Serebrovsky, A. S. On the possibility of a new method for the control of insect pests. Zool. Zh. 19, 618–630 (1940).
Curtis, C. F. Possible use of translocations to fix desirable genes in insect pest populations. Nature 218, 368–369 (1968). This paper is one of the first to describe how reciprocal chromosomal translocations could be used to drive a favoured linked trait in a threshold-dependent fashion.
Google Scholar
Dawkins, R. The Selfish Gene Vol. 345 (Oxford University Press, 1976).
Bastide, H. et al. Rapid rise and fall of selfish sex-ratio X chromosomes in Drosophila simulans: spatiotemporal analysis of phenotypic and molecular data. Mol. Biol. Evol. 28, 2461–2470 (2011).
Google Scholar
Corbett-Detig, R., Medina, P., Frerot, H., Blassiau, C. & Castric, V. Bulk pollen sequencing reveals rapid evolution of segregation distortion in the male germline of Arabidopsis hybrids. Evol. Lett. 3, 93–103 (2019).
Google Scholar
Kingan, S. B., Garrigan, D. & Hartl, D. L. Recurrent selection on the Winters sex-ratio genes in Drosophila simulans. Genetics 184, 253–265 (2010).
Google Scholar
McLaughlin, R. N. Jr. & Malik, H. S. Genetic conflicts: the usual suspects and beyond. J. Exp. Biol. 220, 6–17 (2017).
Google Scholar
Presgraves, D. C., Gerard, P. R., Cherukuri, A. & Lyttle, T. W. Large-scale selective sweep among segregation distorter chromosomes in African populations of Drosophila melanogaster. PLoS Genet. 5, e1000463 (2009).
Google Scholar
Seymour, D. K., Chae, E., Arioz, B. I., Koenig, D. & Weigel, D. Transmission ratio distortion is frequent in Arabidopsis thaliana controlled crosses. Heredity 122, 294–304 (2019).
Google Scholar
Courret, C., Chang, C. H., Wei, K. H., Montchamp-Moreau, C. & Larracuente, A. M. Meiotic drive mechanisms: lessons from Drosophila. Proc. Biol. Sci. 286, 20191430 (2019).
Google Scholar
Kusano, A., Staber, C., Chan, H. Y. & Ganetzky, B. Closing the (Ran)GAP on segregation distortion in Drosophila. Bioessays 25, 108–115 (2003).
Google Scholar
Merel, V., Boulesteix, M., Fablet, M. & Vieira, C. Transposable elements in Drosophila. Mob. DNA 11, 23 (2020).
Google Scholar
Boulesteix, M. & Biemont, C. Transposable elements in mosquitoes. Cytogenet. Genome Res. 110, 500–509 (2005).
Google Scholar
Lee, Y. C. & Langley, C. H. Transposable elements in natural populations of Drosophila melanogaster. Philos. Trans. R. Soc. Lond. B Biol. Sci. 365, 1219–1228 (2010).
Google Scholar
Kelleher, E. S. Reexamining the P-element invasion of Drosophila melanogaster through the lens of piRNA silencing. Genetics 203, 1513–1531 (2016).
Google Scholar
Majumdar, S. & Rio, D. C. P transposable elements in drosophila and other eukaryotic organisms. Microbiol. Spectr. 3, MDNA3–0004-2014 (2015).
Google Scholar
Burns, K. H. & Boeke, J. D. Human transposon tectonics. Cell 149, 740–752 (2012).
Google Scholar
Doring, H. P., Tillmann, E. & Starlinger, P. DNA sequence of the maize transposable element Dissociation. Nature 307, 127–130 (1984).
Google Scholar
Wallau, G. L., Capy, P., Loreto, E. & Hua-Van, A. Genomic landscape and evolutionary dynamics of mariner transposable elements within the Drosophila genus. BMC Genomics 15, 727 (2014).
Google Scholar
Hawkins, J. S., Hu, G., Rapp, R. A., Grafenberg, J. L. & Wendel, J. F. Phylogenetic determination of the pace of transposable element proliferation in plants: copia and LINE-like elements in Gossypium. Genome 51, 11–18 (2008).
