Paaijmans, K. P. et al. Temperature variation makes ectotherms more sensitive to climate change. Glob. Change Biol. 19, 2373–2380 (2013).
Clusella-Trullas, S., Blackburn, T. M. & Chown, S. L. Climatic predictors of temperature performance curve parameters in ectotherms imply complex responses to climate change. Am. Nat. 177, 738–751 (2011).
Google Scholar
Pounds, J. A. et al. Widespread amphibian extinctions from epidemic disease driven by global warming. Nature 439, 161–167 (2006).
Google Scholar
Sinervo, B. et al. Erosion of lizard diversity by climate change and altered thermal niches. Science 328, 894–899 (2010).
Google Scholar
Pacifici, M. et al. Assessing species vulnerability to climate change. Nat. Clim. Change 5, 215–224 (2015).
Angilletta, M. J. Jr Thermal Adaptation: A Theoretical and Empirical Synthesis (Oxford Univ. Press, 2009).
Sunday, J. M., Bates, A. E. & Dulvy, N. K. Global analysis of thermal tolerance and latitude in ectotherms. Proc. R. Soc. B 278, 1823–1830 (2011).
Google Scholar
Jørgensen, L. B., Malte, H. & Overgaard, J. How to assess Drosophila heat tolerance: unifying static and dynamic tolerance assays to predict heat distribution limits. Funct. Ecol. 33, 629–642 (2019).
Pörtner, H.-O., Bock, C. & Mark, F. C. Oxygen- and capacity-limited thermal tolerance: bridging ecology and physiology. J. Exp. Biol. 220, 2685–2696 (2017).
Google Scholar
Gangloff, E. J. & Telemeco, R. S. High temperature, oxygen, and performance: insights from reptiles and amphibians. Integr. Comp. Biol. 58, 9–24 (2018).
Google Scholar
Perry, G. M., Danzmann, R. G., Ferguson, M. M. & Gibson, J. P. Quantitative trait loci for upper thermal tolerance in outbred strains of rainbow trout (Oncorhynchus mykiss). Heredity 86, 333–341 (2001).
Google Scholar
Healy, T. M. & Schulte, P. M. Factors affecting plasticity in whole-organism thermal tolerance in common killifish (Fundulus heteroclitus). J. Comp. Physiol. B 182, 49–62 (2012).
Google Scholar
Hu, X. P. & Appel, A. G. Seasonal variation of critical thermal limits and temperature tolerance in Formosan and eastern subterranean termites (Isoptera: Rhinotermitidae). Environ. Entomol. 33, 197–205 (2004).
Google Scholar
Nyamukondiwa, C. & Terblanche, J. S. Thermal tolerance in adult Mediterranean and Natal fruit flies (Ceratitis capitata and Ceratitis rosa): effects of age, gender and feeding status. J. Therm. Biol. 34, 406–414 (2009).
Greenspan, S. E. et al. Infection increases vulnerability to climate change via effects on host thermal tolerance. Sci. Rep. 7, 9349 (2017).
Google Scholar
Padfield, D., Castledine, M. & Buckling, A. Temperature-dependent changes to host–parasite interactions alter the thermal performance of a bacterial host. ISME J. 14, 389–398 (2020).
Google Scholar
Hooper, L. V., Littman, D. R. & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268–1273 (2012).
Google Scholar
Goodrich, J. K. et al. Human genetics shape the gut microbiome. Cell 159, 789–799 (2014).
Google Scholar
Alberdi, A., Aizpurua, O., Bohmann, K., Zepeda-Mendoza, M. L. & Gilbert, M. T. P. Do vertebrate gut metagenomes confer rapid ecological adaptation? Trends Ecol. Evol. 31, 689–699 (2016).
Google Scholar
Kohl, K. D. & Carey, H. V. A place for host–microbe symbiosis in the comparative physiologist’s toolbox. J. Exp. Biol. 219, 3496–3504 (2016).
Google Scholar
Fontaine, S. S. & Kohl, K. D. Optimal integration between host physiology and functions of the gut microbiome. Phil. Trans. R. Soc. B 375, 20190594 (2020).
Google Scholar
Velagapudi, V. R. et al. The gut microbiota modulates host energy and lipid metabolism in mice. J. Lipid Res. 51, 1101–1112 (2010).
