offer an alternative to existing obesity treatments. Other treatments for obesity include gastric bypass surgery, “stomach stapling” (a surgical procedure in which the stomach capacity is reduced), and drugs including GLP-1 receptor agonists such as semaglutide.The gastric balloon could be an option for patients who are not good candidates for surgery or don’t respond well to weight-loss drugs, Traverso says.“For certain patients who are higher-risk, who cannot undergo surgery, or did not tolerate the medication or had some other contraindication, there are limited options,” he says. “Traditional gastric balloons are still being used, but they come with a caveat that eventually the weight loss can plateau, so this is a way of trying to address that fundamental limitation.”The research was funded by MIT’s Department of Mechanical Engineering, the Karl van Tassel Career Development Professorship, the Whitaker Health Sciences Fund Fellowship, the T.S. Lin Fellowship, the MIT Undergraduate Research Opportunities Program, and the Boston University Yawkey Funded Internship Program.  More

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      Linzixuan (Rhoda) Zhang wins 2024 Collegiate Inventors Competition

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      Linzixuan (Rhoda) Zhang, a doctoral candidate in the MIT Department of Chemical Engineering, recently won the 2024 Collegiate Inventors Competition, medaling in both the Graduate and People’s Choice categories for developing materials to stabilize nutrients in food with the goal of improving global health.  The annual competition, organized by the National Inventors Hall of Fame and United States Patent and Trademark Office (USPTO), celebrates college and university student inventors. The finalists present their inventions to a panel of final-round judges composed of National Inventors Hall of Fame inductees and USPTO officials. No stranger to having her work in the limelight, Zhang is a three-time winner of the Koch Institute Image Awards in 2022, 2023, and 2024, as well as a 2022 fellow at the MIT Abdul Latif Jameel Water and Food Systems Lab.  “Rhoda is an exceptionally dedicated and creative student. Her well-deserved award recognizes the potential of her research on nutrient stabilization, which could have a significant impact on society,” says Ana Jaklenec, one of Zhang’s advisors and a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. Zhang is also advised by David H. Koch (1962) Institute Professor Robert Langer. Frameworks for global healthIn a world where nearly 2 billion people suffer from micronutrient deficiencies, particularly iron, the urgency for effective solutions has never been greater. Iron deficiency is especially harmful for vulnerable populations such as children and pregnant women, since it can lead to weakened immune systems and developmental delays. The World Health Organization has highlighted food fortification as a cost-effective strategy, yet many current methods fall short. Iron and other nutrients can break down during processing or cooking, and synthetic additives often come with high costs and environmental drawbacks. Zhang, along with her teammate, Xin Yang, a postdoc associate at Koch Institute, set out to innovate new technologies for nutrient fortification that are effective, accessible, and sustainable, leading to the invention nutritional metal-organic frameworks (NuMOFs) and the subsequent launch of MOFe Coffee, the world’s first iron-fortified coffee. NuMOFs not only protect essential nutrients such as iron while in food for long periods of time, but also make them more easily absorbed and used once consumed.The inspiration for the coffee came from the success of iodized salt, which significantly reduced iodine deficiency worldwide. Because coffee and tea are associated with low iron absorption, iron fortification would directly address the challenge.However, replicating the success of iodized salt for iron fortification has been extremely challenging due to the micronutrient’s high reactivity and the instability of iron(II) salts. As researchers with backgrounds in material science, chemistry, and food technology, Zhang and Yang leveraged their expertise to develop a solution that could overcome these technical barriers. The fortified coffee serves as a practical example of how NuMOFs can help people increase their iron intake by engaging in a habit that’s already part of their daily routine, with significant potential benefits for women, who are disproportionately affected by iron deficiency. The team plans to expand the technology to incorporate additional nutrients to address a wider array of nutritional deficiencies and improve health equity globally.Fast-track to addressing global health improvementsLooking ahead, Zhang and Yang in the Jaklenec Group are focused on both product commercialization and ongoing research, refining MOFe Coffee to enhance nutrient stability and ensuring the product remains palatable while maximizing iron absorption.Winning the CIC competition means that Zhang, Yang, and the team can fast-track their patent application with the USPTO. The team hopes that their fast-tracked patent will allow them to attract more potential investors and partners, which is crucial for scaling their efforts. A quicker patent process also means that the team can bring the technology to market faster, helping improve global nutrition and health for those who need it most. “Our goal is to make a real difference in addressing micronutrient deficiencies around the world,” says Zhang.   More