Google Scholar
Biemont, C., Vieira, C., Borie, N. & Lepetit, D. Transposable elements and genome evolution: the case of Drosophila simulans. Genetica 107, 113–120 (1999).
Google Scholar
Buchman, A. B., Ivy, T., Marshall, J. M., Akbari, O. S. & Hay, B. A. Engineered reciprocal chromosome translocations drive high threshold, reversible population replacement in drosophila. ACS Synth. Biol. 7, 1359–1370 (2018).
Google Scholar
Akbari, O. S. et al. Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression. ACS Synth. Biol. 3, 915–928 (2014).
Google Scholar
Buchman, A., Marshall, J. M., Ostrovski, D., Yang, T. & Akbari, O. S. Synthetically engineered Medea gene drive system in the worldwide crop pest Drosophila suzukii. Proc. Natl Acad. Sci. USA 115, 4725–4730 (2018).
Google Scholar
Champer, J., Zhao, J., Champer, S. E., Liu, J. & Messer, P. W. Population dynamics of underdominance gene drive systems in continuous space. ACS Synth. Biol. 9, 779–792 (2020).
Google Scholar
Chen, C. C. et al. EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells. DNA Repair. 57, 98–106 (2017).
Google Scholar
Leftwich, P. T. et al. Recent advances in threshold-dependent gene drives for mosquitoes. Biochem. Soc. Trans. 46, 1203–1212 (2018).
Google Scholar
Raban, R. R., Marshall, J. M. & Akbari, O. S. Progress towards engineering gene drives for population control. J. Exp. Biol. 223 (Suppl. 1), jeb208181 (2020).
Google Scholar
Ward, C. M. et al. Medea selfish genetic elements as tools for altering traits of wild populations: a theoretical analysis. Evolution 65, 1149–1162 (2011).
Google Scholar
Oberhofer, G., Ivy, T. & Hay, B. A. Gene drive and resilience through renewal with next generation Cleave and Rescue selfish genetic elements. Proc. Natl Acad. Sci. USA 117, 9013–9021 (2020).
Google Scholar
Oberhofer, G., Ivy, T. & Hay, B. A. Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive. Proc. Natl Acad. Sci. USA 116, 6250–6259 (2019).
Google Scholar
Champer, J. et al. A toxin-antidote CRISPR gene drive system for regional population modification. Nat. Commun. 11, 1082 (2020).
Google Scholar
Yen, P. S. & Failloux, A. B. A review: Wolbachia-based population replacement for mosquito control shares common points with genetically modified control approaches. Pathogens 9, 404 (2020).
Google Scholar
O’Neill, S. L. The use of wolbachia by the world mosquito program to interrupt transmission of aedes aegypti transmitted viruses. Adv. Exp. Med. Biol. 1062, 355–360 (2018).
Google Scholar
Niang, E. H. A., Bassene, H., Fenollar, F. & Mediannikov, O. Biological control of mosquito-borne diseases: the potential of wolbachia-based interventions in an IVM framework. J. Trop. Med. 2018, 1470459 (2018).
Google Scholar
Chevalier, B. S. & Stoddard, B. L. Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility. Nucleic Acids Res. 29, 3757–3774 (2001).
Google Scholar
Macreadie, I. G., Scott, R. M., Zinn, A. R. & Butow, R. A. Transposition of an intron in yeast mitochondria requires a protein encoded by that intron. Cell 41, 395–402 (1985).
Google Scholar
Rong, Y. S. & Golic, K. G. The homologous chromosome is an effective template for the repair of mitotic DNA double-strand breaks in Drosophila. Genetics 165, 1831–1842 (2003).
Google Scholar
Chan, Y. S., Huen, D. S., Glauert, R., Whiteway, E. & Russell, S. Optimising homing endonuclease gene drive performance in a semi-refractory species: the Drosophila melanogaster experience. PLoS ONE 8, e54130 (2013).
Google Scholar
Windbichler, N. et al. A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature 473, 212–215 (2011). This study is the first demonstration of nuclease-mediated gene drive in mosquitoes based on the homing endonuclease gene I-SceI.
Google Scholar
Carroll, D. Genome engineering with targetable nucleases. Annu. Rev. Biochem. 83, 409–439 (2014).