Google Scholar
Donohoe, D. R. et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab. 13, 517–526 (2011).
Google Scholar
Ziegler, M., Seneca, F. O., Yum, L. K., Palumbi, S. R. & Voolstra, C. R. Bacterial community dynamics are linked to patterns of coral heat tolerance. Nat. Commun. 8, 14213 (2017).
Google Scholar
Russell, J. A. & Moran, N. A. Costs and benefits of symbiont infection in aphids: variation among symbionts and across temperatures. Proc. R. Soc. B 273, 603–610 (2006).
Google Scholar
Montllor, C. B., Maxmen, A. & Purcell, A. H. Facultative bacterial endosymbionts benefit pea aphids Acyrthosiphon pisum under heat stress. Ecol. Entomol. 27, 189–195 (2002).
Herrera, M. et al. Unfamiliar partnerships limit cnidarian holobiont acclimation to warming. Glob. Change Biol. 26, 5539–5553 (2020).
Jaramillo, A. & Castaneda, L. E. Gut microbiota of Drosophila subobscura contributes to its heat tolerance and is sensitive to transient thermal stress. Front. Microbiol. 12, 886 (2021).
Moghadam, N. N. et al. Strong responses of Drosophila melanogaster microbiota to developmental temperature. Fly 12, 1–12 (2018).
Google Scholar
Fontaine, S. S., Novarro, A. J. & Kohl, K. D. Environmental temperature alters the digestive performance and gut microbiota of a terrestrial amphibian. J. Exp. Biol. 221, 187559 (2018).
Kohl, K. D. & Yahn, J. Effects of environmental temperature on the gut microbial communities of tadpoles. Environ. Microbiol. 18, 1561–1565 (2016).
Google Scholar
Fontaine, S. S. & Kohl, K. D. The gut microbiota of invasive bullfrog tadpoles responds more rapidly to temperature than a non‐invasive congener. Mol. Ecol. 29, 2449–2462 (2020).
Google Scholar
Bestion, E. et al. Climate warming reduces gut microbiota diversity in a vertebrate ectotherm. Nat. Ecol. Evol. 1, 0161 (2017).
Zhu, L. et al. Environmental temperatures affect the gastrointestinal microbes of the Chinese giant salamander. Front. Microbiol. 12, 493 (2021).
Moeller, A. H. et al. The lizard gut microbiome changes with temperature and is associated with heat tolerance. Appl. Environ. Microbiol. 86, e01181-20 (2020).
Google Scholar
Kokou, F. et al. Host genetic selection for cold tolerance shapes microbiome composition and modulates its response to temperature. eLife 7, e36398 (2018).
Google Scholar
Hanage, W. P. Microbiology: microbiome science needs a healthy dose of scepticism. Nature 512, 247–248 (2014).
Google Scholar
Pascoe, E. L., Hauffe, H. C., Marchesi, J. R. & Perkins, S. E. Network analysis of gut microbiota literature: an overview of the research landscape in non-human animal studies. ISME J. 11, 2644–2651 (2017).
Google Scholar
Mykles, D. L., Ghalambor, C. K., Stillman, J. H. & Tomanek, L. Grand challenges in comparative physiology: integration across disciplines and across levels of biological organization. Integr. Comp. Biol. 50, 6–16 (2010).
Google Scholar
Kohl, K. D. A microbial perspective on the grand challenges in comparative animal physiology. mSystems 3, e00146-17 (2018).
Google Scholar
Gray, K. T., Escobar, A. M., Schaeffer, P. J., Mineo, P. M. & Berner, N. J. Thermal acclimatization in overwintering tadpoles of the green frog, Lithobates clamitans (Latreille, 1801). J. Exp. Zool. A 325, 285–293 (2016).
Brattstrom, B. H. & Lawrence, P. The rate of thermal acclimation in anuran amphibians. Physiol. Zool. 35, 148–156 (1962).
Knutie, S. A., Wilkinson, C. L., Kohl, K. D. & Rohr, J. R. Early-life disruption of amphibian microbiota decreases later-life resistance to parasites. Nat. Commun. 8, 86 (2017).
Google Scholar
Warne, R. W., Kirschman, L. & Zeglin, L. Manipulation of gut microbiota during critical developmental windows affects host physiological performance and disease susceptibility across ontogeny. J. Anim. Ecol. 88, 845–856 (2019).