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      Lemelson-MIT awards 2024-25 InvenTeam grants to eight high school teams

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      The Lemelson-MIT Program has announced the 2024-25 InvenTeams — eight teams of high school students, teachers, and mentors from across the country. Each team will each receive $7,500 in grant funding and year-long support to build a technological invention to solve a problem of their own choosing. The students’ inventions are inspired by real-world problems they identified in their local communities.The InvenTeams were selected by a respected panel consisting of university professors, inventors, entrepreneurs, industry professionals, and college students. Some panel members were former InvenTeam members now working in industry. The InvenTeams are focusing on problems facing their local communities, with a goal that their inventions will have a positive impact on beneficiaries and, ultimately, improve the lives of others beyond their communities.This year’s teams are:Battle Creek Area Mathematics and Science Center (Battle Creek, Michigan)Cambridge Rindge and Latin School (Cambridge, Massachusetts)Colegio Rosa-Bell (Guaynabo, Puerto Rico)Edison High School (Edison, New Jersey)Massachusetts Academy of Math and Science (Worcester, Massachusetts)Nitro High School (Nitro, West Virginia)Southcrest Christian School (Lubbock, Texas)Ygnacio Valley High School (Concord, California)InvenTeams are comprised of students, teachers and community mentors who pursue year-long invention projects involving creative thinking, problem-solving, and hands-on learning in science, technology, engineering, and mathematics. The InvenTeams’ prototype inventions will be showcased at a technical review within their home communities in February 2025, and then again as a final prototype at EurekaFest — an invention celebration taking place June 9-11, 2025, at MIT.“The InvenTeams are focusing on solving problems that impact their local communities,” says Leigh Estabrooks, Lemelson-MIT’s invention education officer. “Teams are focusing their technological solutions — their inventions — on health and well-being, environmental issues, and safety concerns. These high school students are not just problem-solvers of tomorrow, they are problem solvers today helping to make our world healthier, greener, and safer.”This year the Lemelson-MIT Program and the InvenTeams grants initiative celebrate a series of firsts in the annual high school invention grant program. For the first time, a team from their home city of Cambridge, Massachusetts, will participate, representing the Cambridge community’s innovative spirit on a national stage. Additionally, the program welcomes the first team from Puerto Rico, highlighting the expanding reach of the InvenTeams grants initiative. The pioneering teams exemplify the diversity and creativity that fuel invention.The InvenTeams grants initiative, now in its 21st year, has enabled 18 teams of high school students to be awarded U.S. patents for their projects. Intellectual property education is combined with invention education offerings as part of the Lemelson-MIT Program’s deliberate efforts to remedy historic inequities among those who develop inventions, protect their intellectual property, and commercialize their creations. The ongoing efforts empower students from all backgrounds, equipping them with invaluable problem-solving skills that will serve them well throughout their academic journeys, professional pursuits, and personal lives. The program has worked with over 4,000 students across 304 different InvenTeams nationwide and has included:partnering with intellectual property (IP) law firms to provide pro bono legal support;collaborating with industry-leading companies that provide technical guidance and mentoring;providing professional development for teachers on invention education and IP;assisting teams with identifying resources within their communities’ innovation ecosystems to support ongoing invention efforts; andpublishing case studies and research to inform the work of invention educators and policy makers to build support for engaging students in efforts to invent solutions to real-world problems, thus fueling the innovation economy in the U.S.The Lemelson-MIT Program is a national leader in efforts to prepare the next generation of inventors and entrepreneurs, focusing on the expansion of opportunities for people to learn ways inventors find and solve problems that matter to improve lives. A commitment to diversity, equity, and inclusion aims to remedy historic inequities among those who develop inventions, protect their intellectual property, and commercialize their creations.Jerome H. Lemelson, one of U.S. history’s most prolific inventors, and his wife Dorothy founded the Lemelson-MIT Program in 1994. It is funded by The Lemelson Foundation and administered by the MIT School of Engineering. For more information, contact Leigh Estabrooks.  More

