Keller, L. F. & Waller, D. M. Inbreeding effects in wild populations. Trends Ecol. Evol. 17, 230–241 (2002).
Boakes, E. H., Wang, J. & Amos, W. An investigation of inbreeding depression and purging in captive pedigreed populations. Heredity (Edinb). 98, 172–182 (2007).
Bozzuto, C., Biebach, I., Muff, S., Ives, A. R. & Keller, L. F. Inbreeding reduces long-term growth of Alpine ibex populations. Nat. Ecol. Evol. 3, 1359–1364 (2019).
Saccheri, I., Kuussaari, M., Kankare, M., Vikman, P. & Hanski, I. Inbreeding and extinction in a butterfly metapopulation. Nature 392, 491–494 (1998).
Kardos, M., Taylor, H. R., Ellegren, H., Luikart, G. & Allendorf, F. W. Genomics advances the study of inbreeding depression in the wild. Evol. Appl. 9, 1205–1218 (2016).
Allendorf, F. W., Luikart, G. & Aitken, S. N. Conservation and the genetics of populations. (Wiley-Blackwell, 2013).
Johnson, H. E., Mills, L. S., Wehausen, J. D., Stephenson, T. R. & Luikart, G. Translating effects of inbreeding depression on component vital rates to overall population growth in endangered bighorn sheep. Conserv. Biol. 25, 1240–1249 (2011).
Frankham, R. Where are we in conservation genetics and where do we need to go?. Conserv. Genet. 11, 661–663 (2010).
Pierson, J. C. et al. Incorporating evolutionary processes into population viability models. Conserv. Biol. 29, 755–764 (2015).
Huisman, J., Kruuk, L. E. B., Ellisa, P. A., Clutton-Brock, T. & Pemberton, J. M. Inbreeding depression across the lifespan in a wild mammal population. Proc. Natl. Acad. Sci. U. S. A. 113, 3585–3590 (2016).
Grueber, C. E., Laws, R. J., Nakagawa, S. & Jamieson, I. G. Inbreeding depression accumulation across life-history stages of the endangered takahe. Conserv. Biol. 24, 1617–1625 (2010).
Harrisson, K. A. et al. Lifetime fitness costs of inbreeding and being inbred in a critically endangered bird. Curr. Biol. 29, 2711-2717.e4 (2019).
Ralls, K., Ballou, J. D. & Templeton, A. Estimates of lethal equivalents and the cost of inbreeding in mammals. Conserv. Biol. 2, 185–192 (1988).
Hoeck, P. E. A., Wolak, M. E., Switzer, R. A., Kuehler, C. M. & Lieberman, A. A. Effects of inbreeding and parental incubation on captive breeding success in Hawaiian crows. Biol. Conserv. 184, 357–364 (2015).
Jimenez, J. A., Hughes, K. A., Alaks, G., Graham, L. & Lacy, R. C. An experimental study of inbreeding depression in a natural habitat. Science (80-. ). 266, 271–273 (1994).
Van Oosterhout, C., Zijlstra, W. G., Van Heuven, M. K. & Brakefield, P. M. Inbreeding depression and genetic load in laboratory metapopulations of the butterfly Bicyclus anynana. Evolution (N. Y). 54, 218–225 (2000).
Szulkin, M., Garant, D., Mccleery, R. H. & Sheldon, B. C. Inbreeding depression along a life-history continuum in the great tit. J. Evol. Biol. 20, 1531–1543 (2007).
Wolak, M. E., Arcese, P., Keller, L. F., Nietlisbach, P. & Reid, J. M. Sex-specific additive genetic variances and correlations for fitness in a song sparrow (Melospiza melodia) population subject to natural immigration and inbreeding. Evolution (N. Y). 72, 2057–2075 (2018).
Kennedy, E. S., Grueber, C. E., Duncan, R. P. & Jamieson, I. G. Severe inbreeding depression and no evidence of purging in an extremely inbred wild species-the chatham island black robin. Evolution (N. Y). 68, 987–995 (2014).
Jamieson, I. G., Tracy, L. N., Fletcher, D. & Armstrong, D. P. Moderate inbreeding depression in a reintroduced population of North Island robins. Anim. Conserv. 10, 95–102 (2007).