Google Scholar
Morgun, A. et al. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut 64, 1732–1743 (2015).
Google Scholar
Kohl, K. D., Cary, T. L., Karasov, W. H. & Dearing, M. D. Restructuring of the amphibian gut microbiota through metamorphosis. Environ. Microbiol. Rep. 5, 899–903 (2013).
Google Scholar
Vences, M. et al. Gut bacterial communities across tadpole ecomorphs in two diverse tropical anuran faunas. Sci. Nat. 103, 25 (2016).
Fontaine, S. S., Mineo, P. M. & Kohl, K. D. Changes in the gut microbial community of the eastern newt (Notophthalmus viridescens) across its three distinct life stages. FEMS Microbiol. Ecol. 97, fiab021 (2021).
Google Scholar
Anderson, M. J. & Walsh, D. C. PERMANOVA, ANOSIM, and the Mantel test in the face of heterogeneous dispersions: what null hypothesis are you testing? Ecol. Monogr. 83, 557–574 (2013).
Sepulveda, J. & Moeller, A. H. The effects of temperature on animal gut microbiomes. Front. Microbiol. 11, 384 (2020).
Google Scholar
Arango, R. A., Schoville, S. D., Currie, C. R. & Carlos-Shanley, C. Experimental warming reduces survival, cold tolerance, and gut prokaryotic diversity of the eastern subterranean termite, Reticulitermes flavipes (Kollar). Front. Microbiol. 12, 1116 (2021).
Stothart, M. R. et al. Stress and the microbiome: linking glucocorticoids to bacterial community dynamics in wild red squirrels. Biol. Lett. 12, 20150875 (2016).
Google Scholar
Zaneveld, J. R., McMinds, R. & Thurber, R. V. Stress and stability: applying the Anna Karenina principle to animal microbiomes. Nat. Microbiol. 2, 17121 (2017).
Google Scholar
Orrock, J. L. & Watling, J. I. Local community size mediates ecological drift and competition in metacommunities. Proc. R. Soc. B 277, 2185–2191 (2010).
Google Scholar
Deeg, C. M. et al. Chromulinavorax destructans, a pathogen of microzooplankton that provides a window into the enigmatic candidate phylum Dependentiae. PLoS Pathog. 15, e1007801 (2019).
Google Scholar
Kaboré, O. D., Godreuil, S. & Drancourt, M. Planctomycetes as host-associated bacteria: a perspective that holds promise for their future isolations, by mimicking their native environmental niches in clinical microbiology laboratories. Front. Cell. Infect. Microbiol. 10, 729 (2020).
Sheremet, A. et al. Ecological and genomic analyses of candidate phylum WPS‐2 bacteria in an unvegetated soil. Environ. Microbiol. 22, 3143–3157 (2020).
Google Scholar
Correa, D. T. et al. Multilevel community assembly of the tadpole gut microbiome. Preprint at bioRxiv https://doi.org/10.1101/2020.07.05.188698 (2020).
Contijoch, E. J. et al. Gut microbiota density influences host physiology and is shaped by host and microbial factors. eLife 8, e40553 (2019).
Google Scholar
Warne, R. W., Kirschman, L. & Zeglin, L. Manipulation of gut microbiota reveals shifting community structure shaped by host developmental windows in amphibian larvae. Integr. Comp. Biol. 57, 786–794 (2017).
Google Scholar
Trevelline, B. K., Fontaine, S. S., Hartup, B. K. & Kohl, K. D. Conservation biology needs a microbial renaissance: a call for the consideration of host-associated microbiota in wildlife management practices. Proc. R. Soc. B 286, 20182448 (2019).
Google Scholar
Lutterschmidt, W. I. & Hutchison, V. H. The critical thermal maximum: history and critique. Can. J. Zool. 75, 1561–1574 (1997).
Gosner, K. L. A simplified table for staging anuran embryos and larvae with notes on identification. Herpetologica 16, 183–190 (1960).
Daloso, D. M. The ecological context of bilateral symmetry of organ and organisms. Nat. Sci. 6, 43340 (2014).