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      How climate change will impact outdoor activities in the US

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      It can be hard to connect a certain amount of average global warming with one’s everyday experience, so researchers at MIT have devised a different approach to quantifying the direct impact of climate change. Instead of focusing on global averages, they came up with the concept of “outdoor days”: the number days per year in a given location when the temperature is not too hot or cold to enjoy normal outdoor activities, such as going for a walk, playing sports, working in the garden, or dining outdoors.In a study published earlier this year, the researchers applied this method to compare the impact of global climate change on different countries around the world, showing that much of the global south would suffer major losses in the number of outdoor days, while some northern countries could see a slight increase. Now, they have applied the same approach to comparing the outcomes for different parts of the United States, dividing the country into nine climatic regions, and finding similar results: Some states, especially Florida and other parts of the Southeast, should see a significant drop in outdoor days, while some, especially in the Northwest, should see a slight increase.The researchers also looked at correlations between economic activity, such as tourism trends, and changing climate conditions, and examined how numbers of outdoor days could result in significant social and economic impacts. Florida’s economy, for example, is highly dependent on tourism and on people moving there for its pleasant climate; a major drop in days when it is comfortable to spend time outdoors could make the state less of a draw.The new findings were published this month in the journal Geophysical Research Letters, in a paper by researchers Yeon-Woo Choi and Muhammad Khalifa and professor of civil and environmental engineering Elfatih Eltahir.“This is something very new in our attempt to understand impacts of climate change impact, in addition to the changing extremes,” Choi says. It allows people to see how these global changes may impact them on a very personal level, as opposed to focusing on global temperature changes or on extreme events such as powerful hurricanes or increased wildfires. “To the best of my knowledge, nobody else takes this same approach” in quantifying the local impacts of climate change, he says. “I hope that many others will parallel our approach to better understand how climate may affect our daily lives.”The study looked at two different climate scenarios — one where maximum efforts are made to curb global emissions of greenhouse gases and one “worst case” scenario where little is done and global warming continues to accelerate. They used these two scenarios with every available global climate model, 32 in all, and the results were broadly consistent across all 32 models.The reality may lie somewhere in between the two extremes that were modeled, Eltahir suggests. “I don’t think we’re going to act as aggressively” as the low-emissions scenarios suggest, he says, “and we may not be as careless” as the high-emissions scenario. “Maybe the reality will emerge in the middle, toward the end of the century,” he says.The team looked at the difference in temperatures and other conditions over various ranges of decades. The data already showed some slight differences in outdoor days from the 1961-1990 period compared to 1991-2020. The researchers then compared these most recent 30 years with the last 30 years of this century, as projected by the models, and found much greater differences ahead for some regions. The strongest effects in the modeling were seen in the Southeastern states. “It seems like climate change is going to have a significant impact on the Southeast in terms of reducing the number of outdoor days,” Eltahir says, “with implications for the quality of life of the population, and also for the attractiveness of tourism and for people who want to retire there.”He adds that “surprisingly, one of the regions that would benefit a little bit is the Northwest.” But the gain there is modest: an increase of about 14 percent in outdoor days projected for the last three decades of this century, compared to the period from 1976 to 2005. The Southwestern U.S., by comparison, faces an average loss of 23 percent of their outdoor days.The study also digs into the relationship between climate and economic activity by looking at tourism trends from U.S. National Park Service visitation data, and how that aligned with differences in climate conditions. “Accounting for seasonal variations, we find a clear connection between the number of outdoor days and the number of tourist visits in the United States,” Choi says.For much of the country, there will be little overall change in the total number of annual outdoor days, the study found, but the seasonal pattern of those days could change significantly. While most parts of the country now see the most outdoor days in summertime, that will shift as summers get hotter, and spring and fall will become the preferred seasons for outdoor activity.In a way, Eltahir says, “what we are talking about that will happen in the future [for most of the country] is already happening in Florida.” There, he says, “the really enjoyable time of year is in the spring and fall, and summer is not the best time of year.”People’s level of comfort with temperatures varies somewhat among individuals and among regions, so the researchers designed a tool, now freely available online, that allows people to set their own definitions of the lowest and highest temperatures they consider suitable for outdoor activities, and then see what the climate models predict would be the change in the number of outdoor days for their location, using their own standards of comfort. For their study, they used a widely accepted range of 10 degrees Celsius (50 degrees Fahrenheit) to 25 C (77 F), which is the “thermoneutral zone” in which the human body does not require either metabolic heat generation or evaporative cooling to maintain its core temperature — in other words, in that range there is generally no need to either shiver or sweat.The model mainly focuses on temperature but also allows people to include humidity or precipitation in their definition of what constitutes a comfortable outdoor day. The model could be extended to incorporate other variables such as air quality, but the researchers say temperature tends to be the major determinant of comfort for most people.Using their software tool, “If you disagree with how we define an outdoor day, you could define one for yourself, and then you’ll see what the impacts of that are on your number of outdoor days and their seasonality,” Eltahir says.This work was inspired by the realization, he says, that “people’s understanding of climate change is based on the assumption that climate change is something that’s going to happen sometime in the future and going to happen to someone else. It’s not going to impact them directly. And I think that contributes to the fact that we are not doing enough.”Instead, the concept of outdoor days “brings the concept of climate change home, brings it to personal everyday activities,” he says. “I hope that people will find that useful to bridge that gap, and provide a better understanding and appreciation of the problem. And hopefully that would help lead to sound policies that are based on science, regarding climate change.”The research was based on work supported by the Community Jameel for Jameel Observatory CREWSnet and Abdul Latif Jameel Water and Food Systems Lab at MIT. More