Google Scholar
Barrangou, R. et al. CRISPR provides acquired resistance against viruses in prokaryotes. Science 315, 1709–1712 (2007).
Google Scholar
Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012). This foundational study developed the most widely used dual synthetic CRISPR system consisting of Cas9 endonuclease and gRNA components.
Google Scholar
Doudna, J. A., Sternberg, S. H. A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution 281 (Houghton Mifflin Harcourt, 2017).
Gantz, V. M. & Bier, E. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science 348, 442–444 (2015). This study reported the first CRISPR-based gene drive in a metazoan organism (D. melanogaster) with a specialized germline.
Google Scholar
Gantz, V. M. et al. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc. Natl Acad. Sci. USA 112, E6736–E6743 (2015). This study describes the first efficient CRISPR-based gene drive system in mosquitoes, which carried a dual anti-malarial effector cassette.
Google Scholar
Hammond, A. et al. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nat. Biotechnol. 34, 78–83 (2016). This study describes the first efficient CRISPR-based suppression gene drive system in mosquitoes.
Google Scholar
Kyrou, K. et al. A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes. Nat. Biotechnol. 36, 1062–1066 (2018). This study describes a highly efficient suppression gene drive system in mosquitoes targeting an invariant genome target site in the doublesex locus.
Google Scholar
Li, M. et al. Development of a confinable gene drive system in the human disease vector Aedes aegypti. eLife 9, e51701 (2020).
Google Scholar
Grunwald, H. A. et al. Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature 566, 105–109 (2019). This study provided the first proof-of-principle gene drive system in mammals, which selectively sustained drive via the female germline.
Google Scholar
DiCarlo, J. E., Chavez, A., Dietz, S. L., Esvelt, K. M. & Church, G. M. Safeguarding CRISPR-Cas9 gene drives in yeast. Nat. Biotechnol. 33, 1250–1255 (2015). This study demonstrated CRISPR-based gene conversion in diploid yeast, which could then be transmitted meiotically.
Google Scholar
Valderrama, J. A., Kulkarni, S. S., Nizet, V. & Bier, E. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat. Commun. 10, 5726 (2019). This study generalizes the concept of gene drive to bacteria, where it is applied to efficiently reduce the frequency of antibiotic reistance.
Google Scholar
Esvelt, K. M., Smidler, A. L., Catteruccia, F. & Church, G. M. Concerning RNA-guided gene drives for the alteration of wild populations. eLife 3, e03401 (2014).
Google Scholar
Adolfi, A. et al. Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi. Nat. Commun. 11, 5553 (2020). This study reports on the first recoded gene drive in mosquitoes that drove efficiently through both males and females based on the process of lethal/sterile mosaicism.
Google Scholar
Champer, J. et al. A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population. Proc. Natl Acad. Sci. USA 117, 24377–24383 (2020).
Google Scholar
Kandul, N. P., Liu, J., Bennett, J. B., Marshall, J. M. & Akbari, O. S. A confinable home-and-rescue gene drive for population modification. eLife 10, e65939 (2021).
Google Scholar
Terradas, G. et al. Inherently confinable split-drive systems in Drosophila. Nat. Commun. 12, 1480 (2021). This study further develops the strategy of inserting a recoded gene drive in genes essential for viability or reproduction in the context of split drive systems.
Google Scholar
Xu, X. S., Gantz, V. M., Siomava, N. & Bier, E. CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity. eLife 6, e30281 (2017).
Google Scholar
Lopez Del Amo, V. et al. A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment. Nat. Commun. 11, 352 (2020). This study reports on the reconstitution of a full gene drive from split constituent parts.
Google Scholar
Guichard, A. et al. Efficient allelic-drive in Drosophila. Nat. Commun. 10, 1640 (2019). The study develops two allelic drive systems, copy-cutting and copy-grafting, to propagate favoured alleles of an essential gene.
Google Scholar
Kandul, N. P. et al. Assessment of a split homing based gene drive for efficient knockout of multiple genes. G3 10, 827–837 (2020).