Goldstein, J. A., Hoff, K. v. S. & Hillyard, S. D. The effect of temperature on development and behaviour of relict leopard frog tadpoles. Conserv. Physiol. 5, cow075 (2017).
Google Scholar
Harkey, G. A. & Semlitsch, R. D. Effects of temperature on growth, development, and color polymorphism in the ornate chorus frog Pseudacris ornata. Copeia 1998, 1001–1007 (1988).
Marian, M. & Pandian, T. Effect of temperature on development, growth and bioenergetics of the bullfrog tadpole Rana tigrina. J. Therm. Biol. 10, 157–161 (1985).
Alvarez, D. & Nicieza, A. Effects of temperature and food quality on anuran larval growth and metamorphosis. Funct. Ecol. 16, 640–648 (2002).
Kohl, K. D., Brun, A., Bordenstein, S. R., Caviedes‐Vidal, E. & Karasov, W. H. Gut microbes limit growth in house sparrow nestlings (Passer domesticus) but not through limitations in digestive capacity. Integr. Zool. 13, 139–151 (2018).
Google Scholar
Potti, J. et al. Bacteria divert resources from growth for Magellanic penguin chicks. Ecol. Lett. 5, 709–714 (2002).
Coates, M. E., Fuller, R., Harrison, G., Lev, M. & Suffolk, S. A comparison of the growth of chicks in the Gustafsson germ-free apparatus and in a conventional environment, with and without dietary supplements of penicillin. Br. J. Nutr. 17, 141–150 (1963).
Google Scholar
Gaskins, H., Collier, C. & Anderson, D. Antibiotics as growth promotants: mode of action. Anim. Biotechnol. 13, 29–42 (2002).
Google Scholar
Gitsels, A., Sanders, N. & Vanrompay, D. Chlamydial infection from outside to inside. Front. Microbiol. 10, 2329 (2019).
Google Scholar
Denver, R. J. Proximate mechanisms of phenotypic plasticity in amphibian metamorphosis. Am. Zool. 37, 172–184 (1997).
Google Scholar
Chevalier, C. et al. Gut microbiota orchestrates energy homeostasis during cold. Cell 163, 1360–1374 (2015).
Google Scholar
Khakisahneh, S., Zhang, X.-Y., Nouri, Z. & Wang, D.-H. Gut microbiota and host thermoregulation in response to ambient temperature fluctuations. mSystems 5, e00514–e00520 (2020).
Google Scholar
Xie, B. et al. Chlamydomonas reinhardtii thermal tolerance enhancement mediated by a mutualistic interaction with vitamin B12-producing bacteria. ISME J. 7, 1544–1555 (2013).
Google Scholar
Gutiérrez‐Pesquera, L. M. et al. Testing the climate variability hypothesis in thermal tolerance limits of tropical and temperate tadpoles. J. Biogeogr. 43, 1166–1178 (2016).
Litmer, A. R. & Murray, C. M. Critical thermal tolerance of invasion: comparative niche breadth of two invasive lizards. J. Therm. Biol. 86, 102432 (2019).
Google Scholar
Semlitsch, R. D. Effects of body size, sibship, and tail injury on the susceptibility of tadpoles to dragonfly predation. Can. J. Zool. 68, 1027–1030 (1990).
Cabrera-Guzmán, E., Crossland, M. R., Brown, G. P. & Shine, R. Larger body size at metamorphosis enhances survival, growth and performance of young cane toads (Rhinella marina). PLoS ONE 8, e70121 (2013).
Google Scholar
Tejedo, M. Effects of body size and timing of reproduction on reproductive success in female natterjack toads (Bufo calamita). J. Zool. 228, 545–555 (1992).
Warne, R. W., Crespi, E. J. & Brunner, J. L. Escape from the pond: stress and developmental responses to ranavirus infection in wood frog tadpoles. Funct. Ecol. 25, 139–146 (2011).
Urban, M. C. Accelerating extinction risk from climate change. Science 348, 571–573 (2015).
Google Scholar
Pearce, T. A. & Paustian, M. E. Are temperate land snails susceptible to climate change through reduced altitudinal ranges? A Pennsylvania example. Am. Malacol. 31, 213–224 (2013).
Wolfe, D. W. et al. Projected change in climate thresholds in the northeastern US: implications for crops, pests, livestock, and farmers. Mitig. Adapt. Strateg. Glob. Change 13, 555–575 (2008).