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      Study evaluates impacts of summer heat in U.S. prison environments

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      When summer temperatures spike, so does our vulnerability to heat-related illness or even death. For the most part, people can take measures to reduce their heat exposure by opening a window, turning up the air conditioning, or simply getting a glass of water. But for people who are incarcerated, freedom to take such measures is often not an option. Prison populations therefore are especially vulnerable to heat exposure, due to their conditions of confinement.A new study by MIT researchers examines summertime heat exposure in prisons across the United States and identifies characteristics within prison facilities that can further contribute to a population’s vulnerability to summer heat.The study’s authors used high-spatial-resolution air temperature data to determine the daily average outdoor temperature for each of 1,614 prisons in the U.S., for every summer between the years 1990 and 2023. They found that the prisons that are exposed to the most extreme heat are located in the southwestern U.S., while prisons with the biggest changes in summertime heat, compared to the historical record, are in the Pacific Northwest, the Northeast, and parts of the Midwest.Those findings are not entirely unique to prisons, as any non-prison facility or community in the same geographic locations would be exposed to similar outdoor air temperatures. But the team also looked at characteristics specific to prison facilities that could further exacerbate an incarcerated person’s vulnerability to heat exposure. They identified nine such facility-level characteristics, such as highly restricted movement, poor staffing, and inadequate mental health treatment. People living and working in prisons with any one of these characteristics may experience compounded risk to summertime heat. The team also looked at the demographics of 1,260 prisons in their study and found that the prisons with higher heat exposure on average also had higher proportions of non-white and Hispanic populations. The study, appearing today in the journal GeoHealth, provides policymakers and community leaders with ways to estimate, and take steps to address, a prison population’s heat risk, which they anticipate could worsen with climate change.“This isn’t a problem because of climate change. It’s becoming a worse problem because of climate change,” says study lead author Ufuoma Ovienmhada SM ’20, PhD ’24, a graduate of the MIT Media Lab, who recently completed her doctorate in MIT’s Department of Aeronautics and Astronautics (AeroAstro). “A lot of these prisons were not built to be comfortable or humane in the first place. Climate change is just aggravating the fact that prisons are not designed to enable incarcerated populations to moderate their own exposure to environmental risk factors such as extreme heat.”The study’s co-authors include Danielle Wood, MIT associate professor of media arts and sciences, and of AeroAstro; and Brent Minchew, MIT associate professor of geophysics in the Department of Earth, Atmospheric and Planetary Sciences; along with Ahmed Diongue ’24, Mia Hines-Shanks of Grinnell College, and Michael Krisch of Columbia University.Environmental intersectionsThe new study is an extension of work carried out at the Media Lab, where Wood leads the Space Enabled research group. The group aims to advance social and environmental justice issues through the use of satellite data and other space-enabled technologies.The group’s motivation to look at heat exposure in prisons came in 2020 when, as co-president of MIT’s Black Graduate Student Union, Ovienmhada took part in community organizing efforts following the murder of George Floyd by Minneapolis police.