Norén, K., Godoy, E., Dalén, L., Meijer, T. & Angerbjörn, A. Inbreeding depression in a critically endangered carnivore. Mol. Ecol. https://doi.org/10.1111/mec.13674 (2016).
Sæther, B. E. & Bakke, Ø. Avian life history variation and contribution of demographic traits to the population growth rate. Ecology 81, 642–653 (2000).
Beissinger, S. R. & McCullough, D. R. Population viability analysis. (University of Chicago Press, 2002).
Lacy, R. C. Lessons from 30 years of population viability analysis of wildlife populations. Zoo Biol. 38, 67–77 (2019).
Traill, L. W., Bradshaw, C. J. A. & Brook, B. W. Minimum viable population size: A meta-analysis of 30 years of published estimates. Biol. Conserv. 139, 159–166 (2007).
O’Grady, J. J. et al. Realistic levels of inbreeding depression strongly affect extinction risk in wild populations. Biol. Conserv. 133, 42–51 (2006).
Lacy, R. C., Miller, P. S. & Traylor-Holzer, K. Vortex 10 user’s manual. (2017).
Ballou, J. D. & Lacy, R. C. in Population management for survival and recovery (eds. Ballou, J. D., Gilpin, M. & Foose, T. J.) 76–111 (Columbia University Press, 1995).
Armbruster, P. & Reed, D. H. Inbreeding depression in benign and stressful environments. Heredity (Edinb). 95, 235–242 (2005).
Fox, C. W. & Reed, D. H. Inbreeding depression increases with environmental stress: an experimental study and meta-analysis. Evolution (N. Y). 65, 246–258 (2011).
Baker, R. H. The avifauna of Micronesia, its origin, evolution and distribution. (University of Kansas Publications, 1951).
Marshall, J. T. The endemic avifauna of Sapan, Tinian Guam and Palau. Condor 51, 200–221 (1949).
Wiles, G. J., Bart, J., Beck, R. E. & Aguon, C. F. Impacts of the brown tree snake: patterns of decline and species persistence in Guam’s avifauna. Conserv. Biol. 17, 1350–1360 (2003).
Savidge, J. A. Extinction of an island forest avifauna by an introduced snake. Ecology 68, 660–668 (1987).
Haig, S. M., Ballou, J. D. & Casna, N. J. Genetic identification of kin in Micronesian kingfishers. J. Hered. 86, 423–431 (1995).
Lacy, R. C., Ballou, J. D. & Pollak, J. P. PMx: Software package for demographic and genetic analysis and management of pedigreed populations. Methods Ecol. Evol. 3, 433–437 (2012).
Ferrie, G. Using molecular genetic and demographic tools to improve management of ex situ avian populations. (University of Central Florida, 2017). http://stars.library.ucf.edu/etd/5709
Zuur, A. F., Ieno, E. N. & Elphick, C. S. A protocol for data exploration to avoid common statistical problems. Methods Ecol. Evol. 1, 3–14 (2010).
Burnham, K. . & Anderson, D. R. Model selection and multimodel inference: a practical information-theoretic approach. (Springer, 2002).
Whittingham, M. J., Stephens, P. A., Bradbury, R. B. & Freckleton, R. P. Why do we still use stepwise modelling in ecology and behaviour?. J. Anim. Ecol. 75, 1182–1189 (2006).
Nietlisbach, P., Muff, S., Reid, J. M., Whitlock, M. C. & Keller, L. F. Nonequivalent lethal equivalents: Models and inbreeding metrics for unbiased estimation of inbreeding load. Evol. Appl. 12, 266–279 (2018).
Zou, G. A modified poisson regression approach to prospective studies with binary data. Am. J. Epidemiol. 159, 702–706 (2004).
Bates, D., Mächler, M., Bolker, B. M. & Walker, S. C. Fitting linear mixed-effects models using lme4. J. Stat. Softw. 67, 1–48 (2015).
R Development Core Team. R: A language and environment for statistical computing. (2019).
Lacy, R. C. & Pollak, J. P. Vortex: A stochastic simulation of the extinction process. (2017).