Huey, R. B. & Kingsolver, J. G. Evolution of thermal sensitivity of ectotherm performance. Trends Ecol. Evol. 4, 131–135 (1989).
Google Scholar
Bennett, A. F. Thermal dependence of locomotor capacity. Am. J. Physiol. 259, R253–R258 (1990).
Google Scholar
Seebacher, F. & Walter, I. Differences in locomotor performance between individuals: importance of parvalbumin, calcium handling and metabolism. J. Exp. Biol. 215, 663–670 (2012).
Google Scholar
Husak, J. F., Fox, S. F., Lovern, M. B. & Bussche, R. A. V. D. Faster lizards sire more offspring: sexual selection on whole‐animal performance. Evolution 60, 2122–2130 (2006).
Google Scholar
Mineo, P. M., Waldrup, C., Berner, N. J. & Schaeffer, P. J. Differential plasticity of membrane fatty acids in northern and southern populations of the eastern newt (Notophthalmus viridescens). J. Comp. Physiol. B 189, 249–260 (2019).
Google Scholar
Chung, D. J., Sparagna, G. C., Chicco, A. J. & Schulte, P. M. Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J. Exp. Biol. 221, 174458 (2018).
Gladwell, R., Bowler, K. & Duncan, C. Heat death in crayfish Austropotamobius pallipes: ion movements and their effects on excitable tissues during heat death. J. Therm. Biol. 1, 79–94 (1976).
Google Scholar
Wang, Z. et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57–63 (2011).
Google Scholar
Pörtner, H. Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animals. Naturwissenschaften 88, 137–146 (2001).
Google Scholar
Gräns, A. et al. Aerobic scope fails to explain the detrimental effects on growth resulting from warming and elevated CO2 in Atlantic halibut. J. Exp. Biol. 217, 711–717 (2014).
Google Scholar
Jutfelt, F. et al. Oxygen- and capacity-limited thermal tolerance: blurring ecology and physiology. J. Exp. Biol. 221, 169615 (2018).
St-Pierre, J., Charest, P.-M. & Guderley, H. Relative contribution of quantitative and qualitative changes in mitochondria to metabolic compensation during seasonal acclimatisation of rainbow trout Oncorhynchus mykiss. J. Exp. Biol. 201, 2961–2970 (1998).
Google Scholar
Grim, J., Miles, D. & Crockett, E. Temperature acclimation alters oxidative capacities and composition of membrane lipids without influencing activities of enzymatic antioxidants or susceptibility to lipid peroxidation in fish muscle. J. Exp. Biol. 213, 445–452 (2010).
Google Scholar
LeMoine, C. M., Genge, C. E. & Moyes, C. D. Role of the PGC-1 family in the metabolic adaptation of goldfish to diet and temperature. J. Exp. Biol. 211, 1448–1455 (2008).
Google Scholar
McClelland, G. B., Craig, P. M., Dhekney, K. & Dipardo, S. Temperature‐ and exercise‐induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). J. Physiol. 577, 739–751 (2006).
Google Scholar
Pichaud, N. et al. Cardiac mitochondrial plasticity and thermal sensitivity in a fish inhabiting an artificially heated ecosystem. Sci. Rep. 9, 17832 (2019).
Google Scholar
Seebacher, F., Guderley, H., Elsey, R. M. & Trosclair, P. L. Seasonal acclimatisation of muscle metabolic enzymes in a reptile (Alligator mississippiensis). J. Exp. Biol. 206, 1193–1200 (2003).
Google Scholar
Berner, N. J. & Bessay, E. P. Correlation of seasonal acclimatization in metabolic enzyme activity with preferred body temperature in the eastern red spotted newt (Notophthalmus viridescens viridescens). Comp. Biochem. Physiol. A 144, 429–436 (2006).
Vigelsø, A., Andersen, N. B. & Dela, F. The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training. Int. J. Physiol. Pathophysiol. Pharmacol. 6, 84–101 (2014).
Google Scholar
Li, Y., Park, J.-S., Deng, J.-H. & Bai, Y. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. J. Bioenerg. Biomembr. 38, 283–291 (2006).