Google Scholar
Xu, X.-R. S. et al. Active-genetic neutralizing elements for halting or deleting gene-drives. Mol. Cell 80, 246–262 (2020). This study reports on two drive-neutralizing systems that either inactivate (e-CHACR) or delete and replace (ERACR) a gene drive.
Google Scholar
Burt, A. Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc. Biol. Sci. 270, 921–928 (2003). This seminal modelling study provides the theoretical underpinnings for the modern gene-drive field.
Google Scholar
North, A. R., Burt, A. & Godfray, H. C. J. Modelling the potential of genetic control of malaria mosquitoes at national scale. BMC Biol. 17, 26 (2019). This study provides a comprehensive analysis of the perfomance of suppressive gene drives following iterative releases across various topographies.
Google Scholar
North, A. R., Burt, A. & Godfray, H. C. J. Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility. BMC Biol. 18, 98 (2020).
Google Scholar
Collins, C. M., Bonds, J. A. S., Quinlan, M. M. & Mumford, J. D. Effects of the removal or reduction in density of the malaria mosquito, Anopheles gambiae s.l., on interacting predators and competitors in local ecosystems. Med. Vet. Entomol. 33, 1–15 (2019).
Google Scholar
James, A. A. Gene drive systems in mosquitoes: rules of the road. Trends Parasitol. 21, 64–67 (2005).
Google Scholar
Gantz, V. M. & Bier, E. The dawn of active genetics. Bioessays 38, 50–63 (2016).
Google Scholar
Macias, V. M. & James, A. A. in Genetic Control of Malaria and Dengue (ed. Adelman, Z. N.) 423–444 (Elsevier Academic Press, 2015).
Eckhoff, P. A., Wenger, E. A., Godfray, H. C. & Burt, A. Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics. Proc. Natl Acad. Sci. USA 114, E255–E264 (2017). This study provides a detailed analysis of drive parameters relevant to both suppression-based and modification-based drives and is the first to model a drive in the context of a two-dimensional environment.
Google Scholar
Hammond, A. M. et al. The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito. PLoS Genet. 13, e1007039 (2017).
Google Scholar
Joyce, E. F., Paul, A., Chen, K. E., Tanneti, N. & McKim, K. S. Multiple barriers to nonhomologous DNA end joining during meiosis in Drosophila. Genetics 191, 739–746 (2012).
Google Scholar
Bozas, A., Beumer, K. J., Trautman, J. K. & Carroll, D. Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila. Genetics 182, 641–651 (2009).
Google Scholar
Do, A. T., Brooks, J. T., Le Neveu, M. K. & LaRocque, J. R. Double-strand break repair assays determine pathway choice and structure of gene conversion events in Drosophila melanogaster. G3 4, 425–432 (2014).
Google Scholar
Wei, D. S. & Rong, Y. S. A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics 177, 63–77 (2007).
Google Scholar
Lin, C. C. & Potter, C. J. Non-Mendelian dominant maternal effects caused by CRISPR/Cas9 transgenic components in Drosophila melanogaster. G3 6, 3685–3691 (2016).
Google Scholar
Champer, J. et al. Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations. PLoS Genet. 13, e1006796 (2017).
Google Scholar
Anopheles gambiae 1000 Genomes Consortiumet al. Genetic diversity of the African malaria vector Anopheles gambiae. Nature 552, 96–100 (2017).
Google Scholar
Deredec, A., Burt, A. & Godfray, H. C. The population genetics of using homing endonuclease genes in vector and pest management. Genetics 179, 2013–2026 (2008).
Google Scholar
Fasulo, B. et al. A fly model establishes distinct mechanisms for synthetic CRISPR/Cas9 sex distorters. PLoS Genet. 16, e1008647 (2020).
Google Scholar
Galizi, R. et al. A synthetic sex ratio distortion system for the control of the human malaria mosquito. Nat. Commun. 5, 3977 (2014).
Google Scholar
Galizi, R. et al. A CRISPR-Cas9 sex-ratio distortion system for genetic control. Sci. Rep. 6, 31139 (2016).
Google Scholar
Turner, J. M. Meiotic sex chromosome inactivation. Development 134, 1823–1831 (2007).
Google Scholar
Simoni, A. et al. A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. Nat. Biotechnol. 38, 1054–1060 (2020).