“We started to do more organizing on campus around policing and reimagining public safety. Through that lens I learned more about police and prisons as interconnected systems, and came across this intersection between prisons and environmental hazards,” says Ovienmhada, who is leading an effort to map the various environmental hazards that prisons, jails, and detention centers face. “In terms of environmental hazards, extreme heat causes some of the most acute impacts for incarcerated people.”She, Wood, and their colleagues set out to use Earth observation data to characterize U.S. prison populations’ vulnerability, or their risk of experiencing negative impacts, from heat.The team first looked through a database maintained by the U.S. Department of Homeland Security that lists the location and boundaries of carceral facilities in the U.S. From the database’s more than 6,000 prisons, jails, and detention centers, the researchers highlighted 1,614 prison-specific facilities, which together incarcerate nearly 1.4 million people, and employ about 337,000 staff.They then looked to Daymet, a detailed weather and climate database that tracks daily temperatures across the United States, at a 1-kilometer resolution. For each of the 1,614 prison locations, they mapped the daily outdoor temperature, for every summer between the years 1990 to 2023, noting that the majority of current state and federal correctional facilities in the U.S. were built by 1990.The team also obtained U.S. Census data on each facility’s demographic and facility-level characteristics, such as prison labor activities and conditions of confinement. One limitation of the study that the researchers acknowledge is a lack of information regarding a prison’s climate control.“There’s no comprehensive public resource where you can look up whether a facility has air conditioning,” Ovienmhada notes. “Even in facilities with air conditioning, incarcerated people may not have regular access to those cooling systems, so our measurements of outdoor air temperature may not be far off from reality.”Heat factorsFrom their analysis, the researchers found that more than 98 percent of all prisons in the U.S. experienced at least 10 days in the summer that were hotter than every previous summer, on average, for a given location. Their analysis also revealed the most heat-exposed prisons, and the prisons that experienced the highest temperatures on average, were mostly in the Southwestern U.S. The researchers note that with the exception of New Mexico, the Southwest is a region where there are no universal air conditioning regulations in state-operated prisons.“States run their own prison systems, and there is no uniformity of data collection or policy regarding air conditioning,” says Wood, who notes that there is some information on cooling systems in some states and individual prison facilities, but the data is sparse overall, and too inconsistent to include in the group’s nationwide study.While the researchers could not incorporate air conditioning data, they did consider other facility-level factors that could worsen the effects that outdoor heat triggers. They looked through the scientific literature on heat, health impacts, and prison conditions, and focused on 17 measurable facility-level variables that contribute to heat-related health problems. These include factors such as overcrowding and understaffing.“We know that whenever you’re in a room that has a lot of people, it’s going to feel hotter, even if there’s air conditioning in that environment,” Ovienmhada says. “Also, staffing is a huge factor. Facilities that don’t have air conditioning but still try to do heat risk-mitigation procedures might rely on staff to distribute ice or water every few hours. If that facility is understaffed or has neglectful staff, that may increase people’s susceptibility to hot days.”The study found that prisons with any of nine of the 17 variables showed statistically significant greater heat exposures than the prisons without those variables. Additionally, if a prison exhibits any one of the nine variables, this could worsen people’s heat risk through the combination of elevated heat exposure and vulnerability. The variables, they say, could help state regulators and activists identify prisons to prioritize for heat interventions.“The prison population is aging, and even if you’re not in a ‘hot state,’ every state has responsibility to respond,” Wood emphasizes. “For instance, areas in the Northwest, where you might expect to be temperate overall, have experienced a number of days in recent years of increasing heat risk. A few days out of the year can still be dangerous, particularly for a population with reduced agency to regulate their own exposure to heat.”This work was supported, in part, by NASA, the MIT Media Lab, and MIT’s Institute for Data, Systems and Society’s Research Initiative on Combatting Systemic Racism. More