Google Scholar
Pryor, G. S. & Bjorndal, K. A. Symbiotic fermentation, digesta passage, and gastrointestinal morphology in bullfrog tadpoles (Rana catesbeiana). Physiol. Biochem. Zool. 78, 201–215 (2005).
Google Scholar
Clark, A. & Mach, N. The crosstalk between the gut microbiota and mitochondria during exercise. Front. Physiol. 8, 319 (2017).
Google Scholar
Payne, N. L. et al. Temperature dependence of fish performance in the wild: links with species biogeography and physiological thermal tolerance. Funct. Ecol. 30, 903–912 (2016).
Van Dijk, P., Tesch, C., Hardewig, I. & Portner, H. Physiological disturbances at critically high temperatures: a comparison between stenothermal Antarctic and eurythermal temperate eelpouts (Zoarcidae). J. Exp. Biol. 202, 3611–3621 (1999).
Google Scholar
Schulte, P. M. The effects of temperature on aerobic metabolism: towards a mechanistic understanding of the responses of ectotherms to a changing environment. J. Exp. Biol. 218, 1856–1866 (2015).
Google Scholar
Gillooly, J. F., Brown, J. H., West, G. B., Savage, V. M. & Charnov, E. L. Effects of size and temperature on metabolic rate. Science 293, 2248–2251 (2001).
Google Scholar
Hoppeler, H. & Weibel, E. R. Scaling functions to body size: theories and facts. J. Exp. Biol. 208, 1573–1574 (2005).
Google Scholar
Hopkins, W. A., Rowe, C. L. & Congdon, J. D. Elevated trace element concentrations and standard metabolic rate in banded water snakes (Nerodia fasciata) exposed to coal combustion wastes. Environ. Toxicol. Chem. 18, 1258–1263 (1999).
Google Scholar
Sokolova, I. Bioenergetics in environmental adaptation and stress tolerance of aquatic ectotherms: linking physiology and ecology in a multi-stressor landscape. J. Exp. Biol. 224, 236802 (2021).
Sokolova, I. M. & Lannig, G. Interactive effects of metal pollution and temperature on metabolism in aquatic ectotherms: implications of global climate change. Clim. Res. 37, 181–201 (2008).
Peralta-Maraver, I. & Rezende, E. L. Heat tolerance in ectotherms scales predictably with body size. Nat. Clim. Change 11, 58–63 (2021).
Bahrndorff, S., Alemu, T., Alemneh, T. & Lund Nielsen, J. The microbiome of animals: implications for conservation biology. Int. J. Genomics 2016, 5304028 (2016).
Google Scholar
Hauffe, H. C. & Barelli, C. Conserve the germs: the gut microbiota and adaptive potential. Conserv. Genet. 20, 19–27 (2019).
Jiménez, R. R. & Sommer, S. The amphibian microbiome: natural range of variation, pathogenic dysbiosis, and role in conservation. Biodivers. Conserv. 26, 763–786 (2017).
Swaddle, J. P. Fluctuating asymmetry, animal behavior, and evolution. Adv. Study Behav. 32, 169–205 (2003).
R Core Team R: A Language and Environment for Statistical Computing v.3.4.3 (R Foundation for Statistical Computing, 2019).
Bates, D., Machler, M., Bolker, B. & Walker, S. Fitting linear mixed-effects models using lme4. Preprint at https://arxiv.org/abs/1406.5823 (2014).
Pinheiro, J. et al. nlme: Linear and Nonlinear Mixed Effects Models. R package version 3 (2017).
Hulbert, A., Pamplona, R., Buffenstein, R. & Buttemer, W. Life and death: metabolic rate, membrane composition, and life span of animals. Physiol. Rev. 87, 1175–1213 (2007).
Google Scholar
Oksanen, J. et al. vegan: Community Ecology Package. R package version 2 (2013).
Mary-Huard, T., Daudin, J.-J., Baccini, M., Biggeri, A. & Bar-Hen, A. Biases induced by pooling samples in microarray experiments. Bioinformatics 23, i313–i318 (2007).
Google Scholar
Singer, J. D. & Willett, J. B. It’s about time: using discrete-time survival analysis to study duration and the timing of events. J. Educ. Stat. 18, 155–195 (1993).
Mallick, H. et al. Multivariable association discovery in population-scale meta-omics studies. PLoS Comput. Biol. 17, e100442 (2021).
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