Google Scholar
Carballar-Lejarazu, R. & et al. Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae.Proc. Natl Acad. Sci. USA 117, 22805–22814 (2020). This study describes a modification gene drive that propagates with high efficiency through both males and females.
Google Scholar
Pham, T. B. et al. Experimental population modification of the malaria vector mosquito, Anopheles stephensi. PLoS Genet. 15, e1008440 (2019).
Google Scholar
Dong, Y., Simoes, M. L. & Dimopoulos, G. Versatile transgenic multistage effector-gene combinations for Plasmodium falciparum suppression in Anopheles. Sci. Adv. 6, eaay5898 (2020).
Google Scholar
Dong, Y. et al. Engineered anopheles immunity to Plasmodium infection. PLoS Pathog. 7, e1002458 (2011).
Google Scholar
Isaacs, A. T. et al. Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development. Proc. Natl Acad. Sci. USA 109, E1922–E1930 (2012). This study demonstrates 100% protection against parasite transmission in transgenic mosquitoes carrying a dual anti-parasite effector cassette.
Google Scholar
Haber, J. E. TOPping off meiosis. Mol. Cell 57, 577–581 (2015).
Google Scholar
Hammond, A. et al. Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance. PLoS Genet. 17, e1009321 (2021).
Google Scholar
Lee, Y. et al. Genome-wide divergence among invasive populations of Aedes aegypti in California. BMC Genomics 20, 204 (2019).
Google Scholar
Callaway, E. Gene drives thwarted by emergence of resistant organisms. Nature 542, 15 (2017).
Google Scholar
Unckless, R. L., Clark, A. G. & Messer, P. W. Evolution of resistance against CRISPR/Cas9 gene drive. Genetics 205, 827–841 (2017).
Google Scholar
Drury, D. W., Dapper, A. L., Siniard, D. J., Zentner, G. E. & Wade, M. J. CRISPR/Cas9 gene drives in genetically variable and nonrandomly mating wild populations. Sci. Adv. 3, e1601910 (2017).
Google Scholar
Schmidt, H. et al. Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes. Nat. Commun. 11, 1425 (2020). This study provides computational evidence that conserved CRISPR cleavage sites are abundant in the genome.
Google Scholar
Akbari, O. S. et al. Safeguarding gene drive experiments in the laboratory. Science 349, 927–929 (2015).
Google Scholar
Li, J. et al. Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae. Proc. Natl Acad. Sci. USA 110, 20675–20680 (2013).
Google Scholar
Niu, G. et al. The fibrinogen-like domain of FREP1 protein is a broad-spectrum malaria transmission-blocking vaccine antigen. J. Biol. Chem. 292, 11960–11969 (2017).
Google Scholar
Zhang, G. et al. Anopheles midgut FREP1 mediates plasmodium invasion. J. Biol. Chem. 290, 16490–16501 (2015).
Google Scholar
Dong, Y., Simoes, M. L., Marois, E. & Dimopoulos, G. CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection. PLoS Pathog. 14, e1006898 (2018).
Google Scholar
Simoes, M. L., Caragata, E. P. & Dimopoulos, G. Diverse host and restriction factors regulate mosquito-pathogen interactions. Trends Parasitol. 34, 603–616 (2018).
Google Scholar
Nash, A. et al. Integral gene drives for population replacement. Biol. Open 8, bio037762 (2019). This study describes a bipartite drive system that can enable testing of anti-parasite effector cassettes under standard mosquito confinement protocols.
Google Scholar
Enayati, A., Hanafi-Bojd, A. A., Sedaghat, M. M., Zaim, M. & Hemingway, J. Evolution of insecticide resistance and its mechanisms in Anopheles stephensi in the WHO Eastern Mediterranean Region. Malar. J. 19, 258 (2020).
Google Scholar
Ffrench-Constant, R. H., Williamson, M. S., Davies, T. G. & Bass, C. Ion channels as insecticide targets. J. Neurogenet. 30, 163–177 (2016).
Google Scholar
Silva, J. J. & Scott, J. G. Conservation of the voltage-sensitive sodium channel protein within the Insecta. Insect Mol. Biol. 29, 9–18 (2020).