Hemmings, N. L., Slate, J. & Birkhead, T. R. Inbreeding causes early death in a passerine bird. Nat. Commun. 3, 1–4 (2012).
Tiira, K., Piironen, J. & Primmer, C. R. Evidence for reduced genetic variation in severely deformed juvenile salmonids. Can. J. Fish. Aquat. Sci. 63, 2700–2707 (2006).
Wang, J., Hill, W. G., Charlesworth, D. & Charlesworth, B. Dynamics of inbreeding depression due to deleterious mutations in small populations: mutation parameters and inbreeding rate. Genet. Res. 74, 165–178 (1999).
Husband, B. C. & Schemske, D. W. Evolution of the magnitude and timing of inbreeding depression in plants. Evolution (N. Y). 50, 54–70 (1996).
de Boer, R. A., Eens, M. & Müller, W. Sex-specific effects of inbreeding on reproductive senescence. Proc. R. Soc. B Biol. Sci. 285, (2018).
Keller, L. F., Reid, J. M. & Arcese, P. Testing evolutionary models of senescence in a natural population: Age and inbreeding effects on fitness components in song sparrows. Proc. R. Soc. B Biol. Sci. 275, 597–604 (2008).
Partridge, L. & Mangel, M. Messages from mortality: The evolution of death rates in the old. Trends Ecol. Evol. 14, 438–442 (1999).
Charlesworth, B. & Hughes, K. A. Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence. Proc. Natl. Acad. Sci. U. S. A. 93, 6140–6145 (1996).
Kristensen, T. N., Loeschcke, V. & Hoffmann, A. A. Linking inbreeding effects in captive populations with fitness in the wild: Release of replicated Drosophila melanogaster lines under different temperatures. Conserv. Biol. 22, 189–199 (2008).
Ryman, N. & Laikre, L. Effects of supportive breeding on the genetically effective population size. Conserv. Biol. 5, 325–329 (1991).
Hedrick, P. W. & Garcia-Dorado, A. Understanding inbreeding depression, purging, and genetic rescue. Trends Ecol. Evol. 31, 940–952 (2016).
Kalinowski, S. T., Hedrick, P. W. & Miller, P. S. Inbreeding Depression in the Speke’s Gazelle Captive Breeding Program. Conserv. Biol. 14, 1375–1384 (2000).
Gilligan, D. M. & Frankham, R. Dynamics of individual adaptation processes. Conserv. Genet. 4, 189–197 (2003).
Christie, M. R., Marine, M. L., French, R. A. & Blouin, M. S. Genetic adaptation to captivity can occur in a single generation. Proc. Natl. Acad. Sci. U. S. A. 109, 238–242 (2012).
Grueber, C. E., Waters, J. M. & Jamieson, I. G. The imprecision of heterozygosity-fitness correlations hinders the detection of inbreeding and inbreeding depression in a threatened species. Mol. Ecol. 20, 67–79 (2011).
Milligan, M. C., Wells, S. L. & McNew, L. B. A population viability analysis for sharp-tailed grouse to inform reintroductions. J. Fish Wildl. Manag. 9, 565–581 (2018).
Research needs & implications for population management. Moßbrucker, A. M., Imron, M. A., Pudtatmoko, S., Pratje, P. & Sumardi. Modelling the fate of Sumatran elephants in Bukit Tigapuluh, Indonesia. J. For. Sci. 10, 5–18 (2016).
Sharpe, M. & Berggren, P. Indian Ocean humpback dolphin in the Menai Bay off the south coast of Zanzibar, East Africa is Critically Endangered. Aquat. Conserv. Mar. Freshw. Ecosyst. 29, 2133–2146 (2019).
McQuillan, R. et al. Runs of homozygosity in European populations. Am. J. Hum. Genet. 83, 359–372 (2008).
Caballero, A., Bravo, I. & Wang, J. Inbreeding load and purging: Implications for the short-term survival and the conservation management of small populations. Heredity (Edinb). 118, 177–185 (2017).
Liao, W. & Reed, D. H. Inbreeding-environment interactions increase extinction risk. Anim. Conserv. 12, 54–61 (2009).
Melbourne, B. A. & Hastings, A. Extinction risk depends strongly on factors contributing to stochasticity. Nature 454, 100–103 (2008).
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