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      in Environment

      A new way to quantify climate change impacts: “Outdoor days”

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      For most people, reading about the difference between a global average temperature rise of 1.5 C versus 2 C doesn’t conjure up a clear image of how their daily lives will actually be affected. So, researchers at MIT have come up with a different way of measuring and describing what global climate change patterns, in specific regions around the world, will mean for people’s daily activities and their quality of life.

      The new measure, called “outdoor days,” describes the number of days per year that outdoor temperatures are neither too hot nor too cold for people to go about normal outdoor activities, whether work or leisure, in reasonable comfort. Describing the impact of rising temperatures in those terms reveals some significant global disparities, the researchers say.

      The findings are described in a research paper written by MIT professor of civil and environmental engineering Elfatih Eltahir and postdocs Yeon-Woo Choi and Muhammad Khalifa, and published in the Journal of Climate.

      Eltahir says he got the idea for this new system during his hourlong daily walks in the Boston area. “That’s how I interface with the temperature every day,” he says. He found that there have been more winter days recently when he could walk comfortably than in past years. Originally from Sudan, he says that when he returned there for visits, the opposite was the case: In winter, the weather tends to be relatively comfortable, but the number of these clement winter days has been declining. “There are fewer days that are really suitable for outdoor activity,” Eltahir says.

      Rather than predefine what constitutes an acceptable outdoor day, Eltahir and his co-authors created a website where users can set their own definition of the highest and lowest temperatures they consider comfortable for their outside activities, then click on a country within a world map, or a state within the U.S., and get a forecast of how the number of days meeting those criteria will change between now and the end of this century. The website is freely available for anyone to use.

      “This is actually a new feature that’s quite innovative,” he says. “We don’t tell people what an outdoor day should be; we let the user define an outdoor day. Hence, we invite them to participate in defining how future climate change will impact their quality of life, and hopefully, this will facilitate deeper understanding of how climate change will impact individuals directly.”

      After deciding that this was a way of looking at the issue of climate change that might be useful, Eltahir says, “we started looking at the data on this, and we made several discoveries that I think are pretty significant.”

      First of all, there will be winners and losers, and the losers tend to be concentrated in the global south. “In the North, in a place like Russia or Canada, you gain a significant number of outdoor days. And when you go south to places like Bangladesh or Sudan, it’s bad news. You get significantly fewer outdoor days. It is very striking.”

      To derive the data, the software developed by the team uses all of the available climate models, about 50 of them, and provides output showing all of those projections on a single graph to make clear the range of possibilities, as well as the average forecast.

      When we think of climate change, Eltahir says, we tend to look at maps that show that virtually everywhere, temperatures will rise. “But if you think in terms of outdoor days, you see that the world is not flat. The North is gaining; the South is losing.”

      While North-South disparity in exposure and vulnerability has been broadly recognized in the past, he says, this way of quantifying the effects on the hazard (change in weather patterns) helps to bring home how strong the uneven risks from climate change on quality of life will be. “When you look at places like Bangladesh, Colombia, Ivory Coast, Sudan, Indonesia — they are all losing outdoor days.”

      The same kind of disparity shows up in Europe, he says. The effects are already being felt, and are showing up in travel patterns: “There is a shift to people spending time in northern European states. They go to Sweden and places like that instead of the Mediterranean, which is showing a significant drop,” he says.

      Placing this kind of detailed and localized information at people’s fingertips, he says, “I think brings the issue of communication of climate change to a different level.” With this tool, instead of looking at global averages, “we are saying according to your own definition of what a pleasant day is, [this is] how climate change is going to impact you, your activities.”

      And, he adds, “hopefully that will help society make decisions about what to do with this global challenge.”

      The project received support from the MIT Climate Grand Challenges project “Jameel Observatory – Climate Resilience Early Warning System Network,” as well as from the Abdul Latif Jameel Water and Food Systems Lab. More