Google Scholar
Casida, J. E. & Durkin, K. A. Novel GABA receptor pesticide targets. Pestic. Biochem. Physiol. 121, 22–30 (2015).
Google Scholar
Ihara, M., Buckingham, S. D., Matsuda, K. & Sattelle, D. B. Modes of action, resistance and toxicity of insecticides targeting nicotinic acetylcholine receptors. Curr. Med. Chem. 24, 2925–2934 (2017).
Google Scholar
Thapa, S., Lv, M. & Xu, H. Acetylcholinesterase: a primary target for drugs and insecticides. Mini Rev. Med. Chem. 17, 1665–1676 (2017).
Google Scholar
Kleinstiver, B. P. et al. Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing. Nat. Biotechnol. 37, 276–282 (2019).
Google Scholar
Walton, R. T., Christie, K. A., Whittaker, M. N. & Kleinstiver, B. P. Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants. Science 368, 290–296 (2020).
Google Scholar
Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct; Board on Life Sciences; Division on Earth and Life Studies; National Academies of Sciences, Engineering, and Medicine. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (The National Academies Press, 2016). This comprehensive advisory and historical review document summarizes consensus views for how to safely rear and study gene-drive systems in the laboratory.
Adelman, Z. et al. Rules of the road for insect gene drive research and testing. Nat. Biotechnol. 35, 716–718 (2017).
Google Scholar
James, S. et al. Pathway to deployment of gene drive mosquitoes as a potential biocontrol tool for elimination of malaria in Sub-Saharan Africa: recommendations of a scientific working group(dagger). Am. J. Trop. Med. Hyg. 98, 1–49 (2018).
Google Scholar
James, S. L., Marshall, J. M., Christophides, G. K., Okumu, F. O. & Nolan, T. Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing. Vector Borne Zoonotic Dis. 20, 237–251 (2020).
Google Scholar
Warmbrod, K. L. et al. Gene Drives: Pursuing Opportunities, Minimizing Risk – A Johns Hopkins University Report on Responsible Governance (Johns Hopkins Bloomberg School of Public Health, Center for Health Security, Johns Hopkins University, 2020).
Vella, M. R., Gunning, C. E., Lloyd, A. L. & Gould, F. Evaluating strategies for reversing CRISPR-Cas9 gene drives. Sci. Rep. 7, 11038 (2017).
Google Scholar
Rode, N. O., Courtier-Orgogozo, V. & Debarre, F. Can a population targeted by a CRISPR-based homing gene drive be rescued? G3 10, 3403–3415 (2020).
Google Scholar
Fedoroff, N., Wessler, S. & Shure, M. Isolation of the transposable maize controlling elements Ac and Ds. Cell 35, 235–242 (1983).
Google Scholar
Paix, A. et al. Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks. Proc. Natl Acad. Sci. USA 114, E10745–E10754 (2017).
Google Scholar
Wu, B., Luo, L. & Gao, X. J. Cas9-triggered chain ablation of cas9 as a gene drive brake. Nat. Biotechnol. 34, 137–138 (2016).
Google Scholar
Taxiarchi, C. et al. A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression. Nat. Commun. 12, 3977 (2021).
Google Scholar
Conklin, B. R. On the road to a gene drive in mammals. Nature 566, 43–45 (2019).
Google Scholar
Salkeld, D. J. Vaccines for conservation: plague, prairie dogs & black-footed ferrets as a case study. Ecohealth 14, 432–437 (2017).
Google Scholar
Teem, J. L. et al. Genetic biocontrol for invasive species. Front. Bioeng. Biotechnol. 8, 452 (2020).
Google Scholar
Godwin, J. et al. Rodent gene drives for conservation: opportunities and data needs. Proc. Biol. Sci. 286, 20191606 (2019).
Google Scholar
McFarlane, G. R., Whitelaw, C. B. A. & Lillico, S. G. CRISPR-based gene drives for pest control. Trends Biotechnol. 36, 130–133 (2018).
Google Scholar
Klompe, S. E., Vo, P. L. H., Halpin-Healy, T. S. & Sternberg, S. H. Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration. Nature 571, 219–225 (2019).
Google Scholar
Koonin, E. V., Makarova, K. S., Wolf, Y. I. & Krupovic, M. Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire. Nat. Rev. Genet. 21, 119–131 (2020).
Google Scholar
Strecker, J. et al. RNA-guided DNA insertion with CRISPR-associated transposases. Science 365, 48–53 (2019).
Google Scholar
Peters, J. E., Makarova, K. S., Shmakov, S. & Koonin, E. V. Recruitment of CRISPR-Cas systems by Tn7-like transposons. Proc. Natl Acad. Sci. USA 114, E7358–E7366 (2017).
Google Scholar
Wiegand, T. & Wiedenheft, B. CRISPR Surveillance Turns Transposon Taxi. CRISPR J. 3, 10–12 (2020).
Google Scholar
Hamilton, T. A. et al. Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing. Nat. Commun. 10, 4544 (2019).
Google Scholar
Price, V. J. et al. Enterococcus faecalis CRISPR-cas is a robust barrier to conjugative antibiotic resistance dissemination in the murine intestine. mSphere 4, e00464-19 (2019).
Google Scholar
Rodrigues, M., McBride, S. W., Hullahalli, K., Palmer, K. L. & Duerkop, B. A. Conjugative delivery of CRISPR-Cas9 for the selective depletion of antibiotic-resistant enterococci. Antimicrob. Agents Chemother. 63, e01454-19 (2019).
Google Scholar
Carraro, N. et al. Plasmid-like replication of a minimal streptococcal integrative and conjugative element. Microbiology 162, 622–632 (2016).
Google Scholar
Brophy, J. A. N. et al. Engineered integrative and conjugative elements for efficient and inducible DNA transfer to undomesticated bacteria. Nat. Microbiol. 3, 1043–1053 (2018).
Google Scholar
Bikard, D. et al. Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat. Biotechnol. 32, 1146–1150 (2014).
Google Scholar
Citorik, R. J., Mimee, M. & Lu, T. K. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat. Biotechnol. 32, 1141–1145 (2014).
Google Scholar
Yosef, I., Manor, M., Kiro, R. & Qimron, U. Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria. Proc. Natl Acad. Sci. USA 112, 7267–7272 (2015).
Google Scholar
Park, J. Y. et al. Genetic engineering of a temperate phage-based delivery system for CRISPR/Cas9 antimicrobials against Staphylococcus aureus. Sci. Rep. 7, 44929 (2017).
Google Scholar
Pazda, M., Kumirska, J., Stepnowski, P. & Mulkiewicz, E. Antibiotic resistance genes identified in wastewater treatment plant systems – a review. Sci. Total. Env. 697, 134023 (2019).
Google Scholar
Kraemer, S. A., Ramachandran, A. & Perron, G. G. Antibiotic pollution in the environment: from microbial ecology to public policy. Microorganisms 7, 180 (2019).
Google Scholar
Ram, G., Ross, H. F., Novick, R. P., Rodriguez-Pagan, I. & Jiang, D. Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice. Nat. Biotechnol. 36, 971–976 (2018).
Google Scholar
Bier, E. & Nizet, V. Driving to safety: CRISPR-based genetic approaches to reducing antibiotic resistance. Trends Genet. https://doi.org/10.1016/j.tig.2021.02.007 (2021).
Google Scholar
Rossati, A. et al. Climate, environment and transmission of malaria. Infez. Med. 24, 93–104 (2016).
Google Scholar
Fontenille, D. & Powell, J. R. From anonymous to public enemy: how does a mosquito become a feared arbovirus vector? Pathogens 9, 265 (2020).
Google Scholar
Lidani, K. C. F. et al. Chagas disease: from discovery to a worldwide health problem. Front. Public Health 7, 166 (2019).
Google Scholar
Buscher, P., Cecchi, G., Jamonneau, V. & Priotto, G. Human African trypanosomiasis. Lancet 390, 2397–2409 (2017).
Google Scholar
Desjeux, P. Leishmaniasis: current situation and new perspectives. Comp. Immunol. Microbiol. Infect. Dis. 27, 305–318 (2004).
Google Scholar
Saxena, V., Bolling, B. G. & Wang, T. West nile virus. Clin. Lab. Med. 37, 243–252 (2017).
Google Scholar
Simon, L. V., Kong, E. L. & Graham, C. in St. Louis Encephalitis (StatPearls, 2020).
Feng, X. et al. Optimized CRISPR tools and site-directed transgenesis towards gene drive development in Culex quinquefasciatus mosquitoes. Nat. Commun. 12, 2960 (2021).
Google Scholar
Nepomichene, T. N., Andrianaivolambo, L., Boyer, S. & Bourgouin, C. Efficient method for establishing F1 progeny from wild populations of Anopheles mosquitoes. Malar. J. 16, 21 (2017).
Google Scholar
Marchand, R. P. A new cage for observing mating behavior of wild Anopheles gambiae in the laboratory. J. Am. Mosq. Control. Assoc. 1, 234–236 (1985).
Google Scholar
Nunes-da-Fonseca, R., Berni, M., Tobias-Santos, V., Pane, A. & Araujo, H. M. Rhodnius prolixus: from classical physiology to modern developmental biology. Genesis https://doi.org/10.1002/dvg.22995 (2017).
Google Scholar
Chaverra-Rodriguez, D. et al. Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing. Nat. Commun. 9, 3008 (2018).
Google Scholar
Macias, V. M. et al. Cas9-mediated gene-editing in the malaria mosquito anopheles stephensi by ReMOT Control. G3 10, 1353–1360 (2020).
Google Scholar
Chaverra-Rodriguez, D. et al. Germline mutagenesis of Nasonia vitripennis through ovarian delivery of CRISPR-Cas9 ribonucleoprotein. Insect Mol. Biol. 29, 569–577 (2020).
Google Scholar
Heu, C. C., McCullough, F. M., Luan, J. & Rasgon, J. L. CRISPR-Cas9-based genome editing in the silverleaf whitefly (Bemisia tabaci). CRISPR J. 3, 89–96 (2020).
Google Scholar
Prowse, T. A., Adikusuma, F., Cassey, P., Thomas, P. & Ross, J. V. A Y-chromosome shredding gene drive for controlling pest vertebrate populations. eLife 8, e41873 (2019).
Google Scholar
Carballar-Lejarazu, R. & James, A. A. Population modification of Anopheline species to control malaria transmission. Pathog. Glob. Health 111, 424–435 (2017).
Google Scholar
Annas, G. J. et al. A code of ethics for gene drive research. CRISPR J. 4, 19–24 (2021).
Google Scholar
Bier, E. & Sober, E. Gene editing and the war against malaria. Am. Sci. 108, 162–169 (2020).
Google Scholar
Long, K. C. et al. Core commitments for field trials of gene drive organisms. Science 370, 1417–1419 (2020).
Google Scholar
Kormos, A. et al. Application of the relationship-based model to engagement for field trials of genetically engineered malaria vectors.Am. J. Trop. Med. Hyg. 104, 805–811 (2020).
Google Scholar
World Health Organization. Guidance framework for testing of genetically modified mosquitoes. WHO http://apps.who.int/iris/bitstream/10665/127889/1/9789241507486_eng.pdf (2014).
Smith, D. L., McKenzie, F. E., Snow, R. W. & Hay, S. I. Revisiting the basic reproductive number for malaria and its implications for malaria control. PLoS Biol. 5, e42 (2007).
Google Scholar
Brauer, F., Castillo-Chavez, C., Mubayi, A. & Towers, S. Some models for epidemics of vector-transmitted diseases. Infect. Dis. Model. 1, 79–87 (2016).
Google Scholar
Deredec, A., Godfray, H. C. & Burt, A. Requirements for effective malaria control with homing endonuclease genes. Proc. Natl Acad. Sci. USA 108, E874–E880 (2011).
Google Scholar
Escalante, A. A. & Pacheco, M. A. Malaria molecular epidemiology: an evolutionary genetics perspective. Microbiol. Spectr. https://doi.org/10.1128/microbiolspec.AME-0010-2019 (2019).
Google Scholar
Selvaraj, P. et al. Vector genetics, insecticide resistance and gene drives: An agent-based modeling approach to evaluate malaria transmission and elimination. PLoS Comput. Biol. 16, e1008121 (2020).
Google Scholar
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